EIF2S3 (eukaryotic translation initiation factor 2 subunit gamma)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 1968 |
| Gene name | Eukaryotic translation initiation factor 2 subunit gamma |
| Gene symbol | EIF2S3 |
| Synonyms (NCBI Gene) |
EIF2EIF2GEIF2gammaMEHMOMRXSBRKeIF-2gAeIF2gX
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| Chromosome | X |
| Chromosome location | Xp22.11 |
| Summary | The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the recruitment of methionyl-tRNA(i) to the 40 S ribosomal subunit. [provided by RefSeq, Jan 2010] |
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SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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P41091 | ||||||||||||||||||||
| Protein name | Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF2-gamma X) (eIF2gX) | ||||||||||||||||||||
| Protein function | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S | ||||||||||||||||||||
| PDB | 6FEC , 6K71 , 6K72 , 6O81 , 6O85 , 6YBV , 6ZMW , 6ZP4 , 7A09 , 7D43 , 7F66 , 7F67 , 7QP6 , 7QP7 , 8OZ0 , 8PHD , 8PHV , 8PJ1 , 8PJ2 , 8PJ3 , 8PJ4 , 8PPL , 8QZZ | ||||||||||||||||||||
| Family and domains |
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in testis, brain, liver and muscle. {ECO:0000269|PubMed:9736774}. | ||||||||||||||||||||
| Sequence |
MAGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKA |
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| Sequence length | 472 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with EIF2S3 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to EIF2S3 (see Related Genes above), that are NOT already directly curated for EIF2S3 itself -- a lead worth checking, not a confirmed association.
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