Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 16

23 diseases · 50 shared-gene connections
23 Diseases
1,077 Unique genes
0.118 Avg. similarity score
Keratinocyte carcinoma Most-connected disease (11 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Keratinocyte carcinoma 11 11 77
Skin cancer 9 9 84
Skin neoplasms 9 9 145
Cutaneous squamous cell carcinoma 8 8 38
Basal cell carcinoma 7 7 327
Non-melanoma skin carcinoma 7 7 169
Seborrheic keratosis 7 7 31
Non-small cell lung carcinoma 6 6 115
Skin disease 6 6 177
Corneal astigmatism 5 5 71
histidinemia 5 5 1
Congenital posterior urethral valves 3 3 1
Melanoma 3 3 435
Chromosome 20q11-q12 deletion syndrome 2 2 1
Dermatologic disorder 2 2 68
optic atrophy 13 with retinal and foveal abnormalities 2 2 1
progressive essential tremor-speech impairment-facial dysmorphism-intellectual disability-abnormal behavior syndrome 2 2 1
Acromelic frontonasal dysostosis 1 1 1
Deeah syndrome 1 1 1
Diaphanospondylodysostosis 1 1 1
Woolly hair-skin fragility syndrome 1 1 1
hyper-IgE recurrent infection syndrome 3, autosomal recessive 1 1 1
neurodevelopmental disorder, nonprogressive, with spasticity and transient opisthotonus 1 1 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
BNC2 12 / 23 Basal cell carcinoma, Congenital posterior urethral valves, Corneal astigmatism, Cutaneous squamous cell carcinoma and 8 more
CASP8 10 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 6 more
IRF4 10 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 6 more
KRT5 10 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 6 more
LPP 10 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 6 more
RALY 10 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 6 more
SLC45A2 10 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 6 more
TYR 10 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 6 more
BACH2 9 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 5 more
BRCA2 9 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 5 more
CPVL 9 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 5 more
FLACC1 9 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 5 more
HERC2 9 / 23 Basal cell carcinoma, Corneal astigmatism, Keratinocyte carcinoma, Melanoma and 5 more
HLA-DQA1 9 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 5 more
MC1R 9 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 5 more
FOXP1 8 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 4 more
HLA-DRB1 8 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma and 4 more
MICA 8 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma and 4 more
OCA2 8 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Melanoma, Non-melanoma skin carcinoma and 4 more
TERT 8 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-small cell lung carcinoma and 4 more
CLPTM1L 7 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma and 3 more
CTLA4 7 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Melanoma and 3 more
HAL 7 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, histidinemia, Keratinocyte carcinoma and 3 more
HLA-B 7 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma and 3 more
TRPS1 7 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma, Non-small cell lung carcinoma and 3 more
AHR 6 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Melanoma, Skin cancer and 2 more
CUX1 6 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 2 more
CYP1B1 6 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma and 2 more
DEF8 6 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-small cell lung carcinoma and 2 more
EPB41L1 6 / 23 Basal cell carcinoma, Chromosome 20q11-q12 deletion syndrome, Cutaneous squamous cell carcinoma, Keratinocyte carcinoma and 2 more
ICOS 6 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Melanoma, Non-melanoma skin carcinoma and 2 more
MYL10 6 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 2 more
PHTF1 6 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 2 more
PTPN22 6 / 23 Basal cell carcinoma, Melanoma, Seborrheic keratosis, Skin cancer and 2 more
RCC2 6 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma and 2 more
RHOU 6 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma and 2 more
RSBN1 6 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 2 more
TGM3 6 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma and 2 more
TICAM1 6 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma and 2 more
TP53 6 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma and 2 more
ANKRD11 5 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma and 1 more
ATP11A 5 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Skin cancer and 1 more
BCAS4 5 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 1 more
CCDC88B 5 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 1 more
CCR6 5 / 23 Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma, Skin cancer and 1 more
CEP43 5 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Skin cancer and 1 more
CYRIA 5 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 1 more
JDP2 5 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 1 more
PARD6B 5 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 1 more
RGS22 5 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 1 more
SMC2 5 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 1 more
THNSL2 5 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin cancer and 1 more
ZNF276 5 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma and 1 more
ADGRV1 4 / 23 Basal cell carcinoma, Melanoma, Skin cancer, Skin neoplasms
ASIP 4 / 23 Basal cell carcinoma, Melanoma, Non-melanoma skin carcinoma, Skin neoplasms
ATP8B4 4 / 23 Basal cell carcinoma, Non-melanoma skin carcinoma, Skin cancer, Skin neoplasms
CTSS 4 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Melanoma, Non-melanoma skin carcinoma
CTXND2 4 / 23 Cutaneous squamous cell carcinoma, Melanoma, Skin cancer, Skin neoplasms
EMSY 4 / 23 Basal cell carcinoma, Skin cancer, Skin disease, Skin neoplasms
EXOC2 4 / 23 Basal cell carcinoma, Melanoma, Non-melanoma skin carcinoma, Skin disease
FADS2 4 / 23 Basal cell carcinoma, Non-melanoma skin carcinoma, Skin cancer, Skin neoplasms
FANCA 4 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma
HLA-DQB3 4 / 23 Basal cell carcinoma, Non-melanoma skin carcinoma, Skin cancer, Skin neoplasms
IL2RA 4 / 23 Basal cell carcinoma, Skin cancer, Skin disease, Skin neoplasms
KANK1 4 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Skin cancer, Skin neoplasms
KRT6A 4 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Seborrheic keratosis, Skin disease
PPARGC1B 4 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Melanoma, Non-melanoma skin carcinoma
PRDX5 4 / 23 Basal cell carcinoma, Non-melanoma skin carcinoma, Skin cancer, Skin neoplasms
PTGS2 4 / 23 Dermatologic disorder, Melanoma, Skin disease, Skin neoplasms
SCAF1 4 / 23 Basal cell carcinoma, Melanoma, Skin cancer, Skin neoplasms
SLC24A5 4 / 23 Melanoma, Skin cancer, Skin disease, Skin neoplasms
SMAD3 4 / 23 Basal cell carcinoma, Corneal astigmatism, Seborrheic keratosis, Skin disease
SPMIP7 4 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma, Skin disease
TP63 4 / 23 Cutaneous squamous cell carcinoma, Non-small cell lung carcinoma, Seborrheic keratosis, Skin disease
TPCN2 4 / 23 Basal cell carcinoma, Melanoma, Skin cancer, Skin neoplasms
TPRG1 4 / 23 Cutaneous squamous cell carcinoma, Non-small cell lung carcinoma, Seborrheic keratosis, Skin disease
TRPC4AP 4 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Melanoma, Non-melanoma skin carcinoma
ZBTB10 4 / 23 Basal cell carcinoma, Non-melanoma skin carcinoma, Skin cancer, Skin neoplasms
AQP3 3 / 23 Melanoma, Non-small cell lung carcinoma, Skin neoplasms
BCL2L12 3 / 23 Basal cell carcinoma, Skin cancer, Skin neoplasms
CBFA2T2 3 / 23 Basal cell carcinoma, Melanoma, Non-melanoma skin carcinoma
CCRL2 3 / 23 Dermatologic disorder, Non-melanoma skin carcinoma, Skin disease
CFL1 3 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma
DCST1 3 / 23 Basal cell carcinoma, Skin cancer, Skin neoplasms
DLGAP4 3 / 23 Basal cell carcinoma, Melanoma, Non-melanoma skin carcinoma
DTNBP1 3 / 23 Basal cell carcinoma, Corneal astigmatism, Non-small cell lung carcinoma
DUSP22 3 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Non-melanoma skin carcinoma
EDEM2 3 / 23 Basal cell carcinoma, Cutaneous squamous cell carcinoma, Non-melanoma skin carcinoma
ERCC2 3 / 23 Dermatologic disorder, Skin disease, Skin neoplasms
FAM76B 3 / 23 Basal cell carcinoma, Skin cancer, Skin neoplasms
GPX4 3 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma
GRM5 3 / 23 Basal cell carcinoma, Melanoma, Non-melanoma skin carcinoma
HLA-DPA1 3 / 23 Basal cell carcinoma, Keratinocyte carcinoma, Non-melanoma skin carcinoma
IL1A 3 / 23 Dermatologic disorder, Skin disease, Skin neoplasms
IL6 3 / 23 Basal cell carcinoma, Dermatologic disorder, Skin disease
IRF3 3 / 23 Non-melanoma skin carcinoma, Skin cancer, Skin neoplasms
JAZF1 3 / 23 Basal cell carcinoma, Skin cancer, Skin neoplasms
KIAA0930 3 / 23 Melanoma, Skin cancer, Skin neoplasms
MITF 3 / 23 Melanoma, Skin cancer, Skin neoplasms
MTAP 3 / 23 Basal cell carcinoma, Melanoma, Non-small cell lung carcinoma
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Pathways in cancer
BRCA2, CASP8, IL2RA, LAMC1, PIK3R1, RAC1, SMAD3, TERT, TP53, PTCH1, PTCH2, SMO
 KEGG 101 / 533 2.1× 1.53e-13 3.75e-11 ✓ sig.
Human cytomegalovirus infection
CASP8, HLA-B, HLA-C, PIK3R1, RAC1, TP53, ATF2, CREB5, IL6, PIK3CA, RAC3, RB1
 KEGG 53 / 226 2.6× 4.08e-11 6.42e-9 ✓ sig.
Graft-versus-host disease
HLA-B, HLA-C, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, IL6, HLA-DOB, HLA-DQB2, IL1A, IL1B
 KEGG 20 / 45 5.0× 3.42e-10 4.37e-8 ✓ sig.
Hepatitis B
CASP8, PIK3R1, SMAD3, TICAM1, TLR3, TP53, ATF2, CREB5, IL6, JUN, PIK3CA, RB1
 KEGG 41 / 163 2.8× 7.16e-10 8.30e-8 ✓ sig.
Allograft rejection
HLA-B, HLA-C, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DOB, HLA-DQB2, IL10, TNF, HLA-DOA
 KEGG 18 / 39 5.1× 1.23e-9 1.34e-7 ✓ sig.
Type I diabetes mellitus
HLA-B, HLA-C, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DOB, HLA-DQB2, IL1A, IL1B, TNF
 KEGG 19 / 44 4.8× 1.73e-9 1.81e-7 ✓ sig.
Human T-cell leukemia virus 1 infection
HLA-B, HLA-C, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, IL2RA, PIK3R1, SMAD3, TERT, TP53
 KEGG 49 / 224 2.4× 2.80e-9 2.80e-7 ✓ sig.
Bladder cancer
TP53, ERBB2, RB1, CDH1, CDKN2A, UPK3A, CDK4, BRAF, E2F1, HRAS, MAP2K1, MAP2K2
 KEGG 18 / 41 4.9× 3.36e-9 3.31e-7 ✓ sig.
Inflammatory bowel disease
HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, SMAD3, IL6, JUN, TGFB2, HLA-DOB, HLA-DQB2, IL10
 KEGG 23 / 66 3.9× 5.24e-9 4.97e-7 ✓ sig.
Autoimmune thyroid disease
CTLA4, HLA-B, HLA-C, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DOB, HLA-DQB2, IL10, HLA-DOA
 KEGG 20 / 54 4.1× 1.58e-8 1.30e-6 ✓ sig.
Rheumatoid arthritis
CTLA4, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, IL6, JUN, TGFB2, ANGPT1, HLA-DOB, HLA-DQB2
 KEGG 27 / 95 3.2× 3.74e-8 2.76e-6 ✓ sig.
Melanoma
PIK3R1, TP53, PIK3CA, RB1, PDGFRA, CDH1, CDKN2A, MITF, GADD45B, PTEN, CDK4, BRAF
 KEGG 23 / 73 3.5× 4.64e-8 3.34e-6 ✓ sig.
Kaposi sarcoma-associated herpesvirus infection
CASP8, HLA-B, HLA-C, MICA, PIK3R1, RAC1, TICAM1, TLR3, TP53, IL6, JUN, LEF1
 KEGG 42 / 196 2.4× 7.07e-8 4.84e-6 ✓ sig.
Viral myocarditis
CASP8, HLA-B, HLA-C, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, RAC1, SNTA1, SSPN, CAV1
 KEGG 22 / 70 3.5× 9.53e-8 6.26e-6 ✓ sig.
Chronic myeloid leukemia
PIK3R1, SMAD3, TP53, PIK3CA, RB1, TGFB2, BCR, CDKN2A, GADD45B, CDK4, BRAF, E2F1
 KEGG 23 / 77 3.3× 1.40e-7 8.74e-6 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
positive regulation of gene expression
CTSH, DTNBP1, PTPN22, SMAD3, TICAM1, TLR3, TP53, VDR, ZBTB7B, SMO, ATM, ATF2
 GO:0010628 73 / 504 2.5× 2.67e-13 1.39e-10 ✓ sig.
response to lipopolysaccharide
CASP8, FOXP1, GPX4, PTPN22, RAC1, TICAM1, DIO2, DUSP10, EDN1, GJB6, LITAF, SPON2
 GO:0032496 33 / 161 3.6× 1.42e-10 3.93e-8 ✓ sig.
positive regulation of transcription by RNA polymerase II
AHR, BCL2L12, CD200, GRHL1, IKZF4, IRF4, MAFF, MC1R, PIK3R1, PPARGC1B, SBNO2, SMAD3
 GO:0045944 122 / 1,208 1.8× 5.87e-10 1.40e-7 ✓ sig.
negative regulation of transcription by RNA polymerase II
BACH2, CBFA2T2, CUX1, DUSP22, FOXP1, JARID2, JAZF1, JDP2, MAFF, OVOL1, RALY, SLA2
 GO:0000122 106 / 1,002 1.8× 6.86e-10 1.60e-7 ✓ sig.
positive regulation of miRNA transcription
SMAD3, TERT, TP53, IL6, JUN, MYCN, TGFB2, NOTCH2, IL10, TNF, NGFR, PAX6
 GO:1902895 18 / 56 5.6× 1.12e-9 2.49e-7 ✓ sig.
positive regulation of cell population proliferation
CEP43, KRT6A, TSPYL5, SMO, EDN1, IGF2BP1, IL6, MARCKSL1, SOX4, TBX1, TGFB2, PDGFRA
 GO:0008284 67 / 532 2.2× 1.28e-9 2.80e-7 ✓ sig.
regulation of gene expression
AHR, FOXP1, JARID2, MC1R, ZBTB7B, SMO, ATM, BAP1, GLI2, PIK3CA, ROCK1, SHH
 GO:0010468 55 / 402 2.4× 2.09e-9 4.31e-7 ✓ sig.
antigen processing and presentation
CTSH, CTSS, HLA-B, HLA-C, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, RAB5B, HLA-DOB, HLA-DQB2
 GO:0019882 16 / 48 5.8× 5.20e-9 9.66e-7 ✓ sig.
cell population proliferation
BRCA2, JARID2, KANK1, OCA2, SMAD3, TP53, TYR, SMO, BAP1, CAV1, ERBB2, JUN
 GO:0008283 41 / 263 2.7× 5.66e-9 1.04e-6 ✓ sig.
negative regulation of apoptotic process
BCL2L12, CFL1, DSTYK, PIK3R1, PRDX5, SMAD3, TERT, TP53, RASA1, SMO, ERBB2, IL6
 GO:0043066 64 / 524 2.1× 1.01e-8 1.73e-6 ✓ sig.
melanin biosynthetic process
ASIP, MC1R, OCA2, SLC45A2, TYR, MFSD12, SLC24A5, TYRP1, PMEL
 GO:0042438 9 / 14 11.2× 1.05e-8 1.78e-6 ✓ sig.
liver development
JARID2, SMAD3, ARID5B, ATF2, JUN, PIK3CA, NOTCH2, UGT1A10, UGT1A7, UGT1A8, UGT1A9, SOD2
 GO:0001889 21 / 87 4.2× 1.54e-8 2.48e-6 ✓ sig.
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DOB, HLA-DQB2, HLA-DOA, HLA-DRB5
 GO:0002504 9 / 15 10.4× 2.48e-8 3.75e-6 ✓ sig.
positive regulation of DNA-templated transcription
AHR, BRCA2, HLA-DRB1, IRF4, RAI1, SMAD3, TP53, PTCH1, SMO, ARID5B, CHD3, CREB5
 GO:0045893 83 / 778 1.9× 3.76e-8 5.32e-6 ✓ sig.
positive regulation of nitric oxide biosynthetic process
SMAD3, TICAM1, EDN1, IL1B, PTGS2, PTX3, SOD2, TNF, CLU, IFNG, KLRK1, TLR4
 GO:0045429 14 / 42 5.8× 4.74e-8 6.49e-6 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Skin cancer Skin neoplasms 0.565 83 7.36e-180 1.98e-177 ✓ sig.
Dermatologic disorder Skin disease 0.382 68 5.03e-139 8.94e-137 ✓ sig.
Basal cell carcinoma Keratinocyte carcinoma 0.224 74 1.71e-123 2.67e-121 ✓ sig.
Basal cell carcinoma Non-melanoma skin carcinoma 0.195 81 7.31e-92 7.07e-90 ✓ sig.
Keratinocyte carcinoma Skin cancer 0.397 46 4.80e-90 4.52e-88 ✓ sig.
Basal cell carcinoma Skin cancer 0.181 63 1.75e-89 1.64e-87 ✓ sig.
Basal cell carcinoma Skin neoplasms 0.185 74 2.18e-86 1.98e-84 ✓ sig.
Keratinocyte carcinoma Non-melanoma skin carcinoma 0.260 51 5.19e-84 4.59e-82 ✓ sig.
Keratinocyte carcinoma Skin neoplasms 0.267 47 2.48e-78 2.04e-76 ✓ sig.
Non-melanoma skin carcinoma Skin cancer 0.227 47 5.00e-72 3.85e-70 ✓ sig.
Non-melanoma skin carcinoma Skin neoplasms 0.180 48 1.81e-59 1.16e-57 ✓ sig.
Melanoma Skin neoplasms 0.113 59 2.16e-53 1.26e-51 ✓ sig.
Basal cell carcinoma Melanoma 0.112 77 2.38e-49 1.30e-47 ✓ sig.
Cutaneous squamous cell carcinoma Skin cancer 0.255 25 2.59e-49 1.41e-47 ✓ sig.
Melanoma Non-melanoma skin carcinoma 0.108 59 9.69e-49 5.20e-47 ✓ sig.
Cutaneous squamous cell carcinoma Skin neoplasms 0.157 25 1.24e-42 5.80e-41 ✓ sig.
Cutaneous squamous cell carcinoma Keratinocyte carcinoma 0.208 20 2.04e-37 8.40e-36 ✓ sig.
Skin cancer Skin disease 0.124 29 9.08e-36 3.57e-34 ✓ sig.
Keratinocyte carcinoma Non-small cell lung carcinoma 0.149 25 3.57e-35 1.37e-33 ✓ sig.
Seborrheic keratosis Skin disease 0.112 21 2.21e-34 8.26e-33 ✓ sig.
Skin disease Skin neoplasms 0.114 33 7.15e-34 2.63e-32 ✓ sig.
Cutaneous squamous cell carcinoma Non-small cell lung carcinoma 0.149 20 1.54e-33 5.62e-32 ✓ sig.
Keratinocyte carcinoma Skin disease 0.114 26 7.92e-32 2.70e-30 ✓ sig.
Cutaneous squamous cell carcinoma Seborrheic keratosis 0.250 14 5.21e-30 1.68e-28 ✓ sig.
Non-small cell lung carcinoma Skin cancer 0.117 21 7.13e-27 2.04e-25 ✓ sig.
Non-small cell lung carcinoma Skin neoplasms 0.097 23 1.82e-24 4.53e-23 ✓ sig.
Non-small cell lung carcinoma Seborrheic keratosis 0.105 14 1.77e-22 3.97e-21 ✓ sig.
Seborrheic keratosis Skin cancer 0.126 13 2.73e-22 6.07e-21 ✓ sig.
Keratinocyte carcinoma Seborrheic keratosis 0.124 12 1.30e-20 2.71e-19 ✓ sig.
Corneal astigmatism Non-small cell lung carcinoma 0.033 6 1.47e-5 7.50e-5 ✓ sig.
Seborrheic keratosis Woolly hair-skin fragility syndrome 0.031 1 2.01e-3 2.89e-3 ✓ sig.
Congenital posterior urethral valves Seborrheic keratosis 0.031 1 2.01e-3 2.89e-3 ✓ sig.
Chromosome 20q11-q12 deletion syndrome Cutaneous squamous cell carcinoma 0.026 1 2.47e-3 3.36e-3 ✓ sig.
Congenital posterior urethral valves Cutaneous squamous cell carcinoma 0.026 1 2.47e-3 3.36e-3 ✓ sig.
Cutaneous squamous cell carcinoma histidinemia 0.026 1 2.47e-3 3.36e-3 ✓ sig.
Dermatologic disorder optic atrophy 13 with retinal and foveal abnormalities 0.014 1 4.42e-3 5.52e-3 ✓ sig.
Congenital posterior urethral valves Corneal astigmatism 0.014 1 4.61e-3 5.73e-3 ✓ sig.
Corneal astigmatism Deeah syndrome 0.014 1 4.61e-3 5.73e-3 ✓ sig.
Corneal astigmatism Diaphanospondylodysostosis 0.014 1 4.61e-3 5.73e-3 ✓ sig.
Corneal astigmatism neurodevelopmental disorder, nonprogressive, with spasticity and transient opisthotonus 0.014 1 4.61e-3 5.73e-3 ✓ sig.
Keratinocyte carcinoma progressive essential tremor-speech impairment-facial dysmorphism-intellectual disability-abnormal behavior syndrome 0.013 1 5.00e-3 6.13e-3 ✓ sig.
Chromosome 20q11-q12 deletion syndrome Keratinocyte carcinoma 0.013 1 5.00e-3 6.13e-3 ✓ sig.
histidinemia Keratinocyte carcinoma 0.013 1 5.00e-3 6.13e-3 ✓ sig.
histidinemia Skin cancer 0.012 1 5.46e-3 6.63e-3 ✓ sig.
histidinemia Skin neoplasms 0.007 1 9.42e-3 1.07e-2 ✓ sig.
hyper-IgE recurrent infection syndrome 3, autosomal recessive Non-melanoma skin carcinoma 0.006 1 1.10e-2 1.24e-2 ✓ sig.
Acromelic frontonasal dysostosis Non-melanoma skin carcinoma 0.006 1 1.10e-2 1.24e-2 ✓ sig.
optic atrophy 13 with retinal and foveal abnormalities Skin disease 0.006 1 1.15e-2 1.29e-2 ✓ sig.
Basal cell carcinoma progressive essential tremor-speech impairment-facial dysmorphism-intellectual disability-abnormal behavior syndrome 0.003 1 2.12e-2 2.31e-2 ✓ sig.
Basal cell carcinoma histidinemia 0.003 1 2.12e-2 2.31e-2 ✓ sig.