CCR4 (C-C motif chemokine receptor 4)

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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 1233
• Gene name: C-C motif chemokine receptor 4
• Gene symbol: CCR4
• Synonyms (NCBI Gene): CC-CKR-4, CD194, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5
• Chromosome: 3
• Chromosome location: 3p22.3
• Summary: The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell traff

miRNA Show/Hide all (161)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018019	hsa-miR-335-5p	Microarray	18185580
MIRT635508	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT677124	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT677123	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT677122	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT635507	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT635506	hsa-miR-764	HITS-CLIP	23824327
MIRT635505	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT635504	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT635503	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT635502	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT635500	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT635499	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT635498	hsa-miR-4454	HITS-CLIP	23824327
MIRT635497	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635496	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT635495	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT677121	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT635494	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT635493	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT635508	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT677124	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT677123	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT677122	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT635507	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT635506	hsa-miR-764	HITS-CLIP	23824327
MIRT635505	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT635504	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT635503	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT635502	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT635501	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT635500	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT635499	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT635498	hsa-miR-4454	HITS-CLIP	23824327
MIRT635497	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635496	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT635495	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT677121	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT635494	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT635493	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT635508	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT635507	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT635506	hsa-miR-764	HITS-CLIP	23824327
MIRT635505	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT635504	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT635503	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT635502	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT635501	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT635500	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT635499	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT635498	hsa-miR-4454	HITS-CLIP	23824327
MIRT635497	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635496	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT635495	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT635494	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT635493	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT571161	hsa-miR-4695-5p	PAR-CLIP	20371350
MIRT571162	hsa-miR-4459	PAR-CLIP	20371350
MIRT571160	hsa-miR-665	PAR-CLIP	20371350
MIRT571159	hsa-miR-6840-3p	PAR-CLIP	20371350
MIRT571158	hsa-miR-6087	PAR-CLIP	20371350
MIRT571157	hsa-miR-6499-3p	PAR-CLIP	20371350
MIRT571156	hsa-miR-25-5p	PAR-CLIP	20371350
MIRT571155	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT571154	hsa-miR-455-3p	PAR-CLIP	20371350
MIRT571153	hsa-miR-6516-5p	PAR-CLIP	20371350
MIRT571152	hsa-miR-1273e	PAR-CLIP	20371350
MIRT571152	hsa-miR-1273e	PAR-CLIP	27292025
MIRT571156	hsa-miR-25-5p	PAR-CLIP	27292025
MIRT571162	hsa-miR-4459	PAR-CLIP	27292025
MIRT571154	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT571161	hsa-miR-4695-5p	PAR-CLIP	27292025
MIRT571158	hsa-miR-6087	PAR-CLIP	27292025
MIRT571157	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT571153	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT571160	hsa-miR-665	PAR-CLIP	27292025
MIRT571155	hsa-miR-6807-5p	PAR-CLIP	27292025
MIRT571159	hsa-miR-6840-3p	PAR-CLIP	27292025
MIRT735368	hsa-miR-6089	Luciferase reporter assay, Western blotting, qRT-PCR	32552050
MIRT635508	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT677124	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT677123	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT677122	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT635507	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT635506	hsa-miR-764	HITS-CLIP	23824327
MIRT635505	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT635504	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT635503	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT635502	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT635500	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT635499	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT635498	hsa-miR-4454	HITS-CLIP	23824327
MIRT635497	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635496	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT635495	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT677121	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT635494	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT635493	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT635508	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT677124	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT677123	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT677122	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT635507	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT635506	hsa-miR-764	HITS-CLIP	23824327
MIRT635505	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT635504	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT635503	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT635502	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT635501	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT635500	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT635499	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT635498	hsa-miR-4454	HITS-CLIP	23824327
MIRT635497	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635496	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT635495	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT677121	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT635494	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT635493	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT635508	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT635507	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT635506	hsa-miR-764	HITS-CLIP	23824327
MIRT635505	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT635504	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT635503	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT635502	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT635501	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT635500	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT635499	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT635498	hsa-miR-4454	HITS-CLIP	23824327
MIRT635497	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635496	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT635495	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT635494	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT635493	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT571161	hsa-miR-4695-5p	PAR-CLIP	20371350
MIRT571162	hsa-miR-4459	PAR-CLIP	20371350
MIRT571160	hsa-miR-665	PAR-CLIP	20371350
MIRT571159	hsa-miR-6840-3p	PAR-CLIP	20371350
MIRT571158	hsa-miR-6087	PAR-CLIP	20371350
MIRT571157	hsa-miR-6499-3p	PAR-CLIP	20371350
MIRT571156	hsa-miR-25-5p	PAR-CLIP	20371350
MIRT571155	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT571154	hsa-miR-455-3p	PAR-CLIP	20371350
MIRT571153	hsa-miR-6516-5p	PAR-CLIP	20371350
MIRT571152	hsa-miR-1273e	PAR-CLIP	20371350
MIRT873216	hsa-miR-1205	CLIP-seq
MIRT873217	hsa-miR-345	CLIP-seq
MIRT873218	hsa-miR-4690-3p	CLIP-seq
MIRT873219	hsa-miR-4726-3p	CLIP-seq
MIRT873220	hsa-miR-4742-5p	CLIP-seq
MIRT873221	hsa-miR-4763-5p	CLIP-seq
MIRT1959082	hsa-miR-3124-3p	CLIP-seq
MIRT1959083	hsa-miR-3692	CLIP-seq
MIRT1959084	hsa-miR-4318	CLIP-seq
MIRT1959085	hsa-miR-4436b-5p	CLIP-seq
MIRT1959086	hsa-miR-4455	CLIP-seq
MIRT1959087	hsa-miR-511	CLIP-seq
MIRT1959088	hsa-miR-609	CLIP-seq
MIRT1959089	hsa-miR-626	CLIP-seq
MIRT873216	hsa-miR-1205	CLIP-seq
MIRT873221	hsa-miR-4763-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
FOSL2	Activation	22493372
FOXP3	Activation	21036387
JUND	Activation	22493372
TBX21	Repression	14500650

Gene ontology (GO) Show/Hide all (35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001764	Process	Neuron migration	IEA
GO:0002507	Process	Tolerance induction	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004950	Function	Chemokine receptor activity	IEA
GO:0004950	Function	Chemokine receptor activity	TAS	7642634
GO:0005515	Function	Protein binding	IPI	28381538, 32296183
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	7642634
GO:0006935	Process	Chemotaxis	IEA
GO:0006935	Process	Chemotaxis	IEA
GO:0006935	Process	Chemotaxis	TAS	7642634
GO:0006954	Process	Inflammatory response	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0006954	Process	Inflammatory response	TAS	7642634
GO:0006955	Process	Immune response	IBA
GO:0006955	Process	Immune response	IEA
GO:0006955	Process	Immune response	TAS	7642634
GO:0007165	Process	Signal transduction	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	TAS	7642634
GO:0009897	Component	External side of plasma membrane	IBA
GO:0009897	Component	External side of plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0016493	Function	C-C chemokine receptor activity	IBA
GO:0016493	Function	C-C chemokine receptor activity	IEA
GO:0019722	Process	Calcium-mediated signaling	IBA
GO:0019957	Function	C-C chemokine binding	IBA
GO:0048872	Process	Homeostasis of number of cells	IEA
GO:0060326	Process	Cell chemotaxis	IBA
GO:0070098	Process	Chemokine-mediated signaling pathway	IEA
GO:0071345	Process	Cellular response to cytokine stimulus	IEA
GO:1904936	Process	Interneuron migration	IEA

Other IDs

• MIM: 604836
• HGNC: 1605
• e!Ensembl: ENSG00000183813

Protein

• UniProt ID: P51679
• Protein name: C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) (CD antigen CD194)
• Protein function: High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	56 → 304	7 transmembrane receptor (rhodopsin family)	Family

• Tissue specificity: TISSUE SPECIFICITY: Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes (PubMed:10754297, PubMed:9169480). Detected a
• Sequence:

  MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV
  VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVG
  FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT
  ERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKA
  VKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN
  PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
  

• Sequence length: 360

Pathways

KEGG Pathway	Reactome Pathway
Cytokine-cytokine receptor interaction	Chemokine receptors bind chemokines
Viral protein interaction with cytokine and cytokine receptor	G alpha (i) signalling events
Chemokine signaling pathway
Kaposi sarcoma-associated herpesvirus infection
Viral carcinogenesis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (9)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
BRAIN ISCHEMIA	—	CTD, Disgenet CTD, Disgenet	15829914	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CELIAC DISEASE	—	CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog	20190752, 22057235	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	CTD	17522861	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEPATOCELLULAR CARCINOMA	—	GWAS catalog	21105107	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEUKEMIA-LYMPHOMA, ADULT T-CELL	—	CTD	26437031	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER NEOPLASMS	—	CTD	19233941	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	29071344	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	24076602, 31604244	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEZARY SYNDROME	—	CTD	26551670	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

Sort by: Blended Diseases Pathways Evidence source

CCR8 7 shared pathwaysCytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Viral carcinogenesis, G alpha (i) signalling events, Chemokine receptors bind chemokines Related via 7 shared pathways including Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor. CCR3 1 shared diseaseCeliac disease 7 shared pathwaysCytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Viral carcinogenesis, G alpha (i) signalling events, Chemokine receptors bind chemokines 1 shared evidence sourceGWAS catalog (Celiac disease) Related via 7 shared pathways including Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor — evidence mostly GWAS catalog. CXCL11 1 shared diseaseCeliac disease 5 shared pathwaysCytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, G alpha (i) signalling events, Chemokine receptors bind chemokines 2 shared evidence sourcesCTD (Celiac disease), Disgenet (Celiac disease) Related via 5 shared pathways including Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor — evidence mostly CTD. EGLN3 2 shared diseasesCeliac disease, Liver neoplasms 2 shared evidence sourcesGWAS catalog (Celiac disease), CTD (Liver neoplasms) Related via 2 shared diseases including Celiac disease, Liver neoplasms — evidence mostly GWAS catalog. CXCL10 2 shared diseasesBrain ischemia, Celiac disease 5 shared pathwaysCytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, G alpha (i) signalling events, Chemokine receptors bind chemokines 4 shared evidence sourcesCTD (Brain ischemia), Disgenet (Brain ischemia), CTD (Celiac disease), Disgenet (Celiac disease) Related via 5 shared pathways including Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor — evidence mostly CTD.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
CCR8	0	[]	7	["Cytokine-cytokine receptor interaction","Viral protein interaction with cytokine and cytokine receptor","Chemokine signaling pathway","Kaposi sarcoma-associated herpesvirus infection","Viral carcinogenesis","G alpha (i) signalling events","Chemokine receptors bind chemokines"]	0	[]
CCR3	1	["Celiac disease"]	7	["Cytokine-cytokine receptor interaction","Viral protein interaction with cytokine and cytokine receptor","Chemokine signaling pathway","Kaposi sarcoma-associated herpesvirus infection","Viral carcinogenesis","G alpha (i) signalling events","Chemokine receptors bind chemokines"]	1	["GWAS catalog (Celiac disease)"]
CXCL11	1	["Celiac disease"]	5	["Cytokine-cytokine receptor interaction","Viral protein interaction with cytokine and cytokine receptor","Chemokine signaling pathway","G alpha (i) signalling events","Chemokine receptors bind chemokines"]	2	["CTD (Celiac disease)","Disgenet (Celiac disease)"]
EGLN3	2	["Celiac disease","Liver neoplasms"]	0	[]	2	["GWAS catalog (Celiac disease)","CTD (Liver neoplasms)"]
CXCL10	2	["Brain ischemia","Celiac disease"]	5	["Cytokine-cytokine receptor interaction","Viral protein interaction with cytokine and cytokine receptor","Chemokine signaling pathway","G alpha (i) signalling events","Chemokine receptors bind chemokines"]	4	["CTD (Brain ischemia)","Disgenet (Brain ischemia)","CTD (Celiac disease)","Disgenet (Celiac disease)"]

Diseases Linked via Similar Genes

Status epilepticus Linked via 2 of 5 related genesCCR8, CCR3 Atopic dermatitis Linked via 2 of 5 related genesCCR3, CXCL10 Cystitis Linked via 2 of 5 related genesCXCL11, CXCL10 Interstitial cystitis Linked via 2 of 5 related genesCXCL11, CXCL10 Hypothyroidism Linked via 1 of 5 related genesCCR8

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Status epilepticus	2	["CCR8","CCR3"]
Atopic dermatitis	2	["CCR3","CXCL10"]
Cystitis	2	["CXCL11","CXCL10"]
Interstitial cystitis	2	["CXCL11","CXCL10"]
Hypothyroidism	1	["CCR8"]