PLCB2 (phospholipase C beta 2)

Gene

• Entrez ID: 5330
• Gene name: Phospholipase C beta 2
• Gene symbol: PLCB2
• Synonyms (NCBI Gene): PLC-beta-2
• Chromosome: 15
• Chromosome location: 15q15.1
• Summary: The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins a

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028821	hsa-miR-26b-5p	Microarray	19088304
MIRT496162	hsa-miR-4762-5p	PAR-CLIP	22291592
MIRT496162	hsa-miR-4762-5p	PAR-CLIP	22291592
MIRT1239635	hsa-let-7a	CLIP-seq
MIRT1239636	hsa-let-7b	CLIP-seq
MIRT1239637	hsa-let-7c	CLIP-seq
MIRT1239638	hsa-let-7d	CLIP-seq
MIRT1239639	hsa-let-7e	CLIP-seq
MIRT1239640	hsa-let-7f	CLIP-seq
MIRT1239641	hsa-let-7g	CLIP-seq
MIRT1239642	hsa-let-7i	CLIP-seq
MIRT1239643	hsa-miR-1273f	CLIP-seq
MIRT1239644	hsa-miR-1294	CLIP-seq
MIRT1239645	hsa-miR-145	CLIP-seq
MIRT1239646	hsa-miR-196a	CLIP-seq
MIRT1239647	hsa-miR-196b	CLIP-seq
MIRT1239648	hsa-miR-202	CLIP-seq
MIRT1239649	hsa-miR-2467-3p	CLIP-seq
MIRT1239650	hsa-miR-371-3p	CLIP-seq
MIRT1239651	hsa-miR-371b-3p	CLIP-seq
MIRT1239652	hsa-miR-4270	CLIP-seq
MIRT1239653	hsa-miR-4297	CLIP-seq
MIRT1239654	hsa-miR-4300	CLIP-seq
MIRT1239655	hsa-miR-4316	CLIP-seq
MIRT1239656	hsa-miR-4441	CLIP-seq
MIRT1239657	hsa-miR-4458	CLIP-seq
MIRT1239658	hsa-miR-4476	CLIP-seq
MIRT1239659	hsa-miR-4500	CLIP-seq
MIRT1239660	hsa-miR-4514	CLIP-seq
MIRT1239661	hsa-miR-4534	CLIP-seq
MIRT1239662	hsa-miR-455-3p	CLIP-seq
MIRT1239663	hsa-miR-4677-3p	CLIP-seq
MIRT1239664	hsa-miR-4692	CLIP-seq
MIRT1239665	hsa-miR-4716-3p	CLIP-seq
MIRT1239666	hsa-miR-4723-5p	CLIP-seq
MIRT1239667	hsa-miR-4727-5p	CLIP-seq
MIRT1239668	hsa-miR-4728-5p	CLIP-seq
MIRT1239669	hsa-miR-4755-3p	CLIP-seq
MIRT1239670	hsa-miR-4802-5p	CLIP-seq
MIRT1239671	hsa-miR-515-3p	CLIP-seq
MIRT1239672	hsa-miR-518d-5p	CLIP-seq
MIRT1239673	hsa-miR-519b-5p	CLIP-seq
MIRT1239674	hsa-miR-519c-5p	CLIP-seq
MIRT1239675	hsa-miR-519e	CLIP-seq
MIRT1239676	hsa-miR-520c-5p	CLIP-seq
MIRT1239677	hsa-miR-526a	CLIP-seq
MIRT1239678	hsa-miR-544	CLIP-seq
MIRT1239679	hsa-miR-920	CLIP-seq
MIRT1239680	hsa-miR-98	CLIP-seq
MIRT2070485	hsa-miR-3157-5p	CLIP-seq
MIRT1239660	hsa-miR-4514	CLIP-seq
MIRT1239664	hsa-miR-4692	CLIP-seq
MIRT2070486	hsa-miR-4792	CLIP-seq
MIRT2070487	hsa-miR-587	CLIP-seq
MIRT2297631	hsa-miR-125a-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001580	Process	Detection of chemical stimulus involved in sensory perception of bitter taste	IEA
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IBA
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IDA	9188725
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IEA
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IMP	8519600
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	TAS	1644792
GO:0004629	Function	Phospholipase C activity	IEA
GO:0004629	Function	Phospholipase C activity	TAS	7649993
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	21115837
GO:0005543	Function	Phospholipid binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006644	Process	Phospholipid metabolic process	TAS	1644792
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IEA
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	ISS
GO:0008081	Function	Phosphoric diester hydrolase activity	IEA
GO:0016042	Process	Lipid catabolic process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0031680	Component	G-protein beta/gamma-subunit complex	IEA
GO:0031683	Function	G-protein beta/gamma-subunit complex binding	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0046488	Process	Phosphatidylinositol metabolic process	IBA
GO:0046488	Process	Phosphatidylinositol metabolic process	IDA	9188725
GO:0046872	Function	Metal ion binding	IEA
GO:0048015	Process	Phosphatidylinositol-mediated signaling	IBA
GO:0050913	Process	Sensory perception of bitter taste	IEA
GO:0051209	Process	Release of sequestered calcium ion into cytosol	IBA
GO:0098992	Component	Neuronal dense core vesicle	IEA
GO:0120548	Function	Phosphatidylinositol phospholipase C activity	IEA

Other IDs

• MIM: 604114
• HGNC: 9055
• e!Ensembl: ENSG00000137841

Protein

• UniProt ID: Q00722
• Protein name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-2) (Phospholipase C-beta-2) (PLC-beta-2)
• Protein function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:1644792, PubMed:9188725). In neutrophils, partici
• PDB: 2FJU, 2ZKM
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF17787	PH_14	12 → 141	PH domain	Domain
  PF09279	EF-hand_like	211 → 305	Phosphoinositide-specific phospholipase C, efhand-like	Domain
  PF00388	PI-PLC-X	314 → 464	Phosphatidylinositol-specific phospholipase C, X domain	Family
  PF00387	PI-PLC-Y	546 → 660	Phosphatidylinositol-specific phospholipase C, Y domain	Family
  PF00168	C2	682 → 784	C2 domain	Domain
  PF08703	PLC-beta_C	978 → 1153	PLC-beta C terminal	Domain

• Sequence:

  MSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLD
  ITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKE
  NVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKR
  VEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
  LTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPEN
  SVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDC
  WKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKM
  AEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGE
  AEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEV
  TAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQM
  SRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEF
  MRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRT
  KLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHL
  CLHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGL
  PEKPFPLASPVASQVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGVVK
  LQRRHEKELRELERRGARRWEELLQRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLP
  REESAGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMEL
  AREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREINNSHI
  QEVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKE
  SVRACLRTCFPSEAKDKPERACECPPELCEQDPLIAKADAQESRL

• Sequence length: 1185

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CHRONIC KIDNEY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Oromandibular-limb hypogenesis spectrum	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thrombocytopenia	Uncertain significance	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma	Adenocarcinoma	BEFREE	31080817		★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	28578378	Associate	★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	27465150	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	26521046, 29512753		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	22905097, 24330829, 26521046, 28870198, 29512753, 30497437, 30582225	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	12480928	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	30896816	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Intraductal Noninfiltrating	Intraductal noninfiltrating carcinoma	Pubtator	30582225	Stimulate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	28029655	Associate	★☆☆☆☆ Found in Text Mining only
Chronic Kidney Diseases	Kidney Disease	BEFREE	30226566		★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn disease	Pubtator	23437289	Associate	★☆☆☆☆ Found in Text Mining only
Dental Caries	Dental caries	Pubtator	36613519	Inhibit	★☆☆☆☆ Found in Text Mining only
Dental Caries	Dental caries	Pubtator	36613519	Associate	★☆☆☆☆ Found in Text Mining only
Diabetic Angiopathies	Diabetic angiopathies	Pubtator	22916176	Associate	★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	30226566	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypoxia	Hypoxia	Pubtator	30497437	Associate	★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	23437289	Associate	★☆☆☆☆ Found in Text Mining only
Invasive Ductal Breast Carcinoma	Invasive Duct and Lobular Carcinoma	BEFREE	30582225		★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid	Myeloid leukemia	Pubtator	30497437	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	33536360	Associate	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	30896816		★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver cirrhosis	Pubtator	25460309	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	26521046, 29512753		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	24330829, 28870198, 30582225, 30896816, 31746389		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	LHGDN	16525635, 17429106		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	26785288, 28870198, 30582225		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	31746389		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Microvascular Angina	Microvascular angina	Pubtator	22916176	Associate	★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	BEFREE	30226566		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myocardial Infarction	Myocardial infarction	Pubtator	30226566	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neoplasms	Neoplasms	BEFREE	26785288, 30582225		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	22083550	Stimulate	★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	30696932		★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic ovary syndrome	Pubtator	26308735	Associate	★☆☆☆☆ Found in Text Mining only
Sarcoma Ewing	Sarcoma	Pubtator	10638960	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Diseases	Stomach disease	Pubtator	22083550	Associate	★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	24330829		★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	24330829, 28870198	Associate	★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	25921176	Associate	★☆☆☆☆ Found in Text Mining only