Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 20

21 diseases · 58 shared-gene connections
21 Diseases
240 Unique genes
0.116 Avg. similarity score
Genetic steroid-resistant nephrotic syndrome Most-connected disease (14 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Genetic steroid-resistant nephrotic syndrome 14 14 34
Hereditary steroid-resistant nephrotic syndrome 14 14 34
Idiopathic steroid-resistant nephrotic syndrome 12 12 28
Nephrotic syndrome 11 11 166
Focal glomerulosclerosis 10 10 57
Steroid-resistant nephrotic syndrome 6 6 13
Focal segmental glomerulosclerosis 5 5 29
Galloway-mowat syndrome 5 5 12
nephrotic syndrome, type 18 5 5 1
nephrotic syndrome, type 19 4 4 1
nephrotic syndrome, type 20 4 4 1
nephrotic syndrome, type 21 4 4 1
nephrotic syndrome, type 8 4 4 1
Nephrotic syndrome, steroid-resistant, autosomal recessive 3 3 2
Proteinuria 3 3 42
Woolly hair-palmoplantar keratoderma syndrome 3 3 1
nephrotic syndrome, type 3 3 3 1
focal segmental glomerulosclerosis and neurodevelopmental syndrome 2 2 1
schimke immuno-osseous dysplasia 2 2 1
Camos syndrome 1 1 2
Intellectual developmental disorder seizures speech 1 1 2

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
NPHS1 7 / 21 Focal glomerulosclerosis, Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome and 3 more
NPHS2 7 / 21 Focal glomerulosclerosis, Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome and 3 more
PAX2 7 / 21 Focal glomerulosclerosis, Focal segmental glomerulosclerosis, Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome and 3 more
ACTN4 6 / 21 Focal glomerulosclerosis, Focal segmental glomerulosclerosis, Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome and 2 more
ANLN 6 / 21 Focal glomerulosclerosis, Focal segmental glomerulosclerosis, Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome and 2 more
ARHGAP24 6 / 21 Focal glomerulosclerosis, Focal segmental glomerulosclerosis, Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome and 2 more
CRB2 6 / 21 Focal glomerulosclerosis, Focal segmental glomerulosclerosis, Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome and 2 more
INF2 6 / 21 Focal glomerulosclerosis, Focal segmental glomerulosclerosis, Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome and 2 more
MYO1E 6 / 21 Focal glomerulosclerosis, Focal segmental glomerulosclerosis, Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome and 2 more
NUP107 6 / 21 Focal segmental glomerulosclerosis, Galloway-mowat syndrome, Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome and 2 more
NUP133 6 / 21 Galloway-mowat syndrome, Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome and 2 more
PLCE1 6 / 21 Focal glomerulosclerosis, Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome and 2 more
TRPC6 6 / 21 Focal glomerulosclerosis, Focal segmental glomerulosclerosis, Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome and 2 more
WT1 6 / 21 Focal glomerulosclerosis, Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome and 2 more
ARHGDIA 5 / 21 Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome, Nephrotic syndrome and 1 more
AVIL 5 / 21 Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome, Nephrotic syndrome, nephrotic syndrome, type 21 and 1 more
CD2AP 5 / 21 Focal glomerulosclerosis, Focal segmental glomerulosclerosis, Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome and 1 more
COQ8B 5 / 21 Focal glomerulosclerosis, Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome and 1 more
NUP160 5 / 21 Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome, Nephrotic syndrome and 1 more
NUP93 5 / 21 Focal glomerulosclerosis, Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome and 1 more
PTPRO 5 / 21 Focal glomerulosclerosis, Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome and 1 more
TBC1D8B 5 / 21 Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome, Nephrotic syndrome and 1 more
APOL1 4 / 21 Focal glomerulosclerosis, Focal segmental glomerulosclerosis, Hereditary steroid-resistant nephrotic syndrome, Steroid-resistant nephrotic syndrome
AXDND1 4 / 21 Focal glomerulosclerosis, Nephrotic syndrome, Nephrotic syndrome, steroid-resistant, autosomal recessive, Steroid-resistant nephrotic syndrome
COL4A3 4 / 21 Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome, Nephrotic syndrome, Steroid-resistant nephrotic syndrome
EMP2 4 / 21 Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome, Nephrotic syndrome
KANK2 4 / 21 Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome, Nephrotic syndrome, Woolly hair-palmoplantar keratoderma syndrome
LAMA5 4 / 21 Focal glomerulosclerosis, Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome, Nephrotic syndrome
MAGI2 4 / 21 Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome, Nephrotic syndrome
NUP205 4 / 21 Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome, Nephrotic syndrome
NUP85 4 / 21 Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome, Nephrotic syndrome
SMARCAL1 4 / 21 Focal glomerulosclerosis, Nephrotic syndrome, schimke immuno-osseous dysplasia, Steroid-resistant nephrotic syndrome
AGT 3 / 21 Focal glomerulosclerosis, Nephrotic syndrome, Proteinuria
ANKFY1 3 / 21 Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome
COL4A4 3 / 21 Focal glomerulosclerosis, Nephrotic syndrome, Steroid-resistant nephrotic syndrome
COL4A5 3 / 21 Focal glomerulosclerosis, Nephrotic syndrome, Steroid-resistant nephrotic syndrome
DAAM2 3 / 21 Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome, Nephrotic syndrome
FAT1 3 / 21 Focal segmental glomerulosclerosis, Genetic steroid-resistant nephrotic syndrome, Nephrotic syndrome
GAPVD1 3 / 21 Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome
LMX1B 3 / 21 Focal segmental glomerulosclerosis, Nephrotic syndrome, Proteinuria
NUP37 3 / 21 Genetic steroid-resistant nephrotic syndrome, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome
TGFB1 3 / 21 Focal glomerulosclerosis, Nephrotic syndrome, Proteinuria
TRIM8 3 / 21 Focal glomerulosclerosis, Focal segmental glomerulosclerosis, focal segmental glomerulosclerosis and neurodevelopmental syndrome
WDR73 3 / 21 Camos syndrome, Galloway-mowat syndrome, Nephrotic syndrome
ALB 2 / 21 Nephrotic syndrome, Proteinuria
CLCN5 2 / 21 Nephrotic syndrome, Proteinuria
COL4A1 2 / 21 Focal glomerulosclerosis, Nephrotic syndrome
COQ2 2 / 21 Focal glomerulosclerosis, Nephrotic syndrome
CUBN 2 / 21 Focal glomerulosclerosis, Proteinuria
EDN1 2 / 21 Focal glomerulosclerosis, Nephrotic syndrome
FN1 2 / 21 Focal glomerulosclerosis, Nephrotic syndrome
HAVCR1 2 / 21 Focal glomerulosclerosis, Proteinuria
HLA-DQA1 2 / 21 Nephrotic syndrome, Proteinuria
HLA-DRB1 2 / 21 Nephrotic syndrome, Proteinuria
IL1RN 2 / 21 Nephrotic syndrome, Proteinuria
ITGB4 2 / 21 Focal glomerulosclerosis, Nephrotic syndrome
KIRREL2 2 / 21 Focal glomerulosclerosis, Nephrotic syndrome
LAMB2 2 / 21 Focal glomerulosclerosis, Nephrotic syndrome
MPV17 2 / 21 Focal glomerulosclerosis, Proteinuria
MUC16 2 / 21 Nephrotic syndrome, Proteinuria
MYH9 2 / 21 Focal glomerulosclerosis, Nephrotic syndrome
NCK1 2 / 21 Nephrotic syndrome, Proteinuria
NCK2 2 / 21 Nephrotic syndrome, Proteinuria
NOC3L 2 / 21 Focal glomerulosclerosis, Nephrotic syndrome
OSGEP 2 / 21 Galloway-mowat syndrome, Nephrotic syndrome
PAK1 2 / 21 Intellectual developmental disorder seizures speech, Proteinuria
PDSS2 2 / 21 Focal glomerulosclerosis, Nephrotic syndrome
REN 2 / 21 Nephrotic syndrome, Proteinuria
SERPINE1 2 / 21 Focal glomerulosclerosis, Nephrotic syndrome
SOD1 2 / 21 Nephrotic syndrome, Proteinuria
SPP1 2 / 21 Focal glomerulosclerosis, Proteinuria
SYNPO 2 / 21 Focal segmental glomerulosclerosis, Nephrotic syndrome
TPRKB 2 / 21 Galloway-mowat syndrome, Nephrotic syndrome
TSFM 2 / 21 Nephrotic syndrome, Steroid-resistant nephrotic syndrome
ZNF592 2 / 21 Camos syndrome, Galloway-mowat syndrome
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
AGE-RAGE signaling pathway in diabetic complications
PLCE1, AGT, COL4A1, COL4A4, COL4A5, EDN1, FN1, SERPINE1, TGFB1, COL4A3, ICAM1, COL1A1
 KEGG 18 / 101 8.9× 1.17e-12 2.52e-10 ✓ sig.
Amoebiasis
ACTN4, COL4A1, COL4A4, COL4A5, FN1, GNAQ, LAMA5, LAMB2, NOS2, TGFB1, COL4A3, ITGB2
 KEGG 16 / 103 7.8× 1.88e-10 2.55e-8 ✓ sig.
Laminin interactions
COL4A1, COL4A4, COL4A5, ITGB4, LAMA5, LAMB2, COL4A3, COL4A2, ITGA3
 Reactome 9 / 28 16.1× 2.17e-9 2.21e-7 ✓ sig.
Focal adhesion
ACTN4, EMP2, COL4A1, COL4A4, COL4A5, FN1, ITGB4, LAMA5, LAMB2, SPP1, GRB2, COL4A3
 KEGG 20 / 203 4.9× 4.03e-9 3.90e-7 ✓ sig.
Extracellular matrix organization
COL4A1, COL4A4, COL4A5, FN1, COL4A3, COL1A1, COL4A2
 Reactome 7 / 15 23.4× 6.55e-9 6.06e-7 ✓ sig.
Type I diabetes mellitus
CD28, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB5, IL1B, IL2, FAS, HLA-B, IFNG
 KEGG 10 / 44 11.4× 1.15e-8 9.84e-7 ✓ sig.
Nephrin family interactions
NPHS1, NPHS2, KIRREL2, NCK1, NCK2, KIRREL1
 Reactome 6 / 10 30.0× 1.18e-8 1.00e-6 ✓ sig.
Non-integrin membrane-ECM interactions
COL4A1, COL4A4, COL4A5, FN1, COL4A3, COL1A1, COL4A2, FGF2
 Reactome 8 / 24 16.7× 1.26e-8 1.06e-6 ✓ sig.
Graft-versus-host disease
CD28, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB5, IL1B, IL2, FAS, HLA-B, IFNG
 KEGG 10 / 45 11.1× 1.45e-8 1.21e-6 ✓ sig.
ECM-receptor interaction
COL4A1, COL4A4, COL4A5, FN1, ITGB4, LAMA5, LAMB2, SPP1, COL4A3, COL1A1, COL4A2, ITGA3
 KEGG 13 / 89 7.3× 2.14e-8 1.71e-6 ✓ sig.
Allograft rejection
CD28, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB5, IL2, FAS, HLA-B, IFNG
 KEGG 9 / 39 11.5× 5.50e-8 3.88e-6 ✓ sig.
Postmitotic nuclear pore complex (NPC) reformation
NUP107, NUP133, NUP160, NUP205, NUP37, NUP85, NUP93
 Reactome 7 / 22 15.9× 1.54e-7 9.52e-6 ✓ sig.
Interleukin-4 and Interleukin-13 signaling
FN1, LAMA5, NOS2, TGFB1, GATA3, ICAM1, ITGB2, VIM, FGF2, IL1B, POMC, PTGS2
 Reactome 13 / 108 6.0× 2.24e-7 1.32e-5 ✓ sig.
Anchoring fibril formation
COL4A1, COL4A4, COL4A5, COL4A3, COL1A1, COL4A2
 Reactome 6 / 15 20.0× 2.58e-7 1.49e-5 ✓ sig.
Leishmaniasis
NOS2, TGFB1, ITGB2, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB5, IL1B, CYBB, IFNG, PTGS2
 KEGG 11 / 78 7.1× 3.86e-7 2.14e-5 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
regulation of blood pressure
ACTA2, AGT, EDN1, SCNN1G, EDNRB, REN, SOD1, SOD2, LEP, POMC, PTGS2, SCNN1A
 GO:0008217 12 / 83 11.3× 6.62e-10 1.56e-7 ✓ sig.
glomerular basement membrane development
MYO1E, NPHS1, WT1, COL4A4, MPV17, COL4A3
 GO:0032836 6 / 10 46.7× 8.48e-10 1.93e-7 ✓ sig.
kidney development
CD2AP, MYO1E, WT1, AGT, LAMA5, GATA3, REN, SGPL1, TNS2, BMP7, AGTR1, RHOA
 GO:0001822 13 / 146 6.9× 5.24e-8 7.04e-6 ✓ sig.
tRNA threonylcarbamoyladenosine modification
GON7, OSGEP, TPRKB, YRDC
 GO:0002949 4 / 5 62.3× 1.31e-7 1.52e-5 ✓ sig.
nephron development
NUP107, NUP133, NUP160, NUP85, ITGA3
 GO:0072006 5 / 11 35.4× 1.45e-7 1.66e-5 ✓ sig.
positive regulation of T cell proliferation
BTNL2, CD28, IL1B, IL2, NCK1, NCK2, PTPRC, TNFSF4, LEP
 GO:0042102 9 / 67 10.5× 1.83e-7 2.01e-5 ✓ sig.
podocyte differentiation
CD2AP, PTPRO, WT1, EDN1, EDNRB
 GO:0072112 5 / 12 32.4× 2.47e-7 2.59e-5 ✓ sig.
collagen-activated tyrosine kinase receptor signaling pathway
COL4A1, COL4A5, COL4A3, COL1A1, COL4A2
 GO:0038063 5 / 12 32.4× 2.47e-7 2.59e-5 ✓ sig.
glomerulus development
CD2AP, MYO1E, PLCE1, PTPRO, WT1
 GO:0032835 5 / 13 29.9× 3.97e-7 3.85e-5 ✓ sig.
cell-cell adhesion
NPHS1, ITGB4, KIRREL2, MYH9, CDH12, FAT1, ICAM1, ITGB2, CD2, ITGA3, TNXB, BMP7
 GO:0098609 14 / 218 5.0× 9.18e-7 7.74e-5 ✓ sig.
positive regulation of nitric oxide biosynthetic process
EDN1, ITGB2, IL1B, SOD2, APOE, IFNG, PTGS2
 GO:0045429 7 / 42 13.0× 9.71e-7 8.10e-5 ✓ sig.
peptide antigen assembly with MHC class II protein complex
HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB5, B2M
 GO:0002503 5 / 16 24.3× 1.30e-6 1.02e-4 ✓ sig.
positive regulation of cell population proliferation
EMP2, EDN1, FN1, REG1A, TGFB1, FGFR4, PAK1, EDNRB, F2, BTC, EPO, FGF2
 GO:0008284 22 / 532 3.2× 1.54e-6 1.17e-4 ✓ sig.
cell adhesion
EMP2, NPHS1, CCN2, FN1, ITGB4, KIRREL2, LAMA5, LAMB2, MYH10, MYH9, SPP1, CDH12
 GO:0007155 25 / 665 2.9× 1.64e-6 1.23e-4 ✓ sig.
symbiont entry into host cell
ACE2, HAVCR1, MYH10, MYH9, SCARB2, ICAM1, AGTR1, CTSB, CTSL, DPP4
 GO:0046718 10 / 112 7.0× 1.82e-6 1.34e-4 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Genetic steroid-resistant nephrotic syndrome Hereditary steroid-resistant nephrotic syndrome 0.917 33 6.76e-99 7.80e-97 ✓ sig.
Hereditary steroid-resistant nephrotic syndrome Idiopathic steroid-resistant nephrotic syndrome 0.800 28 2.37e-82 2.05e-80 ✓ sig.
Genetic steroid-resistant nephrotic syndrome Idiopathic steroid-resistant nephrotic syndrome 0.800 28 2.37e-82 2.05e-80 ✓ sig.
Genetic steroid-resistant nephrotic syndrome Nephrotic syndrome 0.169 29 1.80e-53 1.05e-51 ✓ sig.
Hereditary steroid-resistant nephrotic syndrome Nephrotic syndrome 0.162 28 9.60e-51 5.35e-49 ✓ sig.
Focal glomerulosclerosis Nephrotic syndrome 0.167 32 3.76e-49 2.04e-47 ✓ sig.
Idiopathic steroid-resistant nephrotic syndrome Nephrotic syndrome 0.134 23 1.09e-41 5.04e-40 ✓ sig.
Focal glomerulosclerosis Hereditary steroid-resistant nephrotic syndrome 0.243 18 1.80e-36 7.28e-35 ✓ sig.
Focal glomerulosclerosis Genetic steroid-resistant nephrotic syndrome 0.227 17 7.29e-34 2.67e-32 ✓ sig.
Focal glomerulosclerosis Idiopathic steroid-resistant nephrotic syndrome 0.229 16 3.61e-33 1.30e-31 ✓ sig.
Focal segmental glomerulosclerosis Hereditary steroid-resistant nephrotic syndrome 0.208 11 3.35e-23 7.85e-22 ✓ sig.
Focal segmental glomerulosclerosis Genetic steroid-resistant nephrotic syndrome 0.208 11 3.35e-23 7.85e-22 ✓ sig.
Focal glomerulosclerosis Steroid-resistant nephrotic syndrome 0.164 10 5.95e-23 1.36e-21 ✓ sig.
Focal segmental glomerulosclerosis Idiopathic steroid-resistant nephrotic syndrome 0.208 10 1.25e-21 2.72e-20 ✓ sig.
Focal glomerulosclerosis Focal segmental glomerulosclerosis 0.145 11 2.11e-20 4.33e-19 ✓ sig.
Hereditary steroid-resistant nephrotic syndrome Steroid-resistant nephrotic syndrome 0.200 8 2.96e-19 5.71e-18 ✓ sig.
Nephrotic syndrome Proteinuria 0.072 14 6.69e-18 1.21e-16 ✓ sig.
Genetic steroid-resistant nephrotic syndrome Steroid-resistant nephrotic syndrome 0.171 7 2.25e-16 3.73e-15 ✓ sig.
Focal glomerulosclerosis Proteinuria 0.075 7 1.59e-10 1.64e-9 ✓ sig.
Camos syndrome Galloway-mowat syndrome 0.154 2 5.57e-7 3.60e-6 ✓ sig.
Nephrotic syndrome, steroid-resistant, autosomal recessive Steroid-resistant nephrotic syndrome 0.143 2 6.58e-7 4.21e-6 ✓ sig.
Focal glomerulosclerosis Nephrotic syndrome, steroid-resistant, autosomal recessive 0.034 2 1.35e-5 6.92e-5 ✓ sig.
Galloway-mowat syndrome Idiopathic steroid-resistant nephrotic syndrome 0.051 2 2.08e-4 5.63e-4 ✓ sig.
Galloway-mowat syndrome Genetic steroid-resistant nephrotic syndrome 0.044 2 3.08e-4 7.58e-4 ✓ sig.
Galloway-mowat syndrome Hereditary steroid-resistant nephrotic syndrome 0.044 2 3.08e-4 7.58e-4 ✓ sig.
Galloway-mowat syndrome nephrotic syndrome, type 18 0.077 1 7.79e-4 1.39e-3 ✓ sig.
schimke immuno-osseous dysplasia Steroid-resistant nephrotic syndrome 0.071 1 8.44e-4 1.48e-3 ✓ sig.
nephrotic syndrome, type 21 Steroid-resistant nephrotic syndrome 0.071 1 8.44e-4 1.48e-3 ✓ sig.
Idiopathic steroid-resistant nephrotic syndrome nephrotic syndrome, type 19 0.034 1 1.82e-3 2.66e-3 ✓ sig.
Idiopathic steroid-resistant nephrotic syndrome nephrotic syndrome, type 20 0.034 1 1.82e-3 2.66e-3 ✓ sig.
Idiopathic steroid-resistant nephrotic syndrome nephrotic syndrome, type 3 0.034 1 1.82e-3 2.66e-3 ✓ sig.
Idiopathic steroid-resistant nephrotic syndrome nephrotic syndrome, type 18 0.034 1 1.82e-3 2.66e-3 ✓ sig.
Idiopathic steroid-resistant nephrotic syndrome nephrotic syndrome, type 8 0.034 1 1.82e-3 2.66e-3 ✓ sig.
Focal segmental glomerulosclerosis focal segmental glomerulosclerosis and neurodevelopmental syndrome 0.033 1 1.88e-3 2.75e-3 ✓ sig.
Genetic steroid-resistant nephrotic syndrome nephrotic syndrome, type 19 0.029 1 2.21e-3 3.10e-3 ✓ sig.
Hereditary steroid-resistant nephrotic syndrome nephrotic syndrome, type 19 0.029 1 2.21e-3 3.10e-3 ✓ sig.
Hereditary steroid-resistant nephrotic syndrome Woolly hair-palmoplantar keratoderma syndrome 0.029 1 2.21e-3 3.10e-3 ✓ sig.
Hereditary steroid-resistant nephrotic syndrome nephrotic syndrome, type 18 0.029 1 2.21e-3 3.10e-3 ✓ sig.
Genetic steroid-resistant nephrotic syndrome nephrotic syndrome, type 20 0.029 1 2.21e-3 3.10e-3 ✓ sig.
Hereditary steroid-resistant nephrotic syndrome nephrotic syndrome, type 20 0.029 1 2.21e-3 3.10e-3 ✓ sig.
Genetic steroid-resistant nephrotic syndrome Woolly hair-palmoplantar keratoderma syndrome 0.029 1 2.21e-3 3.10e-3 ✓ sig.
Genetic steroid-resistant nephrotic syndrome nephrotic syndrome, type 18 0.029 1 2.21e-3 3.10e-3 ✓ sig.
Genetic steroid-resistant nephrotic syndrome nephrotic syndrome, type 21 0.029 1 2.21e-3 3.10e-3 ✓ sig.
Hereditary steroid-resistant nephrotic syndrome nephrotic syndrome, type 21 0.029 1 2.21e-3 3.10e-3 ✓ sig.
Hereditary steroid-resistant nephrotic syndrome nephrotic syndrome, type 8 0.029 1 2.21e-3 3.10e-3 ✓ sig.
Genetic steroid-resistant nephrotic syndrome nephrotic syndrome, type 3 0.029 1 2.21e-3 3.10e-3 ✓ sig.
Hereditary steroid-resistant nephrotic syndrome nephrotic syndrome, type 3 0.029 1 2.21e-3 3.10e-3 ✓ sig.
Genetic steroid-resistant nephrotic syndrome nephrotic syndrome, type 8 0.029 1 2.21e-3 3.10e-3 ✓ sig.
Idiopathic steroid-resistant nephrotic syndrome Nephrotic syndrome, steroid-resistant, autosomal recessive 0.033 1 3.63e-3 4.66e-3 ✓ sig.
Focal glomerulosclerosis focal segmental glomerulosclerosis and neurodevelopmental syndrome 0.017 1 3.70e-3 4.73e-3 ✓ sig.
Focal glomerulosclerosis schimke immuno-osseous dysplasia 0.017 1 3.70e-3 4.73e-3 ✓ sig.
Intellectual developmental disorder seizures speech Proteinuria 0.023 1 5.45e-3 6.63e-3 ✓ sig.
Nephrotic syndrome nephrotic syndrome, type 18 0.006 1 1.08e-2 1.22e-2 ✓ sig.
Nephrotic syndrome nephrotic syndrome, type 8 0.006 1 1.08e-2 1.22e-2 ✓ sig.
Nephrotic syndrome nephrotic syndrome, type 21 0.006 1 1.08e-2 1.22e-2 ✓ sig.
Nephrotic syndrome nephrotic syndrome, type 20 0.006 1 1.08e-2 1.22e-2 ✓ sig.
Nephrotic syndrome nephrotic syndrome, type 19 0.006 1 1.08e-2 1.22e-2 ✓ sig.
Nephrotic syndrome Woolly hair-palmoplantar keratoderma syndrome 0.006 1 1.08e-2 1.22e-2 ✓ sig.