Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 182

8 diseases · 12 shared-gene connections
8 Diseases
612 Unique genes
0.097 Avg. similarity score
Diabetes mellitus Most-connected disease (5 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Diabetes mellitus 5 5 296
Diabetic eye disease 4 4 48
Diabetic neuropathy 4 4 234
Diabetic retinopathy 4 4 164
Gestational diabetes 4 4 90
Perlman syndrome 1 1 1
genitourinary and/or brain malformation syndrome 1 1 1
mehmo syndrome 1 1 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
ADCY5 5 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy and 1 more
CCND2 5 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy and 1 more
CDKAL1 5 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy and 1 more
HLA-DQB1 5 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy and 1 more
IGF2BP2 5 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy and 1 more
KCNQ1 5 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy and 1 more
SLC30A8 5 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy and 1 more
TCF7L2 5 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy and 1 more
ADIPOQ 4 / 8 Diabetes mellitus, Diabetic neuropathy, Diabetic retinopathy, Gestational diabetes
ANK1 4 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy
ARPIN-AP3S2 4 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy
ASCL2 4 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy
CDC123 4 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy
COBLL1 4 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy
FTO 4 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy
GCKR 4 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic retinopathy, Gestational diabetes
GPSM1 4 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy
HMG20A 4 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy
INSR 4 / 8 Diabetes mellitus, Diabetic neuropathy, Diabetic retinopathy, Gestational diabetes
JAZF1 4 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy
MACF1 4 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy
MACIR 4 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy
NRXN3 4 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy
NYAP2 4 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy
PAX4 4 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic retinopathy, Gestational diabetes
PPARG 4 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy
TGFB1 4 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy
TRPS1 4 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy
WFS1 4 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy
ZMIZ1 4 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy, Diabetic retinopathy
AGBL2 3 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic retinopathy
AGMO 3 / 8 Diabetes mellitus, Diabetic neuropathy, Diabetic retinopathy
AP3S2 3 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic retinopathy
APOE 3 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic retinopathy
CCND1 3 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic retinopathy
CENPW 3 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic retinopathy
CEP68 3 / 8 Diabetes mellitus, Diabetic neuropathy, Diabetic retinopathy
FGF2 3 / 8 Diabetic neuropathy, Diabetic retinopathy, Gestational diabetes
HHEX 3 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy
HLA-DQB3 3 / 8 Diabetes mellitus, Diabetic eye disease, Gestational diabetes
IL6 3 / 8 Diabetes mellitus, Diabetic retinopathy, Gestational diabetes
INS 3 / 8 Diabetes mellitus, Diabetic neuropathy, Diabetic retinopathy
KLHL42 3 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic retinopathy
LEPR 3 / 8 Diabetes mellitus, Diabetic neuropathy, Gestational diabetes
MTNR1B 3 / 8 Diabetes mellitus, Diabetic neuropathy, Gestational diabetes
NKX6-3 3 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic neuropathy
PNPLA3 3 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic retinopathy
PON1 3 / 8 Diabetes mellitus, Diabetic neuropathy, Diabetic retinopathy
PROX1 3 / 8 Diabetes mellitus, Diabetic neuropathy, Diabetic retinopathy
THADA 3 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic retinopathy
TLR4 3 / 8 Diabetes mellitus, Diabetic neuropathy, Diabetic retinopathy
TMEM154 3 / 8 Diabetes mellitus, Diabetic eye disease, Diabetic retinopathy
UBE3C 3 / 8 Diabetes mellitus, Diabetic neuropathy, Diabetic retinopathy
ABCB10 2 / 8 Diabetes mellitus, Diabetic retinopathy
ABO 2 / 8 Diabetes mellitus, Diabetic neuropathy
ACE 2 / 8 Diabetic neuropathy, Diabetic retinopathy
ACE2 2 / 8 Diabetic neuropathy, Diabetic retinopathy
ACP1 2 / 8 Diabetes mellitus, Diabetic retinopathy
AGT 2 / 8 Diabetic neuropathy, Diabetic retinopathy
AKR1B1 2 / 8 Diabetic neuropathy, Diabetic retinopathy
ALPK1 2 / 8 Diabetes mellitus, Diabetic neuropathy
ANKH 2 / 8 Diabetes mellitus, Diabetic neuropathy
AOC3 2 / 8 Diabetes mellitus, Diabetic neuropathy
APOB 2 / 8 Diabetes mellitus, Diabetic retinopathy
ARAP1 2 / 8 Diabetes mellitus, Gestational diabetes
ASIP 2 / 8 Diabetes mellitus, Diabetic neuropathy
AUTS2 2 / 8 Diabetes mellitus, Diabetic eye disease
BMP8A 2 / 8 Diabetes mellitus, Diabetic retinopathy
CASP3 2 / 8 Diabetic neuropathy, Diabetic retinopathy
CAT 2 / 8 Diabetes mellitus, Diabetic neuropathy
CDK12 2 / 8 Diabetes mellitus, Diabetic neuropathy
CTRB2 2 / 8 Diabetes mellitus, Diabetic neuropathy
DIS3L2 2 / 8 Diabetic neuropathy, Perlman syndrome
EIF2S3 2 / 8 Diabetes mellitus, mehmo syndrome
EPO 2 / 8 Diabetic neuropathy, Diabetic retinopathy
EXOC6 2 / 8 Diabetic neuropathy, Diabetic retinopathy
FN1 2 / 8 Diabetes mellitus, Diabetic neuropathy
FSTL5 2 / 8 Diabetic neuropathy, Diabetic retinopathy
GAD2 2 / 8 Diabetic retinopathy, Gestational diabetes
GCK 2 / 8 Diabetes mellitus, Gestational diabetes
GIPR 2 / 8 Diabetes mellitus, Diabetic retinopathy
GLIS3 2 / 8 Diabetes mellitus, Gestational diabetes
GPR158 2 / 8 Diabetic neuropathy, Diabetic retinopathy
GRB14 2 / 8 Diabetes mellitus, Diabetic retinopathy
GSTM1 2 / 8 Diabetes mellitus, Diabetic retinopathy
GSTT1 2 / 8 Diabetes mellitus, Diabetic retinopathy
HAPLN4 2 / 8 Diabetes mellitus, Diabetic eye disease
HFE 2 / 8 Diabetes mellitus, Diabetic retinopathy
HLA-DQA1 2 / 8 Diabetes mellitus, Diabetic neuropathy
HLA-DRB1 2 / 8 Diabetic neuropathy, Diabetic retinopathy
HNF1A 2 / 8 Diabetes mellitus, Gestational diabetes
IGF2BP1 2 / 8 Diabetes mellitus, Diabetic neuropathy
ITGA2 2 / 8 Diabetes mellitus, Diabetic retinopathy
KL 2 / 8 Diabetes mellitus, Diabetic neuropathy
LINGO2 2 / 8 Diabetes mellitus, Gestational diabetes
MAU2 2 / 8 Diabetes mellitus, Diabetic retinopathy
MED30 2 / 8 Diabetes mellitus, Gestational diabetes
MMP2 2 / 8 Diabetic neuropathy, Diabetic retinopathy
MMP9 2 / 8 Diabetic neuropathy, Diabetic retinopathy
MTCH2 2 / 8 Diabetic eye disease, Diabetic retinopathy
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
AGE-RAGE signaling pathway in diabetic complications
BCL2, CCND1, CYBB, FN1, IL6, PLCG1, RAC1, TGFB1, AGT, CCL2, COL4A1, NOS3
 KEGG 27 / 101 5.2× 5.27e-13 1.20e-10 ✓ sig.
HIF-1 signaling pathway
BCL2, CYBB, HK1, IL6, INS, INSR, PLCG1, TFRC, TLR4, CDKN1A, NOS3, RELA
 KEGG 22 / 110 3.9× 2.77e-8 2.14e-6 ✓ sig.
PI3K-Akt signaling pathway
BCL2, CCND1, CCND2, CSF1R, FGFR3, FN1, IL6, INS, INSR, IRS1, ITGA2, PDGFC
 KEGG 42 / 361 2.3× 4.45e-7 2.42e-5 ✓ sig.
Malaria
IL6, TGFB1, THBS2, TLR4, CCL2, HBB, HGF, IFNG, GYPA, ICAM1, IL10, THBS1
 KEGG 13 / 50 5.1× 8.53e-7 4.25e-5 ✓ sig.
Type I diabetes mellitus
HLA-C, HLA-DQA1, HLA-DQA2, HLA-DQB1, INS, HLA-DRB1, IFNG, GAD2, HLA-B, LTA, PTPRN2, TNF
 KEGG 12 / 44 5.4× 1.29e-6 6.11e-5 ✓ sig.
Interleukin-4 and Interleukin-13 signaling
BCL2, CCND1, FN1, IL6, POMC, PTGS2, TGFB1, FGF2, CCL2, CDKN1A, VEGFA, JAK1
 Reactome 19 / 108 3.5× 1.93e-6 8.53e-5 ✓ sig.
Type II diabetes mellitus
ABCC8, ADIPOQ, GCK, HK1, INS, INSR, IRS1, KCNJ11, PRKCE, PIK3R1, TNF, HKDC1
 KEGG 12 / 47 5.0× 2.78e-6 1.17e-4 ✓ sig.
Maturity onset diabetes of the young
GCK, HHEX, HNF1A, HNF1B, HNF4A, INS, PAX4, PAX6, RFX6
 KEGG 9 / 26 6.8× 3.12e-6 1.29e-4 ✓ sig.
Human T-cell leukemia virus 1 infection
ADCY5, CALR, CCND1, CCND2, CDKN2C, CRTC1, ETS1, HLA-C, HLA-DQA1, HLA-DQA2, HLA-DQB1, IL6
 KEGG 29 / 224 2.5× 3.42e-6 1.38e-4 ✓ sig.
Leishmaniasis
CYBB, HLA-DQA1, HLA-DQA2, HLA-DQB1, NCF1, PTGS2, TGFB1, TLR4, RELA, HLA-DRB1, JAK1, IFNG
 KEGG 15 / 78 3.8× 7.51e-6 2.64e-4 ✓ sig.
Synthesis, secretion, and deacylation of Ghrelin
CRHR2, INS, LEP, GHRL, GH1, IGF1, PCSK1
 Reactome 7 / 19 7.2× 2.54e-5 7.25e-4 ✓ sig.
Proteoglycans in cancer
ANK1, CCND1, FN1, ITGA2, PLCG1, RAC1, TGFB1, TLR4, FGF2, CDKN1A, KDR, VEGFA
 KEGG 25 / 204 2.4× 4.11e-5 1.09e-3 ✓ sig.
EGFR tyrosine kinase inhibitor resistance
BCL2, FGFR3, IL6, PDGFC, PLCG1, FGF2, AXL, GAS6, KDR, VEGFA, JAK1, HGF
 KEGG 14 / 80 3.4× 4.57e-5 1.19e-3 ✓ sig.
Efferocytosis
ANO4, BCAR1, CALR, CEBPB, CPT1A, PLA2G6, PPARG, PTGS2, RAB7B, RAC1, SIRT1, TGFB1
 KEGG 21 / 157 2.6× 4.66e-5 1.20e-3 ✓ sig.
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
APOB, APOE, CP, FN1, IL6, MEN1, PCSK9, WFS1, ALB, GAS6, KLK1, AMTN
 Reactome 18 / 125 2.8× 6.06e-5 1.49e-3 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
CAT, CSF1R, FGFR3, FN1, INS, INSR, IRS1, PDGFC, RAC1, SIRT1, TCF7L2, TGFB1
 GO:0051897 34 / 217 4.8× 2.98e-14 1.79e-11 ✓ sig.
response to hypoxia
ADIPOQ, ASCL2, CAT, CPT1A, CYP1A1, ITGA2, KCNJ11, PML, SOD3, TFRC, TGFB1, UCP3
 GO:0001666 29 / 176 5.0× 6.46e-13 3.08e-10 ✓ sig.
response to xenobiotic stimulus
ABCC8, ACSL1, ADIPOQ, BCL2, CALR, CAT, CCND1, CPT1A, CYBB, CYP1A1, ITGA2, KCNJ11
 GO:0009410 33 / 248 4.1× 7.59e-12 2.86e-9 ✓ sig.
positive regulation of MAPK cascade
ADRB1, FGFR3, IL6, INS, INSR, KSR2, MAP3K5, SOD1, TGFB1, AR, FGF2, LEP
 GO:0043410 31 / 224 4.2× 1.18e-11 4.29e-9 ✓ sig.
regulation of blood pressure
ATP2B1, KCNQ1, POMC, PPARG, PTGS2, SOD1, LEP, SOD2, ACE, AGT, NOS3, GUCY1A1
 GO:0008217 19 / 83 7.0× 1.69e-11 5.88e-9 ✓ sig.
positive regulation of cell population proliferation
ALDH1A2, BCL2, CALR, CCND1, CCND2, CSF1R, FGFR3, FN1, HMGA2, IGF2BP1, IL6, INS
 GO:0008284 48 / 532 2.8× 2.25e-10 5.94e-8 ✓ sig.
positive regulation of gene expression
ALDH1A2, APOB, BCL3, CALR, CEBPB, ETS1, FN1, HFE, HMGA2, HNF1B, IL6, INS
 GO:0010628 45 / 504 2.7× 1.18e-9 2.59e-7 ✓ sig.
regulation of insulin secretion
CPT1A, GCK, GIPR, HNF4A, IL6, KCNJ11, MTNR1B, RFX6, TFAP2B, LEP, IFNG, GIP
 GO:0050796 13 / 46 8.6× 1.66e-9 3.51e-7 ✓ sig.
response to glucose
ADIPOQ, GCK, GCKR, GIPR, HNF1B, HNF4A, LPL, SLC30A8, TCF7L2, TGFB1, TXNIP, CASP3
 GO:0009749 15 / 68 6.7× 4.01e-9 7.68e-7 ✓ sig.
positive regulation of ERK1 and ERK2 cascade
APOE, CSF1R, FGFR3, NOTCH2, PDE8B, PDGFC, PTPN22, TGFB1, TLR4, CCN2, FGF2, GAS6
 GO:0070374 25 / 201 3.8× 1.09e-8 1.84e-6 ✓ sig.
positive regulation of endothelial cell migration
BCAR1, CALR, ETS1, PROX1, RAC1, FGF2, AGT, KDR, VEGFA, NRP2, SASH1, ANGPT1
 GO:0010595 14 / 66 6.5× 2.27e-8 3.48e-6 ✓ sig.
negative regulation of apoptotic process
BCL2, BCL3, CAT, CCND2, CSF1R, FAIM2, HMGA2, HNF1B, IL6, NOTCH2, PTGS2, SIRT1
 GO:0043066 43 / 524 2.5× 3.35e-8 4.82e-6 ✓ sig.
positive regulation of transcription by RNA polymerase II
ASCL2, AUTS2, BAZ1B, BCL3, BRD3, BSX, CDK12, CEBPB, CHD6, CRTC1, ETS1, GLIS3
 GO:0045944 75 / 1,208 1.9× 6.25e-8 8.17e-6 ✓ sig.
negative regulation of neuron apoptotic process
BCL2, CCND1, CEBPB, FAIM2, MTNR1B, SIRT1, SOD1, TFAP2B, TFAP2D, WFS1, SOD2, AXL
 GO:0043524 21 / 160 4.0× 6.40e-8 8.34e-6 ✓ sig.
positive regulation of blood vessel endothelial cell migration
ETS1, PLCG1, SIRT1, TGFB1, FGF2, KDR, NFE2L2, NOS3, VEGFA, PLG, ANGPT1, THBS1
 GO:0043536 12 / 51 7.2× 6.75e-8 8.72e-6 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Diabetes mellitus Diabetic eye disease 0.154 46 3.32e-78 2.72e-76 ✓ sig.
Diabetic eye disease Diabetic retinopathy 0.217 38 6.59e-68 4.87e-66 ✓ sig.
Diabetes mellitus Diabetic retinopathy 0.158 63 2.67e-66 1.94e-64 ✓ sig.
Diabetic neuropathy Diabetic retinopathy 0.157 54 2.33e-58 1.47e-56 ✓ sig.
Diabetes mellitus Diabetic neuropathy 0.135 63 4.83e-55 2.90e-53 ✓ sig.
Diabetic eye disease Diabetic neuropathy 0.110 28 3.02e-39 1.30e-37 ✓ sig.
Diabetes mellitus Gestational diabetes 0.066 24 3.59e-21 7.63e-20 ✓ sig.
Diabetic retinopathy Gestational diabetes 0.067 16 1.42e-15 2.23e-14 ✓ sig.
Diabetic eye disease Gestational diabetes 0.086 11 2.74e-15 4.20e-14 ✓ sig.
genitourinary and/or brain malformation syndrome Gestational diabetes 0.011 1 5.84e-3 7.05e-3 ✓ sig.
Diabetic neuropathy Perlman syndrome 0.004 1 1.52e-2 1.68e-2 ✓ sig.
Diabetes mellitus mehmo syndrome 0.003 1 1.92e-2 2.10e-2 ✓ sig.