Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▲ Shared cluster
Edema Hypotension
10 genes
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INS(1), CAT(1), TNF(1), IL6(1), POMC(1), TAC1(1), KNG1(1), OXT(1), VIP(1), SLC9A3(1)
0.093 0.204 8.68e-15 1.22e-13 ✓ sig. Cluster 13 →
46,xy gonadal dysgenesis 46,xy sex reversal
5 genes
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4 of 5 corroborated by 2+ sources
NR5A1(2), SRY(1), CBX2(2), DHX37(2), MAP3K1(2)
0.278 0.714 8.74e-15 1.23e-13 ✓ sig. Cluster 38 →
Corneal ulcer Eye disease
7 genes
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UBE2V2(1), RDX(1), ALPK1(1), SLC9A9(1), UTRN(1), NTF4(1), CCBE1(1)
0.072 0.778 8.97e-15 1.26e-13 ✓ sig. Cluster 399 →
Congenital nystagmus Nystagmus
6 genes
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4 of 6 corroborated by 2+ sources
ATF6(2), ROBO1(4), RPE65(2), PAX6(1), AHR(2), TYR(1)
0.130 0.750 9.19e-15 1.29e-13 ✓ sig. —
Lung disease Rhinitis
12 genes
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5 of 12 corroborated by 2+ sources
CAT(2), SERPINE1(1), IL1B(1), IL2(1), TNF(2), PTGS2(2), IL13(2), IL18(1), TLR2(1), CFTR(2), IL4R(1), SFTPD(1)
0.077 0.185 9.79e-15 1.38e-13 ✓ sig. —
Ovarian epithelial cancer Ovarian serous carcinoma
20 genes
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HNF1B(1), TERT(1), BNC2(1), GABRG3(1), HLA-DRB5(1), JAZF1(1), MECOM(1), NSF(1), PLEKHM1(1), TTC28(1), LAMA3(1), RSPO1(1) +8 more
0.055 0.174 9.81e-15 1.38e-13 ✓ sig. Cluster 20 →
Cerebral amyloid angiopathy Dementia
22 genes
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4 of 22 corroborated by 2+ sources
APP(6), ITM2B(3), APOE(3), DOCK10(1), EFHB(1), FSTL5(1), GRIK2(1), KAZN(1), KCNH8(1), NCK2(1), NECTIN2(1), PTPRD(1) +10 more
0.034 0.310 9.96e-15 1.40e-13 ✓ sig. —
Cerebrovascular disorder Large artery stroke
12 genes
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5 of 12 corroborated by 2+ sources
SH2B3(2), HDAC9(2), MMP12(2), SMARCA4(1), ATXN2(1), TWIST1(1), ABO(2), CELSR2(1), LPA(1), MMP13(1), PSRC1(1), EDNRA(2)
0.079 0.154 9.98e-15 1.40e-13 ✓ sig. —
Distal spinal muscular atrophy Motor neuron disease
9 genes
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1 of 9 corroborated by 2+ sources
SETX(1), TRPV4(1), DCTN1(1), DYNC1H1(1), NEFL(1), SH3TC2(1), PLEKHG5(1), GARS1(1), IGHMBP2(3)
0.096 0.290 1.04e-14 1.45e-13 ✓ sig. Cluster 15 →
Fatty liver Hyperglycemia
11 genes
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11 of 11 corroborated by 2+ sources
INS(2), LEP(2), NFE2L2(2), PON1(2), TF(2), SOD1(2), GPX1(2), CCL2(2), COL3A1(2), NUS1(2), LEPR(2)
0.081 0.212 1.05e-14 1.47e-13 ✓ sig. —
Hereditary hearing loss Meniere disease
10 genes
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10 of 10 corroborated by 2+ sources
PCDH15(2), MYO6(2), TRIOBP(2), CDH23(2), MYO7A(2), WFS1(2), MYH14(2), MYH9(2), TECTA(2), USH1C(2)
0.093 0.200 1.08e-14 1.51e-13 ✓ sig. Cluster 26 →
Allergic contact dermatitis Atopic dermatitis
11 genes
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9 of 11 corroborated by 2+ sources
IL10(2), IL2(2), IL4(2), TLR4(1), TNF(2), IFNG(2), CYP1A1(2), IL18(2), IL5(2), NAT2(1), SELE(2)
0.085 0.167 1.08e-14 1.52e-13 ✓ sig. Cluster 16 →
Myositis Polymyositis
8 genes
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2 of 8 corroborated by 2+ sources
DGKQ(1), SDK2(1), HLA-DQB1(2), PTPN22(1), STAT4(2), BLK(1), FAM167A(1), NAB1(1)
0.105 0.364 1.15e-14 1.61e-13 ✓ sig. Cluster 25 →
Atopic dermatitis Lung disease
12 genes
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4 of 12 corroborated by 2+ sources
GSTP1(1), GSTT1(1), IL1B(2), IL2(1), TNF(2), GSTM1(1), TGFB1(2), IL13(2), IL18(1), TLR2(1), IL4R(1), NAT2(1)
0.077 0.182 1.19e-14 1.66e-13 ✓ sig. —
Erythematosquamous dermatosis Sebaceous gland disease
6 genes
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HERC2(1), RALY(1), IRF4(1), TYR(1), MC1R(1), SLC45A2(1)
0.194 0.429 1.20e-14 1.68e-13 ✓ sig. Cluster 162 →
Anemia Iron deficiency anemia
7 genes
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4 of 7 corroborated by 2+ sources
HFE(2), PON1(1), TF(1), TNF(2), SLC11A2(2), GPX1(1), TMPRSS6(3)
0.080 0.700 1.32e-14 1.84e-13 ✓ sig. —
Androgenetic alopecia Osteoarthritis
59 genes
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8 of 59 corroborated by 2+ sources
KANSL1(1), FGFR3(1), TEAD1(1), AKAP1(1), ARHGAP15(1), ARL17B(1), CCDC91(1), CDC5L(1), CDKAL1(1), CLIC4(2), CLIC5(1), CRADD(1) +47 more
0.055 0.145 1.34e-14 1.87e-13 ✓ sig. —
Idiopathic steroid-resistant nephrotic syndrome Nephrotic syndrome, focal segmental type
5 genes
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4 of 5 corroborated by 2+ sources
ACTN4(2), MYO1E(2), PAX2(2), ANLN(1), CRB2(2)
0.172 1.000 1.36e-14 1.90e-13 ✓ sig. —
Angioedema Hereditary angioedema
6 genes
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6 of 6 corroborated by 2+ sources
KNG1(6), SERPING1(7), F12(7), ANGPT1(5), MYOF(5), HS3ST6(4)
0.102 0.857 1.37e-14 1.91e-13 ✓ sig. —
Myelodysplastic syndrome Myeloid leukemia
12 genes
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6 of 12 corroborated by 2+ sources
GATA2(3), RUNX1(4), TERT(3), CTNNA1(1), JAK2(3), KRAS(2), DNMT3A(3), DAPK1(1), MYC(1), STAG2(1), BMI1(1), LYL1(1)
0.065 0.261 1.37e-14 1.91e-13 ✓ sig. Cluster 53 →
Vitamin b deficiency Vitamin deficiency disorder
5 genes
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1 of 5 corroborated by 2+ sources
FUT2(2), TCN2(1), CUBN(1), TCN1(1), OOSP3(1)
0.294 0.556 1.38e-14 1.92e-13 ✓ sig. Cluster 106 →
Ellis-van creveld syndrome Majewski syndrome
5 genes
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3 of 5 corroborated by 2+ sources
EVC(7), EVC2(7), DYNC2LI1(3), WDR35(1), TRAF3IP1(1)
0.294 0.556 1.38e-14 1.92e-13 ✓ sig. —
Megaloblastic anemia Vitamin deficiency disorder
5 genes
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3 of 5 corroborated by 2+ sources
FUT2(1), TCN2(3), CUBN(2), TCN1(2), OOSP3(1)
0.294 0.556 1.38e-14 1.92e-13 ✓ sig. Cluster 106 →
Astrocytoma Scoliosis
60 genes
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5 of 60 corroborated by 2+ sources
WWOX(1), NOTCH1(2), C6orf118(1), CTNNA3(1), DAB1(1), DENND4A(1), DNAH14(1), DOCK1(1), EPHA4(1), GPATCH2L(1), HDAC9(1), HNF4G(1) +48 more
0.047 0.199 1.46e-14 2.02e-13 ✓ sig. —
Crest syndrome Systemic scleroderma
6 genes
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1 of 6 corroborated by 2+ sources
HLA-DRB5(1), IRF5(2), FCGR2B(1), FCGR3B(1), STAT4(1), TNPO3(1)
0.194 0.400 1.46e-14 2.02e-13 ✓ sig. Cluster 25 →

Showing 25 of 20813 pairs, sorted by significance (ascending). Click a column header to sort.