Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 13

23 diseases · 76 shared-gene connections
23 Diseases
492 Unique genes
0.199 Avg. similarity score
Dejerine-sottas disease Most-connected disease (15 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Dejerine-sottas disease 15 15 38
Hereditary motor and sensory neuropathies 12 12 66
Hypertrophic neuropathy 11 11 38
Roussy-levy syndrome 11 11 38
Charcot-marie-tooth disease 10 10 132
Distal spinal muscular atrophy 10 10 31
Peroneal muscle atrophy 10 10 39
Distal hereditary motor neuropathy 9 9 36
Charcot-marie-tooth disease, x-linked 8 8 8
Spinal muscular atrophy 8 8 37
Congenital pes cavus 6 6 12
Charcot-Marie-Tooth disease X-linked dominant 6 5 5 1
Charcot-Marie-Tooth disease axonal type 2P 5 5 1
Charcot-Marie-Tooth disease type 2D 5 5 1
Charcot-Marie-Tooth disease type 4B3 5 5 1
Motor neuron disease 5 5 71
Charcot-Marie-Tooth disease type 2 4 4 2
neuronopathy, distal hereditary motor, autosomal recessive 5 4 4 1
Amyotrophic lateral sclerosis 3 3 332
X-linked hereditary motor and sensory neuropathy 3 3 1
Telangiectasia–intellectual disability–microcephaly–metaphyseal dysplasia–eye abnormalities–short stature syndrome 1 1 1
Vexas syndrome 1 1 1
multiple acyl-CoA dehydrogenase deficiency 1 1 3

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
DYNC1H1 12 / 23 Amyotrophic lateral sclerosis, Charcot-marie-tooth disease, Congenital pes cavus, Dejerine-sottas disease and 8 more
GARS1 12 / 23 Charcot-marie-tooth disease, Charcot-Marie-Tooth disease type 2D, Congenital pes cavus, Dejerine-sottas disease and 8 more
NEFL 12 / 23 Amyotrophic lateral sclerosis, Charcot-marie-tooth disease, Charcot-Marie-Tooth disease type 2, Congenital pes cavus and 8 more
PLEKHG5 11 / 23 Amyotrophic lateral sclerosis, Charcot-marie-tooth disease, Dejerine-sottas disease, Distal hereditary motor neuropathy and 7 more
TRPV4 10 / 23 Charcot-marie-tooth disease, Dejerine-sottas disease, Distal hereditary motor neuropathy, Distal spinal muscular atrophy and 6 more
HSPB1 9 / 23 Charcot-marie-tooth disease, Dejerine-sottas disease, Distal hereditary motor neuropathy, Distal spinal muscular atrophy and 5 more
HSPB8 9 / 23 Charcot-marie-tooth disease, Dejerine-sottas disease, Distal hereditary motor neuropathy, Distal spinal muscular atrophy and 5 more
MPZ 9 / 23 Charcot-marie-tooth disease, Congenital pes cavus, Dejerine-sottas disease, Distal hereditary motor neuropathy and 5 more
SH3TC2 9 / 23 Charcot-marie-tooth disease, Congenital pes cavus, Dejerine-sottas disease, Distal spinal muscular atrophy and 5 more
FIG4 8 / 23 Amyotrophic lateral sclerosis, Charcot-marie-tooth disease, Dejerine-sottas disease, Distal hereditary motor neuropathy and 4 more
GJB1 8 / 23 Charcot-marie-tooth disease, Charcot-marie-tooth disease, x-linked, Congenital pes cavus, Dejerine-sottas disease and 4 more
MFN2 8 / 23 Amyotrophic lateral sclerosis, Charcot-marie-tooth disease, Dejerine-sottas disease, Hereditary motor and sensory neuropathies and 4 more
PDK3 8 / 23 Charcot-marie-tooth disease, Charcot-Marie-Tooth disease X-linked dominant 6, Charcot-marie-tooth disease, x-linked, Dejerine-sottas disease and 4 more
SBF1 8 / 23 Charcot-marie-tooth disease, Charcot-Marie-Tooth disease type 4B3, Charcot-marie-tooth disease, x-linked, Dejerine-sottas disease and 4 more
AARS1 7 / 23 Charcot-marie-tooth disease, Dejerine-sottas disease, Distal spinal muscular atrophy, Hereditary motor and sensory neuropathies and 3 more
AIFM1 7 / 23 Charcot-marie-tooth disease, Charcot-marie-tooth disease, x-linked, Dejerine-sottas disease, Hereditary motor and sensory neuropathies and 3 more
GDAP1 7 / 23 Charcot-marie-tooth disease, Congenital pes cavus, Dejerine-sottas disease, Hereditary motor and sensory neuropathies and 3 more
KIF1B 7 / 23 Charcot-marie-tooth disease, Dejerine-sottas disease, Hereditary motor and sensory neuropathies, Hypertrophic neuropathy and 3 more
LRSAM1 7 / 23 Charcot-marie-tooth disease, Charcot-Marie-Tooth disease axonal type 2P, Dejerine-sottas disease, Hereditary motor and sensory neuropathies and 3 more
MARS1 7 / 23 Charcot-marie-tooth disease, Dejerine-sottas disease, Distal spinal muscular atrophy, Hereditary motor and sensory neuropathies and 3 more
PMP22 7 / 23 Charcot-marie-tooth disease, Dejerine-sottas disease, Distal spinal muscular atrophy, Hereditary motor and sensory neuropathies and 3 more
PRPS1 7 / 23 Charcot-marie-tooth disease, Charcot-marie-tooth disease, x-linked, Dejerine-sottas disease, Hereditary motor and sensory neuropathies and 3 more
PRX 7 / 23 Charcot-marie-tooth disease, Dejerine-sottas disease, Distal spinal muscular atrophy, Hereditary motor and sensory neuropathies and 3 more
VCP 7 / 23 Amyotrophic lateral sclerosis, Charcot-marie-tooth disease, Dejerine-sottas disease, Hereditary motor and sensory neuropathies and 3 more
COX6A1 6 / 23 Charcot-marie-tooth disease, Dejerine-sottas disease, Hereditary motor and sensory neuropathies, Hypertrophic neuropathy and 2 more
DCTN1 6 / 23 Amyotrophic lateral sclerosis, Charcot-marie-tooth disease, Distal hereditary motor neuropathy, Distal spinal muscular atrophy and 2 more
DHTKD1 6 / 23 Charcot-marie-tooth disease, Dejerine-sottas disease, Hereditary motor and sensory neuropathies, Hypertrophic neuropathy and 2 more
EGR2 6 / 23 Charcot-marie-tooth disease, Dejerine-sottas disease, Hereditary motor and sensory neuropathies, Hypertrophic neuropathy and 2 more
FGD4 6 / 23 Charcot-marie-tooth disease, Dejerine-sottas disease, Hereditary motor and sensory neuropathies, Hypertrophic neuropathy and 2 more
GNB4 6 / 23 Charcot-marie-tooth disease, Dejerine-sottas disease, Hereditary motor and sensory neuropathies, Hypertrophic neuropathy and 2 more
HK1 6 / 23 Charcot-marie-tooth disease, Dejerine-sottas disease, Hereditary motor and sensory neuropathies, Hypertrophic neuropathy and 2 more
IGHMBP2 6 / 23 Charcot-marie-tooth disease, Distal hereditary motor neuropathy, Distal spinal muscular atrophy, Hereditary motor and sensory neuropathies and 2 more
INF2 6 / 23 Charcot-marie-tooth disease, Dejerine-sottas disease, Hereditary motor and sensory neuropathies, Hypertrophic neuropathy and 2 more
JPH1 6 / 23 Charcot-marie-tooth disease, Dejerine-sottas disease, Hereditary motor and sensory neuropathies, Hypertrophic neuropathy and 2 more
KARS1 6 / 23 Charcot-marie-tooth disease, Dejerine-sottas disease, Hereditary motor and sensory neuropathies, Hypertrophic neuropathy and 2 more
MME 6 / 23 Charcot-marie-tooth disease, Dejerine-sottas disease, Hereditary motor and sensory neuropathies, Hypertrophic neuropathy and 2 more
NDRG1 6 / 23 Charcot-marie-tooth disease, Dejerine-sottas disease, Hereditary motor and sensory neuropathies, Hypertrophic neuropathy and 2 more
SETX 6 / 23 Amyotrophic lateral sclerosis, Charcot-marie-tooth disease, Distal hereditary motor neuropathy, Distal spinal muscular atrophy and 2 more
SLC12A6 6 / 23 Charcot-marie-tooth disease, Dejerine-sottas disease, Hereditary motor and sensory neuropathies, Hypertrophic neuropathy and 2 more
SURF1 6 / 23 Charcot-marie-tooth disease, Dejerine-sottas disease, Hereditary motor and sensory neuropathies, Hypertrophic neuropathy and 2 more
TRIM2 6 / 23 Charcot-marie-tooth disease, Dejerine-sottas disease, Hereditary motor and sensory neuropathies, Hypertrophic neuropathy and 2 more
DNAJB2 5 / 23 Charcot-marie-tooth disease, Charcot-marie-tooth disease, x-linked, Distal hereditary motor neuropathy, neuronopathy, distal hereditary motor, autosomal recessive 5 and 1 more
HSPB3 5 / 23 Charcot-marie-tooth disease, Distal hereditary motor neuropathy, Distal spinal muscular atrophy, Hereditary motor and sensory neuropathies and 1 more
SIGMAR1 5 / 23 Amyotrophic lateral sclerosis, Charcot-marie-tooth disease, Distal hereditary motor neuropathy, Distal spinal muscular atrophy and 1 more
ATP7A 4 / 23 Charcot-marie-tooth disease, Distal hereditary motor neuropathy, Hereditary motor and sensory neuropathies, Spinal muscular atrophy
BICD2 4 / 23 Amyotrophic lateral sclerosis, Charcot-marie-tooth disease, Distal hereditary motor neuropathy, Spinal muscular atrophy
BSCL2 4 / 23 Charcot-marie-tooth disease, Distal hereditary motor neuropathy, Distal spinal muscular atrophy, Hereditary motor and sensory neuropathies
DRP2 4 / 23 Charcot-marie-tooth disease, Charcot-marie-tooth disease, x-linked, Hereditary motor and sensory neuropathies, X-linked hereditary motor and sensory neuropathy
FBXO38 4 / 23 Charcot-marie-tooth disease, Distal hereditary motor neuropathy, Distal spinal muscular atrophy, Spinal muscular atrophy
MORC2 4 / 23 Charcot-marie-tooth disease, Distal hereditary motor neuropathy, Distal spinal muscular atrophy, Hereditary motor and sensory neuropathies
NEFH 4 / 23 Amyotrophic lateral sclerosis, Charcot-marie-tooth disease, Hereditary motor and sensory neuropathies, Motor neuron disease
SLC5A7 4 / 23 Charcot-marie-tooth disease, Distal hereditary motor neuropathy, Distal spinal muscular atrophy, Hereditary motor and sensory neuropathies
VRK1 4 / 23 Amyotrophic lateral sclerosis, Distal hereditary motor neuropathy, Distal spinal muscular atrophy, Spinal muscular atrophy
BAG3 3 / 23 Charcot-marie-tooth disease, Distal hereditary motor neuropathy, Distal spinal muscular atrophy
KIF5A 3 / 23 Amyotrophic lateral sclerosis, Charcot-marie-tooth disease, Hereditary motor and sensory neuropathies
LITAF 3 / 23 Charcot-marie-tooth disease, Distal spinal muscular atrophy, Hereditary motor and sensory neuropathies
LMNA 3 / 23 Charcot-marie-tooth disease, Distal hereditary motor neuropathy, Hereditary motor and sensory neuropathies
RAB7A 3 / 23 Charcot-marie-tooth disease, Charcot-Marie-Tooth disease type 2, Hereditary motor and sensory neuropathies
REEP1 3 / 23 Charcot-marie-tooth disease, Distal hereditary motor neuropathy, Spinal muscular atrophy
WARS1 3 / 23 Charcot-marie-tooth disease, Distal hereditary motor neuropathy, Distal spinal muscular atrophy
ALS2 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
ARHGEF10 2 / 23 Charcot-marie-tooth disease, Spinal muscular atrophy
BCL2L1 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
BSG 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
CALB2 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
CASP1 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
CD68 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
CD7 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
CHCHD10 2 / 23 Amyotrophic lateral sclerosis, Spinal muscular atrophy
CLU 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
CNTF 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
CREBBP 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
CST3 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
CTSD 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
DBX1 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
DPP6 2 / 23 Amyotrophic lateral sclerosis, Spinal muscular atrophy
DST 2 / 23 Charcot-marie-tooth disease, Distal spinal muscular atrophy
ETFDH 2 / 23 Distal spinal muscular atrophy, multiple acyl-CoA dehydrogenase deficiency
FGF6 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
FMO1 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
FOS 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
FUS 2 / 23 Amyotrophic lateral sclerosis, Distal spinal muscular atrophy
GABRA1 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
GBX2 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
GDI1 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
GFAP 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
GRIA3 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
GSX2 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
HARS1 2 / 23 Charcot-marie-tooth disease, Congenital pes cavus
HOXD10 2 / 23 Amyotrophic lateral sclerosis, Charcot-marie-tooth disease
HSF1 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
IFRD1 2 / 23 Amyotrophic lateral sclerosis, Charcot-marie-tooth disease
INA 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
JAK3 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
JUND 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
KIF3C 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
LAMA2 2 / 23 Amyotrophic lateral sclerosis, Charcot-marie-tooth disease
LAT 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
LDLR 2 / 23 Amyotrophic lateral sclerosis, Motor neuron disease
LRRC8C 2 / 23 Amyotrophic lateral sclerosis, Telangiectasia–intellectual disability–microcephaly–metaphyseal dysplasia–eye abnormalities–short stature syndrome
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Amyotrophic lateral sclerosis
VAPB, ALS2, ANG, ANXA11, ATXN2, CCS, CHCHD10, CHMP2B, DCTN1, ERBB4, FIG4, FUS
 KEGG 46 / 368 3.1× 1.07e-11 1.90e-9 ✓ sig.
Pathways of neurodegeneration - multiple diseases
VAPB, ALS2, ATXN1, ATXN2, ATXN3, CCS, CHMP2B, DCTN1, FIG4, FUS, GSK3B, ITPR2
 KEGG 43 / 480 2.2× 1.09e-6 5.27e-5 ✓ sig.
Cytosolic tRNA aminoacylation
GARS1, AARS1, MARS1, HARS1, YARS1, KARS1, WARS1
 Reactome 7 / 24 7.1× 3.50e-5 9.50e-4 ✓ sig.
EGR2 and SOX10-mediated initiation of Schwann cell myelination
SMARCA4, MPZ, EGR2, PMP22, PRX, SOX10
 Reactome 6 / 20 7.3× 1.09e-4 2.40e-3 ✓ sig.
Apoptosis
ITPR2, MAPK1, TP53, TUBA4A, BCL2L1, CTSD, FOS, TNF, XIAP, LMNA, AIFM1, ITPR3
 KEGG 16 / 137 2.9× 1.50e-4 3.12e-3 ✓ sig.
Detoxification of Reactive Oxygen Species
CCS, GSR, GSTP1, SOD1, SOD2, TXNRD1, PRDX3
 Reactome 7 / 34 5.0× 3.81e-4 6.46e-3 ✓ sig.
Shigellosis
ACTR3B, ARHGEF2, DOCK1, GSK3A, GSK3B, ITPR2, MAPK1, PFN1, SQSTM1, TBK1, TNIP1, TP53
 KEGG 22 / 250 2.1× 6.14e-4 9.37e-3 ✓ sig.
Chylomicron clearance
APOE, LIPC, LDLR
 Reactome 3 / 5 14.6× 6.42e-4 9.70e-3 ✓ sig.
Transcriptional activation of mitochondrial biogenesis
ESRRA, NRF1, PPARGC1A, PPARGC1B, SOD2, TFAM, CREBBP, RXRA
 Reactome 8 / 51 3.8× 1.01e-3 1.36e-2 ✓ sig.
Synthesis of 5-eicosatetraenoic acids
PON1, PON2, PON3
 Reactome 3 / 6 12.2× 1.25e-3 1.60e-2 ✓ sig.
TRKA activation by NGF
NGF, NTRK1
 Reactome 2 / 2 24.4× 1.67e-3 2.00e-2 ✓ sig.
phospho-PLA2 pathway
MAPK1, PLA2G4A
 Reactome 2 / 2 24.4× 1.67e-3 2.00e-2 ✓ sig.
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors
CHRNA3, CHRNA4, CHRNB4
 Reactome 3 / 7 10.5× 2.11e-3 2.38e-2 ✓ sig.
Cell adhesion molecules
CADM1, CD40LG, GLG1, HLA-DQB1, NRXN3, PTPRF, SELL, SELPLG, MPZ, CADM3, CNTNAP1, CNTNAP2
 KEGG 15 / 160 2.3× 2.37e-3 2.59e-2 ✓ sig.
Cholinergic synapse
CACNA1A, CHRNA3, CHRNA4, CHRNB4, CREB5, ITPR2, MAPK1, FOS, GNB4, ITPR3, SLC5A7, GNG3
 KEGG 12 / 115 2.5× 2.61e-3 2.79e-2 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
nervous system development
ACTL6B, ARHGEF2, ATXN3, CHRNA3, CNTN4, DCTN1, DISC1, ELP3, ERBB4, GSK3A, GSK3B, KALRN
 GO:0007399 45 / 631 2.7× 1.43e-9 3.10e-7 ✓ sig.
mitochondrion organization
CAV2, CHCHD10, GSK3B, MFN1, MFN2, PNPT1, PPARGC1A, SOD2, BCL2L1, PARK7, ATP7A, CNTNAP1
 GO:0007005 17 / 130 5.0× 5.61e-8 7.47e-6 ✓ sig.
amyloid-beta clearance by cellular catabolic process
ABCA7, TREM2, LDLR, MME, IDE
 GO:0150094 5 / 8 23.7× 6.50e-7 5.83e-5 ✓ sig.
cellular response to oxidative stress
CCS, GSR, NFE2L2, PNPT1, PPARGC1A, SETX, SLC11A2, SOD1, SOD2, PENK, PARK7, NAGLU
 GO:0034599 14 / 111 4.8× 1.30e-6 1.02e-4 ✓ sig.
positive regulation of gene expression
ALDH1A2, CAV1, EGR1, GSK3A, GSK3B, NFE2L2, PPARGC1A, SEC16B, TP53, TREM2, VDR, CLU
 GO:0010628 33 / 504 2.5× 1.63e-6 1.23e-4 ✓ sig.
neurofilament cytoskeleton organization
ARHGEF28, NEFH, NEFL, SOD1, INA
 GO:0060052 5 / 10 19.0× 2.80e-6 1.89e-4 ✓ sig.
myelination
FIG4, MAPK1, TNFRSF21, MPZ, CNTNAP1, EGR2, MTMR2, PMP22, SBF2, HEXB, NFASC
 GO:0042552 11 / 73 5.7× 3.07e-6 2.03e-4 ✓ sig.
regulation of neuron apoptotic process
EGR1, SARM1, SIGMAR1, TP53, UBB, PARK7, TRIM2
 GO:0043523 7 / 26 10.2× 3.58e-6 2.30e-4 ✓ sig.
positive regulation of cholesterol efflux
ABCA7, APOE, CAV1, PON1, TREM2, RXRA, ABCG1
 GO:0010875 7 / 27 9.8× 4.72e-6 2.87e-4 ✓ sig.
negative regulation of neuron apoptotic process
GRN, PPARGC1A, SOD1, SOD2, BCL2L1, CLU, CNTF, PARK7, AARS1, ATP7A, NGF, NTRK1
 GO:0043524 16 / 160 3.8× 5.22e-6 3.11e-4 ✓ sig.
neuron apoptotic process
PPARGC1A, SPG11, TNFRSF21, TP53, BCL2L1, XIAP, AARS1, COL6A3, ATP7A, NGF, NTRK1, HTRA2
 GO:0051402 12 / 98 4.7× 1.01e-5 5.26e-4 ✓ sig.
response to toxic substance
GSTP1, NEFL, PON1, PON2, PON3, SCFD1, FOS, PENK, AIFM1, SCN11A, SCN9A
 GO:0009636 11 / 83 5.0× 1.10e-5 5.61e-4 ✓ sig.
postsynaptic intermediate filament cytoskeleton organization
NEFH, NEFL, INA
 GO:0099185 3 / 3 38.0× 1.81e-5 8.31e-4 ✓ sig.
lactone catabolic process
PON1, PON2, PON3
 GO:1901335 3 / 3 38.0× 1.81e-5 8.31e-4 ✓ sig.
neuron cellular homeostasis
CHMP2B, CLCN3, DCTN1, DISC1, ATP7A, DNAJB2, HEXB
 GO:0070050 7 / 33 8.1× 1.98e-5 8.91e-4 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Charcot-marie-tooth disease Hereditary motor and sensory neuropathies 0.432 60 1.02e-123 1.62e-121 ✓ sig.
Dejerine-sottas disease Roussy-levy syndrome 0.974 38 4.12e-115 6.09e-113 ✓ sig.
Dejerine-sottas disease Hypertrophic neuropathy 0.974 38 4.12e-115 6.09e-113 ✓ sig.
Hypertrophic neuropathy Roussy-levy syndrome 0.974 38 4.12e-115 6.09e-113 ✓ sig.
Dejerine-sottas disease Peroneal muscle atrophy 0.950 38 1.61e-113 2.31e-111 ✓ sig.
Hypertrophic neuropathy Peroneal muscle atrophy 0.950 38 1.61e-113 2.31e-111 ✓ sig.
Peroneal muscle atrophy Roussy-levy syndrome 0.950 38 1.61e-113 2.31e-111 ✓ sig.
Dejerine-sottas disease Hereditary motor and sensory neuropathies 0.567 38 1.41e-96 1.55e-94 ✓ sig.
Hereditary motor and sensory neuropathies Hypertrophic neuropathy 0.567 38 1.41e-96 1.55e-94 ✓ sig.
Hereditary motor and sensory neuropathies Roussy-levy syndrome 0.567 38 1.41e-96 1.55e-94 ✓ sig.
Hereditary motor and sensory neuropathies Peroneal muscle atrophy 0.559 38 5.47e-95 5.72e-93 ✓ sig.
Amyotrophic lateral sclerosis Motor neuron disease 0.178 61 2.75e-93 2.72e-91 ✓ sig.
Charcot-marie-tooth disease Dejerine-sottas disease 0.286 38 8.10e-82 6.86e-80 ✓ sig.
Charcot-marie-tooth disease Roussy-levy syndrome 0.286 38 8.10e-82 6.86e-80 ✓ sig.
Charcot-marie-tooth disease Hypertrophic neuropathy 0.286 38 8.10e-82 6.86e-80 ✓ sig.
Charcot-marie-tooth disease Peroneal muscle atrophy 0.284 38 3.14e-80 2.63e-78 ✓ sig.
Distal hereditary motor neuropathy Distal spinal muscular atrophy 0.417 20 2.69e-48 1.42e-46 ✓ sig.
Charcot-marie-tooth disease Distal hereditary motor neuropathy 0.182 26 3.17e-47 1.64e-45 ✓ sig.
Distal spinal muscular atrophy Hereditary motor and sensory neuropathies 0.256 20 1.46e-41 6.75e-40 ✓ sig.
Distal hereditary motor neuropathy Hereditary motor and sensory neuropathies 0.212 18 1.61e-34 6.02e-33 ✓ sig.
Distal hereditary motor neuropathy Spinal muscular atrophy 0.254 15 1.03e-31 3.49e-30 ✓ sig.
Dejerine-sottas disease Distal spinal muscular atrophy 0.207 12 1.00e-24 2.56e-23 ✓ sig.
Distal spinal muscular atrophy Hypertrophic neuropathy 0.207 12 1.00e-24 2.56e-23 ✓ sig.
Distal spinal muscular atrophy Roussy-levy syndrome 0.207 12 1.00e-24 2.56e-23 ✓ sig.
Charcot-marie-tooth disease Spinal muscular atrophy 0.104 16 3.69e-24 9.11e-23 ✓ sig.
Distal spinal muscular atrophy Spinal muscular atrophy 0.190 11 2.44e-22 5.42e-21 ✓ sig.
Dejerine-sottas disease Distal hereditary motor neuropathy 0.136 9 1.10e-16 1.86e-15 ✓ sig.
Hereditary motor and sensory neuropathies Motor neuron disease 0.095 12 1.41e-16 2.37e-15 ✓ sig.
Congenital pes cavus Roussy-levy syndrome 0.159 7 2.44e-16 4.02e-15 ✓ sig.
Congenital pes cavus Hypertrophic neuropathy 0.159 7 2.44e-16 4.02e-15 ✓ sig.
Congenital pes cavus Dejerine-sottas disease 0.159 7 2.44e-16 4.02e-15 ✓ sig.
Congenital pes cavus Peroneal muscle atrophy 0.156 7 2.97e-16 4.87e-15 ✓ sig.
Hereditary motor and sensory neuropathies Spinal muscular atrophy 0.106 10 3.26e-16 5.35e-15 ✓ sig.
Distal spinal muscular atrophy Motor neuron disease 0.096 9 1.04e-14 1.54e-13 ✓ sig.
Distal hereditary motor neuropathy Motor neuron disease 0.091 9 4.75e-14 6.67e-13 ✓ sig.
Dejerine-sottas disease Spinal muscular atrophy 0.101 7 3.03e-12 3.68e-11 ✓ sig.
Charcot-marie-tooth disease, x-linked Roussy-levy syndrome 0.119 5 3.88e-12 4.66e-11 ✓ sig.
Charcot-marie-tooth disease, x-linked Hypertrophic neuropathy 0.119 5 3.88e-12 4.66e-11 ✓ sig.
Charcot-marie-tooth disease, x-linked Dejerine-sottas disease 0.119 5 3.88e-12 4.66e-11 ✓ sig.
Charcot-marie-tooth disease, x-linked Peroneal muscle atrophy 0.116 5 4.45e-12 5.33e-11 ✓ sig.
Dejerine-sottas disease Motor neuron disease 0.078 8 5.96e-12 7.10e-11 ✓ sig.
Amyotrophic lateral sclerosis Charcot-marie-tooth disease 0.043 19 5.93e-11 6.39e-10 ✓ sig.
Charcot-Marie-Tooth disease type 2 Hereditary motor and sensory neuropathies 0.030 2 1.81e-5 9.13e-5 ✓ sig.
Charcot-Marie-Tooth disease X-linked dominant 6 Charcot-marie-tooth disease, x-linked 0.111 1 5.20e-4 1.04e-3 ✓ sig.
Charcot-marie-tooth disease, x-linked neuronopathy, distal hereditary motor, autosomal recessive 5 0.111 1 5.20e-4 1.04e-3 ✓ sig.
Charcot-Marie-Tooth disease type 4B3 Charcot-marie-tooth disease, x-linked 0.111 1 5.20e-4 1.04e-3 ✓ sig.
Charcot-marie-tooth disease, x-linked X-linked hereditary motor and sensory neuropathy 0.111 1 5.20e-4 1.04e-3 ✓ sig.
Charcot-Marie-Tooth disease type 2D Congenital pes cavus 0.077 1 7.79e-4 1.39e-3 ✓ sig.
Charcot-Marie-Tooth disease type 2 Congenital pes cavus 0.071 1 1.56e-3 2.36e-3 ✓ sig.
Charcot-Marie-Tooth disease type 2D Distal spinal muscular atrophy 0.031 1 2.01e-3 2.89e-3 ✓ sig.
Distal hereditary motor neuropathy neuronopathy, distal hereditary motor, autosomal recessive 5 0.027 1 2.34e-3 3.23e-3 ✓ sig.
Charcot-Marie-Tooth disease type 2D Distal hereditary motor neuropathy 0.027 1 2.34e-3 3.23e-3 ✓ sig.
neuronopathy, distal hereditary motor, autosomal recessive 5 Spinal muscular atrophy 0.026 1 2.40e-3 3.30e-3 ✓ sig.
Spinal muscular atrophy Vexas syndrome 0.026 1 2.40e-3 3.30e-3 ✓ sig.
Charcot-Marie-Tooth disease type 2D Spinal muscular atrophy 0.026 1 2.40e-3 3.30e-3 ✓ sig.
Charcot-Marie-Tooth disease axonal type 2P Roussy-levy syndrome 0.026 1 2.47e-3 3.36e-3 ✓ sig.
Charcot-Marie-Tooth disease axonal type 2P Hypertrophic neuropathy 0.026 1 2.47e-3 3.36e-3 ✓ sig.
Charcot-Marie-Tooth disease axonal type 2P Dejerine-sottas disease 0.026 1 2.47e-3 3.36e-3 ✓ sig.
Charcot-Marie-Tooth disease type 2D Dejerine-sottas disease 0.026 1 2.47e-3 3.36e-3 ✓ sig.
Charcot-Marie-Tooth disease type 4B3 Dejerine-sottas disease 0.026 1 2.47e-3 3.36e-3 ✓ sig.
Charcot-Marie-Tooth disease type 4B3 Hypertrophic neuropathy 0.026 1 2.47e-3 3.36e-3 ✓ sig.
Charcot-Marie-Tooth disease type 4B3 Roussy-levy syndrome 0.026 1 2.47e-3 3.36e-3 ✓ sig.
Charcot-Marie-Tooth disease X-linked dominant 6 Dejerine-sottas disease 0.026 1 2.47e-3 3.36e-3 ✓ sig.
Charcot-Marie-Tooth disease X-linked dominant 6 Hypertrophic neuropathy 0.026 1 2.47e-3 3.36e-3 ✓ sig.
Charcot-Marie-Tooth disease X-linked dominant 6 Roussy-levy syndrome 0.026 1 2.47e-3 3.36e-3 ✓ sig.
Charcot-Marie-Tooth disease X-linked dominant 6 Peroneal muscle atrophy 0.025 1 2.53e-3 3.44e-3 ✓ sig.
Charcot-Marie-Tooth disease type 4B3 Peroneal muscle atrophy 0.025 1 2.53e-3 3.44e-3 ✓ sig.
Charcot-Marie-Tooth disease axonal type 2P Peroneal muscle atrophy 0.025 1 2.53e-3 3.44e-3 ✓ sig.
Charcot-Marie-Tooth disease type 2 Distal spinal muscular atrophy 0.030 1 4.02e-3 5.08e-3 ✓ sig.
Charcot-Marie-Tooth disease axonal type 2P Hereditary motor and sensory neuropathies 0.015 1 4.29e-3 5.38e-3 ✓ sig.
Hereditary motor and sensory neuropathies X-linked hereditary motor and sensory neuropathy 0.015 1 4.29e-3 5.38e-3 ✓ sig.
Charcot-Marie-Tooth disease type 2 Distal hereditary motor neuropathy 0.026 1 4.67e-3 5.78e-3 ✓ sig.
Distal spinal muscular atrophy multiple acyl-CoA dehydrogenase deficiency 0.029 1 6.03e-3 7.26e-3 ✓ sig.
Charcot-marie-tooth disease neuronopathy, distal hereditary motor, autosomal recessive 5 0.008 1 8.57e-3 9.90e-3 ✓ sig.
Charcot-marie-tooth disease X-linked hereditary motor and sensory neuropathy 0.008 1 8.57e-3 9.90e-3 ✓ sig.
Amyotrophic lateral sclerosis Telangiectasia–intellectual disability–microcephaly–metaphyseal dysplasia–eye abnormalities–short stature syndrome 0.003 1 2.16e-2 2.34e-2 ✓ sig.