CXCL11 (C-X-C motif chemokine ligand 11)

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Gene Gene information from NCBI Gene database.
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Entrez ID 6373
Gene name C-X-C motif chemokine ligand 11
Gene symbol CXCL11
Synonyms (NCBI Gene)
H174I-TACIP-9IP9SCYB11SCYB9Bb-R1
Chromosome 4
Chromosome location 4q21.1
Summary Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chem
miRNA miRNA information provided by mirtarbase database.
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miRTarBase ID miRNA Experiments Reference
MIRT530625 hsa-miR-6835-3p PAR-CLIP 22012620
MIRT530624 hsa-miR-548b-3p PAR-CLIP 22012620
MIRT530623 hsa-miR-4511 PAR-CLIP 22012620
MIRT530622 hsa-miR-30a-5p PAR-CLIP 22012620
MIRT530621 hsa-miR-30b-5p PAR-CLIP 22012620
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0005125 Function Cytokine activity IEA
GO:0005515 Function Protein binding IPI 18275857, 21314817, 25416956, 27044744, 28381538
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
604852 10638 ENSG00000169248
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O14625
Protein name C-X-C motif chemokine 11 (Beta-R1) (H174) (Interferon gamma-inducible protein 9) (IP-9) (Interferon-inducible T-cell alpha chemoattractant) (I-TAC) (Small-inducible cytokine B11)
Protein function Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May
PDB 1RJT , 8HNK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00048 IL8 28 → 89 Small cytokines (intecrine/chemokine), interleukin-8 like Domain
Tissue specificity TISSUE SPECIFICITY: High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin diso
Sequence
Sequence length 94
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway Reactome Pathway
Cytokine-cytokine receptor interaction Chemokine receptors bind chemokines
Viral protein interaction with cytokine and cytokine receptor G alpha (i) signalling events
Chemokine signaling pathway  
Toll-like receptor signaling pathway  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
CARCINOMA, PANCREATIC DUCTAL — CTD 24979617
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CELIAC DISEASE — CTD, Disgenet
CTD, Disgenet 		30097691
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CYSTITIS, INTERSTITIAL — CTD 18957084
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
INTERSTITIAL CYSTITIS — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (183)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Of Esophagus Esophageal Cancer BEFREE 30201443
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult type dermatomyositis Dermatomyositis BEFREE 28487565
★★★★★
★☆☆☆☆
Found in Text Mining only
Age related macular degeneration Age-related macular degeneration BEFREE 21884302, 23601964
★★★★★
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 39929297 Inhibit
★★★★★
★☆☆☆☆
Found in Text Mining only
Amyloidosis cutis dyschromia Amyloidosis Cutis Dyschromia BEFREE 15307136
★★★★★
★☆☆☆☆
Found in Text Mining only
Angioedemas Hereditary Angioedema Pubtator 36142237 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Juvenile Juvenile arthritis Pubtator 34963488 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Psoriatic Psoriatic arthritis Pubtator 35095831 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 21255008 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Asthma Asthma BEFREE 15944327, 28836545
★★★★★
★☆☆☆☆
Found in Text Mining only
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CXCL9 3 shared diseasesCeliac disease, Interstitial cystitis, Cystitis 6 shared pathwaysCytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Toll-like receptor signaling pathway, G alpha (i) signalling events, Chemokine receptors bind chemokines 4 shared evidence sourcesCTD (Celiac disease), Disgenet (Celiac disease), CTD (Cystitis), Disgenet (Interstitial cystitis) Related via 6 shared pathways including Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor — evidence mostly CTD. CXCL10 3 shared diseasesCeliac disease, Interstitial cystitis, Cystitis 6 shared pathwaysCytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Toll-like receptor signaling pathway, G alpha (i) signalling events, Chemokine receptors bind chemokines 4 shared evidence sourcesCTD (Celiac disease), Disgenet (Celiac disease), CTD (Cystitis), Disgenet (Interstitial cystitis) Related via 6 shared pathways including Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor — evidence mostly CTD. CCR4 1 shared diseaseCeliac disease 5 shared pathwaysCytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, G alpha (i) signalling events, Chemokine receptors bind chemokines 2 shared evidence sourcesCTD (Celiac disease), Disgenet (Celiac disease) Related via 5 shared pathways including Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor — evidence mostly CTD. CXCR5 1 shared diseaseCeliac disease 5 shared pathwaysCytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, G alpha (i) signalling events, Chemokine receptors bind chemokines Related via 5 shared pathways including Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor. CXCL13 5 shared pathwaysCytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, G alpha (i) signalling events, Chemokine receptors bind chemokines Related via 5 shared pathways including Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor.
Biliary cirrhosis Linked via 3 of 5 related genesCXCL9, CXCL10, CXCR5 Liver cirrhosis Linked via 3 of 5 related genesCXCL9, CXCL10, CXCR5 Biliary cholangitis Linked via 3 of 5 related genesCXCL9, CXCL10, CXCR5 Major depressive disorder Linked via 3 of 5 related genesCXCL10, CCR4, CXCR5 Endometriosis Linked via 2 of 5 related genesCXCL9, CXCL13