Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 101

12 diseases · 17 shared-gene connections
12 Diseases
1,738 Unique genes
0.078 Avg. similarity score
Systemic lupus erythematosus Most-connected disease (7 links)
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Disease Searched: Mahvash disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Systemic lupus erythematosus 7 7 656
Diabetes mellitus type 1 6 6 479
Hypothyroidism 5 5 377
Rheumatoid arthritis 4 4 661
Iga nephropathy 3 3 203
Sarcoidosis 3 3 163
Autoinflammatory-pancytopenia syndrome 1 1 1
Cherubism 1 1 2
Hypomyelination with brain stem and spinal cord involvement and leg spasticity 1 1 1
Mahvash disease 1 1 1
Midline facial cleft 1 1 1
Neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies 1 1 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
C2 6 / 12 Diabetes mellitus type 1, Hypothyroidism, Iga nephropathy, Rheumatoid arthritis and 2 more
HLA-DQA1 6 / 12 Diabetes mellitus type 1, Hypothyroidism, Iga nephropathy, Rheumatoid arthritis and 2 more
HLA-DQB1 6 / 12 Diabetes mellitus type 1, Hypothyroidism, Iga nephropathy, Rheumatoid arthritis and 2 more
HLA-DQB3 6 / 12 Diabetes mellitus type 1, Hypothyroidism, Iga nephropathy, Rheumatoid arthritis and 2 more
HLA-DRA 6 / 12 Diabetes mellitus type 1, Hypothyroidism, Iga nephropathy, Rheumatoid arthritis and 2 more
HLA-DRB1 6 / 12 Diabetes mellitus type 1, Hypothyroidism, Iga nephropathy, Rheumatoid arthritis and 2 more
TAP2 6 / 12 Diabetes mellitus type 1, Hypothyroidism, Iga nephropathy, Rheumatoid arthritis and 2 more
ATXN2 5 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Sarcoidosis and 1 more
BTNL2 5 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Sarcoidosis and 1 more
CCDC88B 5 / 12 Diabetes mellitus type 1, Hypothyroidism, Iga nephropathy, Rheumatoid arthritis and 1 more
CTLA4 5 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Sarcoidosis and 1 more
ETS1 5 / 12 Diabetes mellitus type 1, Hypothyroidism, Iga nephropathy, Rheumatoid arthritis and 1 more
HLA-B 5 / 12 Diabetes mellitus type 1, Hypothyroidism, Iga nephropathy, Rheumatoid arthritis and 1 more
HLA-DMB 5 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Sarcoidosis and 1 more
HLA-DOB 5 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Sarcoidosis and 1 more
HLA-DPB1 5 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Sarcoidosis and 1 more
HLA-DRB5 5 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Sarcoidosis and 1 more
INPP5B 5 / 12 Diabetes mellitus type 1, Hypothyroidism, Iga nephropathy, Rheumatoid arthritis and 1 more
NOTCH4 5 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Sarcoidosis and 1 more
PSMB8 5 / 12 Diabetes mellitus type 1, Hypothyroidism, Iga nephropathy, Rheumatoid arthritis and 1 more
SH2B3 5 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Sarcoidosis and 1 more
STAT4 5 / 12 Diabetes mellitus type 1, Hypothyroidism, Iga nephropathy, Rheumatoid arthritis and 1 more
TAGAP 5 / 12 Diabetes mellitus type 1, Hypothyroidism, Iga nephropathy, Rheumatoid arthritis and 1 more
TNF 5 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Sarcoidosis and 1 more
TNXB 5 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Sarcoidosis and 1 more
TSBP1 5 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Sarcoidosis and 1 more
TYK2 5 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Sarcoidosis and 1 more
ACOXL 4 / 12 Diabetes mellitus type 1, Iga nephropathy, Rheumatoid arthritis, Sarcoidosis
AFF3 4 / 12 Diabetes mellitus type 1, Iga nephropathy, Rheumatoid arthritis, Systemic lupus erythematosus
AGER 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
ANKRD55 4 / 12 Diabetes mellitus type 1, Iga nephropathy, Rheumatoid arthritis, Systemic lupus erythematosus
BACH2 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
BCL2L15 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
C1ORF141 4 / 12 Diabetes mellitus type 1, Rheumatoid arthritis, Sarcoidosis, Systemic lupus erythematosus
CARD9 4 / 12 Diabetes mellitus type 1, Iga nephropathy, Rheumatoid arthritis, Systemic lupus erythematosus
CD226 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
CD28 4 / 12 Diabetes mellitus type 1, Iga nephropathy, Rheumatoid arthritis, Systemic lupus erythematosus
CFB 4 / 12 Diabetes mellitus type 1, Iga nephropathy, Rheumatoid arthritis, Systemic lupus erythematosus
FCGR3A 4 / 12 Diabetes mellitus type 1, Iga nephropathy, Rheumatoid arthritis, Systemic lupus erythematosus
FCRL3 4 / 12 Hypothyroidism, Iga nephropathy, Rheumatoid arthritis, Systemic lupus erythematosus
FLI1 4 / 12 Diabetes mellitus type 1, Iga nephropathy, Rheumatoid arthritis, Systemic lupus erythematosus
HLA-A 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
HLA-C 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Sarcoidosis
HLA-DOA 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
HLA-DPA1 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
HORMAD2 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Iga nephropathy, Rheumatoid arthritis
ICOS 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
IKZF1 4 / 12 Diabetes mellitus type 1, Iga nephropathy, Rheumatoid arthritis, Systemic lupus erythematosus
IKZF3 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
IL1B 4 / 12 Diabetes mellitus type 1, Iga nephropathy, Rheumatoid arthritis, Systemic lupus erythematosus
IL1RN 4 / 12 Diabetes mellitus type 1, Iga nephropathy, Rheumatoid arthritis, Systemic lupus erythematosus
IL21 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
IL23R 4 / 12 Diabetes mellitus type 1, Rheumatoid arthritis, Sarcoidosis, Systemic lupus erythematosus
IL2RA 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
IL7R 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Iga nephropathy, Systemic lupus erythematosus
LRIG2 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
LTA 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Sarcoidosis
MAGI3 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
MSH5 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
NCR3 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Sarcoidosis
NKX2-3 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
PHTF1 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
PPARG 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Sarcoidosis, Systemic lupus erythematosus
PRDX5 4 / 12 Hypothyroidism, Iga nephropathy, Rheumatoid arthritis, Sarcoidosis
PSMB9 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
PSORS1C1 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
PTPN11 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
PTPN2 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
PTPN22 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
RAD51B 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
RASGRP1 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
RBM17 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
RSBN1 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
SFTA2 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
SLC11A1 4 / 12 Diabetes mellitus type 1, Rheumatoid arthritis, Sarcoidosis, Systemic lupus erythematosus
SLC25A28 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
SOD2 4 / 12 Diabetes mellitus type 1, Rheumatoid arthritis, Sarcoidosis, Systemic lupus erythematosus
TAP1 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
TCF7 4 / 12 Hypothyroidism, Iga nephropathy, Rheumatoid arthritis, Systemic lupus erythematosus
TTC33 4 / 12 Diabetes mellitus type 1, Iga nephropathy, Rheumatoid arthritis, Systemic lupus erythematosus
UBASH3A 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Sarcoidosis
WHR1 4 / 12 Hypothyroidism, Rheumatoid arthritis, Sarcoidosis, Systemic lupus erythematosus
ZFP57 4 / 12 Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
ZMIZ1 4 / 12 Diabetes mellitus type 1, Iga nephropathy, Rheumatoid arthritis, Systemic lupus erythematosus
ACAP1 3 / 12 Diabetes mellitus type 1, Hypothyroidism, Systemic lupus erythematosus
ACE 3 / 12 Diabetes mellitus type 1, Iga nephropathy, Sarcoidosis
ADCY7 3 / 12 Diabetes mellitus type 1, Hypothyroidism, Systemic lupus erythematosus
AIF1 3 / 12 Diabetes mellitus type 1, Rheumatoid arthritis, Systemic lupus erythematosus
APOM 3 / 12 Diabetes mellitus type 1, Rheumatoid arthritis, Sarcoidosis
ARID5B 3 / 12 Hypothyroidism, Rheumatoid arthritis, Systemic lupus erythematosus
ATG16L1 3 / 12 Diabetes mellitus type 1, Rheumatoid arthritis, Systemic lupus erythematosus
ATG5 3 / 12 Rheumatoid arthritis, Sarcoidosis, Systemic lupus erythematosus
ATP6V1G3 3 / 12 Diabetes mellitus type 1, Rheumatoid arthritis, Systemic lupus erythematosus
BLTP1 3 / 12 Diabetes mellitus type 1, Rheumatoid arthritis, Systemic lupus erythematosus
BRD2 3 / 12 Diabetes mellitus type 1, Rheumatoid arthritis, Sarcoidosis
BTN3A1 3 / 12 Diabetes mellitus type 1, Rheumatoid arthritis, Systemic lupus erythematosus
C1QTNF6 3 / 12 Diabetes mellitus type 1, Hypothyroidism, Systemic lupus erythematosus
C6ORF15 3 / 12 Diabetes mellitus type 1, Rheumatoid arthritis, Sarcoidosis
CARMIL1 3 / 12 Diabetes mellitus type 1, Rheumatoid arthritis, Systemic lupus erythematosus
CAT 3 / 12 Diabetes mellitus type 1, Rheumatoid arthritis, Systemic lupus erythematosus
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Inflammatory bowel disease
FOXP3, GATA3, HLA-DPB1, HLA-DQA2, HLA-DRB1, IFNG, IL10, IL18, IL1B, IL23A, IL6, STAT1
 KEGG 50 / 66 5.2× 4.55e-29 1.29e-25 ✓ sig.
Leishmaniasis
CYBB, FCGR2A, HLA-DPB1, HLA-DQA2, HLA-DRB1, IFNG, IL10, IL1B, IRAK1, NCF1, NCF2, PTGS2
 KEGG 50 / 78 4.4× 1.09e-23 1.49e-20 ✓ sig.
Type I diabetes mellitus
CD28, FASLG, HLA-DPB1, HLA-DQA2, HLA-DRB1, IFNG, IL1B, TNF, INS, CD80, CD86, GAD2
 KEGG 36 / 44 5.7× 2.37e-23 3.12e-20 ✓ sig.
Th17 cell differentiation
AHR, CD3E, FOXP3, GATA3, HLA-DPB1, HLA-DQA2, HLA-DRB1, IFNG, IL1B, IL23A, IL2RA, IL2RB
 KEGG 59 / 109 3.7× 2.53e-22 2.84e-19 ✓ sig.
Allograft rejection
CD28, CD40, FASLG, HLA-DPB1, HLA-DQA2, HLA-DRB1, IFNG, IL10, TNF, CD80, CD86, HLA-DPA1
 KEGG 32 / 39 5.7× 5.82e-21 5.17e-18 ✓ sig.
Cytokine-cytokine receptor interaction
ACKR3, BMP4, BMP6, CCL21, CCL8, CCR6, CD40, CSF2, CXCL2, CXCL6, CXCL8, CXCR4
 KEGG 107 / 298 2.5× 8.42e-21 7.23e-18 ✓ sig.
Toxoplasmosis
ALOX5, CD40, CIITA, HLA-DPB1, HLA-DQA2, HLA-DRB1, IFNG, IL10, IRAK1, ITGA6, LY96, STAT1
 KEGG 54 / 112 3.3× 1.47e-17 7.32e-15 ✓ sig.
Th1 and Th2 cell differentiation
CD3E, GATA3, HLA-DPB1, HLA-DQA2, HLA-DRB1, IFNG, IL2RA, IL2RB, NFKBIE, PRKCQ, RBPJ, STAT1
 KEGG 48 / 93 3.6× 2.76e-17 1.31e-14 ✓ sig.
Autoimmune thyroid disease
CD28, CD40, CTLA4, FASLG, HLA-DPB1, HLA-DQA2, HLA-DRB1, IL10, CD80, CD86, HLA-DPA1, HLA-DQA1
 KEGG 35 / 54 4.5× 3.36e-17 1.55e-14 ✓ sig.
Herpes simplex virus 1 infection
FASLG, HLA-DPB1, HLA-DQA2, HLA-DRB1, IFNG, IL1B, IL6, IRAK1, STAT1, TLR2, TNF, TNFRSF14
 KEGG 72 / 182 2.7× 5.50e-17 2.45e-14 ✓ sig.
Interleukin-10 signaling
CSF2, CXCL2, CXCL8, IL10, IL18, IL1B, IL1RN, IL6, PTGS2, TNF, TYK2, CCR5
 Reactome 32 / 47 4.7× 8.66e-17 3.66e-14 ✓ sig.
Intestinal immune network for IgA production
CD28, CD40, CXCR4, HLA-DPB1, HLA-DQA2, HLA-DRB1, IL10, IL6, CD80, CD86, CXCL12, HLA-DPA1
 KEGG 33 / 50 4.6× 1.20e-16 4.95e-14 ✓ sig.
Rheumatoid arthritis
CD28, CSF2, CTLA4, CXCL2, CXCL6, CXCL8, HLA-DPB1, HLA-DQA2, HLA-DRB1, IFNG, IL18, IL1B
 KEGG 47 / 95 3.4× 5.15e-16 1.92e-13 ✓ sig.
Viral protein interaction with cytokine and cytokine receptor
ACKR3, CCL21, CCL8, CCR6, CXCL2, CXCL6, CXCL8, CXCR4, IL10, IL18, IL2RA, IL2RB
 KEGG 48 / 100 3.3× 1.16e-15 3.96e-13 ✓ sig.
Tuberculosis
CIITA, CTSD, FCGR2A, HLA-DPB1, HLA-DQA2, HLA-DRB1, IFNG, IL10, IL18, IL1B, IL23A, IL6
 KEGG 68 / 181 2.6× 8.76e-15 2.52e-12 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
immune response
ACKR3, BMP6, CCL21, CCL8, CCR6, CD2, CD244, CD28, CIITA, CSF2, CTLA4, CXCL2
 GO:0006955 149 / 543 3.0× 3.14e-35 2.49e-31 ✓ sig.
inflammatory response
ADORA2A, AGER, ALOX5, BDKRB2, BMP6, CCL21, CCL8, CD40, CRP, CXCL2, CXCL6, CXCL8
 GO:0006954 122 / 467 2.8× 8.14e-27 3.29e-23 ✓ sig.
positive regulation of type II interferon production
CD2, CD244, CD3E, HLA-DPB1, IL18, IL1B, IL23A, IRF8, PTPN22, SLC11A1, TNF, TYK2
 GO:0032729 37 / 77 5.2× 1.51e-18 1.92e-15 ✓ sig.
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
CAT, CCL21, CD28, F2, GATA3, HCLS1, IL18, IL1B, PTK2, TNF, VEGFA, INS
 GO:0051897 64 / 217 3.2× 1.92e-17 2.13e-14 ✓ sig.
positive regulation of MAPK cascade
CAV2, CD3E, CD40, GSDME, HLA-DRB1, IGFBP3, IL1B, IL6, IL6R, PTPRC, TNF, VEGFA
 GO:0043410 65 / 224 3.1× 2.67e-17 2.88e-14 ✓ sig.
positive regulation of T cell proliferation
CD28, CD3E, HLA-DPB1, IL1B, IL23A, IL2RA, IL6, IL6ST, PTPRC, TRAF6, TYK2, AIF1
 GO:0042102 33 / 67 5.3× 4.19e-17 4.36e-14 ✓ sig.
positive regulation of transcription by RNA polymerase II
AHR, BMP4, BMP6, CCN1, CD28, CD40, CIITA, FOXP3, GATA3, HCLS1, HDAC1, HOXD10
 GO:0045944 201 / 1,208 1.8× 5.51e-17 5.66e-14 ✓ sig.
immune system process
CD244, CD28, CD3E, CD40, CD83, CTLA4, FCGR2A, GATA3, HLA-DPB1, HLA-DQA2, HLA-DRB1, IL23A
 GO:0002376 167 / 943 1.9× 9.20e-17 9.07e-14 ✓ sig.
cell surface receptor signaling pathway via JAK-STAT
CD40, CSF2, IFNG, IL23A, IL6, IL6R, IL6ST, STAT1, STAT4, TNF, TYK2, CCR2
 GO:0007259 32 / 67 5.1× 3.95e-16 3.44e-13 ✓ sig.
positive regulation of cell population proliferation
AGER, BMP4, BMP6, CSF2, F2, FASLG, HCLS1, HDAC1, IFNG, IL1B, IL6, IL6R
 GO:0008284 108 / 532 2.2× 3.62e-15 2.67e-12 ✓ sig.
positive regulation of smooth muscle cell proliferation
BMP4, HDAC1, IL18, IL6, IL6R, IRAK1, MMP2, NR4A3, STAT1, TNF, AIF1, CCL5
 GO:0048661 27 / 52 5.6× 5.55e-15 3.97e-12 ✓ sig.
cytokine-mediated signaling pathway
IL18, IL1B, IL2RB, IL6, IL6R, IL6ST, IRAK1, IRF5, STAT4, TYK2, CCR2, GH1
 GO:0019221 47 / 145 3.5× 6.78e-15 4.77e-12 ✓ sig.
positive regulation of T cell activation
CD28, CD3E, HLA-DPB1, HLA-DQA2, HLA-DRB1, PRKCQ, CCR2, HLA-DPA1, HLA-DQA1, HLA-DQB1, CARD11, CCDC88B
 GO:0050870 25 / 45 6.0× 6.98e-15 4.89e-12 ✓ sig.
positive regulation of tumor necrosis factor production
AGER, CD2, CYBB, FCGR2A, IFNG, IL23A, IL6, LY96, MIF, PTPRC, TLR2, ABCC8
 GO:0032760 40 / 113 3.8× 2.52e-14 1.62e-11 ✓ sig.
cell surface receptor signaling pathway
AGER, BDKRB2, CD2, CD28, CD3E, F2, FCGR2A, IFNG, IL18, IL2RA, LY96, MIF
 GO:0007166 83 / 373 2.4× 3.28e-14 2.06e-11 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Rheumatoid arthritis Systemic lupus erythematosus 0.196 216 7.37e-140 3.94e-138 ✓ sig.
Diabetes mellitus type 1 Rheumatoid arthritis 0.197 188 1.20e-136 6.30e-135 ✓ sig.
Hypothyroidism Rheumatoid arthritis 0.166 148 5.60e-106 2.48e-104 ✓ sig.
Diabetes mellitus type 1 Systemic lupus erythematosus 0.163 159 1.41e-101 5.99e-100 ✓ sig.
Diabetes mellitus type 1 Hypothyroidism 0.143 107 3.25e-74 1.10e-72 ✓ sig.
Hypothyroidism Systemic lupus erythematosus 0.118 109 1.87e-61 5.71e-60 ✓ sig.
Rheumatoid arthritis Sarcoidosis 0.076 58 3.84e-38 8.76e-37 ✓ sig.
Diabetes mellitus type 1 Sarcoidosis 0.075 45 1.94e-30 3.83e-29 ✓ sig.
Iga nephropathy Systemic lupus erythematosus 0.060 49 7.16e-24 1.18e-22 ✓ sig.
Hypothyroidism Sarcoidosis 0.067 34 2.49e-22 3.91e-21 ✓ sig.
Diabetes mellitus type 1 Iga nephropathy 0.056 36 1.23e-17 1.66e-16 ✓ sig.
Hypothyroidism Midline facial cleft 0.003 1 2.43e-2 2.59e-2 ✓ sig.
Cherubism Iga nephropathy 0.005 1 2.60e-2 2.76e-2 ✓ sig.
Diabetes mellitus type 1 Neurodevelopmental disorder with microcephaly, arthrogryposis, and structural brain anomalies 0.002 1 3.09e-2 3.25e-2 ✓ sig.
Mahvash disease Systemic lupus erythematosus 0.002 1 4.24e-2 4.40e-2 ✓ sig.
Autoinflammatory-pancytopenia syndrome Systemic lupus erythematosus 0.002 1 4.24e-2 4.40e-2 ✓ sig.
Hypomyelination with brain stem and spinal cord involvement and leg spasticity Systemic lupus erythematosus 0.002 1 4.24e-2 4.40e-2 ✓ sig.