Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 1

110 diseases · 325 shared-gene connections
110 Diseases
760 Unique genes
0.172 Avg. similarity score
Bouillaud’s disease Most-connected disease (49 links)
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Disease Searched: optic atrophy 10 with or without ataxia, intellectual disability, and seizures Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.
optic atrophy 10 with or without ataxia, intellectual disability, and seizures Bouillaud’s disease Autoimmune polyendocrine syndrome Oropharyngeal neoplasms Benign mucous membrane pemphigoid with ocular involvement Acute disseminated encephalomyelitis

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Bouillaud’s disease 49 49 3
Autoimmune polyendocrine syndrome 36 36 4
Oropharyngeal neoplasms 23 23 4
Benign mucous membrane pemphigoid with ocular involvement 18 18 3
Acute disseminated encephalomyelitis 17 17 3
Pemphigus vulgaris 15 15 7
Skeletal system disease 15 15 3
Wheat allergic reaction 15 15 3
Uveomeningoencephalitic syndrome 13 13 7
Pemphigus 12 12 8
Autoimmune pancreatitis 11 11 2
Central nervous system non-hodgkin lymphoma 11 11 7
Esophageal achalasia 11 11 4
Henoch schoenlein purpura 11 11 18
Autoimmune pulmonary alveolar proteinosis 10 10 1
Cervical intraepithelial neoplasia 10 10 6
Heerfordt syndrome 10 10 1
Tongue cancer 10 10 2
Chorea 9 9 18
Antiphospholipid syndrome 8 8 20
Cold paroxysmal hemoglobinuria 8 8 6
Gastritis 8 8 22
Interstitial cystitis 8 8 40
Narcolepsy 8 8 51
Thromboangiitis obliterans 8 8 2
Arthritis 7 7 26
Benign hereditary chorea 7 7 7
Benign mucous membrane pemphigoid 7 7 3
Bullous pemphigoid 7 7 23
Cutaneous lupus erythematosus 7 7 11
Latent autoimmune diabetes in adults 7 7 12
Autoimmune musculoskeletal system disorder 6 6 12
Bronchitis 6 6 33
Diabetic nephropathy type 1 6 6 6
Follicular lymphoma 6 6 9
Gastroparesis 6 6 11
Hemoglobinuria paroxysmal 6 6 6
Lymphedema 6 6 16
Membranous glomerulonephritis 6 6 31
Paroxysmal nocturnal hemoglobinuria 6 6 6
Thyroiditis 6 6 16
Vogt-koyanagi-harada disease 6 6 7
Anti-glomerular basement membrane disease 5 5 4
Aortic arch syndrome 5 5 6
Apolipoprotein b hypobetalipoproteinemia 5 5 4
Cartilage disease 5 5 14
Churg-strauss syndrome 5 5 4
Collagenous colitis 5 5 1
Congenital pulmonary artery atresia 5 5 11
Cryoglobulinemia 5 5 6
Lupus nephritis 5 5 42
Lymphoma 5 5 53
Myasthenia gravis 5 5 38
Nasopharyngeal neoplasms 5 5 43
Obstructive asthma 5 5 8
Ocular sarcoidosis 5 5 58
Optic neuritis 5 5 13
Pulmonary alveolar proteinosis 5 5 9
Respiratory system neoplasm 5 5 5
Rosacea 5 5 14
Tonsil cancer 5 5 3
Duodenitis 4 4 8
Giant cell arteritis 4 4 18
Hepatitis c induced liver cirrhosis 4 4 3
Oral cavity carcinoma 4 4 28
Sinusitis 4 4 22
Thiopurine immunosuppressant-induced pancreatitis 4 4 1
Anti-neutrophil antibody associated vasculitis 3 3 23
Diffuse large b-cell lymphoma 3 3 57
Head and neck cancer 3 3 10
Immune system disease 3 3 46
Osteomyelitis 3 3 9
Primary immunodeficiency with defective natural killer cell cytotoxicity 3 3 1
Thyrotoxic periodic paralysis 3 3 12
Waldenstrom macroglobulinemia 3 3 4
atypical hemolytic-uremic syndrome with C3 anomaly 3 3 1
Blepharitis 2 2 2
Bronchial disease 2 2 18
Choreoacanthocytosis 2 2 1
Disabling pansclerotic morphea of childhood 2 2 1
Dysbiosis 2 2 1
Intellectual developmental disorder seizures movement 2 2 1
Parapsoriasis 2 2 2
immunodeficiency 60 2 2 1
Autoimmune gastritis 1 1 1
Autonomic nervous system disease 1 1 2
Birbeck granule deficiency 1 1 1
Cataplexy and narcolepsy 1 1 4
Congenital isolated acth deficiency 1 1 1
Hypoparathyroidism 1 1 3
IMPDH1-related retinopathy 1 1 1
KIZ-related retinopathy 1 1 1
Keratosis palmoplantaris papulosa 1 1 2
Neurodevelopmental disorder with dilated cardiomyopathy 1 1 1
Parenchymal hematoma 1 1 6
Peeling skin syndrome with leukonychia and acral punctate keratoses 1 1 2
Pulmonary surfactant metabolism dysfunction 1 1 6
Uric acid urolithiasis 1 1 1
Vici syndrome 1 1 1
X-linked epilepsy with or without intellectual disability and dysmorphic features 1 1 1
autosomal recessive osteopetrosis 3 1 1 1
congenital disorder of glycosylation type II 1 1 1
distal myopathy with vocal cord weakness 1 1 1
hsd10 mitochondrial disease 1 1 1
immunodeficiency 106, susceptibility to viral infections 1 1 1
immunodeficiency 126, susceptibility to 1 1 1
neurodevelopmental disorder with microcephaly, seizures, and cortical atrophy 1 1 1
optic atrophy 10 with or without ataxia, intellectual disability, and seizures 1 1 1
platelet abnormalities with eosinophilia and immune-mediated inflammatory disease 1 1 1
scalp-ear-nipple syndrome 1 1 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
HLA-DQA1 45 / 110 Anti-neutrophil antibody associated vasculitis, Antiphospholipid syndrome, Arthritis, Autoimmune musculoskeletal system disorder and 41 more
HLA-DQB1 45 / 110 Acute disseminated encephalomyelitis, Antiphospholipid syndrome, Apolipoprotein b hypobetalipoproteinemia, Arthritis and 41 more
HLA-DRB1 45 / 110 Acute disseminated encephalomyelitis, Anti-glomerular basement membrane disease, Antiphospholipid syndrome, Aortic arch syndrome and 41 more
HLA-B 10 / 110 Aortic arch syndrome, Cervical intraepithelial neoplasia, Diffuse large b-cell lymphoma, Giant cell arteritis and 6 more
C3 8 / 110 atypical hemolytic-uremic syndrome with C3 anomaly, Cold paroxysmal hemoglobinuria, Hemoglobinuria paroxysmal, Henoch schoenlein purpura and 4 more
HLA-DRA 7 / 110 Antiphospholipid syndrome, Bullous pemphigoid, Henoch schoenlein purpura, Hepatitis c induced liver cirrhosis and 3 more
IRF4 7 / 110 Central nervous system non-hodgkin lymphoma, Diffuse large b-cell lymphoma, Lymphoma, Membranous glomerulonephritis and 3 more
PTPN22 7 / 110 Diabetic nephropathy type 1, Giant cell arteritis, Immune system disease, Latent autoimmune diabetes in adults and 3 more
HLA-DQB3 6 / 110 Anti-neutrophil antibody associated vasculitis, Henoch schoenlein purpura, Interstitial cystitis, Narcolepsy and 2 more
HLA-DRB5 6 / 110 Acute disseminated encephalomyelitis, Bullous pemphigoid, Central nervous system non-hodgkin lymphoma, Henoch schoenlein purpura and 2 more
C6ORF15 5 / 110 Immune system disease, Membranous glomerulonephritis, Myasthenia gravis, Nasopharyngeal neoplasms and 1 more
CTLA4 5 / 110 Anti-glomerular basement membrane disease, Immune system disease, Latent autoimmune diabetes in adults, Lupus nephritis and 1 more
FAS 5 / 110 Diffuse large b-cell lymphoma, Lupus nephritis, Myasthenia gravis, Uveomeningoencephalitic syndrome and 1 more
FCGR3A 5 / 110 Anti-glomerular basement membrane disease, Arthritis, Giant cell arteritis, Lupus nephritis and 1 more
HLA-DPB1 5 / 110 Anti-glomerular basement membrane disease, Anti-neutrophil antibody associated vasculitis, Gastroparesis, Myasthenia gravis and 1 more
CLPTM1L 4 / 110 Cervical intraepithelial neoplasia, Head and neck cancer, Nasopharyngeal neoplasms, Oral cavity carcinoma
EXOC2 4 / 110 Central nervous system non-hodgkin lymphoma, Diffuse large b-cell lymphoma, Lymphoma, Waldenstrom macroglobulinemia
STAT4 4 / 110 Autoimmune musculoskeletal system disorder, Disabling pansclerotic morphea of childhood, Immune system disease, Uveomeningoencephalitic syndrome
TERT 4 / 110 Head and neck cancer, Nasopharyngeal neoplasms, Osteomyelitis, Tongue cancer
ATXN2 3 / 110 Immune system disease, Latent autoimmune diabetes in adults, Myasthenia gravis
BACH2 3 / 110 Central nervous system non-hodgkin lymphoma, immunodeficiency 60, Latent autoimmune diabetes in adults
BCL2 3 / 110 Diffuse large b-cell lymphoma, Follicular lymphoma, Lymphoma
C5 3 / 110 Cold paroxysmal hemoglobinuria, Hemoglobinuria paroxysmal, Paroxysmal nocturnal hemoglobinuria
CCL2 3 / 110 Giant cell arteritis, Henoch schoenlein purpura, Lupus nephritis
CDKN2A 3 / 110 Diffuse large b-cell lymphoma, Lymphoma, Nasopharyngeal neoplasms
CRP 3 / 110 Antiphospholipid syndrome, Arthritis, Lupus nephritis
HLA-A 3 / 110 Aortic arch syndrome, Parapsoriasis, Thromboangiitis obliterans
HLA-DOB 3 / 110 Bullous pemphigoid, Interstitial cystitis, Lymphoma
HLA-DPA1 3 / 110 Anti-neutrophil antibody associated vasculitis, Interstitial cystitis, Ocular sarcoidosis
HLA-DQB2 3 / 110 Bullous pemphigoid, Interstitial cystitis, Lymphoma
IL2 3 / 110 Aortic arch syndrome, Bullous pemphigoid, Pemphigus
ITGAM 3 / 110 Autoimmune musculoskeletal system disorder, Cutaneous lupus erythematosus, Lupus nephritis
MC1R 3 / 110 Blepharitis, Respiratory system neoplasm, Rosacea
MMP2 3 / 110 Giant cell arteritis, Lupus nephritis, Nasopharyngeal neoplasms
MOG 3 / 110 Narcolepsy, Nasopharyngeal neoplasms, Optic neuritis
MYD88 3 / 110 Diffuse large b-cell lymphoma, Lymphoma, Waldenstrom macroglobulinemia
NOTCH4 3 / 110 Cryoglobulinemia, Interstitial cystitis, Lupus nephritis
PDE2A 3 / 110 Chorea, Intellectual developmental disorder seizures movement, Oral cavity carcinoma
PIGA 3 / 110 Cold paroxysmal hemoglobinuria, Hemoglobinuria paroxysmal, Paroxysmal nocturnal hemoglobinuria
PIGT 3 / 110 Cold paroxysmal hemoglobinuria, Hemoglobinuria paroxysmal, Paroxysmal nocturnal hemoglobinuria
TLR4 3 / 110 Arthritis, Dysbiosis, Giant cell arteritis
VPS13A 3 / 110 Benign hereditary chorea, Chorea, Choreoacanthocytosis
ABCA3 2 / 110 Pulmonary alveolar proteinosis, Pulmonary surfactant metabolism dysfunction
ABCB1 2 / 110 Cryoglobulinemia, Diffuse large b-cell lymphoma
ABCG8 2 / 110 Duodenitis, Gastritis
ADCY5 2 / 110 Benign hereditary chorea, Chorea
ADH1B 2 / 110 Oral cavity carcinoma, Respiratory system neoplasm
AIRE 2 / 110 Autoimmune polyendocrine syndrome, Hypoparathyroidism
ARPC1B 2 / 110 Gastritis, platelet abnormalities with eosinophilia and immune-mediated inflammatory disease
ATP4B 2 / 110 Autoimmune gastritis, Gastritis
ATP6AP1 2 / 110 congenital disorder of glycosylation type II, Lymphoma
B2M 2 / 110 Arthritis, Diffuse large b-cell lymphoma
BTNL2 2 / 110 Hepatitis c induced liver cirrhosis, Membranous glomerulonephritis
CA2 2 / 110 Autoimmune pancreatitis, autosomal recessive osteopetrosis 3
CACNA2D2 2 / 110 Benign hereditary chorea, Chorea
CAMK2D 2 / 110 Bronchitis, Neurodevelopmental disorder with dilated cardiomyopathy
CASP14 2 / 110 Bronchial disease, Bronchitis
CAST 2 / 110 Peeling skin syndrome with leukonychia and acral punctate keratoses, Pemphigus
CAT 2 / 110 Diffuse large b-cell lymphoma, Optic neuritis
CD207 2 / 110 Birbeck granule deficiency, Narcolepsy
CD40 2 / 110 Arthritis, Pemphigus
CD40LG 2 / 110 Antiphospholipid syndrome, Lupus nephritis
CD86 2 / 110 Diffuse large b-cell lymphoma, Henoch schoenlein purpura
CDH18 2 / 110 Antiphospholipid syndrome, Gastritis
CDKN2B 2 / 110 Lymphoma, Nasopharyngeal neoplasms
CEP43 2 / 110 Immune system disease, Myasthenia gravis
CFB 2 / 110 Membranous glomerulonephritis, Myasthenia gravis
CHRNA1 2 / 110 Immune system disease, Myasthenia gravis
COL11A2 2 / 110 Cartilage disease, Interstitial cystitis
COL14A1 2 / 110 Gastritis, Keratosis palmoplantaris papulosa
COL2A1 2 / 110 Arthritis, Cartilage disease
CSF2 2 / 110 Lymphoma, Pulmonary alveolar proteinosis
CSF2RA 2 / 110 Pulmonary alveolar proteinosis, Pulmonary surfactant metabolism dysfunction
CSF2RB 2 / 110 Pulmonary alveolar proteinosis, Pulmonary surfactant metabolism dysfunction
CXCL8 2 / 110 Bullous pemphigoid, Gastritis
CYP2A6 2 / 110 Bronchitis, Nasopharyngeal neoplasms
DDX6 2 / 110 Immune system disease, Lymphoma
EBF1 2 / 110 Blepharitis, Lymphoma
EGFR 2 / 110 Nasopharyngeal neoplasms, Ocular sarcoidosis
ELMO1 2 / 110 Autonomic nervous system disease, Immune system disease
EPG5 2 / 110 Bronchial disease, Vici syndrome
EXOC6 2 / 110 Diffuse large b-cell lymphoma, Follicular lymphoma
EZH2 2 / 110 Diffuse large b-cell lymphoma, Lymphoma
FAM76B 2 / 110 Immune system disease, Myasthenia gravis
FCGR2A 2 / 110 Giant cell arteritis, Lupus nephritis
FKBPL 2 / 110 Interstitial cystitis, Membranous glomerulonephritis
FRMD4A 2 / 110 Antiphospholipid syndrome, Ocular sarcoidosis
FTO 2 / 110 Oral cavity carcinoma, Osteomyelitis
GABRA3 2 / 110 Thyrotoxic periodic paralysis, X-linked epilepsy with or without intellectual disability and dysmorphic features
GATA2 2 / 110 Cartilage disease, Lymphedema
GRB7 2 / 110 Immune system disease, Myasthenia gravis
GSTM1 2 / 110 Gastritis, Optic neuritis
HLA-C 2 / 110 Interstitial cystitis, Sinusitis
HLA-DOA 2 / 110 Interstitial cystitis, Ocular sarcoidosis
HOMEZ 2 / 110 Bronchial disease, Bronchitis
HSD17B10 2 / 110 Chorea, hsd10 mitochondrial disease
IFNA2 2 / 110 Lymphoma, Uveomeningoencephalitic syndrome
IFNAR1 2 / 110 immunodeficiency 106, susceptibility to viral infections, Narcolepsy
IFNG 2 / 110 Giant cell arteritis, Lupus nephritis
IKZF1 2 / 110 Lymphoma, Rosacea
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Allograft rejection
HLA-DPB1, HLA-DRB1, HLA-DPA1, HLA-DQA1, CD40LG, HLA-DQB1, HLA-DRA, HLA-A, HLA-B, IL2, CD40, HLA-DOB
 KEGG 26 / 39 10.5× 1.67e-22 1.88e-19 ✓ sig.
Leishmaniasis
FCGR3A, HLA-DPB1, HLA-DRB1, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, NOS2, JAK2, TLR4, ITGAM, NCF2
 KEGG 35 / 78 7.1× 7.01e-22 6.96e-19 ✓ sig.
Autoimmune thyroid disease
CTLA4, HLA-DPB1, HLA-DRB1, HLA-DPA1, HLA-DQA1, CD40LG, HLA-DQB1, HLA-DRA, TSHR, HLA-A, HLA-B, IL2
 KEGG 28 / 54 8.2× 6.57e-20 4.74e-17 ✓ sig.
Type I diabetes mellitus
HLA-DPB1, HLA-DRB1, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-A, HLA-B, IL2, HLA-DOB, HLA-DQB2, HLA-DRB5
 KEGG 25 / 44 9.0× 3.29e-19 2.16e-16 ✓ sig.
Inflammatory bowel disease
HLA-DPB1, HLA-DRB1, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, IL2, IL23R, TLR4, STAT4, HLA-DOB, HLA-DQB2
 KEGG 29 / 66 6.9× 4.90e-18 2.75e-15 ✓ sig.
Graft-versus-host disease
HLA-DPB1, HLA-DRB1, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-A, HLA-B, IL2, HLA-DOB, HLA-DQB2, HLA-DRB5
 KEGG 24 / 45 8.4× 1.27e-17 6.51e-15 ✓ sig.
Tuberculosis
FCGR3A, HLA-DPB1, HLA-DRB1, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, NOS2, JAK2, SYK, TLR4, ITGAM
 KEGG 47 / 181 4.1× 2.54e-17 1.25e-14 ✓ sig.
Rheumatoid arthritis
CTLA4, HLA-DPB1, HLA-DRB1, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, TLR4, VEGFA, HLA-DOB, HLA-DQB2, HLA-DRB5
 KEGG 33 / 95 5.5× 1.25e-16 5.38e-14 ✓ sig.
Herpes simplex virus 1 infection
HLA-DPB1, HLA-DRB1, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-A, HLA-B, B2M, JAK2, SYK, HLA-DOB
 KEGG 46 / 182 4.0× 1.75e-16 7.38e-14 ✓ sig.
Toxoplasmosis
HLA-DPB1, HLA-DRB1, HLA-DPA1, HLA-DQA1, CD40LG, HLA-DQB1, HLA-DRA, NOS2, CD40, JAK2, TLR4, HLA-DOB
 KEGG 35 / 112 4.9× 6.44e-16 2.50e-13 ✓ sig.
Asthma
HLA-DPB1, HLA-DRB1, HLA-DPA1, HLA-DQA1, CD40LG, HLA-DQB1, HLA-DRA, CD40, HLA-DOB, HLA-DQB2, HLA-DRB5, HLA-DOA
 KEGG 18 / 32 8.9× 4.43e-14 1.19e-11 ✓ sig.
Th1 and Th2 cell differentiation
HLA-DPB1, HLA-DRB1, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, IL2, JAK2, STAT4, HLA-DOB, HLA-DQB2, HLA-DRB5
 KEGG 28 / 93 4.8× 1.50e-12 3.14e-10 ✓ sig.
Epstein-Barr virus infection
HLA-DPB1, HLA-DRB1, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-A, HLA-B, B2M, CD40, SYK, HLA-DOB
 KEGG 43 / 204 3.3× 1.54e-12 3.22e-10 ✓ sig.
Influenza A
HLA-DPB1, HLA-DRB1, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, JAK2, TLR4, HLA-DOB, HLA-DQB2, HLA-DRB5, HLA-DOA
 KEGG 39 / 173 3.6× 1.88e-12 3.86e-10 ✓ sig.
Human T-cell leukemia virus 1 infection
HLA-DPB1, HLA-DRB1, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-A, HLA-B, IL2, B2M, CD40, ZFP36
 KEGG 45 / 224 3.2× 2.73e-12 5.45e-10 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
immune response
CTLA4, FCGR3A, HLA-DPB1, HLA-DRB1, HLA-DPA1, HLA-DQA1, CD40LG, HLA-DQB1, HLA-DRA, HLA-A, HLA-B, IL2
 GO:0006955 75 / 543 3.4× 8.04e-21 1.41e-17 ✓ sig.
peptide antigen assembly with MHC class II protein complex
HLA-DPB1, HLA-DRB1, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, B2M, HLA-DOB, HLA-DQB2, HLA-DRB5, HLA-DOA, HLA-DMA
 GO:0002503 14 / 16 21.5× 3.36e-18 4.02e-15 ✓ sig.
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
HLA-DPB1, HLA-DRB1, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DOB, HLA-DQB2, HLA-DRB5, HLA-DOA, HLA-DMA, HLA-DMB
 GO:0002504 13 / 15 21.3× 7.34e-17 7.07e-14 ✓ sig.
positive regulation of T cell activation
HLA-DPB1, HLA-DRB1, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, B2M, HLA-DOB, HLA-DQB2, HLA-DRB5, HLA-DOA, CCL2
 GO:0050870 20 / 45 10.9× 1.46e-16 1.35e-13 ✓ sig.
cellular response to lipopolysaccharide
NOS2, B2M, CD40, JAK2, TLR4, ZFP36, DAB2IP, ABCB1, CD86, CXCL8, NOD2, IL1B
 GO:0071222 34 / 187 4.5× 1.67e-13 8.86e-11 ✓ sig.
antigen processing and presentation
HLA-DPB1, HLA-DRB1, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-A, HLA-B, HLA-DOB, HLA-DQB2, HLA-DRB5, HLA-C
 GO:0019882 18 / 48 9.2× 1.76e-13 9.33e-11 ✓ sig.
cell surface receptor signaling pathway via JAK-STAT
CD40, IL23R, JAK2, STAT4, TSLP, IFNL3, IFNL4, CCL2, IFNG, IL4, JAK1, STAT1
 GO:0007259 20 / 67 7.3× 1.14e-12 5.24e-10 ✓ sig.
positive regulation of immune response
HLA-DPB1, HLA-DRB1, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, B2M, HLA-DOB, HLA-DQB2, HLA-DRB5, HLA-DOA, IFNL3
 GO:0050778 16 / 40 9.8× 1.21e-12 5.50e-10 ✓ sig.
antigen processing and presentation of exogenous peptide antigen via MHC class II
HLA-DPB1, HLA-DRB1, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, B2M, HLA-DOB, HLA-DQB2, HLA-DRB5, HLA-DOA, HLA-DMA
 GO:0019886 14 / 31 11.1× 4.20e-12 1.71e-9 ✓ sig.
positive regulation of cell population proliferation
PRTN3, TSC22D1, GRK5, TSHR, IL2, IL23R, JAK2, NPY, VEGFA, TNC, BMP4, EDN1
 GO:0008284 58 / 532 2.7× 7.84e-12 2.96e-9 ✓ sig.
immune system process
CTLA4, FCGR3A, HLA-DPB1, HLA-DRB1, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-A, HLA-B, IL2, B2M
 GO:0002376 84 / 943 2.2× 8.91e-12 3.32e-9 ✓ sig.
inflammatory response
AZU1, CD40LG, CRP, NOS2, CD40, HP, IL23R, TLR4, PTGER3, EPG5, TACR1, CYBB
 GO:0006954 53 / 467 2.8× 1.42e-11 5.07e-9 ✓ sig.
regulation of cell population proliferation
NOS2, NF1, STAT4, EMILIN2, DNMT1, TBX19, BCL6, AGT, PLAU, ARG1, CXCL10, CXCL11
 GO:0042127 32 / 201 3.9× 3.44e-11 1.12e-8 ✓ sig.
positive regulation of interleukin-12 production
CD40LG, CD40, IL23R, SYK, TLR4, TLR2, IFNG, IL17A, SCIMP, AGER, TLR9, TNFSF4
 GO:0032735 15 / 43 8.6× 6.29e-11 1.93e-8 ✓ sig.
phosphatidylinositol 3-kinase/protein kinase B signal transduction
FCGR3A, CD40, NF1, EDN1, MAPKAP1, BTN2A2, BANK1, PTEN, PDPK1, PIK3CA, PIK3CB, PIK3CD
 GO:0043491 21 / 92 5.6× 8.89e-11 2.62e-8 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Immune system disease Myasthenia gravis 0.308 20 8.03e-43 3.56e-41 ✓ sig.
Cold paroxysmal hemoglobinuria Hemoglobinuria paroxysmal 0.857 6 5.41e-23 1.17e-21 ✓ sig.
Cold paroxysmal hemoglobinuria Paroxysmal nocturnal hemoglobinuria 0.857 6 5.41e-23 1.17e-21 ✓ sig.
Hemoglobinuria paroxysmal Paroxysmal nocturnal hemoglobinuria 0.857 6 5.41e-23 1.17e-21 ✓ sig.
Benign hereditary chorea Chorea 0.368 7 7.83e-22 1.62e-20 ✓ sig.
Giant cell arteritis Lupus nephritis 0.151 8 6.47e-17 1.05e-15 ✓ sig.
Pulmonary alveolar proteinosis Pulmonary surfactant metabolism dysfunction 0.455 5 1.05e-16 1.68e-15 ✓ sig.
Interstitial cystitis Pemphigus vulgaris 0.143 6 1.45e-15 2.15e-14 ✓ sig.
Henoch schoenlein purpura Pemphigus vulgaris 0.238 5 2.49e-14 3.39e-13 ✓ sig.
Uveomeningoencephalitic syndrome Vogt-koyanagi-harada disease 0.364 4 5.23e-13 6.47e-12 ✓ sig.
Myasthenia gravis Uveomeningoencephalitic syndrome 0.122 5 1.46e-12 1.74e-11 ✓ sig.
Benign mucous membrane pemphigoid Benign mucous membrane pemphigoid with ocular involvement 0.750 3 1.64e-12 1.92e-11 ✓ sig.
Autoimmune polyendocrine syndrome Bouillaud’s disease 0.600 3 6.58e-12 7.30e-11 ✓ sig.
Bouillaud’s disease Oropharyngeal neoplasms 0.600 3 6.58e-12 7.30e-11 ✓ sig.
Bullous pemphigoid Interstitial cystitis 0.103 6 2.03e-11 2.16e-10 ✓ sig.
Autoimmune polyendocrine syndrome Oropharyngeal neoplasms 0.500 3 2.63e-11 2.77e-10 ✓ sig.
Bullous pemphigoid Henoch schoenlein purpura 0.135 5 3.95e-11 4.07e-10 ✓ sig.
Latent autoimmune diabetes in adults Myasthenia gravis 0.109 5 5.45e-11 5.58e-10 ✓ sig.
Benign hereditary chorea Bouillaud’s disease 0.375 3 5.75e-11 5.86e-10 ✓ sig.
Bouillaud’s disease Pemphigus vulgaris 0.375 3 5.75e-11 5.86e-10 ✓ sig.
Bouillaud’s disease Uveomeningoencephalitic syndrome 0.375 3 5.75e-11 5.86e-10 ✓ sig.
Antiphospholipid syndrome Pemphigus vulgaris 0.167 4 7.22e-11 7.29e-10 ✓ sig.
Henoch schoenlein purpura Pemphigus 0.174 4 9.12e-11 9.12e-10 ✓ sig.
Bouillaud’s disease Pemphigus 0.333 3 9.21e-11 9.15e-10 ✓ sig.
Bullous pemphigoid Pemphigus vulgaris 0.148 4 1.32e-10 1.30e-9 ✓ sig.
Interstitial cystitis Membranous glomerulonephritis 0.091 6 1.46e-10 1.43e-9 ✓ sig.
Autoimmune polyendocrine syndrome Benign hereditary chorea 0.333 3 2.30e-10 2.21e-9 ✓ sig.
Autoimmune polyendocrine syndrome Pemphigus vulgaris 0.333 3 2.30e-10 2.21e-9 ✓ sig.
Benign hereditary chorea Oropharyngeal neoplasms 0.333 3 2.30e-10 2.21e-9 ✓ sig.
Oropharyngeal neoplasms Pemphigus vulgaris 0.333 3 2.30e-10 2.21e-9 ✓ sig.
Autoimmune polyendocrine syndrome Uveomeningoencephalitic syndrome 0.333 3 2.30e-10 2.21e-9 ✓ sig.
Oropharyngeal neoplasms Uveomeningoencephalitic syndrome 0.333 3 2.30e-10 2.21e-9 ✓ sig.
Bullous pemphigoid Pemphigus 0.143 4 2.64e-10 2.52e-9 ✓ sig.
Autoimmune polyendocrine syndrome Pemphigus 0.300 3 3.68e-10 3.48e-9 ✓ sig.
Oropharyngeal neoplasms Pemphigus 0.300 3 3.68e-10 3.48e-9 ✓ sig.
Henoch schoenlein purpura Interstitial cystitis 0.093 5 7.63e-10 6.98e-9 ✓ sig.
Cervical intraepithelial neoplasia Nasopharyngeal neoplasms 0.087 4 7.87e-10 7.19e-9 ✓ sig.
Diffuse large b-cell lymphoma Lymphoma 0.067 7 8.79e-10 7.99e-9 ✓ sig.
Henoch schoenlein purpura Lupus nephritis 0.089 5 9.85e-10 8.93e-9 ✓ sig.
Diabetic nephropathy type 1 Uveomeningoencephalitic syndrome 0.273 3 1.15e-9 1.04e-8 ✓ sig.
Bouillaud’s disease Chorea 0.158 3 1.34e-9 1.20e-8 ✓ sig.
Bouillaud’s disease Henoch schoenlein purpura 0.158 3 1.34e-9 1.20e-8 ✓ sig.
Acute disseminated encephalomyelitis Henoch schoenlein purpura 0.158 3 1.34e-9 1.20e-8 ✓ sig.
Lupus nephritis Uveomeningoencephalitic syndrome 0.087 4 1.66e-9 1.48e-8 ✓ sig.
Antiphospholipid syndrome Lupus nephritis 0.086 5 1.78e-9 1.57e-8 ✓ sig.
Cold paroxysmal hemoglobinuria Pemphigus 0.250 3 1.84e-9 1.62e-8 ✓ sig.
Hemoglobinuria paroxysmal Pemphigus 0.250 3 1.84e-9 1.62e-8 ✓ sig.
Paroxysmal nocturnal hemoglobinuria Pemphigus 0.250 3 1.84e-9 1.62e-8 ✓ sig.
Antiphospholipid syndrome Bouillaud’s disease 0.143 3 1.87e-9 1.65e-8 ✓ sig.
Benign hereditary chorea Pemphigus vulgaris 0.250 3 2.01e-9 1.76e-8 ✓ sig.
Pemphigus vulgaris Uveomeningoencephalitic syndrome 0.250 3 2.01e-9 1.76e-8 ✓ sig.
Immune system disease Uveomeningoencephalitic syndrome 0.080 4 2.42e-9 2.10e-8 ✓ sig.
Bouillaud’s disease Bullous pemphigoid 0.125 3 2.91e-9 2.51e-8 ✓ sig.
Acute disseminated encephalomyelitis Bullous pemphigoid 0.125 3 2.91e-9 2.51e-8 ✓ sig.
Narcolepsy Pemphigus vulgaris 0.073 4 3.71e-9 3.16e-8 ✓ sig.
Central nervous system non-hodgkin lymphoma Lymphoma 0.070 4 4.34e-9 3.68e-8 ✓ sig.
Lymphoma Uveomeningoencephalitic syndrome 0.070 4 4.34e-9 3.68e-8 ✓ sig.
Autoimmune polyendocrine syndrome Chorea 0.150 3 5.36e-9 4.51e-8 ✓ sig.
Chorea Oropharyngeal neoplasms 0.150 3 5.36e-9 4.51e-8 ✓ sig.
Autoimmune polyendocrine syndrome Henoch schoenlein purpura 0.150 3 5.36e-9 4.51e-8 ✓ sig.
Diabetic nephropathy type 1 Latent autoimmune diabetes in adults 0.188 3 7.22e-9 6.01e-8 ✓ sig.
Antiphospholipid syndrome Autoimmune polyendocrine syndrome 0.136 3 7.49e-9 6.21e-8 ✓ sig.
Antiphospholipid syndrome Oropharyngeal neoplasms 0.136 3 7.49e-9 6.21e-8 ✓ sig.
Membranous glomerulonephritis Myasthenia gravis 0.077 5 1.13e-8 9.02e-8 ✓ sig.
Autoimmune musculoskeletal system disorder Uveomeningoencephalitic syndrome 0.176 3 1.26e-8 1.00e-7 ✓ sig.
Latent autoimmune diabetes in adults Uveomeningoencephalitic syndrome 0.176 3 1.26e-8 1.00e-7 ✓ sig.
Cutaneous lupus erythematosus Interstitial cystitis 0.083 4 1.27e-8 1.01e-7 ✓ sig.
Bullous pemphigoid Lymphoma 0.069 5 1.28e-8 1.02e-7 ✓ sig.
Bouillaud’s disease Nasopharyngeal neoplasms 0.068 3 2.03e-8 1.59e-7 ✓ sig.
Central nervous system non-hodgkin lymphoma Rosacea 0.158 3 2.09e-8 1.63e-7 ✓ sig.
Bouillaud’s disease Narcolepsy 0.058 3 3.42e-8 2.58e-7 ✓ sig.
Chorea Pemphigus vulgaris 0.130 3 4.68e-8 3.48e-7 ✓ sig.
Bronchial disease Bronchitis 0.083 4 5.24e-8 3.83e-7 ✓ sig.
Autoimmune musculoskeletal system disorder Cutaneous lupus erythematosus 0.143 3 5.95e-8 4.33e-7 ✓ sig.
Myasthenia gravis Nasopharyngeal neoplasms 0.065 5 6.26e-8 4.55e-7 ✓ sig.
Antiphospholipid syndrome Benign hereditary chorea 0.120 3 6.54e-8 4.74e-7 ✓ sig.
Acute disseminated encephalomyelitis Benign mucous membrane pemphigoid with ocular involvement 0.400 2 7.59e-8 5.41e-7 ✓ sig.
Acute disseminated encephalomyelitis Bouillaud’s disease 0.400 2 7.59e-8 5.41e-7 ✓ sig.
Acute disseminated encephalomyelitis Benign mucous membrane pemphigoid 0.400 2 7.59e-8 5.41e-7 ✓ sig.
Benign mucous membrane pemphigoid Bouillaud’s disease 0.400 2 7.59e-8 5.41e-7 ✓ sig.
Benign mucous membrane pemphigoid with ocular involvement Bouillaud’s disease 0.400 2 7.59e-8 5.41e-7 ✓ sig.
Bouillaud’s disease Skeletal system disease 0.400 2 7.59e-8 5.41e-7 ✓ sig.
Bouillaud’s disease Wheat allergic reaction 0.400 2 7.59e-8 5.41e-7 ✓ sig.
Skeletal system disease Wheat allergic reaction 0.400 2 7.59e-8 5.41e-7 ✓ sig.
Autoimmune polyendocrine syndrome Nasopharyngeal neoplasms 0.067 3 8.10e-8 5.76e-7 ✓ sig.
Nasopharyngeal neoplasms Oropharyngeal neoplasms 0.067 3 8.10e-8 5.76e-7 ✓ sig.
Cervical intraepithelial neoplasia Oral cavity carcinoma 0.094 3 1.07e-7 7.48e-7 ✓ sig.
Aortic arch syndrome Thromboangiitis obliterans 0.286 2 1.27e-7 8.71e-7 ✓ sig.
Cataplexy and narcolepsy Narcolepsy 0.057 3 1.37e-7 9.38e-7 ✓ sig.
Autoimmune polyendocrine syndrome Narcolepsy 0.057 3 1.37e-7 9.38e-7 ✓ sig.
Acute disseminated encephalomyelitis Autoimmune polyendocrine syndrome 0.333 2 1.52e-7 1.03e-6 ✓ sig.
Acute disseminated encephalomyelitis Oropharyngeal neoplasms 0.333 2 1.52e-7 1.03e-6 ✓ sig.
Autoimmune polyendocrine syndrome Skeletal system disease 0.333 2 1.52e-7 1.03e-6 ✓ sig.
Autoimmune polyendocrine syndrome Benign mucous membrane pemphigoid 0.333 2 1.52e-7 1.03e-6 ✓ sig.
Benign mucous membrane pemphigoid Oropharyngeal neoplasms 0.333 2 1.52e-7 1.03e-6 ✓ sig.
Autoimmune polyendocrine syndrome Benign mucous membrane pemphigoid with ocular involvement 0.333 2 1.52e-7 1.03e-6 ✓ sig.
Benign mucous membrane pemphigoid with ocular involvement Oropharyngeal neoplasms 0.333 2 1.52e-7 1.03e-6 ✓ sig.
Bouillaud’s disease Esophageal achalasia 0.333 2 1.52e-7 1.03e-6 ✓ sig.
Oropharyngeal neoplasms Skeletal system disease 0.333 2 1.52e-7 1.03e-6 ✓ sig.
Autoimmune polyendocrine syndrome Wheat allergic reaction 0.333 2 1.52e-7 1.03e-6 ✓ sig.
Oropharyngeal neoplasms Wheat allergic reaction 0.333 2 1.52e-7 1.03e-6 ✓ sig.
Diffuse large b-cell lymphoma Waldenstrom macroglobulinemia 0.051 3 1.92e-7 1.28e-6 ✓ sig.
Arthritis Pemphigus 0.094 3 2.38e-7 1.56e-6 ✓ sig.
Central nervous system non-hodgkin lymphoma Membranous glomerulonephritis 0.083 3 2.57e-7 1.68e-6 ✓ sig.
Autoimmune polyendocrine syndrome Esophageal achalasia 0.286 2 3.04e-7 1.95e-6 ✓ sig.
Esophageal achalasia Oropharyngeal neoplasms 0.286 2 3.04e-7 1.95e-6 ✓ sig.
Osteomyelitis Tongue cancer 0.200 2 3.04e-7 1.95e-6 ✓ sig.
Henoch schoenlein purpura Narcolepsy 0.061 4 3.16e-7 2.02e-6 ✓ sig.
Cartilage disease Lymphedema 0.107 3 3.33e-7 2.13e-6 ✓ sig.
Bouillaud’s disease Cervical intraepithelial neoplasia 0.250 2 3.80e-7 2.39e-6 ✓ sig.
Bouillaud’s disease Cold paroxysmal hemoglobinuria 0.250 2 3.80e-7 2.39e-6 ✓ sig.
Bouillaud’s disease Cryoglobulinemia 0.250 2 3.80e-7 2.39e-6 ✓ sig.
Cryoglobulinemia Skeletal system disease 0.250 2 3.80e-7 2.39e-6 ✓ sig.
Cryoglobulinemia Wheat allergic reaction 0.250 2 3.80e-7 2.39e-6 ✓ sig.
Bouillaud’s disease Diabetic nephropathy type 1 0.250 2 3.80e-7 2.39e-6 ✓ sig.
Bouillaud’s disease Hemoglobinuria paroxysmal 0.250 2 3.80e-7 2.39e-6 ✓ sig.
Bouillaud’s disease Paroxysmal nocturnal hemoglobinuria 0.250 2 3.80e-7 2.39e-6 ✓ sig.
Head and neck cancer Tongue cancer 0.182 2 3.80e-7 2.39e-6 ✓ sig.
Membranous glomerulonephritis Pemphigus 0.081 3 4.11e-7 2.58e-6 ✓ sig.
Bouillaud’s disease Central nervous system non-hodgkin lymphoma 0.222 2 5.31e-7 3.27e-6 ✓ sig.
Central nervous system non-hodgkin lymphoma Skeletal system disease 0.222 2 5.31e-7 3.27e-6 ✓ sig.
Central nervous system non-hodgkin lymphoma Wheat allergic reaction 0.222 2 5.31e-7 3.27e-6 ✓ sig.
Acute disseminated encephalomyelitis Central nervous system non-hodgkin lymphoma 0.222 2 5.31e-7 3.27e-6 ✓ sig.
Bouillaud’s disease Vogt-koyanagi-harada disease 0.222 2 5.31e-7 3.27e-6 ✓ sig.
Skeletal system disease Vogt-koyanagi-harada disease 0.222 2 5.31e-7 3.27e-6 ✓ sig.
Vogt-koyanagi-harada disease Wheat allergic reaction 0.222 2 5.31e-7 3.27e-6 ✓ sig.
Bouillaud’s disease Obstructive asthma 0.200 2 7.08e-7 4.27e-6 ✓ sig.
Gastritis Optic neuritis 0.091 3 7.17e-7 4.32e-6 ✓ sig.
Autoimmune polyendocrine syndrome Cervical intraepithelial neoplasia 0.222 2 7.59e-7 4.54e-6 ✓ sig.
Cervical intraepithelial neoplasia Esophageal achalasia 0.222 2 7.59e-7 4.54e-6 ✓ sig.
Cervical intraepithelial neoplasia Oropharyngeal neoplasms 0.222 2 7.59e-7 4.54e-6 ✓ sig.
Autoimmune polyendocrine syndrome Cold paroxysmal hemoglobinuria 0.222 2 7.59e-7 4.54e-6 ✓ sig.
Autoimmune polyendocrine syndrome Cryoglobulinemia 0.222 2 7.59e-7 4.54e-6 ✓ sig.
Cryoglobulinemia Oropharyngeal neoplasms 0.222 2 7.59e-7 4.54e-6 ✓ sig.
Autoimmune polyendocrine syndrome Diabetic nephropathy type 1 0.222 2 7.59e-7 4.54e-6 ✓ sig.
Diabetic nephropathy type 1 Esophageal achalasia 0.222 2 7.59e-7 4.54e-6 ✓ sig.
Diabetic nephropathy type 1 Oropharyngeal neoplasms 0.222 2 7.59e-7 4.54e-6 ✓ sig.
Cold paroxysmal hemoglobinuria Esophageal achalasia 0.222 2 7.59e-7 4.54e-6 ✓ sig.
Autoimmune polyendocrine syndrome Hemoglobinuria paroxysmal 0.222 2 7.59e-7 4.54e-6 ✓ sig.
Autoimmune polyendocrine syndrome Paroxysmal nocturnal hemoglobinuria 0.222 2 7.59e-7 4.54e-6 ✓ sig.
Acute disseminated encephalomyelitis Pulmonary alveolar proteinosis 0.182 2 9.11e-7 5.37e-6 ✓ sig.
Autoimmune polyendocrine syndrome Central nervous system non-hodgkin lymphoma 0.200 2 1.06e-6 6.21e-6 ✓ sig.
Autoimmune polyendocrine syndrome Vogt-koyanagi-harada disease 0.200 2 1.06e-6 6.21e-6 ✓ sig.
Central nervous system non-hodgkin lymphoma Waldenstrom macroglobulinemia 0.200 2 1.06e-6 6.21e-6 ✓ sig.
Cutaneous lupus erythematosus Membranous glomerulonephritis 0.075 3 1.21e-6 6.99e-6 ✓ sig.
Bouillaud’s disease Cutaneous lupus erythematosus 0.154 2 1.39e-6 7.96e-6 ✓ sig.
Cutaneous lupus erythematosus Skeletal system disease 0.154 2 1.39e-6 7.96e-6 ✓ sig.
Cutaneous lupus erythematosus Wheat allergic reaction 0.154 2 1.39e-6 7.96e-6 ✓ sig.
Bouillaud’s disease Gastroparesis 0.154 2 1.39e-6 7.96e-6 ✓ sig.
Lymphedema Sinusitis 0.083 3 1.40e-6 8.01e-6 ✓ sig.
Autoimmune polyendocrine syndrome Obstructive asthma 0.182 2 1.42e-6 8.09e-6 ✓ sig.
Esophageal achalasia Obstructive asthma 0.182 2 1.42e-6 8.09e-6 ✓ sig.
Obstructive asthma Oropharyngeal neoplasms 0.182 2 1.42e-6 8.09e-6 ✓ sig.
Autoimmune musculoskeletal system disorder Bouillaud’s disease 0.143 2 1.67e-6 9.43e-6 ✓ sig.
Autoimmune musculoskeletal system disorder Skeletal system disease 0.143 2 1.67e-6 9.43e-6 ✓ sig.
Autoimmune musculoskeletal system disorder Wheat allergic reaction 0.143 2 1.67e-6 9.43e-6 ✓ sig.
Bouillaud’s disease Latent autoimmune diabetes in adults 0.143 2 1.67e-6 9.43e-6 ✓ sig.
Cervical intraepithelial neoplasia Cold paroxysmal hemoglobinuria 0.182 2 1.90e-6 1.06e-5 ✓ sig.
Benign mucous membrane pemphigoid with ocular involvement Optic neuritis 0.133 2 1.97e-6 1.10e-5 ✓ sig.
Bouillaud’s disease Optic neuritis 0.133 2 1.97e-6 1.10e-5 ✓ sig.
Acute disseminated encephalomyelitis Optic neuritis 0.133 2 1.97e-6 1.10e-5 ✓ sig.
Benign mucous membrane pemphigoid Optic neuritis 0.133 2 1.97e-6 1.10e-5 ✓ sig.
Bouillaud’s disease Cartilage disease 0.125 2 2.30e-6 1.26e-5 ✓ sig.
Cartilage disease Skeletal system disease 0.125 2 2.30e-6 1.26e-5 ✓ sig.
Cartilage disease Wheat allergic reaction 0.125 2 2.30e-6 1.26e-5 ✓ sig.
Bouillaud’s disease Rosacea 0.125 2 2.30e-6 1.26e-5 ✓ sig.
Rosacea Skeletal system disease 0.125 2 2.30e-6 1.26e-5 ✓ sig.
Rosacea Wheat allergic reaction 0.125 2 2.30e-6 1.26e-5 ✓ sig.
Autoimmune polyendocrine syndrome Cutaneous lupus erythematosus 0.143 2 2.78e-6 1.51e-5 ✓ sig.
Autoimmune polyendocrine syndrome Gastroparesis 0.143 2 2.78e-6 1.51e-5 ✓ sig.
Esophageal achalasia Gastroparesis 0.143 2 2.78e-6 1.51e-5 ✓ sig.
Gastroparesis Oropharyngeal neoplasms 0.143 2 2.78e-6 1.51e-5 ✓ sig.
Bouillaud’s disease Lymphedema 0.111 2 3.04e-6 1.63e-5 ✓ sig.
Lymphedema Skeletal system disease 0.111 2 3.04e-6 1.63e-5 ✓ sig.
Lymphedema Wheat allergic reaction 0.111 2 3.04e-6 1.63e-5 ✓ sig.
Bouillaud’s disease Thyroiditis 0.111 2 3.04e-6 1.63e-5 ✓ sig.
Skeletal system disease Thyroiditis 0.111 2 3.04e-6 1.63e-5 ✓ sig.
Thyroiditis Wheat allergic reaction 0.111 2 3.04e-6 1.63e-5 ✓ sig.
Autoimmune polyendocrine syndrome Latent autoimmune diabetes in adults 0.133 2 3.34e-6 1.79e-5 ✓ sig.
Aortic arch syndrome Pemphigus 0.154 2 3.54e-6 1.89e-5 ✓ sig.
Cervical intraepithelial neoplasia Obstructive asthma 0.154 2 3.54e-6 1.89e-5 ✓ sig.
Diffuse large b-cell lymphoma Follicular lymphoma 0.047 3 3.98e-6 2.10e-5 ✓ sig.
Autoimmune polyendocrine syndrome Cartilage disease 0.118 2 4.60e-6 2.40e-5 ✓ sig.
Cervical intraepithelial neoplasia Head and neck cancer 0.133 2 5.69e-6 2.92e-5 ✓ sig.
Benign mucous membrane pemphigoid with ocular involvement Gastritis 0.083 2 5.84e-6 2.99e-5 ✓ sig.
Bouillaud’s disease Gastritis 0.083 2 5.84e-6 2.99e-5 ✓ sig.
Acute disseminated encephalomyelitis Gastritis 0.083 2 5.84e-6 2.99e-5 ✓ sig.
Benign mucous membrane pemphigoid Gastritis 0.083 2 5.84e-6 2.99e-5 ✓ sig.
Bouillaud’s disease Sinusitis 0.083 2 5.84e-6 2.99e-5 ✓ sig.
Sinusitis Skeletal system disease 0.083 2 5.84e-6 2.99e-5 ✓ sig.
Sinusitis Wheat allergic reaction 0.083 2 5.84e-6 2.99e-5 ✓ sig.
Autoimmune polyendocrine syndrome Lymphedema 0.105 2 6.07e-6 3.10e-5 ✓ sig.
Autoimmune polyendocrine syndrome Thyroiditis 0.105 2 6.07e-6 3.10e-5 ✓ sig.
Oropharyngeal neoplasms Thyroiditis 0.105 2 6.07e-6 3.10e-5 ✓ sig.
Central nervous system non-hodgkin lymphoma Pulmonary alveolar proteinosis 0.133 2 6.37e-6 3.24e-5 ✓ sig.
Cervical intraepithelial neoplasia Gastroparesis 0.125 2 6.95e-6 3.52e-5 ✓ sig.
Anti-glomerular basement membrane disease Giant cell arteritis 0.095 2 7.73e-6 3.90e-5 ✓ sig.
Arthritis Bouillaud’s disease 0.071 2 8.22e-6 4.11e-5 ✓ sig.
Latent autoimmune diabetes in adults Ocular sarcoidosis 0.044 3 1.09e-5 5.36e-5 ✓ sig.
Hepatitis c induced liver cirrhosis Membranous glomerulonephritis 0.061 2 1.18e-5 5.75e-5 ✓ sig.
Bouillaud’s disease Bronchitis 0.057 2 1.33e-5 6.49e-5 ✓ sig.
Head and neck cancer Osteomyelitis 0.111 2 1.36e-5 6.60e-5 ✓ sig.
Interstitial cystitis Ocular sarcoidosis 0.042 4 1.50e-5 7.22e-5 ✓ sig.
Arthritis Autoimmune polyendocrine syndrome 0.069 2 1.64e-5 7.87e-5 ✓ sig.
Arthritis Esophageal achalasia 0.069 2 1.64e-5 7.87e-5 ✓ sig.
Arthritis Oropharyngeal neoplasms 0.069 2 1.64e-5 7.87e-5 ✓ sig.
Autoimmune polyendocrine syndrome Bronchitis 0.056 2 2.67e-5 1.24e-4 ✓ sig.
Bronchitis Esophageal achalasia 0.056 2 2.67e-5 1.24e-4 ✓ sig.
Bronchitis Oropharyngeal neoplasms 0.056 2 2.67e-5 1.24e-4 ✓ sig.
Oral cavity carcinoma Respiratory system neoplasm 0.063 2 3.18e-5 1.47e-4 ✓ sig.
Anti-neutrophil antibody associated vasculitis Pemphigus vulgaris 0.069 2 4.46e-5 2.03e-4 ✓ sig.
Autoimmune pulmonary alveolar proteinosis Heerfordt syndrome 0.500 1 6.49e-5 2.33e-4 ✓ sig.
Antiphospholipid syndrome Ocular sarcoidosis 0.039 3 5.52e-5 2.33e-4 ✓ sig.
Oral cavity carcinoma Pemphigus vulgaris 0.059 2 6.66e-5 2.39e-4 ✓ sig.
Autoimmune pancreatitis autosomal recessive osteopetrosis 3 0.333 1 1.30e-4 3.93e-4 ✓ sig.
Autoimmune pulmonary alveolar proteinosis Thromboangiitis obliterans 0.333 1 1.30e-4 3.93e-4 ✓ sig.
Heerfordt syndrome Thromboangiitis obliterans 0.333 1 1.30e-4 3.93e-4 ✓ sig.
Anti-neutrophil antibody associated vasculitis Gastroparesis 0.061 2 1.16e-4 3.93e-4 ✓ sig.
Autoimmune pulmonary alveolar proteinosis Benign mucous membrane pemphigoid with ocular involvement 0.250 1 1.95e-4 5.35e-4 ✓ sig.
Autoimmune pulmonary alveolar proteinosis Bouillaud’s disease 0.250 1 1.95e-4 5.35e-4 ✓ sig.
Acute disseminated encephalomyelitis Autoimmune pulmonary alveolar proteinosis 0.250 1 1.95e-4 5.35e-4 ✓ sig.
Bouillaud’s disease Collagenous colitis 0.250 1 1.95e-4 5.35e-4 ✓ sig.
Collagenous colitis Skeletal system disease 0.250 1 1.95e-4 5.35e-4 ✓ sig.
Collagenous colitis Wheat allergic reaction 0.250 1 1.95e-4 5.35e-4 ✓ sig.
Benign mucous membrane pemphigoid with ocular involvement Heerfordt syndrome 0.250 1 1.95e-4 5.35e-4 ✓ sig.
Bouillaud’s disease Heerfordt syndrome 0.250 1 1.95e-4 5.35e-4 ✓ sig.
Acute disseminated encephalomyelitis Heerfordt syndrome 0.250 1 1.95e-4 5.35e-4 ✓ sig.
Autoimmune pancreatitis Tongue cancer 0.250 1 2.60e-4 6.51e-4 ✓ sig.
Parapsoriasis Thromboangiitis obliterans 0.250 1 2.60e-4 6.51e-4 ✓ sig.
Anti-glomerular basement membrane disease Autoimmune pulmonary alveolar proteinosis 0.200 1 2.60e-4 6.51e-4 ✓ sig.
Anti-glomerular basement membrane disease Heerfordt syndrome 0.200 1 2.60e-4 6.51e-4 ✓ sig.
Anti-glomerular basement membrane disease Primary immunodeficiency with defective natural killer cell cytotoxicity 0.200 1 2.60e-4 6.51e-4 ✓ sig.
Autoimmune polyendocrine syndrome Collagenous colitis 0.200 1 2.60e-4 6.51e-4 ✓ sig.
Collagenous colitis Esophageal achalasia 0.200 1 2.60e-4 6.51e-4 ✓ sig.
Autoimmune pancreatitis Benign mucous membrane pemphigoid with ocular involvement 0.200 1 3.90e-4 8.67e-4 ✓ sig.
Autoimmune pancreatitis Bouillaud’s disease 0.200 1 3.90e-4 8.67e-4 ✓ sig.
Acute disseminated encephalomyelitis Autoimmune pancreatitis 0.200 1 3.90e-4 8.67e-4 ✓ sig.
Benign mucous membrane pemphigoid with ocular involvement Thromboangiitis obliterans 0.200 1 3.90e-4 8.67e-4 ✓ sig.
Benign mucous membrane pemphigoid with ocular involvement Tongue cancer 0.200 1 3.90e-4 8.67e-4 ✓ sig.
Autoimmune pancreatitis Tonsil cancer 0.200 1 3.90e-4 8.67e-4 ✓ sig.
Tongue cancer Tonsil cancer 0.200 1 3.90e-4 8.67e-4 ✓ sig.
Aortic arch syndrome Autoimmune pulmonary alveolar proteinosis 0.143 1 3.90e-4 8.67e-4 ✓ sig.
Aortic arch syndrome Heerfordt syndrome 0.143 1 3.90e-4 8.67e-4 ✓ sig.
atypical hemolytic-uremic syndrome with C3 anomaly Cold paroxysmal hemoglobinuria 0.143 1 3.90e-4 8.67e-4 ✓ sig.
atypical hemolytic-uremic syndrome with C3 anomaly Hemoglobinuria paroxysmal 0.143 1 3.90e-4 8.67e-4 ✓ sig.
atypical hemolytic-uremic syndrome with C3 anomaly Paroxysmal nocturnal hemoglobinuria 0.143 1 3.90e-4 8.67e-4 ✓ sig.
Benign hereditary chorea Choreoacanthocytosis 0.125 1 4.55e-4 9.73e-4 ✓ sig.
Disabling pansclerotic morphea of childhood Uveomeningoencephalitic syndrome 0.125 1 4.55e-4 9.73e-4 ✓ sig.
distal myopathy with vocal cord weakness Vogt-koyanagi-harada disease 0.125 1 4.55e-4 9.73e-4 ✓ sig.
Central nervous system non-hodgkin lymphoma immunodeficiency 60 0.125 1 4.55e-4 9.73e-4 ✓ sig.
Pemphigus vulgaris Thiopurine immunosuppressant-induced pancreatitis 0.125 1 4.55e-4 9.73e-4 ✓ sig.
Anti-glomerular basement membrane disease Thromboangiitis obliterans 0.167 1 5.19e-4 1.06e-3 ✓ sig.
Apolipoprotein b hypobetalipoproteinemia Autoimmune pancreatitis 0.167 1 5.19e-4 1.06e-3 ✓ sig.
Apolipoprotein b hypobetalipoproteinemia Tongue cancer 0.167 1 5.19e-4 1.06e-3 ✓ sig.
Autoimmune pancreatitis Churg-strauss syndrome 0.167 1 5.19e-4 1.06e-3 ✓ sig.
Churg-strauss syndrome Tongue cancer 0.167 1 5.19e-4 1.06e-3 ✓ sig.
Congenital isolated acth deficiency Duodenitis 0.111 1 5.20e-4 1.06e-3 ✓ sig.
Benign mucous membrane pemphigoid with ocular involvement Tonsil cancer 0.167 1 5.84e-4 1.16e-3 ✓ sig.
Bouillaud’s disease Tonsil cancer 0.167 1 5.84e-4 1.16e-3 ✓ sig.
Acute disseminated encephalomyelitis Tonsil cancer 0.167 1 5.84e-4 1.16e-3 ✓ sig.
Autoimmune pulmonary alveolar proteinosis Follicular lymphoma 0.100 1 5.84e-4 1.16e-3 ✓ sig.
Follicular lymphoma Heerfordt syndrome 0.100 1 5.84e-4 1.16e-3 ✓ sig.
Autoimmune pulmonary alveolar proteinosis Pulmonary alveolar proteinosis 0.100 1 5.84e-4 1.16e-3 ✓ sig.
Heerfordt syndrome Pulmonary alveolar proteinosis 0.100 1 5.84e-4 1.16e-3 ✓ sig.
Blepharitis Respiratory system neoplasm 0.143 1 6.49e-4 1.24e-3 ✓ sig.
Autoimmune pancreatitis Respiratory system neoplasm 0.143 1 6.49e-4 1.24e-3 ✓ sig.
Respiratory system neoplasm Tongue cancer 0.143 1 6.49e-4 1.24e-3 ✓ sig.
Autoimmune pulmonary alveolar proteinosis Congenital pulmonary artery atresia 0.083 1 7.14e-4 1.34e-3 ✓ sig.
Congenital pulmonary artery atresia Heerfordt syndrome 0.083 1 7.14e-4 1.34e-3 ✓ sig.
Apolipoprotein b hypobetalipoproteinemia Benign mucous membrane pemphigoid with ocular involvement 0.143 1 7.79e-4 1.41e-3 ✓ sig.
Apolipoprotein b hypobetalipoproteinemia Bouillaud’s disease 0.143 1 7.79e-4 1.41e-3 ✓ sig.
Acute disseminated encephalomyelitis Apolipoprotein b hypobetalipoproteinemia 0.143 1 7.79e-4 1.41e-3 ✓ sig.
Benign mucous membrane pemphigoid with ocular involvement Churg-strauss syndrome 0.143 1 7.79e-4 1.41e-3 ✓ sig.
Bouillaud’s disease Churg-strauss syndrome 0.143 1 7.79e-4 1.41e-3 ✓ sig.
Acute disseminated encephalomyelitis Churg-strauss syndrome 0.143 1 7.79e-4 1.41e-3 ✓ sig.
Autoimmune polyendocrine syndrome Hypoparathyroidism 0.143 1 7.79e-4 1.41e-3 ✓ sig.
Aortic arch syndrome Parapsoriasis 0.125 1 7.79e-4 1.41e-3 ✓ sig.
Autoimmune musculoskeletal system disorder Disabling pansclerotic morphea of childhood 0.077 1 7.79e-4 1.41e-3 ✓ sig.
immunodeficiency 60 Latent autoimmune diabetes in adults 0.077 1 7.79e-4 1.41e-3 ✓ sig.
Thyrotoxic periodic paralysis X-linked epilepsy with or without intellectual disability and dysmorphic features 0.077 1 7.79e-4 1.41e-3 ✓ sig.
Autoimmune pancreatitis Duodenitis 0.100 1 1.04e-3 1.74e-3 ✓ sig.
Duodenitis Tongue cancer 0.100 1 1.04e-3 1.74e-3 ✓ sig.
Peeling skin syndrome with leukonychia and acral punctate keratoses Pemphigus 0.100 1 1.04e-3 1.74e-3 ✓ sig.
IMPDH1-related retinopathy Thyroiditis 0.059 1 1.04e-3 1.74e-3 ✓ sig.
Follicular lymphoma Thromboangiitis obliterans 0.091 1 1.17e-3 1.90e-3 ✓ sig.
Bronchial disease Vici syndrome 0.053 1 1.17e-3 1.90e-3 ✓ sig.
Chorea Choreoacanthocytosis 0.053 1 1.17e-3 1.90e-3 ✓ sig.
Dysbiosis Giant cell arteritis 0.053 1 1.17e-3 1.90e-3 ✓ sig.
Chorea hsd10 mitochondrial disease 0.053 1 1.17e-3 1.90e-3 ✓ sig.
Chorea Intellectual developmental disorder seizures movement 0.053 1 1.17e-3 1.90e-3 ✓ sig.
Chorea optic atrophy 10 with or without ataxia, intellectual disability, and seizures 0.053 1 1.17e-3 1.90e-3 ✓ sig.
Giant cell arteritis Primary immunodeficiency with defective natural killer cell cytotoxicity 0.053 1 1.17e-3 1.90e-3 ✓ sig.
Henoch schoenlein purpura Thiopurine immunosuppressant-induced pancreatitis 0.053 1 1.17e-3 1.90e-3 ✓ sig.
Respiratory system neoplasm Waldenstrom macroglobulinemia 0.111 1 1.30e-3 2.06e-3 ✓ sig.
Hepatitis c induced liver cirrhosis Pemphigus vulgaris 0.100 1 1.36e-3 2.15e-3 ✓ sig.
Congenital pulmonary artery atresia Thromboangiitis obliterans 0.077 1 1.43e-3 2.23e-3 ✓ sig.
Autoimmune gastritis Gastritis 0.043 1 1.43e-3 2.23e-3 ✓ sig.
Gastritis platelet abnormalities with eosinophilia and immune-mediated inflammatory disease 0.043 1 1.43e-3 2.23e-3 ✓ sig.
Anti-neutrophil antibody associated vasculitis Thiopurine immunosuppressant-induced pancreatitis 0.042 1 1.49e-3 2.31e-3 ✓ sig.
Benign mucous membrane pemphigoid with ocular involvement Duodenitis 0.091 1 1.56e-3 2.38e-3 ✓ sig.
Autoimmune pancreatitis Thyrotoxic periodic paralysis 0.071 1 1.56e-3 2.38e-3 ✓ sig.
Thyrotoxic periodic paralysis Tongue cancer 0.071 1 1.56e-3 2.38e-3 ✓ sig.
Arthritis Dysbiosis 0.037 1 1.69e-3 2.53e-3 ✓ sig.
Arthritis Primary immunodeficiency with defective natural killer cell cytotoxicity 0.037 1 1.69e-3 2.53e-3 ✓ sig.
Benign mucous membrane pemphigoid with ocular involvement Follicular lymphoma 0.083 1 1.75e-3 2.61e-3 ✓ sig.
Bouillaud’s disease Follicular lymphoma 0.083 1 1.75e-3 2.61e-3 ✓ sig.
Blepharitis Rosacea 0.063 1 1.82e-3 2.68e-3 ✓ sig.
Intellectual developmental disorder seizures movement Oral cavity carcinoma 0.034 1 1.82e-3 2.68e-3 ✓ sig.
Benign mucous membrane pemphigoid with ocular involvement Congenital pulmonary artery atresia 0.071 1 2.14e-3 3.04e-3 ✓ sig.
Bouillaud’s disease Congenital pulmonary artery atresia 0.071 1 2.14e-3 3.04e-3 ✓ sig.
Bronchitis Neurodevelopmental disorder with dilated cardiomyopathy 0.029 1 2.14e-3 3.04e-3 ✓ sig.
Interstitial cystitis neurodevelopmental disorder with microcephaly, seizures, and cortical atrophy 0.024 1 2.60e-3 3.51e-3 ✓ sig.
Interstitial cystitis Thiopurine immunosuppressant-induced pancreatitis 0.024 1 2.60e-3 3.51e-3 ✓ sig.
KIZ-related retinopathy Lupus nephritis 0.023 1 2.73e-3 3.66e-3 ✓ sig.
Gastritis Keratosis palmoplantaris papulosa 0.042 1 2.86e-3 3.81e-3 ✓ sig.
Birbeck granule deficiency Narcolepsy 0.019 1 3.31e-3 4.31e-3 ✓ sig.
immunodeficiency 106, susceptibility to viral infections Narcolepsy 0.019 1 3.31e-3 4.31e-3 ✓ sig.
Narcolepsy Uric acid urolithiasis 0.019 1 3.31e-3 4.31e-3 ✓ sig.
congenital disorder of glycosylation type II Lymphoma 0.019 1 3.44e-3 4.45e-3 ✓ sig.
Osteomyelitis Parenchymal hematoma 0.067 1 3.50e-3 4.52e-3 ✓ sig.
Henoch schoenlein purpura Hepatitis c induced liver cirrhosis 0.048 1 3.50e-3 4.52e-3 ✓ sig.
immunodeficiency 126, susceptibility to Ocular sarcoidosis 0.017 1 3.77e-3 4.81e-3 ✓ sig.
Ocular sarcoidosis scalp-ear-nipple syndrome 0.017 1 3.77e-3 4.81e-3 ✓ sig.
Antiphospholipid syndrome Hepatitis c induced liver cirrhosis 0.043 1 3.89e-3 4.94e-3 ✓ sig.
Autonomic nervous system disease Immune system disease 0.021 1 5.97e-3 7.19e-3 ✓ sig.