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Gene Gene information from NCBI Gene database.
Entrez ID 648
Gene name BMI1 proto-oncogene, polycomb ring finger
Gene symbol BMI1
Synonyms (NCBI Gene)
FLVI2/BMI1PCGF4RNF51flvi-2/bmi-1
Chromosome 10
Chromosome location 10p12.2
Summary This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development
miRNA miRNA information provided by mirtarbase database.
595 Show/Hide all (595)
miRTarBase ID miRNA Experiments Reference
MIRT000197 hsa-miR-200c-3p Review 20026422
MIRT004645 hsa-miR-128-3p Review 20029422
MIRT004645 hsa-miR-128-3p ImmunohistochemistryIn situ hybridizationMicroarrayqRT-PCRWestern blot 19010882
MIRT000197 hsa-miR-200c-3p Luciferase reporter assayWestern blot 19665978
MIRT000197 hsa-miR-200c-3p Luciferase reporter assayWestern blot 19665978
Transcription factors Transcription factors information provided by TRRUST V2 database.
4
Transcription factor Regulation Reference
E2F1 Unknown 17360938
MYC Activation 21856782
MYCN Activation 21856782
TWIST1 Activation 21876555
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
54 Show/Hide all (54)
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 19636380
GO:0000151 Component Ubiquitin ligase complex IDA 16714294
GO:0000792 Component Heterochromatin IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
164831 1066 ENSG00000168283
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Polycomb repressive complex Oxidative Stress Induced Senescence
Signaling pathways regulating pluripotency of stem cells SUMOylation of DNA damage response and repair proteins
Transcriptional misregulation in cancer SUMOylation of transcription cofactors
MicroRNAs in cancer SUMOylation of chromatin organization proteins
  SUMOylation of RNA binding proteins
  RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
  Regulation of PTEN gene transcription
  Transcriptional Regulation by E2F6
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (6)
Phenotype Name Clinical Significance Source Reference Evidence Score
GLIOBLASTOMA — CTD 19823589
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOMA — CTD 23383216
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HIRSCHSPRUNG DISEASE — CTD, Disgenet
CTD, Disgenet
29429387
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LEUKEMIA, MYELOID, ACCELERATED PHASE — CTD 24571310
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MYELODYSPLASTIC SYNDROMES — CTD 24571310
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations