Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 22

19 diseases · 33 shared-gene connections
19 Diseases
487 Unique genes
0.086 Avg. similarity score
Obstructive airway disease Most-connected disease (9 links)
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Disease Searched: Pulmonary fibrosis Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Obstructive airway disease 9 9 100
Chronic obstructive pulmonary disease 7 7 42
Interstitial lung disease 5 5 66
Lung disease 5 5 101
Pulmonary fibrosis 5 5 107
Asbestosis 4 4 17
Bronchopulmonary dysplasia 4 4 45
Cystic fibrosis 4 4 62
Idiopathic pulmonary fibrosis 4 4 82
Oral submucous fibrosis 4 4 20
Sepsis 3 3 34
Emphysema 2 2 36
Hepatolenticular degeneration 2 2 27
interstitial lung disease 2 2 2 1
susceptibility to respiratory infections associated with CD8alpha chain mutation 2 2 1
ALG11-congenital disorder of glycosylation 1 1 1
Brain calcification 1 1 1
Genetic generalized epilepsy 1 1 1
lung disease, immunodeficiency, and chromosome breakage syndrome; 1 1 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
TNF 11 / 19 Asbestosis, Bronchopulmonary dysplasia, Chronic obstructive pulmonary disease, Cystic fibrosis and 7 more
IL1B 7 / 19 Asbestosis, Bronchopulmonary dysplasia, Cystic fibrosis, Lung disease and 3 more
SERPINA1 7 / 19 Asbestosis, Chronic obstructive pulmonary disease, Cystic fibrosis, Emphysema and 3 more
TGFB1 7 / 19 Chronic obstructive pulmonary disease, Cystic fibrosis, Lung disease, Obstructive airway disease and 3 more
GSTM1 6 / 19 Asbestosis, Bronchopulmonary dysplasia, Cystic fibrosis, Lung disease and 2 more
GSTT1 6 / 19 Asbestosis, Bronchopulmonary dysplasia, Cystic fibrosis, Lung disease and 2 more
IL6 6 / 19 Chronic obstructive pulmonary disease, Hepatolenticular degeneration, Obstructive airway disease, Oral submucous fibrosis and 2 more
MMP9 6 / 19 Chronic obstructive pulmonary disease, Lung disease, Obstructive airway disease, Oral submucous fibrosis and 2 more
PTGS2 6 / 19 Cystic fibrosis, Idiopathic pulmonary fibrosis, Lung disease, Obstructive airway disease and 2 more
SFTPA1 6 / 19 Bronchopulmonary dysplasia, Idiopathic pulmonary fibrosis, Interstitial lung disease, Lung disease and 2 more
ABCA3 5 / 19 Emphysema, Idiopathic pulmonary fibrosis, Interstitial lung disease, Lung disease and 1 more
DSP 5 / 19 Chronic obstructive pulmonary disease, Idiopathic pulmonary fibrosis, Interstitial lung disease, Obstructive airway disease and 1 more
FAM13A 5 / 19 Chronic obstructive pulmonary disease, Idiopathic pulmonary fibrosis, Interstitial lung disease, Obstructive airway disease and 1 more
MIF 5 / 19 Chronic obstructive pulmonary disease, Cystic fibrosis, Lung disease, Obstructive airway disease and 1 more
NOS2 5 / 19 Asbestosis, Chronic obstructive pulmonary disease, Emphysema, Obstructive airway disease and 1 more
SFTPC 5 / 19 Idiopathic pulmonary fibrosis, Interstitial lung disease, Lung disease, Obstructive airway disease and 1 more
CXCL8 4 / 19 Chronic obstructive pulmonary disease, Hepatolenticular degeneration, Oral submucous fibrosis, Pulmonary fibrosis
EPHX1 4 / 19 Asbestosis, Chronic obstructive pulmonary disease, Cystic fibrosis, Obstructive airway disease
HIF1A 4 / 19 Chronic obstructive pulmonary disease, Idiopathic pulmonary fibrosis, Lung disease, Obstructive airway disease
HMOX1 4 / 19 Chronic obstructive pulmonary disease, Cystic fibrosis, Obstructive airway disease, Pulmonary fibrosis
IL1RN 4 / 19 Bronchopulmonary dysplasia, Interstitial lung disease, Obstructive airway disease, Pulmonary fibrosis
MBL2 4 / 19 Bronchopulmonary dysplasia, Cystic fibrosis, Obstructive airway disease, Pulmonary fibrosis
NOS3 4 / 19 Chronic obstructive pulmonary disease, Cystic fibrosis, Obstructive airway disease, Sepsis
RTEL1 4 / 19 Idiopathic pulmonary fibrosis, Interstitial lung disease, Obstructive airway disease, Pulmonary fibrosis
SFTPB 4 / 19 Bronchopulmonary dysplasia, Lung disease, Obstructive airway disease, Pulmonary fibrosis
SFTPD 4 / 19 Bronchopulmonary dysplasia, Chronic obstructive pulmonary disease, Lung disease, Obstructive airway disease
TERT 4 / 19 Idiopathic pulmonary fibrosis, Interstitial lung disease, Obstructive airway disease, Pulmonary fibrosis
ACE 3 / 19 Lung disease, Obstructive airway disease, Pulmonary fibrosis
ADRB2 3 / 19 Cystic fibrosis, Lung disease, Obstructive airway disease
CD8A 3 / 19 Chronic obstructive pulmonary disease, Obstructive airway disease, susceptibility to respiratory infections associated with CD8alpha chain mutation
CFTR 3 / 19 Cystic fibrosis, Lung disease, Obstructive airway disease
CHRNA5 3 / 19 Emphysema, Lung disease, Obstructive airway disease
CSF3 3 / 19 Lung disease, Pulmonary fibrosis, Sepsis
CXCL2 3 / 19 Chronic obstructive pulmonary disease, Obstructive airway disease, Pulmonary fibrosis
CYP1A1 3 / 19 Chronic obstructive pulmonary disease, Cystic fibrosis, Obstructive airway disease
ELN 3 / 19 Chronic obstructive pulmonary disease, Obstructive airway disease, Pulmonary fibrosis
GSTP1 3 / 19 Bronchopulmonary dysplasia, Lung disease, Obstructive airway disease
HDAC2 3 / 19 Chronic obstructive pulmonary disease, Emphysema, Obstructive airway disease
HLA-DPB1 3 / 19 Interstitial lung disease, Lung disease, Obstructive airway disease
HSPA1A 3 / 19 Cystic fibrosis, Obstructive airway disease, Pulmonary fibrosis
IL13 3 / 19 Lung disease, Obstructive airway disease, Pulmonary fibrosis
MMP1 3 / 19 Interstitial lung disease, Lung disease, Oral submucous fibrosis
MUC5AC 3 / 19 Idiopathic pulmonary fibrosis, Interstitial lung disease, Pulmonary fibrosis
MUC5B 3 / 19 Idiopathic pulmonary fibrosis, Interstitial lung disease, Pulmonary fibrosis
NFE2L2 3 / 19 Emphysema, Lung disease, Pulmonary fibrosis
PLAU 3 / 19 Emphysema, Idiopathic pulmonary fibrosis, Pulmonary fibrosis
SFTPA2 3 / 19 Idiopathic pulmonary fibrosis, Interstitial lung disease, interstitial lung disease 2
SOD3 3 / 19 Chronic obstructive pulmonary disease, Obstructive airway disease, Pulmonary fibrosis
SPDL1 3 / 19 Idiopathic pulmonary fibrosis, Interstitial lung disease, Pulmonary fibrosis
TIMP1 3 / 19 Hepatolenticular degeneration, Oral submucous fibrosis, Pulmonary fibrosis
TLR4 3 / 19 Chronic obstructive pulmonary disease, Obstructive airway disease, Sepsis
TNFRSF8 3 / 19 Chronic obstructive pulmonary disease, Emphysema, Obstructive airway disease
TOLLIP 3 / 19 Idiopathic pulmonary fibrosis, Interstitial lung disease, Obstructive airway disease
TP53 3 / 19 Chronic obstructive pulmonary disease, Emphysema, Obstructive airway disease
ZKSCAN1 3 / 19 Idiopathic pulmonary fibrosis, Interstitial lung disease, Pulmonary fibrosis
A2M 2 / 19 Hepatolenticular degeneration, Lung disease
ACTRT3 2 / 19 Idiopathic pulmonary fibrosis, Pulmonary fibrosis
AGER 2 / 19 Chronic obstructive pulmonary disease, Cystic fibrosis
AGTR2 2 / 19 Cystic fibrosis, Lung disease
AKAP13 2 / 19 Idiopathic pulmonary fibrosis, Interstitial lung disease
ALG11 2 / 19 ALG11-congenital disorder of glycosylation, Hepatolenticular degeneration
AP3B1 2 / 19 Lung disease, Pulmonary fibrosis
APIP 2 / 19 Cystic fibrosis, Lung disease
APOE 2 / 19 Emphysema, Hepatolenticular degeneration
ARL17B 2 / 19 Interstitial lung disease, Pulmonary fibrosis
ATP11A 2 / 19 Idiopathic pulmonary fibrosis, Interstitial lung disease
CAT 2 / 19 Lung disease, Pulmonary fibrosis
CCN2 2 / 19 Lung disease, Pulmonary fibrosis
CDKN1A 2 / 19 Chronic obstructive pulmonary disease, Obstructive airway disease
CDKN2A 2 / 19 Chronic obstructive pulmonary disease, Obstructive airway disease
CEBPA 2 / 19 Emphysema, Pulmonary fibrosis
CEBPB 2 / 19 Cystic fibrosis, Pulmonary fibrosis
CFD 2 / 19 Asbestosis, Pulmonary fibrosis
CHRM3 2 / 19 Obstructive airway disease, Pulmonary fibrosis
CHRNA3 2 / 19 Lung disease, Obstructive airway disease
CRP 2 / 19 Chronic obstructive pulmonary disease, Obstructive airway disease
CSMD1 2 / 19 Emphysema, Interstitial lung disease
CTLA4 2 / 19 Obstructive airway disease, Oral submucous fibrosis
CTNNA3 2 / 19 Bronchopulmonary dysplasia, Interstitial lung disease
CXCL1 2 / 19 Chronic obstructive pulmonary disease, Obstructive airway disease
CYP1A2 2 / 19 Chronic obstructive pulmonary disease, Obstructive airway disease
DEFB1 2 / 19 Lung disease, Obstructive airway disease
DEPTOR 2 / 19 Idiopathic pulmonary fibrosis, Interstitial lung disease
DPP9 2 / 19 Idiopathic pulmonary fibrosis, Interstitial lung disease
EDN1 2 / 19 Obstructive airway disease, Pulmonary fibrosis
EDNRA 2 / 19 Cystic fibrosis, Lung disease
EEFSEC 2 / 19 Chronic obstructive pulmonary disease, Obstructive airway disease
EHF 2 / 19 Cystic fibrosis, Lung disease
FARSB 2 / 19 Brain calcification, Interstitial lung disease
FGF2 2 / 19 Oral submucous fibrosis, Pulmonary fibrosis
FOXO3 2 / 19 Chronic obstructive pulmonary disease, Obstructive airway disease
HGF 2 / 19 Lung disease, Pulmonary fibrosis
HMGB1 2 / 19 Pulmonary fibrosis, Sepsis
HSPA1B 2 / 19 Obstructive airway disease, Pulmonary fibrosis
HTR1A 2 / 19 Bronchopulmonary dysplasia, Interstitial lung disease
HTR2A 2 / 19 Chronic obstructive pulmonary disease, Obstructive airway disease
ICAM1 2 / 19 Chronic obstructive pulmonary disease, Obstructive airway disease
IFNG 2 / 19 Oral submucous fibrosis, Sepsis
IL10 2 / 19 Hepatolenticular degeneration, Sepsis
IL12B 2 / 19 Obstructive airway disease, Pulmonary fibrosis
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Interleukin-4 and Interleukin-13 signaling
IL1B, NOS2, TNF, CDKN1A, FOXO3, HIF1A, HMOX1, ICAM1, IL12B, IL13, IL13RA1, IL6
 Reactome 38 / 108 8.7× 4.75e-26 8.11e-23 ✓ sig.
Interleukin-10 signaling
IL1B, TNF, IL1RN, CD86, CXCL1, CXCL2, ICAM1, IL12B, IL6, PTGS2, TNFRSF1A, CXCL8
 Reactome 24 / 47 12.6× 1.52e-21 1.38e-18 ✓ sig.
Lipid and atherosclerosis
ATF6, DDIT3, HSPA5, IL1B, NLRP3, TNF, NFKBIA, CYP2A6, CXCL1, CXCL2, CYBA, CYP1A1
 KEGG 45 / 216 5.1× 3.67e-20 2.70e-17 ✓ sig.
Pathways in cancer
GSTM1, GSTT1, NOS2, CTNNA3, GSTP1, NFKBIA, ITGA3, BDKRB2, CDKN1A, CDKN2A, EDN1, HDAC2
 KEGG 72 / 533 3.3× 5.16e-20 3.72e-17 ✓ sig.
Rheumatoid arthritis
IL1B, TNF, FLT1, CD86, CTLA4, CXCL1, CXCL2, HLA-DPB1, ICAM1, IL6, TGFB1, TLR4
 KEGG 29 / 95 7.5× 3.37e-18 1.90e-15 ✓ sig.
Inflammatory bowel disease
IL1B, TNF, HLA-DPB1, IL12B, IL13, IL6, NOD2, TGFB1, TLR4, TLR5, IL17A, IL10
 KEGG 24 / 66 9.0× 2.87e-17 1.37e-14 ✓ sig.
IL-17 signaling pathway
IL1B, TNF, NFKBIA, CXCL1, CXCL2, IL13, IL6, MMP9, PTGS2, CEBPB, IL17A, CXCL8
 KEGG 27 / 94 7.1× 2.81e-16 1.07e-13 ✓ sig.
Chagas disease
IL1B, NOS2, TNF, NFKBIA, ACE, BDKRB2, IL12B, IL6, TGFB1, TLR4, FAS, TLR9
 KEGG 26 / 103 6.2× 3.08e-14 8.00e-12 ✓ sig.
Amoebiasis
ARG1, IL1B, NOS2, PRDX1, TNF, CXCL1, CXCL2, IL12B, IL6, TGFB1, TLR4, CD14
 KEGG 26 / 103 6.2× 3.08e-14 8.00e-12 ✓ sig.
Cytokine-cytokine receptor interaction
IL1B, TNF, IL1RN, CCL1, CXCL1, CXCL2, IL12B, IL13, IL13RA1, IL27, IL6, LEP
 KEGG 43 / 298 3.6× 2.83e-13 6.12e-11 ✓ sig.
PI3K-Akt signaling pathway
SPP1, FLT1, MAGI2, ITGA3, CDKN1A, FOXO3, IL6, NOS3, TLR4, TP53, PIK3CG, TSC2
 KEGG 47 / 361 3.2× 9.91e-13 1.98e-10 ✓ sig.
HIF-1 signaling pathway
NOS2, FLT1, CDKN1A, EDN1, HIF1A, HMOX1, IL6, NOS3, TLR4, CAMK2A, TIMP1, STAT3
 KEGG 25 / 110 5.6× 1.27e-12 2.45e-10 ✓ sig.
Fluid shear stress and atherosclerosis
GSTM1, GSTT1, IL1B, TNF, GSTP1, TXN, CYBA, EDN1, HMOX1, ICAM1, MMP9, NOS3
 KEGG 28 / 141 4.9× 1.93e-12 3.66e-10 ✓ sig.
Tuberculosis
IL1B, NOS2, TNF, VDR, HLA-DPB1, IL12B, IL6, NOD2, TGFB1, TLR4, CD14, FCGR2A
 KEGG 31 / 181 4.2× 7.49e-12 1.30e-9 ✓ sig.
TNF signaling pathway
IL1B, TNF, NFKBIA, CXCL1, CXCL2, EDN1, ICAM1, IL6, MMP14, MMP9, NOD2, PTGS2
 KEGG 25 / 119 5.2× 8.21e-12 1.41e-9 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
inflammatory response
IL1B, NLRP3, NOS2, TNF, IL1RN, NFKBIA, BDKRB2, CCL1, CRP, CXCL1, CXCL2, CYBA
 GO:0006954 62 / 467 5.1× 1.58e-26 6.47e-23 ✓ sig.
immune response
IL1B, TNF, IL1RN, CCL1, CD86, CD8A, CRHR1, CTLA4, CXCL1, CXCL2, DEFB1, HLA-DPB1
 GO:0006955 60 / 543 4.2× 1.63e-21 3.25e-18 ✓ sig.
response to hypoxia
NOS2, TNF, ABAT, POSTN, CHRNA4, CHRNA7, CYBA, CYP1A1, EDN1, HIF1A, LEP, MMP14
 GO:0001666 33 / 176 7.2× 3.49e-19 4.86e-16 ✓ sig.
positive regulation of interleukin-8 production
DDIT3, IL1B, NOS2, TNF, F2RL1, HSPA1A, HSPA1B, IL6, LEP, NOD2, TLR4, CD14
 GO:0032757 22 / 65 13.0× 3.82e-19 5.28e-16 ✓ sig.
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
IL1B, TNF, FLT1, TXN, F2RL1, LEP, TGFB1, ENG, PIK3CG, IL17A, EFNA5, GPER1
 GO:0051897 36 / 217 6.4× 5.54e-19 7.40e-16 ✓ sig.
positive regulation of cell migration
HSPA5, IL1B, FLT1, CCL1, EDN1, F2RL1, MMP14, TGFB1, AGER, CEACAM6, SNAI1, PLAU
 GO:0030335 41 / 292 5.4× 1.02e-18 1.32e-15 ✓ sig.
lung development
ITGA3, CYP1A2, MMP14, NOS3, ABCA3, CEBPA, GLI3, LOX, WNT5A, EPAS1, NKX2-1, FGF10
 GO:0030324 26 / 108 9.2× 3.23e-18 3.88e-15 ✓ sig.
positive regulation of gene expression
IL1B, TNF, VDR, ITGA3, CDKN2A, CRP, HIF1A, HSPA1A, HSPA1B, IL13, IL6, NOS3
 GO:0010628 53 / 504 4.0× 3.95e-18 4.64e-15 ✓ sig.
positive regulation of inflammatory response
IL1B, NLRP3, TNF, NFKBIA, ABCC1, CCL1, HTR2A, IL12B, TGFB1, TLR4, TRPV4, TLR9
 GO:0050729 27 / 122 8.5× 7.43e-18 8.42e-15 ✓ sig.
positive regulation of cell population proliferation
IL1B, FLT1, HTR1A, NANOGP8, CD86, CDKN1A, CHRNA7, EDN1, HDAC2, HTR2A, IL6, KLF5
 GO:0008284 54 / 532 3.9× 9.02e-18 1.00e-14 ✓ sig.
response to lipopolysaccharide
IL1B, NOS2, PRDX2, TNF, NFKBIA, CYP1A1, EDN1, HDAC2, IL13, NOS3, NQO1, SCGB1A1
 GO:0032496 30 / 161 7.1× 1.80e-17 1.91e-14 ✓ sig.
positive regulation of tumor necrosis factor production
CYBA, HDAC2, IL12B, IL6, LEP, MIF, NOD2, TGFB1, TLR4, TNFRSF8, AGER, CD14
 GO:0032760 25 / 113 8.5× 1.27e-16 1.18e-13 ✓ sig.
positive regulation of MAPK cascade
IL1B, PRDX2, TNF, FLT1, ADRB1, ADRB2, CHRNA7, EDN1, IL6, LEP, NOD2, TGFB1
 GO:0043410 33 / 224 5.7× 6.49e-16 5.28e-13 ✓ sig.
positive regulation of transcription by RNA polymerase II
ATF6, DDIT3, HSPA5, IL1B, NLRP3, TNF, GRHL2, KLF12, NFKBIA, VDR, ZNF728, ADRB2
 GO:0045944 82 / 1,208 2.6× 8.68e-16 6.86e-13 ✓ sig.
cellular response to lipopolysaccharide
IL1B, NLRP3, NOS2, TNF, CARD16, GSTP1, CD86, IL12B, IL6, MMP9, NOD2, TLR4
 GO:0071222 30 / 187 6.2× 1.31e-15 1.00e-12 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Chronic obstructive pulmonary disease Obstructive airway disease 0.388 40 3.20e-89 2.85e-87 ✓ sig.
Lung disease Obstructive airway disease 0.154 27 3.45e-37 1.34e-35 ✓ sig.
Obstructive airway disease Pulmonary fibrosis 0.149 27 2.02e-36 7.70e-35 ✓ sig.
Idiopathic pulmonary fibrosis Interstitial lung disease 0.155 20 9.28e-31 2.88e-29 ✓ sig.
Cystic fibrosis Lung disease 0.131 19 1.89e-27 5.23e-26 ✓ sig.
Lung disease Pulmonary fibrosis 0.112 21 9.96e-26 2.52e-24 ✓ sig.
Cystic fibrosis Obstructive airway disease 0.116 17 9.12e-24 2.08e-22 ✓ sig.
Idiopathic pulmonary fibrosis Pulmonary fibrosis 0.105 18 1.30e-22 2.77e-21 ✓ sig.
Interstitial lung disease Pulmonary fibrosis 0.088 14 1.46e-17 2.46e-16 ✓ sig.
Chronic obstructive pulmonary disease Pulmonary fibrosis 0.087 12 6.25e-17 1.01e-15 ✓ sig.
Bronchopulmonary dysplasia Obstructive airway disease 0.081 11 4.17e-15 5.98e-14 ✓ sig.
Chronic obstructive pulmonary disease Sepsis 0.116 8 2.60e-14 3.54e-13 ✓ sig.
Chronic obstructive pulmonary disease Cystic fibrosis 0.094 9 6.10e-14 8.03e-13 ✓ sig.
Asbestosis Cystic fibrosis 0.081 6 3.97e-11 4.10e-10 ✓ sig.
Idiopathic pulmonary fibrosis Obstructive airway disease 0.058 10 1.23e-10 1.21e-9 ✓ sig.
Hepatolenticular degeneration Oral submucous fibrosis 0.116 5 1.71e-10 1.66e-9 ✓ sig.
Interstitial lung disease Obstructive airway disease 0.057 9 3.88e-10 3.66e-9 ✓ sig.
Bronchopulmonary dysplasia Lung disease 0.058 8 4.56e-10 4.27e-9 ✓ sig.
Oral submucous fibrosis Sepsis 0.100 5 5.85e-10 5.40e-9 ✓ sig.
Chronic obstructive pulmonary disease Oral submucous fibrosis 0.086 5 1.78e-9 1.57e-8 ✓ sig.
Chronic obstructive pulmonary disease Emphysema 0.068 5 4.18e-8 3.13e-7 ✓ sig.
Asbestosis Sepsis 0.083 4 4.62e-8 3.44e-7 ✓ sig.
Emphysema Obstructive airway disease 0.046 6 1.07e-7 7.48e-7 ✓ sig.
Asbestosis Bronchopulmonary dysplasia 0.068 4 1.47e-7 1.01e-6 ✓ sig.
Asbestosis Oral submucous fibrosis 0.086 3 1.26e-6 7.29e-6 ✓ sig.
ALG11-congenital disorder of glycosylation Hepatolenticular degeneration 0.036 1 1.75e-3 2.61e-3 ✓ sig.
Chronic obstructive pulmonary disease susceptibility to respiratory infections associated with CD8alpha chain mutation 0.023 1 2.73e-3 3.66e-3 ✓ sig.
Bronchopulmonary dysplasia Genetic generalized epilepsy 0.022 1 2.92e-3 3.87e-3 ✓ sig.
Interstitial lung disease interstitial lung disease 2 0.015 1 4.29e-3 5.38e-3 ✓ sig.
Brain calcification Interstitial lung disease 0.015 1 4.29e-3 5.38e-3 ✓ sig.
Idiopathic pulmonary fibrosis interstitial lung disease 2 0.012 1 5.33e-3 6.49e-3 ✓ sig.
Obstructive airway disease susceptibility to respiratory infections associated with CD8alpha chain mutation 0.010 1 6.49e-3 7.75e-3 ✓ sig.
Lung disease lung disease, immunodeficiency, and chromosome breakage syndrome; 0.010 1 6.56e-3 7.81e-3 ✓ sig.