DUSP10 (dual specificity phosphatase 10)

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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 11221
• Gene name: Dual specificity phosphatase 10
• Gene symbol: DUSP10
• Synonyms (NCBI Gene): MKP-5, MKP5
• Chromosome: 1
• Chromosome location: 1q41
• Summary: Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular pro

miRNA Show/Hide all (121)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006323	hsa-miR-21-5p	Luciferase reporter assay, qRT-PCR, Western blot	22387553
MIRT006323	hsa-miR-21-5p	Luciferase reporter assay, qRT-PCR, Western blot	22387553
MIRT006323	hsa-miR-21-5p	Luciferase reporter assay, qRT-PCR, Western blot	22387553
MIRT006323	hsa-miR-21-5p	Luciferase reporter assay, qRT-PCR, Western blot	22387553
MIRT006323	hsa-miR-21-5p	Luciferase reporter assay, qRT-PCR, Western blot	22387553
MIRT006323	hsa-miR-21-5p	Luciferase reporter assay, qRT-PCR, Western blot	22387553
MIRT027621	hsa-miR-98-5p	Microarray	19088304
MIRT438170	hsa-miR-92a-3p	ELISA, Luciferase reporter assay, qRT-PCR, Western blot	24332650
MIRT438170	hsa-miR-92a-3p	ELISA, Luciferase reporter assay, qRT-PCR, Western blot	24332650
MIRT646225	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT646224	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT646223	hsa-miR-4289	HITS-CLIP	23824327
MIRT646222	hsa-miR-6072	HITS-CLIP	23824327
MIRT646221	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT646220	hsa-miR-5193	HITS-CLIP	23824327
MIRT646219	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT646218	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT646217	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT646216	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT646215	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT646214	hsa-miR-3163	HITS-CLIP	23824327
MIRT646213	hsa-miR-410-3p	HITS-CLIP	23824327
MIRT646212	hsa-miR-454-5p	HITS-CLIP	23824327
MIRT646211	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT646210	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT646209	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT646208	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT646207	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT646206	hsa-miR-190a-5p	HITS-CLIP	23824327
MIRT646205	hsa-miR-190b	HITS-CLIP	23824327
MIRT646204	hsa-miR-3201	HITS-CLIP	23824327
MIRT646203	hsa-miR-4791	HITS-CLIP	23824327
MIRT646202	hsa-miR-642b-5p	HITS-CLIP	23824327
MIRT646201	hsa-miR-6883-3p	HITS-CLIP	23824327
MIRT646200	hsa-miR-623	HITS-CLIP	23824327
MIRT646199	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT646198	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT646197	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT646196	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT646195	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT646194	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT615029	hsa-miR-450a-5p	HITS-CLIP	23824327
MIRT615028	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT438170	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT727844	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT727843	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT734965	hsa-miR-363-3p	Luciferase reporter assay, Western blotting, qRT-PCR, Flow cytometry	33208005
MIRT646225	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT646224	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT646223	hsa-miR-4289	HITS-CLIP	23824327
MIRT646222	hsa-miR-6072	HITS-CLIP	23824327
MIRT646221	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT646220	hsa-miR-5193	HITS-CLIP	23824327
MIRT646219	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT646218	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT646217	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT646216	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT646215	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT646214	hsa-miR-3163	HITS-CLIP	23824327
MIRT646213	hsa-miR-410-3p	HITS-CLIP	23824327
MIRT646212	hsa-miR-454-5p	HITS-CLIP	23824327
MIRT646211	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT646210	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT646209	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT646208	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT646207	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT646206	hsa-miR-190a-5p	HITS-CLIP	23824327
MIRT646205	hsa-miR-190b	HITS-CLIP	23824327
MIRT646204	hsa-miR-3201	HITS-CLIP	23824327
MIRT646203	hsa-miR-4791	HITS-CLIP	23824327
MIRT646202	hsa-miR-642b-5p	HITS-CLIP	23824327
MIRT646201	hsa-miR-6883-3p	HITS-CLIP	23824327
MIRT646200	hsa-miR-623	HITS-CLIP	23824327
MIRT646199	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT646198	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT646197	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT646196	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT646195	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT646194	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT615029	hsa-miR-450a-5p	HITS-CLIP	23824327
MIRT615028	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT947345	hsa-miR-3158-3p	CLIP-seq
MIRT947346	hsa-miR-3940-5p	CLIP-seq
MIRT947347	hsa-miR-4507	CLIP-seq
MIRT947348	hsa-miR-629	CLIP-seq
MIRT947349	hsa-miR-659	CLIP-seq
MIRT2215611	hsa-miR-1279	CLIP-seq
MIRT2215612	hsa-miR-1283	CLIP-seq
MIRT2215613	hsa-miR-137	CLIP-seq
MIRT2215614	hsa-miR-185	CLIP-seq
MIRT2215615	hsa-miR-223	CLIP-seq
MIRT2215616	hsa-miR-2278	CLIP-seq
MIRT2215617	hsa-miR-25	CLIP-seq
MIRT2215618	hsa-miR-32	CLIP-seq
MIRT2215619	hsa-miR-329	CLIP-seq
MIRT2215620	hsa-miR-362-3p	CLIP-seq
MIRT2215621	hsa-miR-363	CLIP-seq
MIRT2215622	hsa-miR-367	CLIP-seq
MIRT2215623	hsa-miR-3910	CLIP-seq
MIRT2215624	hsa-miR-3941	CLIP-seq
MIRT2215625	hsa-miR-421	CLIP-seq
MIRT2215626	hsa-miR-4277	CLIP-seq
MIRT2215627	hsa-miR-4306	CLIP-seq
MIRT2215628	hsa-miR-4493	CLIP-seq
MIRT2215629	hsa-miR-4644	CLIP-seq
MIRT2215630	hsa-miR-466	CLIP-seq
MIRT2215631	hsa-miR-4672	CLIP-seq
MIRT2215632	hsa-miR-4676-5p	CLIP-seq
MIRT2215633	hsa-miR-4709-5p	CLIP-seq
MIRT2215634	hsa-miR-4731-3p	CLIP-seq
MIRT2215635	hsa-miR-4786-3p	CLIP-seq
MIRT2215636	hsa-miR-4795-3p	CLIP-seq
MIRT2215637	hsa-miR-4801	CLIP-seq
MIRT2215638	hsa-miR-507	CLIP-seq
MIRT2215639	hsa-miR-557	CLIP-seq
MIRT2215640	hsa-miR-575	CLIP-seq
MIRT2215641	hsa-miR-656	CLIP-seq
MIRT2215642	hsa-miR-767-5p	CLIP-seq
MIRT2215643	hsa-miR-92a	CLIP-seq
MIRT2215644	hsa-miR-92b	CLIP-seq
MIRT2215645	hsa-miR-942	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ATF2	Unknown	17681939

Gene ontology (GO) Show/Hide all (54)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002682	Process	Regulation of immune system process	IEA
GO:0002819	Process	Regulation of adaptive immune response	IEA
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0005515	Function	Protein binding	IPI	16288922, 27880917, 32296183, 32814053
GO:0005634	Component	Nucleus	IDA	10391943
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	10391943
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0007165	Process	Signal transduction	IBA
GO:0008330	Function	Protein tyrosine/threonine phosphatase activity	IBA
GO:0008330	Function	Protein tyrosine/threonine phosphatase activity	IDA	10391943
GO:0008432	Function	JUN kinase binding	IDA	10391943
GO:0010633	Process	Negative regulation of epithelial cell migration	IEA
GO:0010633	Process	Negative regulation of epithelial cell migration	ISS
GO:0016311	Process	Dephosphorylation	IDA	24531476
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IDA	16806267, 24531476
GO:0017017	Function	MAP kinase tyrosine/serine/threonine phosphatase activity	IBA
GO:0017017	Function	MAP kinase tyrosine/serine/threonine phosphatase activity	IEA
GO:0030336	Process	Negative regulation of cell migration	NAS	23993976
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0032873	Process	Negative regulation of stress-activated MAPK cascade	IEA
GO:0033549	Function	MAP kinase phosphatase activity	IDA	22375048
GO:0033549	Function	MAP kinase phosphatase activity	IEA
GO:0033549	Function	MAP kinase phosphatase activity	ISS
GO:0033550	Function	MAP kinase tyrosine phosphatase activity	IBA
GO:0045088	Process	Regulation of innate immune response	IEA
GO:0045591	Process	Positive regulation of regulatory T cell differentiation	IMP	22387553
GO:0046329	Process	Negative regulation of JNK cascade	IBA
GO:0046329	Process	Negative regulation of JNK cascade	IDA	10391943
GO:0046329	Process	Negative regulation of JNK cascade	IEA
GO:0046329	Process	Negative regulation of JNK cascade	IEA
GO:0048273	Function	Mitogen-activated protein kinase p38 binding	IPI	10391943
GO:0048709	Process	Oligodendrocyte differentiation	IEA
GO:0048715	Process	Negative regulation of oligodendrocyte differentiation	IEA
GO:0050680	Process	Negative regulation of epithelial cell proliferation	IEA
GO:0050680	Process	Negative regulation of epithelial cell proliferation	ISS
GO:0051239	Process	Regulation of multicellular organismal process	IEA
GO:0051403	Process	Stress-activated MAPK cascade	IEA
GO:0060266	Process	Negative regulation of respiratory burst involved in inflammatory response	IEA
GO:0060284	Process	Regulation of cell development	IEA
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	IEA
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	ISS
GO:0090335	Process	Regulation of brown fat cell differentiation	IEA
GO:1903753	Process	Negative regulation of p38MAPK cascade	IDA	10391943
GO:1903753	Process	Negative regulation of p38MAPK cascade	NAS	23993976
GO:1905042	Process	Negative regulation of epithelium regeneration	IEA
GO:1905042	Process	Negative regulation of epithelium regeneration	ISS

Other IDs

• MIM: 608867
• HGNC: 3065
• e!Ensembl: ENSG00000143507

Protein

• UniProt ID: Q9Y6W6
• Protein name: Dual specificity protein phosphatase 10 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5)
• Protein function: Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. {ECO:0000269|PubMed:10391943, ECO:0000269|PubMed:10597297, ECO:0000269|PubMed:2
• PDB: 1ZZW , 2OUC , 2OUD , 3TG1 , 6MC1 , 7U4O , 7U4R , 7UMU , 7UMV , 7UN0 , 7UN4 , 7Y4B , 7Y4C , 7Y4D , 7Y4E
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00581	Rhodanese	154 → 279	Rhodanese-like domain	Domain
  PF00782	DSPc	329 → 461	Dual specificity phosphatase, catalytic domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in keratinocytes (at protein level) (PubMed:29043977). Detected in brain (PubMed:16806267). {ECO:0000269|PubMed:16806267, ECO:0000269|PubMed:29043977}.
• Sequence:

  MPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSANPGSNSHPPVIATTVVSLKAANLTY
  MPSSSGSARSLNCGCSSASCCTVATYDKDNQAQTQAIAAGTTTTAIGTSTTCPANQMVNN
  NENTGSLSPSSGVGSPVSGTPKQLASIKIIYPNDLAKKMTKCSKSHLPSQGPVIIDCRPF
  MEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENT
  NEPSRVMPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHENLCDNSLQLQECREVGGGA
  SAASSLLPQPIPTTPDIENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPL
  YHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVI
  AYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRILTPKLMGVET
  VV

• Sequence length: 482

Pathways

KEGG Pathway	Reactome Pathway
MAPK signaling pathway	RAF-independent MAPK1/3 activation
	Negative regulation of MAPK pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (11)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
CARCINOMA, BASAL CELL	—	CTD	36428691	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DRY EYE SYNDROME	—	GWAS catalog	38767906	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DUPUYTREN CONTRACTURE	—	GWAS catalog	20971583	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPEROPIA	—	GWAS catalog	33830181	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MALIGNANT EPITHELIAL TUMOR OF OVARY	—	GWAS catalog	30898391	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	30898391	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	31374203	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (30)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma	Adenocarcinoma	BEFREE	16618780		★☆☆☆☆ Found in Text Mining only
Antiphospholipid Syndrome	Antiphospholipid syndrome	Pubtator	38155384	Associate	★☆☆☆☆ Found in Text Mining only
Aortic Aneurysm Abdominal	Aortic aneurysm	Pubtator	25993293	Associate	★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	BEFREE	31122150		★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	31122150	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	22711061		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	20413845, 25201346	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	22711061		★☆☆☆☆ Found in Text Mining only
Celiac Disease	Celiac disease	Pubtator	23936387	Associate	★☆☆☆☆ Found in Text Mining only
Celiac Disease	Celiac disease	BEFREE	23936387		★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	BEFREE	25772234		★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	22711061		★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic Neoplasms	BEFREE	25772234		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	23872954, 25772234, 25973098, 31717606		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	25973098, 35812248	Associate	★☆☆☆☆ Found in Text Mining only
Dejerine-Sottas Disease (disorder)	Charcot-Marie-Tooth disease	BEFREE	25772234		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	37387540	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Idiopathic Pulmonary Fibrosis	Pulmonary Fibrosis	BEFREE	31483681		★☆☆☆☆ Found in Text Mining only
Immune System Diseases	Immune System Diseases	BEFREE	15306813		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	22711061		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	16618780		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	14767517, 16618780, 30939861		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	22711061		★☆☆☆☆ Found in Text Mining only
Muscular Dystrophy	Muscular dystrophy	BEFREE	31483681		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	16618780		★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	24361742	Associate	★☆☆☆☆ Found in Text Mining only
Progressive supranuclear palsy	Progressive Supranuclear Palsy	BEFREE	29986742		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	16618780		★☆☆☆☆ Found in Text Mining only
Pulmonary Fibrosis	Pulmonary Fibrosis	BEFREE	31483681		★☆☆☆☆ Found in Text Mining only
Supranuclear Palsy Progressive	Progressive supranuclear palsy	Pubtator	29986742, 35842134	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

TACC2 2 shared diseasesDupuytren contracture, Ovarian epithelial cancer 2 shared evidence sourcesGWAS catalog (Dupuytren contracture), GWAS catalog (Ovarian epithelial cancer) Related via 2 shared diseases including Dupuytren contracture, Ovarian epithelial cancer — evidence mostly GWAS catalog. DUSP2 3 shared pathwaysMAPK signaling pathway, RAF-independent MAPK1/3 activation, Negative regulation of MAPK pathway Related via 3 shared pathways including MAPK signaling pathway, RAF-independent MAPK1/3 activation. DUSP5 3 shared pathwaysMAPK signaling pathway, RAF-independent MAPK1/3 activation, Negative regulation of MAPK pathway Related via 3 shared pathways including MAPK signaling pathway, RAF-independent MAPK1/3 activation. DUSP8 3 shared pathwaysMAPK signaling pathway, RAF-independent MAPK1/3 activation, Negative regulation of MAPK pathway Related via 3 shared pathways including MAPK signaling pathway, RAF-independent MAPK1/3 activation. DUSP9 3 shared pathwaysMAPK signaling pathway, RAF-independent MAPK1/3 activation, Negative regulation of MAPK pathway Related via 3 shared pathways including MAPK signaling pathway, RAF-independent MAPK1/3 activation.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
TACC2	2	["Dupuytren contracture","Ovarian epithelial cancer"]	0	[]	2	["GWAS catalog (Dupuytren contracture)","GWAS catalog (Ovarian epithelial cancer)"]
DUSP2	0	[]	3	["MAPK signaling pathway","RAF-independent MAPK1\/3 activation","Negative regulation of MAPK pathway"]	0	[]
DUSP5	0	[]	3	["MAPK signaling pathway","RAF-independent MAPK1\/3 activation","Negative regulation of MAPK pathway"]	0	[]
DUSP8	0	[]	3	["MAPK signaling pathway","RAF-independent MAPK1\/3 activation","Negative regulation of MAPK pathway"]	0	[]
DUSP9	0	[]	3	["MAPK signaling pathway","RAF-independent MAPK1\/3 activation","Negative regulation of MAPK pathway"]	0	[]

Diseases Linked via Similar Genes

Diabetes mellitus type 2 Linked via 2 of 5 related genesTACC2, DUSP9 Alzheimer disease Linked via 1 of 5 related genesTACC2 Attention deficit hyperactivity disorder Linked via 1 of 5 related genesTACC2 Breast cancer Linked via 1 of 5 related genesTACC2 Lymphocytic leukemia Linked via 1 of 5 related genesTACC2

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Diabetes mellitus type 2	2	["TACC2","DUSP9"]
Alzheimer disease	1	["TACC2"]
Attention deficit hyperactivity disorder	1	["TACC2"]
Breast cancer	1	["TACC2"]
Lymphocytic leukemia	1	["TACC2"]