Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	53405
Gene name	Chloride intracellular channel 5
Gene symbol	CLIC5
Synonyms (NCBI Gene)	DFNB102DFNB103MST130MSTP130
Chromosome	6
Chromosome location	6p21.1
Summary	This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair cell stereocilia form

SNP ID	Visualize variation	Clinical significance	Consequence
rs189893797	C>T	Likely-benign, conflicting-interpretations-of-pathogenicity	Genic upstream transcript variant, coding sequence variant, non coding transcript variant, intron variant, missense variant
rs199808624	C>T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, genic upstream transcript variant, non coding transcript variant, missense variant
rs606231308	A>T	Pathogenic	5 prime UTR variant, coding sequence variant, non coding transcript variant, genic upstream transcript variant, stop gained
rs1043716893	C>G,T	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, stop gained, missense variant, non coding transcript variant

346 Show/Hide all (346)

miRTarBase ID	miRNA	Experiments	Reference
MIRT718083	hsa-miR-500b-3p	HITS-CLIP	19536157
MIRT718082	hsa-miR-4301	HITS-CLIP	19536157
MIRT718081	hsa-miR-5193	HITS-CLIP	19536157
MIRT718080	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT718079	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT718078	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT718077	hsa-miR-412-3p	HITS-CLIP	19536157
MIRT718076	hsa-miR-6754-3p	HITS-CLIP	19536157
MIRT718075	hsa-miR-6837-3p	HITS-CLIP	19536157
MIRT718074	hsa-miR-6802-3p	HITS-CLIP	19536157
MIRT718073	hsa-miR-3156-3p	HITS-CLIP	19536157
MIRT624321	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT718072	hsa-miR-4279	HITS-CLIP	19536157
MIRT718083	hsa-miR-500b-3p	HITS-CLIP	19536157
MIRT718082	hsa-miR-4301	HITS-CLIP	19536157
MIRT718081	hsa-miR-5193	HITS-CLIP	19536157
MIRT718080	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT718079	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT718078	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT718077	hsa-miR-412-3p	HITS-CLIP	19536157
MIRT718076	hsa-miR-6754-3p	HITS-CLIP	19536157
MIRT718075	hsa-miR-6837-3p	HITS-CLIP	19536157
MIRT718074	hsa-miR-6802-3p	HITS-CLIP	19536157
MIRT718073	hsa-miR-3156-3p	HITS-CLIP	19536157
MIRT624321	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT718072	hsa-miR-4279	HITS-CLIP	19536157
MIRT624332	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT624331	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT624330	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT624329	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT624328	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT624326	hsa-miR-4469	HITS-CLIP	23824327
MIRT624324	hsa-miR-3671	HITS-CLIP	23824327
MIRT624322	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT624321	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT624320	hsa-miR-3686	HITS-CLIP	23824327
MIRT624319	hsa-miR-607	HITS-CLIP	23824327
MIRT624323	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT636614	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT636613	hsa-miR-4282	HITS-CLIP	23824327
MIRT636612	hsa-miR-3622a-3p	HITS-CLIP	23824327
MIRT636611	hsa-miR-3622b-3p	HITS-CLIP	23824327
MIRT636610	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT636609	hsa-miR-221-5p	HITS-CLIP	23824327
MIRT636608	hsa-miR-8073	HITS-CLIP	23824327
MIRT636607	hsa-miR-6868-5p	HITS-CLIP	23824327
MIRT636606	hsa-miR-34a-5p	HITS-CLIP	23824327
MIRT636605	hsa-miR-34c-5p	HITS-CLIP	23824327
MIRT636604	hsa-miR-449a	HITS-CLIP	23824327
MIRT636603	hsa-miR-449b-5p	HITS-CLIP	23824327
MIRT636602	hsa-miR-548au-3p	HITS-CLIP	23824327
MIRT659473	hsa-miR-5579-3p	HITS-CLIP	23824327
MIRT636601	hsa-miR-5096	HITS-CLIP	23824327
MIRT636600	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT624332	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT624331	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT624330	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT624329	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT624328	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT624326	hsa-miR-4469	HITS-CLIP	23824327
MIRT624324	hsa-miR-3671	HITS-CLIP	23824327
MIRT624322	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT624321	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT659472	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT624320	hsa-miR-3686	HITS-CLIP	23824327
MIRT624319	hsa-miR-607	HITS-CLIP	23824327
MIRT624323	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT636612	hsa-miR-3622a-3p	HITS-CLIP	23824327
MIRT636611	hsa-miR-3622b-3p	HITS-CLIP	23824327
MIRT636610	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT636609	hsa-miR-221-5p	HITS-CLIP	23824327
MIRT636608	hsa-miR-8073	HITS-CLIP	23824327
MIRT636607	hsa-miR-6868-5p	HITS-CLIP	23824327
MIRT636606	hsa-miR-34a-5p	HITS-CLIP	23824327
MIRT636605	hsa-miR-34c-5p	HITS-CLIP	23824327
MIRT636604	hsa-miR-449a	HITS-CLIP	23824327
MIRT636603	hsa-miR-449b-5p	HITS-CLIP	23824327
MIRT636602	hsa-miR-548au-3p	HITS-CLIP	23824327
MIRT636601	hsa-miR-5096	HITS-CLIP	23824327
MIRT636600	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT636614	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT636613	hsa-miR-4282	HITS-CLIP	23824327
MIRT636612	hsa-miR-3622a-3p	HITS-CLIP	23824327
MIRT636611	hsa-miR-3622b-3p	HITS-CLIP	23824327
MIRT636610	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT636609	hsa-miR-221-5p	HITS-CLIP	23824327
MIRT636608	hsa-miR-8073	HITS-CLIP	23824327
MIRT636607	hsa-miR-6868-5p	HITS-CLIP	23824327
MIRT636606	hsa-miR-34a-5p	HITS-CLIP	23824327
MIRT636605	hsa-miR-34c-5p	HITS-CLIP	23824327
MIRT636604	hsa-miR-449a	HITS-CLIP	23824327
MIRT636603	hsa-miR-449b-5p	HITS-CLIP	23824327
MIRT636602	hsa-miR-548au-3p	HITS-CLIP	23824327
MIRT636601	hsa-miR-5096	HITS-CLIP	23824327
MIRT636600	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT624332	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT624331	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT624330	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT624329	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT624328	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT624327	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT624326	hsa-miR-4469	HITS-CLIP	23824327
MIRT624325	hsa-miR-3182	HITS-CLIP	23824327
MIRT624324	hsa-miR-3671	HITS-CLIP	23824327
MIRT624323	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT624322	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT624321	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT624320	hsa-miR-3686	HITS-CLIP	23824327
MIRT624319	hsa-miR-607	HITS-CLIP	23824327
MIRT443457	hsa-miR-1252-3p	PAR-CLIP	22100165
MIRT443456	hsa-miR-5680	PAR-CLIP	22100165
MIRT443455	hsa-miR-3691-3p	PAR-CLIP	22100165
MIRT443453	hsa-miR-4251	PAR-CLIP	22100165
MIRT443454	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT443452	hsa-miR-4480	PAR-CLIP	22100165
MIRT443451	hsa-miR-4663	PAR-CLIP	22100165
MIRT443450	hsa-miR-7160-5p	PAR-CLIP	22100165
MIRT443449	hsa-miR-8077	PAR-CLIP	22100165
MIRT443448	hsa-miR-6807-5p	PAR-CLIP	22100165
MIRT443447	hsa-miR-628-5p	PAR-CLIP	22100165
MIRT718083	hsa-miR-500b-3p	HITS-CLIP	19536157
MIRT718082	hsa-miR-4301	HITS-CLIP	19536157
MIRT718081	hsa-miR-5193	HITS-CLIP	19536157
MIRT718080	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT718079	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT718078	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT718077	hsa-miR-412-3p	HITS-CLIP	19536157
MIRT718076	hsa-miR-6754-3p	HITS-CLIP	19536157
MIRT718075	hsa-miR-6837-3p	HITS-CLIP	19536157
MIRT718074	hsa-miR-6802-3p	HITS-CLIP	19536157
MIRT718073	hsa-miR-3156-3p	HITS-CLIP	19536157
MIRT624321	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT718072	hsa-miR-4279	HITS-CLIP	19536157
MIRT718083	hsa-miR-500b-3p	HITS-CLIP	19536157
MIRT718082	hsa-miR-4301	HITS-CLIP	19536157
MIRT718081	hsa-miR-5193	HITS-CLIP	19536157
MIRT718080	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT718079	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT718078	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT718077	hsa-miR-412-3p	HITS-CLIP	19536157
MIRT718076	hsa-miR-6754-3p	HITS-CLIP	19536157
MIRT718075	hsa-miR-6837-3p	HITS-CLIP	19536157
MIRT718074	hsa-miR-6802-3p	HITS-CLIP	19536157
MIRT718073	hsa-miR-3156-3p	HITS-CLIP	19536157
MIRT624321	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT718072	hsa-miR-4279	HITS-CLIP	19536157
MIRT624332	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT624331	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT624330	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT624329	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT624328	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT624326	hsa-miR-4469	HITS-CLIP	23824327
MIRT624324	hsa-miR-3671	HITS-CLIP	23824327
MIRT624322	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT624321	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT624320	hsa-miR-3686	HITS-CLIP	23824327
MIRT624319	hsa-miR-607	HITS-CLIP	23824327
MIRT624323	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT636614	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT636613	hsa-miR-4282	HITS-CLIP	23824327
MIRT636612	hsa-miR-3622a-3p	HITS-CLIP	23824327
MIRT636611	hsa-miR-3622b-3p	HITS-CLIP	23824327
MIRT636610	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT636609	hsa-miR-221-5p	HITS-CLIP	23824327
MIRT636608	hsa-miR-8073	HITS-CLIP	23824327
MIRT636607	hsa-miR-6868-5p	HITS-CLIP	23824327
MIRT636606	hsa-miR-34a-5p	HITS-CLIP	23824327
MIRT636605	hsa-miR-34c-5p	HITS-CLIP	23824327
MIRT636604	hsa-miR-449a	HITS-CLIP	23824327
MIRT636603	hsa-miR-449b-5p	HITS-CLIP	23824327
MIRT636602	hsa-miR-548au-3p	HITS-CLIP	23824327
MIRT659473	hsa-miR-5579-3p	HITS-CLIP	23824327
MIRT636601	hsa-miR-5096	HITS-CLIP	23824327
MIRT636600	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT624332	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT624331	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT624330	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT624329	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT624328	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT624326	hsa-miR-4469	HITS-CLIP	23824327
MIRT624324	hsa-miR-3671	HITS-CLIP	23824327
MIRT624322	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT624321	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT659472	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT624320	hsa-miR-3686	HITS-CLIP	23824327
MIRT624319	hsa-miR-607	HITS-CLIP	23824327
MIRT624323	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT636612	hsa-miR-3622a-3p	HITS-CLIP	23824327
MIRT636611	hsa-miR-3622b-3p	HITS-CLIP	23824327
MIRT636610	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT636609	hsa-miR-221-5p	HITS-CLIP	23824327
MIRT636608	hsa-miR-8073	HITS-CLIP	23824327
MIRT636607	hsa-miR-6868-5p	HITS-CLIP	23824327
MIRT636606	hsa-miR-34a-5p	HITS-CLIP	23824327
MIRT636605	hsa-miR-34c-5p	HITS-CLIP	23824327
MIRT636604	hsa-miR-449a	HITS-CLIP	23824327
MIRT636603	hsa-miR-449b-5p	HITS-CLIP	23824327
MIRT636602	hsa-miR-548au-3p	HITS-CLIP	23824327
MIRT636601	hsa-miR-5096	HITS-CLIP	23824327
MIRT636600	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT636614	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT636613	hsa-miR-4282	HITS-CLIP	23824327
MIRT636612	hsa-miR-3622a-3p	HITS-CLIP	23824327
MIRT636611	hsa-miR-3622b-3p	HITS-CLIP	23824327
MIRT636610	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT636609	hsa-miR-221-5p	HITS-CLIP	23824327
MIRT636608	hsa-miR-8073	HITS-CLIP	23824327
MIRT636607	hsa-miR-6868-5p	HITS-CLIP	23824327
MIRT636606	hsa-miR-34a-5p	HITS-CLIP	23824327
MIRT636605	hsa-miR-34c-5p	HITS-CLIP	23824327
MIRT636604	hsa-miR-449a	HITS-CLIP	23824327
MIRT636603	hsa-miR-449b-5p	HITS-CLIP	23824327
MIRT636602	hsa-miR-548au-3p	HITS-CLIP	23824327
MIRT636601	hsa-miR-5096	HITS-CLIP	23824327
MIRT636600	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT624332	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT624331	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT624330	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT624329	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT624328	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT624327	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT624326	hsa-miR-4469	HITS-CLIP	23824327
MIRT624325	hsa-miR-3182	HITS-CLIP	23824327
MIRT624324	hsa-miR-3671	HITS-CLIP	23824327
MIRT624323	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT624322	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT624321	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT624320	hsa-miR-3686	HITS-CLIP	23824327
MIRT624319	hsa-miR-607	HITS-CLIP	23824327
MIRT443457	hsa-miR-1252-3p	PAR-CLIP	22100165
MIRT443456	hsa-miR-5680	PAR-CLIP	22100165
MIRT443455	hsa-miR-3691-3p	PAR-CLIP	22100165
MIRT443453	hsa-miR-4251	PAR-CLIP	22100165
MIRT443454	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT443452	hsa-miR-4480	PAR-CLIP	22100165
MIRT443451	hsa-miR-4663	PAR-CLIP	22100165
MIRT443450	hsa-miR-7160-5p	PAR-CLIP	22100165
MIRT443449	hsa-miR-8077	PAR-CLIP	22100165
MIRT443448	hsa-miR-6807-5p	PAR-CLIP	22100165
MIRT443447	hsa-miR-628-5p	PAR-CLIP	22100165
MIRT896366	hsa-miR-122	CLIP-seq
MIRT896367	hsa-miR-216b	CLIP-seq
MIRT896368	hsa-miR-3074-5p	CLIP-seq
MIRT896369	hsa-miR-3180-5p	CLIP-seq
MIRT896370	hsa-miR-342-5p	CLIP-seq
MIRT896371	hsa-miR-3611	CLIP-seq
MIRT896372	hsa-miR-3675-3p	CLIP-seq
MIRT896373	hsa-miR-3677-5p	CLIP-seq
MIRT896374	hsa-miR-432	CLIP-seq
MIRT896375	hsa-miR-4453	CLIP-seq
MIRT896376	hsa-miR-4506	CLIP-seq
MIRT896377	hsa-miR-4538	CLIP-seq
MIRT896378	hsa-miR-4651	CLIP-seq
MIRT896379	hsa-miR-4664-5p	CLIP-seq
MIRT896380	hsa-miR-4722-3p	CLIP-seq
MIRT896381	hsa-miR-4757-5p	CLIP-seq
MIRT896382	hsa-miR-516a-3p	CLIP-seq
MIRT896383	hsa-miR-520a-5p	CLIP-seq
MIRT896384	hsa-miR-525-5p	CLIP-seq
MIRT896385	hsa-miR-608	CLIP-seq
MIRT896386	hsa-miR-618	CLIP-seq
MIRT896387	hsa-miR-646	CLIP-seq
MIRT896388	hsa-miR-1178	CLIP-seq
MIRT896389	hsa-miR-1227	CLIP-seq
MIRT896390	hsa-miR-134	CLIP-seq
MIRT896391	hsa-miR-298	CLIP-seq
MIRT896368	hsa-miR-3074-5p	CLIP-seq
MIRT896392	hsa-miR-3118	CLIP-seq
MIRT896393	hsa-miR-3145-3p	CLIP-seq
MIRT896394	hsa-miR-3155	CLIP-seq
MIRT896395	hsa-miR-3155b	CLIP-seq
MIRT896396	hsa-miR-3160-5p	CLIP-seq
MIRT896397	hsa-miR-3164	CLIP-seq
MIRT896398	hsa-miR-3185	CLIP-seq
MIRT896399	hsa-miR-4303	CLIP-seq
MIRT896400	hsa-miR-4522	CLIP-seq
MIRT896401	hsa-miR-4677-3p	CLIP-seq
MIRT896402	hsa-miR-4678	CLIP-seq
MIRT896403	hsa-miR-4679	CLIP-seq
MIRT896404	hsa-miR-4698	CLIP-seq
MIRT896405	hsa-miR-4714-5p	CLIP-seq
MIRT896406	hsa-miR-4715-3p	CLIP-seq
MIRT896380	hsa-miR-4722-3p	CLIP-seq
MIRT896407	hsa-miR-4743	CLIP-seq
MIRT896408	hsa-miR-4762-3p	CLIP-seq
MIRT896409	hsa-miR-4772-5p	CLIP-seq
MIRT896410	hsa-miR-484	CLIP-seq
MIRT896382	hsa-miR-516a-3p	CLIP-seq
MIRT896382	hsa-miR-516a-3p	CLIP-seq
MIRT1965780	hsa-miR-3192	CLIP-seq
MIRT2201709	hsa-miR-103a	CLIP-seq
MIRT2201710	hsa-miR-107	CLIP-seq
MIRT2201711	hsa-miR-1179	CLIP-seq
MIRT2201712	hsa-miR-1184	CLIP-seq
MIRT2201713	hsa-miR-4269	CLIP-seq
MIRT2201714	hsa-miR-4310	CLIP-seq
MIRT2201715	hsa-miR-4420	CLIP-seq
MIRT2201716	hsa-miR-4514	CLIP-seq
MIRT2201717	hsa-miR-4692	CLIP-seq
MIRT2201718	hsa-miR-4742-5p	CLIP-seq
MIRT2201719	hsa-miR-503	CLIP-seq
MIRT2201720	hsa-miR-511	CLIP-seq
MIRT2201721	hsa-miR-634	CLIP-seq
MIRT2201722	hsa-miR-940	CLIP-seq
MIRT2386175	hsa-miR-4271	CLIP-seq
MIRT2386176	hsa-miR-4725-3p	CLIP-seq
MIRT2442083	hsa-miR-3977	CLIP-seq
MIRT2447176	hsa-miR-1245b-5p	CLIP-seq
MIRT2447177	hsa-miR-3142	CLIP-seq
MIRT2447178	hsa-miR-3620	CLIP-seq
MIRT2447179	hsa-miR-3653	CLIP-seq
MIRT2447180	hsa-miR-4263	CLIP-seq
MIRT2447181	hsa-miR-4426	CLIP-seq
MIRT2447182	hsa-miR-4493	CLIP-seq
MIRT2447183	hsa-miR-4647	CLIP-seq
MIRT2447184	hsa-miR-4662b	CLIP-seq
MIRT2447185	hsa-miR-4699-5p	CLIP-seq
MIRT2447186	hsa-miR-548n	CLIP-seq
MIRT2447187	hsa-miR-548t	CLIP-seq
MIRT2447188	hsa-miR-561	CLIP-seq
MIRT2447189	hsa-miR-576-5p	CLIP-seq
MIRT2201721	hsa-miR-634	CLIP-seq
MIRT2504629	hsa-miR-127-5p	CLIP-seq
MIRT2504630	hsa-miR-1289	CLIP-seq
MIRT2504631	hsa-miR-23a	CLIP-seq
MIRT2504632	hsa-miR-23b	CLIP-seq
MIRT2504633	hsa-miR-23c	CLIP-seq
MIRT2504634	hsa-miR-3135b	CLIP-seq
MIRT2504635	hsa-miR-3198	CLIP-seq
MIRT2504636	hsa-miR-320e	CLIP-seq
MIRT2447178	hsa-miR-3620	CLIP-seq
MIRT2442083	hsa-miR-3977	CLIP-seq
MIRT2504637	hsa-miR-4294	CLIP-seq
MIRT2504638	hsa-miR-4309	CLIP-seq
MIRT2504639	hsa-miR-4717-3p	CLIP-seq
MIRT2201720	hsa-miR-511	CLIP-seq
MIRT2201721	hsa-miR-634	CLIP-seq
MIRT2504640	hsa-miR-924	CLIP-seq
MIRT2504631	hsa-miR-23a	CLIP-seq
MIRT2504632	hsa-miR-23b	CLIP-seq
MIRT2504633	hsa-miR-23c	CLIP-seq
MIRT2447178	hsa-miR-3620	CLIP-seq
MIRT2442083	hsa-miR-3977	CLIP-seq
MIRT2504639	hsa-miR-4717-3p	CLIP-seq
MIRT2201720	hsa-miR-511	CLIP-seq
MIRT2201721	hsa-miR-634	CLIP-seq

28 Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005254	Function	Chloride channel activity	IEA
GO:0005515	Function	Protein binding	IPI	10793131, 12163479, 16831863, 24285636, 28514442, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005794	Component	Golgi apparatus	IDA	12163479
GO:0005794	Component	Golgi apparatus	IEA
GO:0005813	Component	Centrosome	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005938	Component	Cell cortex	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006821	Process	Chloride transport	IDA	10793131
GO:0006821	Process	Chloride transport	IEA
GO:0007565	Process	Female pregnancy	TAS	10793131
GO:0007601	Process	Visual perception	IEA
GO:0007605	Process	Sensory perception of sound	IEA
GO:0007605	Process	Sensory perception of sound	IMP	24781754
GO:0015629	Component	Actin cytoskeleton	IDA	10793131
GO:0016020	Component	Membrane	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0032420	Component	Stereocilium	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034702	Component	Monoatomic ion channel complex	IEA
GO:0034707	Component	Chloride channel complex	IEA
GO:0042995	Component	Cell projection	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:1902476	Process	Chloride transmembrane transport	IEA

MIM	HGNC	e!Ensembl
607293	13517	ENSG00000112782

Q9NZA1

Protein name

Chloride intracellular channel protein 5 (Glutaredoxin-like oxidoreductase CLIC5) (EC 1.8.-.-)

Protein function

In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form non-selective ion channels almost equally permeable to Na(+), K(+

PDB

6Y2H , 8Q4I , 8Q4J

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13409	GST_N_2	190 → 254	Glutathione S-transferase, N-terminal domain	Domain
PF13410	GST_C_2	273 → 379		Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed in both fetal and adult human tissues (PubMed:24781754). Isoform 1 is expressed in renal glomeruli endothelial cells and podocytes (at protein level). {ECO:0000269|PubMed:20335315, ECO:0000269|PubMed:24781754}.

Sequence

MNDEDYSTIYDTIQNERTYEVPDQPEENESPHYDDVHEYLRPENDLYATQLNTHEYDFVS
VYTIKGEETSLASVQSEDRGYLLPDEIYSELQEAHPGEPQEDRGISMEGLYSSTQDQQLC
AAELQENGSVMKEDLPSPSSFTIQHSKAFSTTKYSCYSDAEGLEEKEGAHMNPEIYLFVK
AGIDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDV
KTDVNKIEEFLEETLTPEKYPKLAAKHRESNTAGIDIFSKFSAYIKNTKQQNNAALERGL
TKALKKLDDYLNTPLPEEIDANTCGEDKGSRRKFLDGDELTLADCNLLPKLHVVKIVAKK
YRNYDIPAEMTGLWRYLKNAYARDEFTNTCAADSEIELAYADVAKRLSRS

Sequence length

410

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Autosomal recessive nonsyndromic hearing loss 103	Pathogenic	rs606231308	RCV000148034	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Hearing loss, autosomal recessive	Likely pathogenic	rs1043716893	RCV000855670	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal. Show/Hide Unknown Diseases (23)
ALZHEIMER DISEASE	—	GWAS catalog	35589863, 40708016	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANDROGENETIC ALOPECIA	—	GWAS catalog	30573740	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTOSOMAL RECESSIVE ISOLATED SENSORINEURAL DEAFNESS TYPE DFNB	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CLIC5-related disorder	Benign; Likely benign; Conflicting classifications of pathogenicity	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	32077919	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE 103	—	CTD, Disgenet, HPO CTD, Disgenet, HPO CTD, Disgenet, HPO	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	40708016	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLAUCOMA	—	GWAS catalog	23326517	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	32238385	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hearing impairment	Uncertain significance	ClinVar Disgenet	—	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
HODGKINS LYMPHOMA	—	GWAS catalog	40883272	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL OR BEHAVIOURAL DISORDER	—	GWAS catalog	39024449	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	37386247, 38382466	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	40205036	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, HIP	—	GWAS catalog	40205036	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIODONTITIS	—	GWAS catalog	22699663	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSYCHOSIS	—	GWAS catalog	39024449	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SENSORINEURAL HEARING LOSS OF BILATERAL EARS	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	GWAS catalog	38317187	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Conflicting classifications of pathogenicity	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	35893037	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (20)
Autosomal recessive non-syndromic sensorineural deafness type DFNB	Non-Syndromic Sensorineural Deafness	Orphanet			★★★★★ ★☆☆☆☆ Found in Text Mining only
Bilateral Vestibulopathy	Bilateral Vestibulopathy	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	24172169	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	34766585	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	Pubtator	37511188	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	27540136		★★★★★ ★☆☆☆☆ Found in Text Mining only
DEAFNESS, AUTOSOMAL RECESSIVE (disorder)	Deafness	CLINGEN_DG	17021174, 24285636, 24781754		★★★★★ ★☆☆☆☆ Found in Text Mining only
DEAFNESS, AUTOSOMAL RECESSIVE 103	Deafness	GENOMICS_ENGLAND_DG	24781754		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE 103	Deafness	CTD_human_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE 103	Deafness	CLINVAR_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetic Nephropathies	Diabetic neuropathy	Pubtator	36092962, 37492198	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathies	Diabetic neuropathy	Pubtator	37916327	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hearing Loss	Hearing loss	Pubtator	24781754, 33114113	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney disease	Pubtator	24781754	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nonsyndromic Deafness	Nonsyndromic Deafness	BEFREE	24781754		★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Insufficiency	Renal Insufficiency	BEFREE	24781754		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sensorineural Deafness With Mild Renal Dysfunction	Sensorineural deafness with renal dysfunction	Pubtator	24781754	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sensorineural Hearing Loss (disorder)	Hearing Loss	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Small Cell Lung Carcinoma	Small cell lung carcinoma	Pubtator	35845940	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Vestibular Diseases	Vestibular disease	Pubtator	24781754	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
RIPOR2	4	["Isolated sensorineural deafness","Nonsyndromic hearing loss","Glaucoma","Deafness"]	[]	8	["Disgenet (Isolated sensorineural deafness)","Disgenet (Nonsyndromic hearing loss)","ClinVar (Nonsyndromic hearing loss)","GenCC (Nonsyndromic hearing loss)","CTD (Deafness)","Disgenet (Deafness)","HPO (Deafness)","GWAS catalog (Glaucoma)"]
GIPC3	3	["Isolated sensorineural deafness","Nonsyndromic hearing loss","Deafness"]	[]	7	["Disgenet (Isolated sensorineural deafness)","Disgenet (Nonsyndromic hearing loss)","ClinVar (Nonsyndromic hearing loss)","CTD (Deafness)","Disgenet (Deafness)","HPO (Deafness)","Disgenet (Hearing loss)"]
TRIOBP	4	["Isolated sensorineural deafness","Nonsyndromic hearing loss","Glaucoma","Deafness"]	[]	9	["Disgenet (Isolated sensorineural deafness)","Disgenet (Nonsyndromic hearing loss)","ClinVar (Nonsyndromic hearing loss)","GenCC (Nonsyndromic hearing loss)","CTD (Deafness)","Disgenet (Deafness)","HPO (Deafness)","GWAS catalog (Glaucoma)","Disgenet (Hearing loss)"]
KCNQ4	3	["Isolated sensorineural deafness","Nonsyndromic hearing loss","Deafness"]	[]	8	["Disgenet (Isolated sensorineural deafness)","Disgenet (Nonsyndromic hearing loss)","ClinVar (Nonsyndromic hearing loss)","GenCC (Nonsyndromic hearing loss)","CTD (Deafness)","Disgenet (Deafness)","HPO (Deafness)","Disgenet (Hearing loss)"]
EPS8	3	["Isolated sensorineural deafness","Nonsyndromic hearing loss","Deafness"]	[]	7	["Disgenet (Isolated sensorineural deafness)","Disgenet (Nonsyndromic hearing loss)","ClinVar (Nonsyndromic hearing loss)","CTD (Deafness)","Disgenet (Deafness)","HPO (Deafness)","Disgenet (Hearing loss)"]

CLIC5 (chloride intracellular channel 5)

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