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Gene Gene information from NCBI Gene database.
Entrez ID 7001
Gene name Peroxiredoxin 2
Gene symbol PRDX2
Synonyms (NCBI Gene)
HEL-S-2aNKEF-BNKEFBPRPPRX2PRXIIPTX1TDPX1TPX1TSA
Chromosome 19
Chromosome location 19p13.13
Summary This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of C
miRNA miRNA information provided by mirtarbase database.
213 Show/Hide all (213)
miRTarBase ID miRNA Experiments Reference
MIRT023992 hsa-miR-1-3p Proteomics;Microarray 18668037
MIRT047661 hsa-miR-10a-5p CLASH 23622248
MIRT046023 hsa-miR-125b-5p CLASH 23622248
MIRT042800 hsa-miR-339-5p CLASH 23622248
MIRT039753 hsa-miR-615-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
45 Show/Hide all (45)
GO ID Ontology Definition Evidence Reference
GO:0002357 Process Defense response to tumor cell IMP 30429596
GO:0002536 Process Respiratory burst involved in inflammatory response IEA
GO:0004601 Function Peroxidase activity IEA
GO:0005515 Function Protein binding IPI 17557078, 25402766
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600538 9353 ENSG00000167815
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P32119
Protein name Peroxiredoxin-2 (EC 1.11.1.24) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thioredoxin-dependent peroxiredoxin 2)
Protein function Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrog
PDB 1QMV , 5B8A , 5B8B , 5IJT , 7KIZ , 7KJ0 , 7KJ1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00578 AhpC-TSA 8 → 141 AhpC/TSA family Domain
PF10417 1-cysPrx_C 161 → 196 C-terminal domain of 1-Cys peroxiredoxin Domain
Sequence
Sequence length 198
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Detoxification of Reactive Oxygen Species
TP53 Regulates Metabolic Genes
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
9
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (9)
Phenotype Name Clinical Significance Source Reference Evidence Score
ASBESTOSIS — CTD, Disgenet
CTD, Disgenet
22537621
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA — CTD 16316942
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR — CTD 21472284
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DOWN SYNDROME — CTD, Disgenet
CTD, Disgenet
11771762
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (200)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acoustic Neuroma Acoustic Neuroma BEFREE 31146115
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute Erythroblastic Leukemia Erythroblastic Leukemia BEFREE 21750082
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute monocytic leukemia Monocytic Leukemia BEFREE 22207736
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 15034014, 31197039
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 11048804
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenomatous Polyposis Coli Multiple polyposis syndrome BEFREE 28683851
★★★★★
★☆☆☆☆
Found in Text Mining only
Alopecia Alopecia BEFREE 29443105
★★★★★
★☆☆☆☆
Found in Text Mining only
Alopecia, Male Pattern Alopecia, Male Pattern BEFREE 29443105
★★★★★
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 18752637 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Amyloidosis Amyloidosis BEFREE 31194501
★★★★★
★☆☆☆☆
Found in Text Mining only