Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 1

88 diseases · 262 shared-gene connections
88 Diseases
701 Unique genes
0.167 Avg. similarity score
Bouillaud’s disease Most-connected disease (42 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.
Bouillaud’s disease Autoimmune polyendocrine syndrome Oropharyngeal neoplasms Pemphigus vulgaris Skeletal system disease Wheat allergic reaction

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Bouillaud’s disease 42 42 3
Autoimmune polyendocrine syndrome 32 32 4
Oropharyngeal neoplasms 23 23 4
Pemphigus vulgaris 15 15 7
Skeletal system disease 15 15 3
Wheat allergic reaction 15 15 3
Acute disseminated encephalomyelitis 14 14 3
Benign mucous membrane pemphigoid with ocular involvement 13 13 3
Uveomeningoencephalitic syndrome 13 13 7
Henoch schoenlein purpura 11 11 18
Tongue cancer 11 11 2
Autoimmune pancreatitis 10 10 2
Central nervous system non-hodgkin lymphoma 10 10 7
Esophageal achalasia 10 10 4
Cervical intraepithelial neoplasia 9 9 6
Chorea 9 9 18
Antiphospholipid syndrome 8 8 20
Gastritis 8 8 22
Interstitial cystitis 8 8 40
Narcolepsy 8 8 51
Pemphigus 8 8 8
Benign hereditary chorea 7 7 7
Benign mucous membrane pemphigoid 7 7 3
Bullous pemphigoid 7 7 23
Cutaneous lupus erythematosus 7 7 11
Latent autoimmune diabetes in adults 7 7 12
Autoimmune musculoskeletal system disorder 6 6 12
Diabetic nephropathy type 1 6 6 6
Gastroparesis 6 6 11
Lymphedema 6 6 16
Membranous glomerulonephritis 6 6 31
Thyroiditis 6 6 16
Vogt-koyanagi-harada disease 6 6 7
Apolipoprotein b hypobetalipoproteinemia 5 5 4
Arthritis 5 5 26
Cartilage disease 5 5 14
Churg-strauss syndrome 5 5 4
Collagenous colitis 5 5 1
Cryoglobulinemia 5 5 6
Lymphoma 5 5 53
Myasthenia gravis 5 5 38
Nasopharyngeal neoplasms 5 5 43
Obstructive asthma 5 5 8
Ocular sarcoidosis 5 5 58
Optic neuritis 5 5 13
Respiratory system neoplasm 5 5 5
Rosacea 5 5 14
Tonsil cancer 5 5 3
Bronchitis 4 4 33
Duodenitis 4 4 8
Head and neck cancer 4 4 10
Hepatitis c induced liver cirrhosis 4 4 3
Lupus nephritis 4 4 42
Oral cavity carcinoma 4 4 28
Sinusitis 4 4 22
Thiopurine immunosuppressant-induced pancreatitis 4 4 1
Anti-neutrophil antibody associated vasculitis 3 3 23
Osteomyelitis 3 3 9
Waldenstrom macroglobulinemia 3 3 4
dyskeratosis congenita, autosomal dominant 2 3 3 1
Blepharitis 2 2 2
Choreoacanthocytosis 2 2 1
Cri-du-chat syndrome 2 2 2
Diffuse large b-cell lymphoma 2 2 57
Disabling pansclerotic morphea of childhood 2 2 1
Immune system disease 2 2 46
Intellectual developmental disorder seizures movement 2 2 1
immunodeficiency 60 2 2 1
Autoimmune gastritis 1 1 1
Birbeck granule deficiency 1 1 1
Cataplexy and narcolepsy 1 1 4
Congenital isolated acth deficiency 1 1 1
IMPDH1-related retinopathy 1 1 1
KIZ-related retinopathy 1 1 1
Keratosis palmoplantaris papulosa 1 1 2
Parenchymal hematoma 1 1 6
Peeling skin syndrome with leukonychia and acral punctate keratoses 1 1 2
Uric acid urolithiasis 1 1 1
autosomal recessive osteopetrosis 3 1 1 1
congenital disorder of glycosylation type II 1 1 1
distal myopathy with vocal cord weakness 1 1 1
hsd10 mitochondrial disease 1 1 1
immunodeficiency 106, susceptibility to viral infections 1 1 1
immunodeficiency 126, susceptibility to 1 1 1
neurodevelopmental disorder with microcephaly, seizures, and cortical atrophy 1 1 1
optic atrophy 10 with or without ataxia, intellectual disability, and seizures 1 1 1
platelet abnormalities with eosinophilia and immune-mediated inflammatory disease 1 1 1
scalp-ear-nipple syndrome 1 1 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
HLA-DQA1 42 / 88 Anti-neutrophil antibody associated vasculitis, Antiphospholipid syndrome, Arthritis, Autoimmune musculoskeletal system disorder and 38 more
HLA-DQB1 41 / 88 Acute disseminated encephalomyelitis, Antiphospholipid syndrome, Apolipoprotein b hypobetalipoproteinemia, Arthritis and 37 more
HLA-DRB1 36 / 88 Acute disseminated encephalomyelitis, Antiphospholipid syndrome, Autoimmune musculoskeletal system disorder, Autoimmune polyendocrine syndrome and 32 more
HLA-B 8 / 88 Cervical intraepithelial neoplasia, Diffuse large b-cell lymphoma, Immune system disease, Membranous glomerulonephritis and 4 more
HLA-DRA 7 / 88 Antiphospholipid syndrome, Bullous pemphigoid, Henoch schoenlein purpura, Hepatitis c induced liver cirrhosis and 3 more
IRF4 7 / 88 Central nervous system non-hodgkin lymphoma, Diffuse large b-cell lymphoma, Lymphoma, Membranous glomerulonephritis and 3 more
HLA-DQB3 6 / 88 Anti-neutrophil antibody associated vasculitis, Henoch schoenlein purpura, Interstitial cystitis, Narcolepsy and 2 more
PTPN22 6 / 88 Diabetic nephropathy type 1, Immune system disease, Latent autoimmune diabetes in adults, Myasthenia gravis and 2 more
TERT 6 / 88 Cri-du-chat syndrome, dyskeratosis congenita, autosomal dominant 2, Head and neck cancer, Nasopharyngeal neoplasms and 2 more
FAS 5 / 88 Diffuse large b-cell lymphoma, Lupus nephritis, Myasthenia gravis, Uveomeningoencephalitic syndrome and 1 more
HLA-DRB5 5 / 88 Acute disseminated encephalomyelitis, Bullous pemphigoid, Central nervous system non-hodgkin lymphoma, Henoch schoenlein purpura and 1 more
C3 4 / 88 Henoch schoenlein purpura, Lupus nephritis, Membranous glomerulonephritis, Pemphigus
C6ORF15 4 / 88 Immune system disease, Membranous glomerulonephritis, Myasthenia gravis, Nasopharyngeal neoplasms
CLPTM1L 4 / 88 Cervical intraepithelial neoplasia, Head and neck cancer, Nasopharyngeal neoplasms, Oral cavity carcinoma
CTLA4 4 / 88 Immune system disease, Latent autoimmune diabetes in adults, Lupus nephritis, Myasthenia gravis
EXOC2 4 / 88 Central nervous system non-hodgkin lymphoma, Diffuse large b-cell lymphoma, Lymphoma, Waldenstrom macroglobulinemia
HLA-DPB1 4 / 88 Anti-neutrophil antibody associated vasculitis, Gastroparesis, Myasthenia gravis, Narcolepsy
STAT4 4 / 88 Autoimmune musculoskeletal system disorder, Disabling pansclerotic morphea of childhood, Immune system disease, Uveomeningoencephalitic syndrome
ATXN2 3 / 88 Immune system disease, Latent autoimmune diabetes in adults, Myasthenia gravis
BACH2 3 / 88 Central nervous system non-hodgkin lymphoma, immunodeficiency 60, Latent autoimmune diabetes in adults
CDKN2A 3 / 88 Diffuse large b-cell lymphoma, Lymphoma, Nasopharyngeal neoplasms
CRP 3 / 88 Antiphospholipid syndrome, Arthritis, Lupus nephritis
HLA-DOB 3 / 88 Bullous pemphigoid, Interstitial cystitis, Lymphoma
HLA-DPA1 3 / 88 Anti-neutrophil antibody associated vasculitis, Interstitial cystitis, Ocular sarcoidosis
HLA-DQB2 3 / 88 Bullous pemphigoid, Interstitial cystitis, Lymphoma
ITGAM 3 / 88 Autoimmune musculoskeletal system disorder, Cutaneous lupus erythematosus, Lupus nephritis
MC1R 3 / 88 Blepharitis, Respiratory system neoplasm, Rosacea
MOG 3 / 88 Narcolepsy, Nasopharyngeal neoplasms, Optic neuritis
MYD88 3 / 88 Diffuse large b-cell lymphoma, Lymphoma, Waldenstrom macroglobulinemia
NOTCH4 3 / 88 Cryoglobulinemia, Interstitial cystitis, Lupus nephritis
PDE2A 3 / 88 Chorea, Intellectual developmental disorder seizures movement, Oral cavity carcinoma
VPS13A 3 / 88 Benign hereditary chorea, Chorea, Choreoacanthocytosis
ABCB1 2 / 88 Cryoglobulinemia, Diffuse large b-cell lymphoma
ABCG8 2 / 88 Duodenitis, Gastritis
ADCY5 2 / 88 Benign hereditary chorea, Chorea
ADH1B 2 / 88 Oral cavity carcinoma, Respiratory system neoplasm
ARPC1B 2 / 88 Gastritis, platelet abnormalities with eosinophilia and immune-mediated inflammatory disease
ATP4B 2 / 88 Autoimmune gastritis, Gastritis
ATP6AP1 2 / 88 congenital disorder of glycosylation type II, Lymphoma
B2M 2 / 88 Arthritis, Diffuse large b-cell lymphoma
BCL2 2 / 88 Diffuse large b-cell lymphoma, Lymphoma
BTNL2 2 / 88 Hepatitis c induced liver cirrhosis, Membranous glomerulonephritis
CA2 2 / 88 Autoimmune pancreatitis, autosomal recessive osteopetrosis 3
CACNA2D2 2 / 88 Benign hereditary chorea, Chorea
CAST 2 / 88 Peeling skin syndrome with leukonychia and acral punctate keratoses, Pemphigus
CAT 2 / 88 Diffuse large b-cell lymphoma, Optic neuritis
CCL2 2 / 88 Henoch schoenlein purpura, Lupus nephritis
CD207 2 / 88 Birbeck granule deficiency, Narcolepsy
CD40 2 / 88 Arthritis, Pemphigus
CD40LG 2 / 88 Antiphospholipid syndrome, Lupus nephritis
CD86 2 / 88 Diffuse large b-cell lymphoma, Henoch schoenlein purpura
CDH18 2 / 88 Antiphospholipid syndrome, Gastritis
CDKN2B 2 / 88 Lymphoma, Nasopharyngeal neoplasms
CEP43 2 / 88 Immune system disease, Myasthenia gravis
CFB 2 / 88 Membranous glomerulonephritis, Myasthenia gravis
CHRNA1 2 / 88 Immune system disease, Myasthenia gravis
COL11A2 2 / 88 Cartilage disease, Interstitial cystitis
COL14A1 2 / 88 Gastritis, Keratosis palmoplantaris papulosa
COL2A1 2 / 88 Arthritis, Cartilage disease
CXCL8 2 / 88 Bullous pemphigoid, Gastritis
CYP2A6 2 / 88 Bronchitis, Nasopharyngeal neoplasms
DDX6 2 / 88 Immune system disease, Lymphoma
EBF1 2 / 88 Blepharitis, Lymphoma
EGFR 2 / 88 Nasopharyngeal neoplasms, Ocular sarcoidosis
EZH2 2 / 88 Diffuse large b-cell lymphoma, Lymphoma
FAM76B 2 / 88 Immune system disease, Myasthenia gravis
FCGR3A 2 / 88 Arthritis, Lupus nephritis
FKBPL 2 / 88 Interstitial cystitis, Membranous glomerulonephritis
FRMD4A 2 / 88 Antiphospholipid syndrome, Ocular sarcoidosis
FTO 2 / 88 Oral cavity carcinoma, Osteomyelitis
GATA2 2 / 88 Cartilage disease, Lymphedema
GRB7 2 / 88 Immune system disease, Myasthenia gravis
GSTM1 2 / 88 Gastritis, Optic neuritis
HLA-C 2 / 88 Interstitial cystitis, Sinusitis
HLA-DOA 2 / 88 Interstitial cystitis, Ocular sarcoidosis
HSD17B10 2 / 88 Chorea, hsd10 mitochondrial disease
IFNA2 2 / 88 Lymphoma, Uveomeningoencephalitic syndrome
IFNAR1 2 / 88 immunodeficiency 106, susceptibility to viral infections, Narcolepsy
IKZF1 2 / 88 Lymphoma, Rosacea
IKZF3 2 / 88 Immune system disease, Myasthenia gravis
IL2 2 / 88 Bullous pemphigoid, Pemphigus
IL23R 2 / 88 Arthritis, Vogt-koyanagi-harada disease
IMPDH1 2 / 88 IMPDH1-related retinopathy, Thyroiditis
KCNMB2 2 / 88 Cutaneous lupus erythematosus, Diabetic nephropathy type 1
KCTD1 2 / 88 Ocular sarcoidosis, scalp-ear-nipple syndrome
KIZ 2 / 88 KIZ-related retinopathy, Lupus nephritis
KMT2D 2 / 88 Diffuse large b-cell lymphoma, Lymphoma
MAGI3 2 / 88 Immune system disease, Myasthenia gravis
MATR3 2 / 88 distal myopathy with vocal cord weakness, Vogt-koyanagi-harada disease
MET 2 / 88 Lymphedema, Sinusitis
MICA 2 / 88 Cervical intraepithelial neoplasia, Thyroiditis
MMP2 2 / 88 Lupus nephritis, Nasopharyngeal neoplasms
MUC21 2 / 88 Apolipoprotein b hypobetalipoproteinemia, Cutaneous lupus erythematosus
MUCL3 2 / 88 Interstitial cystitis, Membranous glomerulonephritis
NKX2-1 2 / 88 Benign hereditary chorea, Chorea
P2RY11 2 / 88 Cataplexy and narcolepsy, Narcolepsy
PDCD1 2 / 88 Lupus nephritis, Narcolepsy
PFKFB3 2 / 88 Latent autoimmune diabetes in adults, Ocular sarcoidosis
POMC 2 / 88 Immune system disease, Myasthenia gravis
PON1 2 / 88 Henoch schoenlein purpura, Lymphoma
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Leishmaniasis
HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, FCGR3A, JAK2, TLR4, ITGAM, NCF2, CYBB
 KEGG 33 / 78 7.2× 8.31e-21 7.40e-18 ✓ sig.
Allograft rejection
HLA-DPA1, HLA-DPB1, HLA-DQA1, CD40LG, HLA-DQB1, HLA-DRA, HLA-DRB1, CD40, HLA-DOB, HLA-DQB2, HLA-DRB5, IL2
 KEGG 23 / 39 10.1× 4.59e-19 3.23e-16 ✓ sig.
Type I diabetes mellitus
HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DOB, HLA-DQB2, HLA-DRB5, IL2, HLA-B, HLA-C
 KEGG 23 / 44 9.0× 1.86e-17 9.62e-15 ✓ sig.
Autoimmune thyroid disease
HLA-DPA1, HLA-DPB1, HLA-DQA1, CD40LG, HLA-DQB1, HLA-DRA, HLA-DRB1, TSHR, CD40, HLA-DOB, HLA-DQB2, HLA-DRB5
 KEGG 25 / 54 7.9× 3.17e-17 1.56e-14 ✓ sig.
Tuberculosis
HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, FCGR3A, JAK2, SYK, TLR4, ITGAM, HLA-DOB
 KEGG 45 / 181 4.3× 3.46e-17 1.67e-14 ✓ sig.
Toxoplasmosis
HLA-DPA1, HLA-DPB1, HLA-DQA1, CD40LG, HLA-DQB1, HLA-DRA, HLA-DRB1, CD40, JAK2, TLR4, HLA-DOB, HLA-DQB2
 KEGG 34 / 112 5.2× 4.00e-16 1.66e-13 ✓ sig.
Graft-versus-host disease
HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DOB, HLA-DQB2, HLA-DRB5, IL2, HLA-B, HLA-C
 KEGG 22 / 45 8.4× 6.00e-16 2.41e-13 ✓ sig.
Rheumatoid arthritis
HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, TLR4, VEGFA, HLA-DOB, HLA-DQB2, HLA-DRB5, TLR2
 KEGG 30 / 95 5.4× 6.73e-15 2.22e-12 ✓ sig.
Herpes simplex virus 1 infection
HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, B2M, JAK2, SYK, HLA-DOB, HLA-DQB2, HLA-DRB5
 KEGG 42 / 182 4.0× 6.88e-15 2.26e-12 ✓ sig.
Inflammatory bowel disease
HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, IL23R, TLR4, STAT4, HLA-DOB, HLA-DQB2, HLA-DRB5
 KEGG 25 / 66 6.5× 1.01e-14 3.15e-12 ✓ sig.
Asthma
HLA-DPA1, HLA-DPB1, HLA-DQA1, CD40LG, HLA-DQB1, HLA-DRA, HLA-DRB1, CD40, HLA-DOB, HLA-DQB2, HLA-DRB5, HLA-DOA
 KEGG 17 / 32 9.1× 2.17e-13 5.21e-11 ✓ sig.
Th1 and Th2 cell differentiation
HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, JAK2, STAT4, HLA-DOB, HLA-DQB2, HLA-DRB5, IL2
 KEGG 27 / 93 5.0× 1.48e-12 3.16e-10 ✓ sig.
Influenza A
HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, JAK2, TLR4, HLA-DOB, HLA-DQB2, HLA-DRB5, HLA-DOA
 KEGG 37 / 173 3.7× 3.40e-12 6.66e-10 ✓ sig.
Epstein-Barr virus infection
HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, B2M, CD40, SYK, HLA-DOB, HLA-DQB2, HLA-DRB5
 KEGG 40 / 204 3.4× 8.29e-12 1.52e-9 ✓ sig.
Human T-cell leukemia virus 1 infection
HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, B2M, CD40, ZFP36, ADCY5, HLA-DOB, HLA-DQB2
 KEGG 42 / 224 3.2× 1.14e-11 2.01e-9 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
immune response
HLA-DPA1, HLA-DPB1, HLA-DQA1, CD40LG, HLA-DQB1, HLA-DRA, HLA-DRB1, B2M, FCGR3A, JAK2, TLR4, STAT4
 GO:0006955 70 / 543 3.4× 9.56e-20 1.49e-16 ✓ sig.
peptide antigen assembly with MHC class II protein complex
HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, B2M, HLA-DOB, HLA-DQB2, HLA-DRB5, HLA-DOA, HLA-DMA
 GO:0002503 14 / 16 23.3× 1.08e-18 1.43e-15 ✓ sig.
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DOB, HLA-DQB2, HLA-DRB5, HLA-DOA, HLA-DMA, HLA-DMB
 GO:0002504 13 / 15 23.1× 2.56e-17 2.78e-14 ✓ sig.
positive regulation of T cell activation
HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, B2M, HLA-DOB, HLA-DQB2, HLA-DRB5, HLA-DOA, CCL2
 GO:0050870 20 / 45 11.8× 3.06e-17 3.26e-14 ✓ sig.
positive regulation of immune response
HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, B2M, HLA-DOB, HLA-DQB2, HLA-DRB5, HLA-DOA, IFNL3
 GO:0050778 16 / 40 10.7× 3.52e-13 1.76e-10 ✓ sig.
cellular response to lipopolysaccharide
B2M, CD40, JAK2, TLR4, ZFP36, DAB2IP, ABCB1, CD86, CXCL8, NOD2, IL1B, CCL2
 GO:0071222 32 / 187 4.6× 5.55e-13 2.68e-10 ✓ sig.
antigen processing and presentation of exogenous peptide antigen via MHC class II
HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, B2M, HLA-DOB, HLA-DQB2, HLA-DRB5, HLA-DOA, HLA-DMA
 GO:0019886 14 / 31 12.0× 1.41e-12 6.29e-10 ✓ sig.
positive regulation of cell population proliferation
PRTN3, TSC22D1, GRK5, TSHR, IL23R, JAK2, NPY, VEGFA, IL2, TNC, BMP4, EDN1
 GO:0008284 56 / 532 2.8× 3.04e-12 1.26e-9 ✓ sig.
antigen processing and presentation
HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DOB, HLA-DQB2, HLA-DRB5, HLA-B, HLA-C, HLA-DOA
 GO:0019882 16 / 48 8.9× 9.55e-12 3.53e-9 ✓ sig.
phosphatidylinositol 3-kinase/protein kinase B signal transduction
CD40, FCGR3A, NF1, EDN1, MAPKAP1, BTN2A2, BANK1, PTEN, PDPK1, PIK3CA, PIK3CB, PIK3CD
 GO:0043491 21 / 92 6.1× 1.99e-11 6.79e-9 ✓ sig.
immune system process
HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, B2M, CD40, FCGR3A, HP, IL23R, JAK2
 GO:0002376 77 / 943 2.2× 9.32e-11 2.68e-8 ✓ sig.
regulation of cell population proliferation
NF1, STAT4, EMILIN2, DNMT1, TBX19, AGT, PLAU, ARG1, CXCL10, CXCL11, CXCL9, STAT1
 GO:0042127 30 / 201 4.0× 1.03e-10 2.94e-8 ✓ sig.
positive regulation of canonical NF-kappaB signal transduction
CD40LG, HLA-DRB1, CD40, PARP1, TLR4, ATP2C1, VEGFA, TLR2, DAB2IP, EDN1, PELI2, UBE2V1
 GO:0043123 32 / 232 3.7× 1.98e-10 5.29e-8 ✓ sig.
positive regulation of interleukin-12 production
CD40LG, CD40, IL23R, SYK, TLR4, TLR2, SCIMP, AGER, IFNG, TLR9, TNFSF4, LTB
 GO:0032735 14 / 43 8.7× 2.75e-10 7.08e-8 ✓ sig.
cell surface receptor signaling pathway via JAK-STAT
CD40, IL23R, JAK2, STAT4, TSLP, IFNL3, IFNL4, CCL2, IFNG, JAK1, STAT1, CSF2
 GO:0007259 17 / 67 6.8× 2.78e-10 7.15e-8 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Immune system disease Myasthenia gravis 0.308 20 8.03e-43 3.77e-41 ✓ sig.
Benign hereditary chorea Chorea 0.368 7 7.83e-22 1.71e-20 ✓ sig.
Interstitial cystitis Pemphigus vulgaris 0.143 6 1.45e-15 2.27e-14 ✓ sig.
Henoch schoenlein purpura Pemphigus vulgaris 0.238 5 2.49e-14 3.59e-13 ✓ sig.
Uveomeningoencephalitic syndrome Vogt-koyanagi-harada disease 0.364 4 5.23e-13 6.86e-12 ✓ sig.
Myasthenia gravis Uveomeningoencephalitic syndrome 0.122 5 1.46e-12 1.84e-11 ✓ sig.
Benign mucous membrane pemphigoid Benign mucous membrane pemphigoid with ocular involvement 0.750 3 1.64e-12 2.04e-11 ✓ sig.
Autoimmune polyendocrine syndrome Bouillaud’s disease 0.600 3 6.58e-12 7.74e-11 ✓ sig.
Bouillaud’s disease Oropharyngeal neoplasms 0.600 3 6.58e-12 7.74e-11 ✓ sig.
Bullous pemphigoid Interstitial cystitis 0.103 6 2.03e-11 2.29e-10 ✓ sig.
Autoimmune polyendocrine syndrome Oropharyngeal neoplasms 0.500 3 2.63e-11 2.94e-10 ✓ sig.
Bullous pemphigoid Henoch schoenlein purpura 0.135 5 3.95e-11 4.31e-10 ✓ sig.
Latent autoimmune diabetes in adults Myasthenia gravis 0.109 5 5.45e-11 5.90e-10 ✓ sig.
Benign hereditary chorea Bouillaud’s disease 0.375 3 5.75e-11 6.20e-10 ✓ sig.
Bouillaud’s disease Pemphigus vulgaris 0.375 3 5.75e-11 6.20e-10 ✓ sig.
Bouillaud’s disease Uveomeningoencephalitic syndrome 0.375 3 5.75e-11 6.20e-10 ✓ sig.
Antiphospholipid syndrome Pemphigus vulgaris 0.167 4 7.22e-11 7.72e-10 ✓ sig.
Henoch schoenlein purpura Pemphigus 0.174 4 9.12e-11 9.66e-10 ✓ sig.
Bouillaud’s disease Pemphigus 0.333 3 9.21e-11 9.69e-10 ✓ sig.
Bullous pemphigoid Pemphigus vulgaris 0.148 4 1.32e-10 1.37e-9 ✓ sig.
Interstitial cystitis Membranous glomerulonephritis 0.091 6 1.46e-10 1.51e-9 ✓ sig.
Autoimmune polyendocrine syndrome Benign hereditary chorea 0.333 3 2.30e-10 2.34e-9 ✓ sig.
Autoimmune polyendocrine syndrome Pemphigus vulgaris 0.333 3 2.30e-10 2.34e-9 ✓ sig.
Benign hereditary chorea Oropharyngeal neoplasms 0.333 3 2.30e-10 2.34e-9 ✓ sig.
Oropharyngeal neoplasms Pemphigus vulgaris 0.333 3 2.30e-10 2.34e-9 ✓ sig.
Autoimmune polyendocrine syndrome Uveomeningoencephalitic syndrome 0.333 3 2.30e-10 2.34e-9 ✓ sig.
Oropharyngeal neoplasms Uveomeningoencephalitic syndrome 0.333 3 2.30e-10 2.34e-9 ✓ sig.
Bullous pemphigoid Pemphigus 0.143 4 2.64e-10 2.67e-9 ✓ sig.
Autoimmune polyendocrine syndrome Pemphigus 0.300 3 3.68e-10 3.68e-9 ✓ sig.
Oropharyngeal neoplasms Pemphigus 0.300 3 3.68e-10 3.68e-9 ✓ sig.
Henoch schoenlein purpura Interstitial cystitis 0.093 5 7.63e-10 7.39e-9 ✓ sig.
Cervical intraepithelial neoplasia Nasopharyngeal neoplasms 0.087 4 7.87e-10 7.61e-9 ✓ sig.
Diffuse large b-cell lymphoma Lymphoma 0.067 7 8.79e-10 8.46e-9 ✓ sig.
Henoch schoenlein purpura Lupus nephritis 0.089 5 9.85e-10 9.45e-9 ✓ sig.
Diabetic nephropathy type 1 Uveomeningoencephalitic syndrome 0.273 3 1.15e-9 1.10e-8 ✓ sig.
Bouillaud’s disease Chorea 0.158 3 1.34e-9 1.27e-8 ✓ sig.
Bouillaud’s disease Henoch schoenlein purpura 0.158 3 1.34e-9 1.27e-8 ✓ sig.
Acute disseminated encephalomyelitis Henoch schoenlein purpura 0.158 3 1.34e-9 1.27e-8 ✓ sig.
Lupus nephritis Uveomeningoencephalitic syndrome 0.087 4 1.66e-9 1.56e-8 ✓ sig.
Antiphospholipid syndrome Lupus nephritis 0.086 5 1.78e-9 1.66e-8 ✓ sig.
Antiphospholipid syndrome Bouillaud’s disease 0.143 3 1.87e-9 1.75e-8 ✓ sig.
Benign hereditary chorea Pemphigus vulgaris 0.250 3 2.01e-9 1.86e-8 ✓ sig.
Pemphigus vulgaris Uveomeningoencephalitic syndrome 0.250 3 2.01e-9 1.86e-8 ✓ sig.
Immune system disease Uveomeningoencephalitic syndrome 0.080 4 2.42e-9 2.23e-8 ✓ sig.
Bouillaud’s disease Bullous pemphigoid 0.125 3 2.91e-9 2.66e-8 ✓ sig.
Acute disseminated encephalomyelitis Bullous pemphigoid 0.125 3 2.91e-9 2.66e-8 ✓ sig.
Narcolepsy Pemphigus vulgaris 0.073 4 3.71e-9 3.34e-8 ✓ sig.
Central nervous system non-hodgkin lymphoma Lymphoma 0.070 4 4.34e-9 3.90e-8 ✓ sig.
Lymphoma Uveomeningoencephalitic syndrome 0.070 4 4.34e-9 3.90e-8 ✓ sig.
Autoimmune polyendocrine syndrome Chorea 0.150 3 5.36e-9 4.77e-8 ✓ sig.
Chorea Oropharyngeal neoplasms 0.150 3 5.36e-9 4.77e-8 ✓ sig.
Autoimmune polyendocrine syndrome Henoch schoenlein purpura 0.150 3 5.36e-9 4.77e-8 ✓ sig.
Diabetic nephropathy type 1 Latent autoimmune diabetes in adults 0.188 3 7.22e-9 6.36e-8 ✓ sig.
Antiphospholipid syndrome Autoimmune polyendocrine syndrome 0.136 3 7.49e-9 6.57e-8 ✓ sig.
Antiphospholipid syndrome Oropharyngeal neoplasms 0.136 3 7.49e-9 6.57e-8 ✓ sig.
Membranous glomerulonephritis Myasthenia gravis 0.077 5 1.13e-8 9.53e-8 ✓ sig.
Autoimmune musculoskeletal system disorder Uveomeningoencephalitic syndrome 0.176 3 1.26e-8 1.06e-7 ✓ sig.
Latent autoimmune diabetes in adults Uveomeningoencephalitic syndrome 0.176 3 1.26e-8 1.06e-7 ✓ sig.
Cutaneous lupus erythematosus Interstitial cystitis 0.083 4 1.27e-8 1.07e-7 ✓ sig.
Bullous pemphigoid Lymphoma 0.069 5 1.28e-8 1.07e-7 ✓ sig.
Bouillaud’s disease Nasopharyngeal neoplasms 0.068 3 2.03e-8 1.68e-7 ✓ sig.
Central nervous system non-hodgkin lymphoma Rosacea 0.158 3 2.09e-8 1.72e-7 ✓ sig.
Bouillaud’s disease Narcolepsy 0.058 3 3.42e-8 2.72e-7 ✓ sig.
Chorea Pemphigus vulgaris 0.130 3 4.68e-8 3.68e-7 ✓ sig.
Autoimmune musculoskeletal system disorder Cutaneous lupus erythematosus 0.143 3 5.95e-8 4.57e-7 ✓ sig.
Myasthenia gravis Nasopharyngeal neoplasms 0.065 5 6.26e-8 4.81e-7 ✓ sig.
Antiphospholipid syndrome Benign hereditary chorea 0.120 3 6.54e-8 5.00e-7 ✓ sig.
Acute disseminated encephalomyelitis Benign mucous membrane pemphigoid with ocular involvement 0.400 2 7.59e-8 5.72e-7 ✓ sig.
Acute disseminated encephalomyelitis Bouillaud’s disease 0.400 2 7.59e-8 5.72e-7 ✓ sig.
Acute disseminated encephalomyelitis Benign mucous membrane pemphigoid 0.400 2 7.59e-8 5.72e-7 ✓ sig.
Benign mucous membrane pemphigoid Bouillaud’s disease 0.400 2 7.59e-8 5.72e-7 ✓ sig.
Benign mucous membrane pemphigoid with ocular involvement Bouillaud’s disease 0.400 2 7.59e-8 5.72e-7 ✓ sig.
Bouillaud’s disease Skeletal system disease 0.400 2 7.59e-8 5.72e-7 ✓ sig.
Bouillaud’s disease Wheat allergic reaction 0.400 2 7.59e-8 5.72e-7 ✓ sig.
Skeletal system disease Wheat allergic reaction 0.400 2 7.59e-8 5.72e-7 ✓ sig.
Autoimmune polyendocrine syndrome Nasopharyngeal neoplasms 0.067 3 8.10e-8 6.08e-7 ✓ sig.
Nasopharyngeal neoplasms Oropharyngeal neoplasms 0.067 3 8.10e-8 6.08e-7 ✓ sig.
Cervical intraepithelial neoplasia Oral cavity carcinoma 0.094 3 1.07e-7 7.90e-7 ✓ sig.
Cataplexy and narcolepsy Narcolepsy 0.057 3 1.37e-7 9.91e-7 ✓ sig.
Autoimmune polyendocrine syndrome Narcolepsy 0.057 3 1.37e-7 9.91e-7 ✓ sig.
Acute disseminated encephalomyelitis Autoimmune polyendocrine syndrome 0.333 2 1.52e-7 1.09e-6 ✓ sig.
Acute disseminated encephalomyelitis Oropharyngeal neoplasms 0.333 2 1.52e-7 1.09e-6 ✓ sig.
Autoimmune polyendocrine syndrome Skeletal system disease 0.333 2 1.52e-7 1.09e-6 ✓ sig.
Autoimmune polyendocrine syndrome Benign mucous membrane pemphigoid 0.333 2 1.52e-7 1.09e-6 ✓ sig.
Benign mucous membrane pemphigoid Oropharyngeal neoplasms 0.333 2 1.52e-7 1.09e-6 ✓ sig.
Autoimmune polyendocrine syndrome Benign mucous membrane pemphigoid with ocular involvement 0.333 2 1.52e-7 1.09e-6 ✓ sig.
Benign mucous membrane pemphigoid with ocular involvement Oropharyngeal neoplasms 0.333 2 1.52e-7 1.09e-6 ✓ sig.
Bouillaud’s disease Esophageal achalasia 0.333 2 1.52e-7 1.09e-6 ✓ sig.
Oropharyngeal neoplasms Skeletal system disease 0.333 2 1.52e-7 1.09e-6 ✓ sig.
Autoimmune polyendocrine syndrome Wheat allergic reaction 0.333 2 1.52e-7 1.09e-6 ✓ sig.
Oropharyngeal neoplasms Wheat allergic reaction 0.333 2 1.52e-7 1.09e-6 ✓ sig.
Diffuse large b-cell lymphoma Waldenstrom macroglobulinemia 0.051 3 1.92e-7 1.35e-6 ✓ sig.
Arthritis Pemphigus 0.094 3 2.38e-7 1.65e-6 ✓ sig.
Central nervous system non-hodgkin lymphoma Membranous glomerulonephritis 0.083 3 2.57e-7 1.77e-6 ✓ sig.
Autoimmune polyendocrine syndrome Esophageal achalasia 0.286 2 3.04e-7 2.06e-6 ✓ sig.
Esophageal achalasia Oropharyngeal neoplasms 0.286 2 3.04e-7 2.06e-6 ✓ sig.
Osteomyelitis Tongue cancer 0.200 2 3.04e-7 2.06e-6 ✓ sig.
Henoch schoenlein purpura Narcolepsy 0.061 4 3.16e-7 2.14e-6 ✓ sig.
Cartilage disease Lymphedema 0.107 3 3.33e-7 2.25e-6 ✓ sig.
Bouillaud’s disease Cervical intraepithelial neoplasia 0.250 2 3.80e-7 2.53e-6 ✓ sig.
Bouillaud’s disease Cryoglobulinemia 0.250 2 3.80e-7 2.53e-6 ✓ sig.
Cryoglobulinemia Skeletal system disease 0.250 2 3.80e-7 2.53e-6 ✓ sig.
Cryoglobulinemia Wheat allergic reaction 0.250 2 3.80e-7 2.53e-6 ✓ sig.
Bouillaud’s disease Diabetic nephropathy type 1 0.250 2 3.80e-7 2.53e-6 ✓ sig.
Head and neck cancer Tongue cancer 0.182 2 3.80e-7 2.53e-6 ✓ sig.
Membranous glomerulonephritis Pemphigus 0.081 3 4.11e-7 2.73e-6 ✓ sig.
Bouillaud’s disease Central nervous system non-hodgkin lymphoma 0.222 2 5.31e-7 3.46e-6 ✓ sig.
Central nervous system non-hodgkin lymphoma Skeletal system disease 0.222 2 5.31e-7 3.46e-6 ✓ sig.
Central nervous system non-hodgkin lymphoma Wheat allergic reaction 0.222 2 5.31e-7 3.46e-6 ✓ sig.
Acute disseminated encephalomyelitis Central nervous system non-hodgkin lymphoma 0.222 2 5.31e-7 3.46e-6 ✓ sig.
Bouillaud’s disease Vogt-koyanagi-harada disease 0.222 2 5.31e-7 3.46e-6 ✓ sig.
Skeletal system disease Vogt-koyanagi-harada disease 0.222 2 5.31e-7 3.46e-6 ✓ sig.
Vogt-koyanagi-harada disease Wheat allergic reaction 0.222 2 5.31e-7 3.46e-6 ✓ sig.
Bouillaud’s disease Obstructive asthma 0.200 2 7.08e-7 4.51e-6 ✓ sig.
Gastritis Optic neuritis 0.091 3 7.17e-7 4.56e-6 ✓ sig.
Autoimmune polyendocrine syndrome Cervical intraepithelial neoplasia 0.222 2 7.59e-7 4.79e-6 ✓ sig.
Cervical intraepithelial neoplasia Esophageal achalasia 0.222 2 7.59e-7 4.79e-6 ✓ sig.
Cervical intraepithelial neoplasia Oropharyngeal neoplasms 0.222 2 7.59e-7 4.79e-6 ✓ sig.
Autoimmune polyendocrine syndrome Cryoglobulinemia 0.222 2 7.59e-7 4.79e-6 ✓ sig.
Cryoglobulinemia Oropharyngeal neoplasms 0.222 2 7.59e-7 4.79e-6 ✓ sig.
Autoimmune polyendocrine syndrome Diabetic nephropathy type 1 0.222 2 7.59e-7 4.79e-6 ✓ sig.
Diabetic nephropathy type 1 Esophageal achalasia 0.222 2 7.59e-7 4.79e-6 ✓ sig.
Diabetic nephropathy type 1 Oropharyngeal neoplasms 0.222 2 7.59e-7 4.79e-6 ✓ sig.
Autoimmune polyendocrine syndrome Central nervous system non-hodgkin lymphoma 0.200 2 1.06e-6 6.56e-6 ✓ sig.
Autoimmune polyendocrine syndrome Vogt-koyanagi-harada disease 0.200 2 1.06e-6 6.56e-6 ✓ sig.
Central nervous system non-hodgkin lymphoma Waldenstrom macroglobulinemia 0.200 2 1.06e-6 6.56e-6 ✓ sig.
Cutaneous lupus erythematosus Membranous glomerulonephritis 0.075 3 1.21e-6 7.39e-6 ✓ sig.
Bouillaud’s disease Cutaneous lupus erythematosus 0.154 2 1.39e-6 8.41e-6 ✓ sig.
Cutaneous lupus erythematosus Skeletal system disease 0.154 2 1.39e-6 8.41e-6 ✓ sig.
Cutaneous lupus erythematosus Wheat allergic reaction 0.154 2 1.39e-6 8.41e-6 ✓ sig.
Bouillaud’s disease Gastroparesis 0.154 2 1.39e-6 8.41e-6 ✓ sig.
Lymphedema Sinusitis 0.083 3 1.40e-6 8.47e-6 ✓ sig.
Autoimmune polyendocrine syndrome Obstructive asthma 0.182 2 1.42e-6 8.55e-6 ✓ sig.
Esophageal achalasia Obstructive asthma 0.182 2 1.42e-6 8.55e-6 ✓ sig.
Obstructive asthma Oropharyngeal neoplasms 0.182 2 1.42e-6 8.55e-6 ✓ sig.
Autoimmune musculoskeletal system disorder Bouillaud’s disease 0.143 2 1.67e-6 9.97e-6 ✓ sig.
Autoimmune musculoskeletal system disorder Skeletal system disease 0.143 2 1.67e-6 9.97e-6 ✓ sig.
Autoimmune musculoskeletal system disorder Wheat allergic reaction 0.143 2 1.67e-6 9.97e-6 ✓ sig.
Bouillaud’s disease Latent autoimmune diabetes in adults 0.143 2 1.67e-6 9.97e-6 ✓ sig.
Benign mucous membrane pemphigoid with ocular involvement Optic neuritis 0.133 2 1.97e-6 1.16e-5 ✓ sig.
Bouillaud’s disease Optic neuritis 0.133 2 1.97e-6 1.16e-5 ✓ sig.
Acute disseminated encephalomyelitis Optic neuritis 0.133 2 1.97e-6 1.16e-5 ✓ sig.
Benign mucous membrane pemphigoid Optic neuritis 0.133 2 1.97e-6 1.16e-5 ✓ sig.
Bouillaud’s disease Cartilage disease 0.125 2 2.30e-6 1.34e-5 ✓ sig.
Cartilage disease Skeletal system disease 0.125 2 2.30e-6 1.34e-5 ✓ sig.
Cartilage disease Wheat allergic reaction 0.125 2 2.30e-6 1.34e-5 ✓ sig.
Bouillaud’s disease Rosacea 0.125 2 2.30e-6 1.34e-5 ✓ sig.
Rosacea Skeletal system disease 0.125 2 2.30e-6 1.34e-5 ✓ sig.
Rosacea Wheat allergic reaction 0.125 2 2.30e-6 1.34e-5 ✓ sig.
Autoimmune polyendocrine syndrome Cutaneous lupus erythematosus 0.143 2 2.78e-6 1.59e-5 ✓ sig.
Autoimmune polyendocrine syndrome Gastroparesis 0.143 2 2.78e-6 1.59e-5 ✓ sig.
Esophageal achalasia Gastroparesis 0.143 2 2.78e-6 1.59e-5 ✓ sig.
Gastroparesis Oropharyngeal neoplasms 0.143 2 2.78e-6 1.59e-5 ✓ sig.
Bouillaud’s disease Lymphedema 0.111 2 3.04e-6 1.72e-5 ✓ sig.
Lymphedema Skeletal system disease 0.111 2 3.04e-6 1.72e-5 ✓ sig.
Lymphedema Wheat allergic reaction 0.111 2 3.04e-6 1.72e-5 ✓ sig.
Bouillaud’s disease Thyroiditis 0.111 2 3.04e-6 1.72e-5 ✓ sig.
Skeletal system disease Thyroiditis 0.111 2 3.04e-6 1.72e-5 ✓ sig.
Thyroiditis Wheat allergic reaction 0.111 2 3.04e-6 1.72e-5 ✓ sig.
Autoimmune polyendocrine syndrome Latent autoimmune diabetes in adults 0.133 2 3.34e-6 1.89e-5 ✓ sig.
Cervical intraepithelial neoplasia Obstructive asthma 0.154 2 3.54e-6 1.99e-5 ✓ sig.
Autoimmune polyendocrine syndrome Cartilage disease 0.118 2 4.60e-6 2.54e-5 ✓ sig.
Cervical intraepithelial neoplasia Head and neck cancer 0.133 2 5.69e-6 3.09e-5 ✓ sig.
Benign mucous membrane pemphigoid with ocular involvement Gastritis 0.083 2 5.84e-6 3.17e-5 ✓ sig.
Bouillaud’s disease Gastritis 0.083 2 5.84e-6 3.17e-5 ✓ sig.
Acute disseminated encephalomyelitis Gastritis 0.083 2 5.84e-6 3.17e-5 ✓ sig.
Benign mucous membrane pemphigoid Gastritis 0.083 2 5.84e-6 3.17e-5 ✓ sig.
Bouillaud’s disease Sinusitis 0.083 2 5.84e-6 3.17e-5 ✓ sig.
Sinusitis Skeletal system disease 0.083 2 5.84e-6 3.17e-5 ✓ sig.
Sinusitis Wheat allergic reaction 0.083 2 5.84e-6 3.17e-5 ✓ sig.
Autoimmune polyendocrine syndrome Lymphedema 0.105 2 6.07e-6 3.27e-5 ✓ sig.
Autoimmune polyendocrine syndrome Thyroiditis 0.105 2 6.07e-6 3.27e-5 ✓ sig.
Oropharyngeal neoplasms Thyroiditis 0.105 2 6.07e-6 3.27e-5 ✓ sig.
Cervical intraepithelial neoplasia Gastroparesis 0.125 2 6.95e-6 3.72e-5 ✓ sig.
Arthritis Bouillaud’s disease 0.071 2 8.22e-6 4.35e-5 ✓ sig.
Latent autoimmune diabetes in adults Ocular sarcoidosis 0.044 3 1.09e-5 5.67e-5 ✓ sig.
Hepatitis c induced liver cirrhosis Membranous glomerulonephritis 0.061 2 1.18e-5 6.08e-5 ✓ sig.
Bouillaud’s disease Bronchitis 0.057 2 1.33e-5 6.87e-5 ✓ sig.
Head and neck cancer Osteomyelitis 0.111 2 1.36e-5 6.99e-5 ✓ sig.
Interstitial cystitis Ocular sarcoidosis 0.042 4 1.50e-5 7.64e-5 ✓ sig.
Arthritis Autoimmune polyendocrine syndrome 0.069 2 1.64e-5 8.33e-5 ✓ sig.
Arthritis Esophageal achalasia 0.069 2 1.64e-5 8.33e-5 ✓ sig.
Arthritis Oropharyngeal neoplasms 0.069 2 1.64e-5 8.33e-5 ✓ sig.
Autoimmune polyendocrine syndrome Bronchitis 0.056 2 2.67e-5 1.31e-4 ✓ sig.
Bronchitis Esophageal achalasia 0.056 2 2.67e-5 1.31e-4 ✓ sig.
Bronchitis Oropharyngeal neoplasms 0.056 2 2.67e-5 1.31e-4 ✓ sig.
Oral cavity carcinoma Respiratory system neoplasm 0.063 2 3.18e-5 1.55e-4 ✓ sig.
Anti-neutrophil antibody associated vasculitis Pemphigus vulgaris 0.069 2 4.46e-5 2.14e-4 ✓ sig.
Antiphospholipid syndrome Ocular sarcoidosis 0.039 3 5.52e-5 2.34e-4 ✓ sig.
Oral cavity carcinoma Pemphigus vulgaris 0.059 2 6.66e-5 2.40e-4 ✓ sig.
Autoimmune pancreatitis autosomal recessive osteopetrosis 3 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Cri-du-chat syndrome dyskeratosis congenita, autosomal dominant 2 0.333 1 1.30e-4 3.90e-4 ✓ sig.
dyskeratosis congenita, autosomal dominant 2 Tongue cancer 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Anti-neutrophil antibody associated vasculitis Gastroparesis 0.061 2 1.16e-4 3.90e-4 ✓ sig.
Bouillaud’s disease Collagenous colitis 0.250 1 1.95e-4 5.28e-4 ✓ sig.
Collagenous colitis Skeletal system disease 0.250 1 1.95e-4 5.28e-4 ✓ sig.
Collagenous colitis Wheat allergic reaction 0.250 1 1.95e-4 5.28e-4 ✓ sig.
Autoimmune pancreatitis Tongue cancer 0.250 1 2.60e-4 6.40e-4 ✓ sig.
Cri-du-chat syndrome Tongue cancer 0.250 1 2.60e-4 6.40e-4 ✓ sig.
Autoimmune polyendocrine syndrome Collagenous colitis 0.200 1 2.60e-4 6.40e-4 ✓ sig.
Collagenous colitis Esophageal achalasia 0.200 1 2.60e-4 6.40e-4 ✓ sig.
Autoimmune pancreatitis Benign mucous membrane pemphigoid with ocular involvement 0.200 1 3.90e-4 8.52e-4 ✓ sig.
Autoimmune pancreatitis Bouillaud’s disease 0.200 1 3.90e-4 8.52e-4 ✓ sig.
Acute disseminated encephalomyelitis Autoimmune pancreatitis 0.200 1 3.90e-4 8.52e-4 ✓ sig.
Benign mucous membrane pemphigoid with ocular involvement Tongue cancer 0.200 1 3.90e-4 8.52e-4 ✓ sig.
Autoimmune pancreatitis Tonsil cancer 0.200 1 3.90e-4 8.52e-4 ✓ sig.
Tongue cancer Tonsil cancer 0.200 1 3.90e-4 8.52e-4 ✓ sig.
Benign hereditary chorea Choreoacanthocytosis 0.125 1 4.55e-4 9.55e-4 ✓ sig.
Disabling pansclerotic morphea of childhood Uveomeningoencephalitic syndrome 0.125 1 4.55e-4 9.55e-4 ✓ sig.
distal myopathy with vocal cord weakness Vogt-koyanagi-harada disease 0.125 1 4.55e-4 9.55e-4 ✓ sig.
Central nervous system non-hodgkin lymphoma immunodeficiency 60 0.125 1 4.55e-4 9.55e-4 ✓ sig.
Pemphigus vulgaris Thiopurine immunosuppressant-induced pancreatitis 0.125 1 4.55e-4 9.55e-4 ✓ sig.
Apolipoprotein b hypobetalipoproteinemia Autoimmune pancreatitis 0.167 1 5.19e-4 1.04e-3 ✓ sig.
Apolipoprotein b hypobetalipoproteinemia Tongue cancer 0.167 1 5.19e-4 1.04e-3 ✓ sig.
Autoimmune pancreatitis Churg-strauss syndrome 0.167 1 5.19e-4 1.04e-3 ✓ sig.
Churg-strauss syndrome Tongue cancer 0.167 1 5.19e-4 1.04e-3 ✓ sig.
Congenital isolated acth deficiency Duodenitis 0.111 1 5.20e-4 1.04e-3 ✓ sig.
Benign mucous membrane pemphigoid with ocular involvement Tonsil cancer 0.167 1 5.84e-4 1.14e-3 ✓ sig.
Bouillaud’s disease Tonsil cancer 0.167 1 5.84e-4 1.14e-3 ✓ sig.
Acute disseminated encephalomyelitis Tonsil cancer 0.167 1 5.84e-4 1.14e-3 ✓ sig.
Blepharitis Respiratory system neoplasm 0.143 1 6.49e-4 1.22e-3 ✓ sig.
Autoimmune pancreatitis Respiratory system neoplasm 0.143 1 6.49e-4 1.22e-3 ✓ sig.
Respiratory system neoplasm Tongue cancer 0.143 1 6.49e-4 1.22e-3 ✓ sig.
dyskeratosis congenita, autosomal dominant 2 Head and neck cancer 0.091 1 6.49e-4 1.22e-3 ✓ sig.
Apolipoprotein b hypobetalipoproteinemia Benign mucous membrane pemphigoid with ocular involvement 0.143 1 7.79e-4 1.39e-3 ✓ sig.
Apolipoprotein b hypobetalipoproteinemia Bouillaud’s disease 0.143 1 7.79e-4 1.39e-3 ✓ sig.
Acute disseminated encephalomyelitis Apolipoprotein b hypobetalipoproteinemia 0.143 1 7.79e-4 1.39e-3 ✓ sig.
Benign mucous membrane pemphigoid with ocular involvement Churg-strauss syndrome 0.143 1 7.79e-4 1.39e-3 ✓ sig.
Bouillaud’s disease Churg-strauss syndrome 0.143 1 7.79e-4 1.39e-3 ✓ sig.
Acute disseminated encephalomyelitis Churg-strauss syndrome 0.143 1 7.79e-4 1.39e-3 ✓ sig.
Autoimmune musculoskeletal system disorder Disabling pansclerotic morphea of childhood 0.077 1 7.79e-4 1.39e-3 ✓ sig.
immunodeficiency 60 Latent autoimmune diabetes in adults 0.077 1 7.79e-4 1.39e-3 ✓ sig.
Autoimmune pancreatitis Duodenitis 0.100 1 1.04e-3 1.72e-3 ✓ sig.
Duodenitis Tongue cancer 0.100 1 1.04e-3 1.72e-3 ✓ sig.
Peeling skin syndrome with leukonychia and acral punctate keratoses Pemphigus 0.100 1 1.04e-3 1.72e-3 ✓ sig.
IMPDH1-related retinopathy Thyroiditis 0.059 1 1.04e-3 1.72e-3 ✓ sig.
Chorea Choreoacanthocytosis 0.053 1 1.17e-3 1.88e-3 ✓ sig.
Chorea hsd10 mitochondrial disease 0.053 1 1.17e-3 1.88e-3 ✓ sig.
Chorea Intellectual developmental disorder seizures movement 0.053 1 1.17e-3 1.88e-3 ✓ sig.
Chorea optic atrophy 10 with or without ataxia, intellectual disability, and seizures 0.053 1 1.17e-3 1.88e-3 ✓ sig.
Henoch schoenlein purpura Thiopurine immunosuppressant-induced pancreatitis 0.053 1 1.17e-3 1.88e-3 ✓ sig.
Respiratory system neoplasm Waldenstrom macroglobulinemia 0.111 1 1.30e-3 2.04e-3 ✓ sig.
Hepatitis c induced liver cirrhosis Pemphigus vulgaris 0.100 1 1.36e-3 2.13e-3 ✓ sig.
Autoimmune gastritis Gastritis 0.043 1 1.43e-3 2.21e-3 ✓ sig.
Gastritis platelet abnormalities with eosinophilia and immune-mediated inflammatory disease 0.043 1 1.43e-3 2.21e-3 ✓ sig.
Anti-neutrophil antibody associated vasculitis Thiopurine immunosuppressant-induced pancreatitis 0.042 1 1.49e-3 2.29e-3 ✓ sig.
Benign mucous membrane pemphigoid with ocular involvement Duodenitis 0.091 1 1.56e-3 2.36e-3 ✓ sig.
Blepharitis Rosacea 0.063 1 1.82e-3 2.66e-3 ✓ sig.
Intellectual developmental disorder seizures movement Oral cavity carcinoma 0.034 1 1.82e-3 2.66e-3 ✓ sig.
Interstitial cystitis neurodevelopmental disorder with microcephaly, seizures, and cortical atrophy 0.024 1 2.60e-3 3.50e-3 ✓ sig.
Interstitial cystitis Thiopurine immunosuppressant-induced pancreatitis 0.024 1 2.60e-3 3.50e-3 ✓ sig.
KIZ-related retinopathy Lupus nephritis 0.023 1 2.73e-3 3.65e-3 ✓ sig.
Gastritis Keratosis palmoplantaris papulosa 0.042 1 2.86e-3 3.80e-3 ✓ sig.
Birbeck granule deficiency Narcolepsy 0.019 1 3.31e-3 4.30e-3 ✓ sig.
immunodeficiency 106, susceptibility to viral infections Narcolepsy 0.019 1 3.31e-3 4.30e-3 ✓ sig.
Narcolepsy Uric acid urolithiasis 0.019 1 3.31e-3 4.30e-3 ✓ sig.
congenital disorder of glycosylation type II Lymphoma 0.019 1 3.44e-3 4.44e-3 ✓ sig.
Osteomyelitis Parenchymal hematoma 0.067 1 3.50e-3 4.51e-3 ✓ sig.
Henoch schoenlein purpura Hepatitis c induced liver cirrhosis 0.048 1 3.50e-3 4.51e-3 ✓ sig.
immunodeficiency 126, susceptibility to Ocular sarcoidosis 0.017 1 3.77e-3 4.80e-3 ✓ sig.
Ocular sarcoidosis scalp-ear-nipple syndrome 0.017 1 3.77e-3 4.80e-3 ✓ sig.
Antiphospholipid syndrome Hepatitis c induced liver cirrhosis 0.043 1 3.89e-3 4.94e-3 ✓ sig.