DUSP8 (dual specificity phosphatase 8)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 1850 |
| Gene name | Dual specificity phosphatase 8 |
| Gene symbol | DUSP8 |
| Synonyms (NCBI Gene) |
C11orf81HB5HVH-5HVH8
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| Chromosome | 11 |
| Chromosome location | 11p15.5 |
| Summary | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regu |
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miRNA
miRNA information provided by mirtarbase database.
399
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q13202 | |||||||||||||||
| Protein name | Dual specificity protein phosphatase 8 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH-5) | |||||||||||||||
| Protein function | Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphot | |||||||||||||||
| PDB | 4JMK | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Abundant in brain, heart and skeletal muscle. {ECO:0000269|PubMed:7561881}. | |||||||||||||||
| Sequence |
MAGDRLPRKVMDAKKLASLLRGGPGGPLVIDSRSFVEYNSWHVLSSVNICCSKLVKRRLQ |
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| Sequence length | 625 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Related Genes
Genes most often co-reported with DUSP8 across shared curated disease and pathway associations.
5
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to DUSP8 (see Related Genes above), that are NOT already directly curated for DUSP8 itself -- a lead worth checking, not a confirmed association.
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