Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 133

10 diseases · 16 shared-gene connections
10 Diseases
337 Unique genes
0.097 Avg. similarity score
Obstructive airway disease Most-connected disease (7 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Obstructive airway disease 7 7 100
Chronic obstructive pulmonary disease 5 5 42
Lung disease 5 5 101
Bronchopulmonary dysplasia 3 3 45
Cystic fibrosis 3 3 62
Pulmonary fibrosis 3 3 107
Emphysema 2 2 36
susceptibility to respiratory infections associated with CD8alpha chain mutation 2 2 1
Genetic generalized epilepsy 1 1 1
lung disease, immunodeficiency, and chromosome breakage syndrome; 1 1 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
SERPINA1 6 / 10 Chronic obstructive pulmonary disease, Cystic fibrosis, Emphysema, Lung disease and 2 more
TNF 6 / 10 Bronchopulmonary dysplasia, Chronic obstructive pulmonary disease, Cystic fibrosis, Lung disease and 2 more
IL1B 5 / 10 Bronchopulmonary dysplasia, Cystic fibrosis, Lung disease, Obstructive airway disease and 1 more
TGFB1 5 / 10 Chronic obstructive pulmonary disease, Cystic fibrosis, Lung disease, Obstructive airway disease and 1 more
GSTM1 4 / 10 Bronchopulmonary dysplasia, Cystic fibrosis, Lung disease, Obstructive airway disease
GSTT1 4 / 10 Bronchopulmonary dysplasia, Cystic fibrosis, Lung disease, Obstructive airway disease
HMOX1 4 / 10 Chronic obstructive pulmonary disease, Cystic fibrosis, Obstructive airway disease, Pulmonary fibrosis
MBL2 4 / 10 Bronchopulmonary dysplasia, Cystic fibrosis, Obstructive airway disease, Pulmonary fibrosis
MIF 4 / 10 Chronic obstructive pulmonary disease, Cystic fibrosis, Lung disease, Obstructive airway disease
MMP9 4 / 10 Chronic obstructive pulmonary disease, Lung disease, Obstructive airway disease, Pulmonary fibrosis
PTGS2 4 / 10 Cystic fibrosis, Lung disease, Obstructive airway disease, Pulmonary fibrosis
SFTPA1 4 / 10 Bronchopulmonary dysplasia, Lung disease, Obstructive airway disease, Pulmonary fibrosis
SFTPB 4 / 10 Bronchopulmonary dysplasia, Lung disease, Obstructive airway disease, Pulmonary fibrosis
SFTPD 4 / 10 Bronchopulmonary dysplasia, Chronic obstructive pulmonary disease, Lung disease, Obstructive airway disease
ABCA3 3 / 10 Emphysema, Lung disease, Pulmonary fibrosis
ACE 3 / 10 Lung disease, Obstructive airway disease, Pulmonary fibrosis
ADRB2 3 / 10 Cystic fibrosis, Lung disease, Obstructive airway disease
CD8A 3 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease, susceptibility to respiratory infections associated with CD8alpha chain mutation
CFTR 3 / 10 Cystic fibrosis, Lung disease, Obstructive airway disease
CHRNA5 3 / 10 Emphysema, Lung disease, Obstructive airway disease
CXCL2 3 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease, Pulmonary fibrosis
CYP1A1 3 / 10 Chronic obstructive pulmonary disease, Cystic fibrosis, Obstructive airway disease
DSP 3 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease, Pulmonary fibrosis
ELN 3 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease, Pulmonary fibrosis
EPHX1 3 / 10 Chronic obstructive pulmonary disease, Cystic fibrosis, Obstructive airway disease
FAM13A 3 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease, Pulmonary fibrosis
GSTP1 3 / 10 Bronchopulmonary dysplasia, Lung disease, Obstructive airway disease
HDAC2 3 / 10 Chronic obstructive pulmonary disease, Emphysema, Obstructive airway disease
HIF1A 3 / 10 Chronic obstructive pulmonary disease, Lung disease, Obstructive airway disease
HSPA1A 3 / 10 Cystic fibrosis, Obstructive airway disease, Pulmonary fibrosis
IL13 3 / 10 Lung disease, Obstructive airway disease, Pulmonary fibrosis
IL1RN 3 / 10 Bronchopulmonary dysplasia, Obstructive airway disease, Pulmonary fibrosis
IL6 3 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease, Pulmonary fibrosis
NFE2L2 3 / 10 Emphysema, Lung disease, Pulmonary fibrosis
NOS2 3 / 10 Chronic obstructive pulmonary disease, Emphysema, Obstructive airway disease
NOS3 3 / 10 Chronic obstructive pulmonary disease, Cystic fibrosis, Obstructive airway disease
SFTPC 3 / 10 Lung disease, Obstructive airway disease, Pulmonary fibrosis
SOD3 3 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease, Pulmonary fibrosis
TNFRSF8 3 / 10 Chronic obstructive pulmonary disease, Emphysema, Obstructive airway disease
TP53 3 / 10 Chronic obstructive pulmonary disease, Emphysema, Obstructive airway disease
AGER 2 / 10 Chronic obstructive pulmonary disease, Cystic fibrosis
AGTR2 2 / 10 Cystic fibrosis, Lung disease
AP3B1 2 / 10 Lung disease, Pulmonary fibrosis
APIP 2 / 10 Cystic fibrosis, Lung disease
CAT 2 / 10 Lung disease, Pulmonary fibrosis
CCN2 2 / 10 Lung disease, Pulmonary fibrosis
CDKN1A 2 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease
CDKN2A 2 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease
CEBPA 2 / 10 Emphysema, Pulmonary fibrosis
CEBPB 2 / 10 Cystic fibrosis, Pulmonary fibrosis
CHRM3 2 / 10 Obstructive airway disease, Pulmonary fibrosis
CHRNA3 2 / 10 Lung disease, Obstructive airway disease
CRP 2 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease
CSF3 2 / 10 Lung disease, Pulmonary fibrosis
CXCL1 2 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease
CXCL8 2 / 10 Chronic obstructive pulmonary disease, Pulmonary fibrosis
CYP1A2 2 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease
DEFB1 2 / 10 Lung disease, Obstructive airway disease
EDN1 2 / 10 Obstructive airway disease, Pulmonary fibrosis
EDNRA 2 / 10 Cystic fibrosis, Lung disease
EEFSEC 2 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease
EHF 2 / 10 Cystic fibrosis, Lung disease
FOXO3 2 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease
HGF 2 / 10 Lung disease, Pulmonary fibrosis
HLA-DPB1 2 / 10 Lung disease, Obstructive airway disease
HSPA1B 2 / 10 Obstructive airway disease, Pulmonary fibrosis
HTR2A 2 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease
ICAM1 2 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease
IL12B 2 / 10 Obstructive airway disease, Pulmonary fibrosis
IL1A 2 / 10 Lung disease, Pulmonary fibrosis
KLF12 2 / 10 Bronchopulmonary dysplasia, Emphysema
KLF5 2 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease
LCN1 2 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease
MMP14 2 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease
MPO 2 / 10 Cystic fibrosis, Lung disease
MTCL1 2 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease
MUC4 2 / 10 Cystic fibrosis, Lung disease
NAT2 2 / 10 Lung disease, Obstructive airway disease
NQO1 2 / 10 Lung disease, Obstructive airway disease
NR3C1 2 / 10 Lung disease, Obstructive airway disease
NSMCE3 2 / 10 Lung disease, lung disease, immunodeficiency, and chromosome breakage syndrome;
PDGFA 2 / 10 Lung disease, Pulmonary fibrosis
PLAU 2 / 10 Emphysema, Pulmonary fibrosis
PTX3 2 / 10 Cystic fibrosis, Pulmonary fibrosis
RAPGEF3 2 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease
RTEL1 2 / 10 Obstructive airway disease, Pulmonary fibrosis
SCGB1A1 2 / 10 Lung disease, Obstructive airway disease
SCNN1A 2 / 10 Cystic fibrosis, Lung disease
SCNN1B 2 / 10 Cystic fibrosis, Lung disease
SERPINA3 2 / 10 Cystic fibrosis, Obstructive airway disease
SERPINE1 2 / 10 Lung disease, Pulmonary fibrosis
SLC9A3 2 / 10 Cystic fibrosis, Lung disease
TERT 2 / 10 Obstructive airway disease, Pulmonary fibrosis
TLR4 2 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease
TNFSF8 2 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease
TNK2 2 / 10 Bronchopulmonary dysplasia, Genetic generalized epilepsy
TNNT2 2 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease
TRPV4 2 / 10 Chronic obstructive pulmonary disease, Obstructive airway disease
VDR 2 / 10 Bronchopulmonary dysplasia, Obstructive airway disease
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Interleukin-4 and Interleukin-13 signaling
IL1B, TNF, CDKN1A, FOXO3, HIF1A, HMOX1, ICAM1, IL12B, IL13, IL13RA1, IL6, MMP9
 Reactome 33 / 108 10.9× 1.19e-25 2.36e-22 ✓ sig.
Interleukin-10 signaling
IL1B, IL1RN, TNF, CD86, CXCL1, CXCL2, ICAM1, IL12B, IL6, PTGS2, TNFRSF1A, CSF3
 Reactome 23 / 47 17.4× 8.39e-24 1.25e-20 ✓ sig.
Pathways in cancer
CTNNA3, GSTM1, GSTP1, GSTT1, NFKBIA, ITGA3, BDKRB2, CDKN1A, CDKN2A, EDN1, HDAC2, HHIP
 KEGG 59 / 533 3.9× 3.89e-20 3.05e-17 ✓ sig.
Inflammatory bowel disease
IL1B, TNF, HLA-DPB1, IL12B, IL13, IL6, NOD2, TGFB1, TLR4, TLR5, IL17A, IL18
 KEGG 20 / 66 10.8× 6.58e-16 2.63e-13 ✓ sig.
Rheumatoid arthritis
FLT1, IL1B, TNF, CD86, CTLA4, CXCL1, CXCL2, HLA-DPB1, ICAM1, IL6, TGFB1, TLR4
 KEGG 23 / 95 8.6× 1.00e-15 3.88e-13 ✓ sig.
Fluid shear stress and atherosclerosis
GSTM1, GSTP1, GSTT1, IL1B, TNF, TXN, CYBA, EDN1, HMOX1, ICAM1, MMP9, NOS3
 KEGG 27 / 141 6.8× 1.69e-15 6.31e-13 ✓ sig.
Lipid and atherosclerosis
IL1B, NFKBIA, TNF, CYP2A6, CXCL1, CXCL2, CYBA, CYP1A1, HSPA1A, HSPA1B, HSPA1L, ICAM1
 KEGG 32 / 216 5.3× 8.34e-15 2.65e-12 ✓ sig.
Cytokine-cytokine receptor interaction
IL1B, IL1RN, TNF, CCL1, CXCL1, CXCL2, IL12B, IL13, IL13RA1, IL27, IL6, LEP
 KEGG 37 / 298 4.4× 1.92e-14 5.63e-12 ✓ sig.
Chagas disease
IL1B, NFKBIA, TNF, ACE, BDKRB2, IL12B, IL6, NOS2, TGFB1, TLR4, FAS, TLR9
 KEGG 22 / 103 7.6× 7.04e-14 1.85e-11 ✓ sig.
IL-17 signaling pathway
IL1B, NFKBIA, TNF, CXCL1, CXCL2, IL13, IL6, MMP9, PTGS2, CEBPB, IL17A, CSF3
 KEGG 21 / 94 8.0× 1.02e-13 2.62e-11 ✓ sig.
Legionellosis
IL1B, NFKBIA, TNF, CXCL1, CXCL2, HSPA1A, HSPA1B, HSPA1L, IL12B, IL6, TLR4, CD14
 KEGG 16 / 56 10.2× 1.56e-12 3.30e-10 ✓ sig.
PI3K-Akt signaling pathway
FLT1, MAGI2, ITGA3, CDKN1A, FOXO3, IL6, NOS3, TLR4, TP53, PIK3CG, TSC2, PPP2R2A
 KEGG 38 / 361 3.8× 1.62e-12 3.43e-10 ✓ sig.
HIF-1 signaling pathway
FLT1, CDKN1A, EDN1, HIF1A, HMOX1, IL6, NOS2, NOS3, TLR4, IGF1R, INSR, LDHC
 KEGG 19 / 110 6.2× 1.87e-10 2.54e-8 ✓ sig.
AGE-RAGE signaling pathway in diabetic complications
IL1B, TNF, EDN1, ICAM1, IL6, NOS3, TGFB1, AGER, VEGFA, IL1A, SERPINE1, CXCL8
 KEGG 18 / 101 6.4× 3.33e-10 4.27e-8 ✓ sig.
Malaria
IL1B, TNF, ICAM1, IL6, TGFB1, TLR4, TLR9, CSF3, IL18, TLR2, HGF, CXCL8
 KEGG 13 / 50 9.3× 7.39e-10 8.54e-8 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
inflammatory response
IL1B, IL1RN, NFKBIA, TNF, BDKRB2, CCL1, CRP, CXCL1, CXCL2, CYBA, F2RL1, IL13
 GO:0006954 53 / 467 6.3× 3.18e-27 1.33e-23 ✓ sig.
response to hypoxia
ABAT, POSTN, TNF, CHRNA4, CHRNA7, CYBA, CYP1A1, EDN1, HIF1A, LEP, MMP14, NOS2
 GO:0001666 30 / 176 9.5× 7.90e-21 1.43e-17 ✓ sig.
positive regulation of gene expression
IL1B, TNF, VDR, ITGA3, CDKN2A, CRP, HIF1A, HSPA1A, HSPA1B, IL13, IL6, NOS3
 GO:0010628 47 / 504 5.2× 1.45e-20 2.58e-17 ✓ sig.
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
FLT1, IL1B, TNF, TXN, F2RL1, LEP, TGFB1, ENG, PIK3CG, IL17A, ADRA2B, CAT
 GO:0051897 32 / 217 8.2× 3.63e-20 6.20e-17 ✓ sig.
immune response
IL1B, IL1RN, TNF, CCL1, CD86, CD8A, CRHR1, CTLA4, CXCL1, CXCL2, DEFB1, HLA-DPB1
 GO:0006955 48 / 543 4.9× 5.13e-20 8.43e-17 ✓ sig.
positive regulation of cell migration
FLT1, IL1B, CCL1, EDN1, F2RL1, MMP14, TGFB1, AGER, CEACAM6, SNAI1, PLAU, IGF1R
 GO:0030335 36 / 292 6.8× 6.75e-20 1.08e-16 ✓ sig.
positive regulation of cell population proliferation
FLT1, HTR1A, IL1B, NANOGP8, CD86, CDKN1A, CHRNA7, EDN1, HDAC2, HTR2A, IL6, KLF5
 GO:0008284 46 / 532 4.8× 7.97e-19 1.07e-15 ✓ sig.
positive regulation of interleukin-8 production
IL1B, TNF, F2RL1, HSPA1A, HSPA1B, IL6, LEP, NOD2, NOS2, TLR4, CD14, TLR5
 GO:0032757 19 / 65 16.2× 2.57e-18 3.21e-15 ✓ sig.
lung development
ITGA3, CYP1A2, MMP14, NOS3, ABCA3, CEBPA, GLI3, CCN2, CRISPLD2, NKX2-1, PDGFRA, SPRY2
 GO:0030324 22 / 108 11.3× 2.59e-17 2.80e-14 ✓ sig.
positive regulation of inflammatory response
IL1B, NFKBIA, TNF, ABCC1, CCL1, HTR2A, IL12B, TGFB1, TLR4, TRPV4, TLR9, TNFRSF1A
 GO:0050729 23 / 122 10.5× 2.98e-17 3.18e-14 ✓ sig.
positive regulation of tumor necrosis factor production
CYBA, HDAC2, IL12B, IL6, LEP, MIF, NOD2, TGFB1, TLR4, TNFRSF8, AGER, CD14
 GO:0032760 22 / 113 10.8× 7.21e-17 7.13e-14 ✓ sig.
positive regulation of MAPK cascade
FLT1, IL1B, TNF, ADRB1, ADRB2, CHRNA7, EDN1, IL6, LEP, NOD2, TGFB1, TLR9
 GO:0043410 28 / 224 6.9× 7.25e-16 5.83e-13 ✓ sig.
positive regulation of transcription by RNA polymerase II
GRHL2, IL1B, KLF12, NFKBIA, TNF, VDR, ZNF728, ADRB2, CDKN2A, EDN1, F2RL1, FOXO3
 GO:0045944 64 / 1,208 2.9× 4.33e-15 3.02e-12 ✓ sig.
positive regulation of interleukin-6 production
IL1B, TNF, CYBA, F2RL1, IL6, LEP, NOD2, NOS2, TGFB1, TLR4, TRPV4, AGER
 GO:0032755 19 / 103 10.2× 2.75e-14 1.65e-11 ✓ sig.
positive regulation of ERK1 and ERK2 cascade
IL1B, TNF, CHRNA7, F2RL1, HTR2A, ICAM1, MIF, NOD2, TGFB1, TLR4, TRPV4, AGER
 GO:0070374 25 / 201 6.9× 3.05e-14 1.82e-11 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Chronic obstructive pulmonary disease Obstructive airway disease 0.388 40 3.20e-89 2.99e-87 ✓ sig.
Lung disease Obstructive airway disease 0.154 27 3.45e-37 1.42e-35 ✓ sig.
Obstructive airway disease Pulmonary fibrosis 0.149 27 2.02e-36 8.15e-35 ✓ sig.
Cystic fibrosis Lung disease 0.131 19 1.89e-27 5.53e-26 ✓ sig.
Lung disease Pulmonary fibrosis 0.112 21 9.96e-26 2.66e-24 ✓ sig.
Cystic fibrosis Obstructive airway disease 0.116 17 9.12e-24 2.20e-22 ✓ sig.
Chronic obstructive pulmonary disease Pulmonary fibrosis 0.087 12 6.25e-17 1.07e-15 ✓ sig.
Bronchopulmonary dysplasia Obstructive airway disease 0.081 11 4.17e-15 6.32e-14 ✓ sig.
Chronic obstructive pulmonary disease Cystic fibrosis 0.094 9 6.10e-14 8.50e-13 ✓ sig.
Bronchopulmonary dysplasia Lung disease 0.058 8 4.56e-10 4.52e-9 ✓ sig.
Chronic obstructive pulmonary disease Emphysema 0.068 5 4.18e-8 3.30e-7 ✓ sig.
Emphysema Obstructive airway disease 0.046 6 1.07e-7 7.90e-7 ✓ sig.
Chronic obstructive pulmonary disease susceptibility to respiratory infections associated with CD8alpha chain mutation 0.023 1 2.73e-3 3.65e-3 ✓ sig.
Bronchopulmonary dysplasia Genetic generalized epilepsy 0.022 1 2.92e-3 3.87e-3 ✓ sig.
Obstructive airway disease susceptibility to respiratory infections associated with CD8alpha chain mutation 0.010 1 6.49e-3 7.76e-3 ✓ sig.
Lung disease lung disease, immunodeficiency, and chromosome breakage syndrome; 0.010 1 6.56e-3 7.82e-3 ✓ sig.