Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 369

5 diseases · 7 shared-gene connections
5 Diseases
539 Unique genes
0.106 Avg. similarity score
Dilated cardiomyopathy Most-connected disease (4 links)
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Disease Searched: cardiomyopathy, dilated, 2h Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Dilated cardiomyopathy 4 4 273
Cardiomyopathy 3 3 244
Hypertrophic cardiomyopathy 3 3 256
dilated cardiomyopathy 1M 3 3 1
cardiomyopathy, dilated, 2h 1 1 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
CSRP3 4 / 5 Cardiomyopathy, Dilated cardiomyopathy, dilated cardiomyopathy 1M, Hypertrophic cardiomyopathy
ABCC9 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
ACTC1 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
ACTN2 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
ANK2 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
ANKRD1 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
BAG3 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
CACNA1C 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
CALR3 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
CDKN1A 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
CEP85L 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
CRYAB 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
CS 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
CTF1 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
DMD 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
DNAAF3 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
DSC2 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
DSG2 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
DSP 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
DTNA 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
EMD 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
FASN 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
FHOD3 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
FLNC 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
HCN4 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
HSPB7 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
JPH2 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
JUP 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
KCNE1 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
LAMP2 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
LDB3 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
LMNA 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
LSM3 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
LZTR1 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
MAP3K7CL 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
MYBPC3 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
MYH6 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
MYH7 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
MYH7B 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
MYL2 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
MYL3 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
MYLK2 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
MYOM1 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
MYPN 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
NEBL 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
NEXN 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
OBSCN 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
PDLIM3 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
PKP2 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
PLN 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
PRKAG2 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
RAF1 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
RBM20 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
RYR2 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
SCN5A 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
SCO2 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
SLC30A5 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
SMARCB1 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
TCAP 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
TMEM43 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
TMPO 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
TNNC1 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
TNNI3 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
TNNT2 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
TPM1 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
TRPM4 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
TTN 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
VCL 3 / 5 Cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy
ACADVL 2 / 5 Cardiomyopathy, Dilated cardiomyopathy
ADRB2 2 / 5 Cardiomyopathy, Dilated cardiomyopathy
AGT 2 / 5 Cardiomyopathy, Hypertrophic cardiomyopathy
AKAP9 2 / 5 Dilated cardiomyopathy, Hypertrophic cardiomyopathy
ALPK3 2 / 5 Cardiomyopathy, Hypertrophic cardiomyopathy
BAG5 2 / 5 Cardiomyopathy, Dilated cardiomyopathy
BRAF 2 / 5 Dilated cardiomyopathy, Hypertrophic cardiomyopathy
C2ORF49 2 / 5 Cardiomyopathy, Dilated cardiomyopathy
CACNB2 2 / 5 Dilated cardiomyopathy, Hypertrophic cardiomyopathy
CASQ2 2 / 5 Cardiomyopathy, Hypertrophic cardiomyopathy
CAV3 2 / 5 Cardiomyopathy, Hypertrophic cardiomyopathy
CCDC136 2 / 5 Dilated cardiomyopathy, Hypertrophic cardiomyopathy
CD36 2 / 5 Cardiomyopathy, Dilated cardiomyopathy
CHRM2 2 / 5 Cardiomyopathy, Dilated cardiomyopathy
CLCNKA 2 / 5 Cardiomyopathy, Hypertrophic cardiomyopathy
COL1A1 2 / 5 Dilated cardiomyopathy, Hypertrophic cardiomyopathy
COMT 2 / 5 Cardiomyopathy, Dilated cardiomyopathy
COX15 2 / 5 Cardiomyopathy, Hypertrophic cardiomyopathy
CTNNA3 2 / 5 Cardiomyopathy, Dilated cardiomyopathy
DNAJC18 2 / 5 Dilated cardiomyopathy, Hypertrophic cardiomyopathy
DNASE1L1 2 / 5 Cardiomyopathy, Dilated cardiomyopathy
DOLK 2 / 5 Cardiomyopathy, Dilated cardiomyopathy
EYA4 2 / 5 Cardiomyopathy, Dilated cardiomyopathy
FAAP20 2 / 5 Dilated cardiomyopathy, Hypertrophic cardiomyopathy
FAS 2 / 5 Cardiomyopathy, Dilated cardiomyopathy
FASLG 2 / 5 Cardiomyopathy, Dilated cardiomyopathy
FBXO32 2 / 5 Dilated cardiomyopathy, Hypertrophic cardiomyopathy
FERMT2 2 / 5 Dilated cardiomyopathy, Hypertrophic cardiomyopathy
FHL1 2 / 5 Cardiomyopathy, Hypertrophic cardiomyopathy
FHL2 2 / 5 Cardiomyopathy, Dilated cardiomyopathy
GAA 2 / 5 Cardiomyopathy, Hypertrophic cardiomyopathy
GET3 2 / 5 cardiomyopathy, dilated, 2h, Dilated cardiomyopathy
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Cytoskeleton in muscle cells
ANKRD1, ACTC1, ACTN2, ANK2, CSRP3, DMD, DSC2, DSG2, DSP, DTNA, EMD, FHL2
 KEGG 66 / 232 6.3× 2.25e-35 8.62e-32 ✓ sig.
Hypertrophic cardiomyopathy
ACTC1, AGT, CACNA1C, CAV3, DMD, DTNA, EDN1, EMD, IL6, ITGB1, LMNA, MYBPC3
 KEGG 35 / 99 7.9× 1.10e-22 1.33e-19 ✓ sig.
Dilated cardiomyopathy
ACTC1, ADCY5, AGT, CACNA1C, CAV3, DMD, DTNA, EMD, ITGB1, LMNA, MYBPC3, MYH6
 KEGG 34 / 105 7.2× 1.18e-20 9.41e-18 ✓ sig.
Striated Muscle Contraction
ACTC1, ACTN2, DMD, MYBPC3, MYH6, MYL2, MYL3, MYL4, TCAP, TNNC1, TNNI3, TNNT1
 Reactome 20 / 36 12.4× 2.91e-18 1.73e-15 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy
ACTN2, CACNA1C, CAV3, DMD, DSC2, DSG2, DSP, DTNA, EMD, ITGB1, JUP, LMNA
 KEGG 26 / 86 6.7× 2.88e-15 9.89e-13 ✓ sig.
Adrenergic signaling in cardiomyocytes
ACTC1, ADCY5, ADRB2, AGT, AKT1, CACNA1C, KCNE1, MAPK1, MAPK11, MAPK14, MAPK3, MYH6
 KEGG 33 / 154 4.8× 3.47e-14 9.66e-12 ✓ sig.
Proteoglycans in cancer
AKT1, ANK2, CAV3, FAS, FASLG, HGF, ITGB1, MAPK1, MAPK11, MAPK14, MAPK3, STAT3
 KEGG 34 / 204 3.7× 2.64e-11 4.37e-9 ✓ sig.
Endometrial cancer
AKT1, MAPK1, MAPK3, TP53, CDKN1A, DDB2, AXIN2, BRAF, CTNNA3, CTNNB1, EGFR, GSK3B
 KEGG 18 / 59 6.8× 4.80e-11 7.51e-9 ✓ sig.
cGMP-PKG signaling pathway
ADCY5, ADRB2, AKT1, BDKRB2, CACNA1C, MAPK1, MAPK3, MYH6, MYH7, MYLK2, NOS3, NPPB
 KEGG 30 / 166 4.0× 5.04e-11 7.85e-9 ✓ sig.
Oxytocin signaling pathway
ADCY5, CACNA1C, MAPK1, MAPK3, MYLK2, NOS3, OXTR, PRKAA2, PRKAG2, PTGS2, RYR2, CDKN1A
 KEGG 28 / 154 4.1× 1.94e-10 2.65e-8 ✓ sig.
Lipid and atherosclerosis
AKT1, CYP2C9, FAS, FASLG, HSPD1, IL1B, IL6, MAP3K5, MAPK1, MAPK11, MAPK14, MAPK3
 KEGG 33 / 216 3.4× 5.52e-10 6.88e-8 ✓ sig.
Cardiac muscle contraction
ACTC1, CACNA1C, CASQ2, COX1, MYH6, MYH7, MYL2, MYL3, MYL4, RYR2, TNNC1, TNNI3
 KEGG 20 / 87 5.1× 1.11e-9 1.28e-7 ✓ sig.
Diabetic cardiomyopathy
AGT, AKT1, COX1, MAPK11, MAPK14, NDUFS2, NDUFV2, NOS3, PARP1, PDK2, PLN, RYR2
 KEGG 31 / 205 3.4× 2.40e-9 2.56e-7 ✓ sig.
AGE-RAGE signaling pathway in diabetic complications
AGT, AKT1, EDN1, IL1A, IL1B, IL6, MAPK1, MAPK11, MAPK14, MAPK3, NOS3, PRKCE
 KEGG 21 / 101 4.6× 3.01e-9 3.15e-7 ✓ sig.
VEGF signaling pathway
AKT1, MAPK1, MAPK11, MAPK14, MAPK3, NOS3, PTGS2, PPP3R1, PRKCA, PRKCB, RAC1, RAF1
 KEGG 16 / 60 5.9× 5.19e-9 5.17e-7 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
cardiac muscle contraction
ACTC1, CASQ2, CSRP3, DMD, GRK2, MYBPC3, MYH6, MYH7, MYL2, MYL3, MYL4, MYLK2
 GO:0060048 29 / 43 23.4× 5.61e-35 3.89e-31 ✓ sig.
regulation of heart rate by cardiac conduction
ANK2, CACNA1C, DSC2, DSG2, DSP, HCN4, JUP, KCNE1, PKP2, SCN1B, SCN5A, TRPM4
 GO:0086091 24 / 43 19.4× 3.19e-26 1.13e-22 ✓ sig.
sarcomere organization
ANKRD1, ACTN2, CSRP3, FHOD3, FLNC, ITGB1, LDB3, MYBPC3, MYH6, MYOM1, MYOZ2, MYPN
 GO:0045214 24 / 43 19.4× 3.19e-26 1.13e-22 ✓ sig.
heart development
ABCC9, ALPK3, CACNA1C, CSRP3, DNAAF3, EDN1, GRK2, LDB3, MAPK1, MYL2, PKP2, PPARD
 GO:0007507 47 / 273 6.0× 2.68e-23 6.93e-20 ✓ sig.
ventricular cardiac muscle cell action potential
ANK2, CAV3, KCNE1, PKP2, RYR2, SCN5A, GPD1L, KCNE2, NEDD4L, KCNH2, SNTA1, GJA5
 GO:0086005 13 / 17 26.5× 1.78e-17 1.92e-14 ✓ sig.
muscle contraction
CACNA1C, CRYAB, DMD, EMD, HCN4, MYH6, MYH7, MYL3, MYL4, MYOT, OXTR, TRIM63
 GO:0006936 22 / 85 9.0× 2.02e-15 1.53e-12 ✓ sig.
regulation of ventricular cardiac muscle cell membrane repolarization
ANK2, CAV3, KCNE1, SCN1B, SCN5A, AKAP9, KCNE2, SCN4B, KCNH2, SNTA1, GJA5, KCNQ1
 GO:0060307 12 / 21 19.8× 6.82e-14 3.84e-11 ✓ sig.
positive regulation of gene expression
ACTC1, ADCYAP1, AKT1, ANK2, APP, ATF3, AVP, AVPR2, HFE, IL1A, IL1B, IL4
 GO:0010628 49 / 504 3.4× 9.42e-14 5.17e-11 ✓ sig.
regulation of ventricular cardiac muscle cell action potential
CACNA1C, DSC2, DSG2, DSP, JUP, PKP2, RYR2, TRPM4, CTNNA3
 GO:0098911 9 / 11 28.4× 6.76e-13 3.20e-10 ✓ sig.
regulation of heart rate
ANK2, CASQ2, CAV3, DMD, HCN4, MYH6, MYH7, RYR2, SCN5A, GPD1L, TNNI3K, CALM3
 GO:0002027 14 / 39 12.4× 1.82e-12 7.95e-10 ✓ sig.
vasodilation
ABCC9, ADORA2A, BDKRB2, NOS3, NPPB, PPARD, SOD2, TNF, APOE, GPX1, NPPA, INS
 GO:0042311 15 / 50 10.4× 5.83e-12 2.29e-9 ✓ sig.
cardiac myofibril assembly
ACTC1, CSRP3, FHOD3, MYL2, SRF, TCAP, TTN, MYLK3, ADPRHL1
 GO:0055003 9 / 13 24.0× 8.35e-12 3.14e-9 ✓ sig.
ventricular cardiac muscle tissue morphogenesis
MYBPC3, MYH6, MYH7, MYL2, MYL3, PKP2, TNNC1, TNNI3, TNNT2, TPM1, ISL1
 GO:0055010 11 / 24 15.9× 1.85e-11 6.44e-9 ✓ sig.
regulation of the force of heart contraction
CSRP3, GRK2, MYH6, MYH7, MYL2, MYL3, MYL4, PLN, GAA, SLC9A1
 GO:0002026 10 / 19 18.2× 2.68e-11 9.04e-9 ✓ sig.
cardiac muscle cell development
ACTN2, ALPK3, CAV3, MYH6, SGCB, SGCD, TCAP, TTN, LRRC10, NKX2-5, PLEC
 GO:0055013 11 / 25 15.3× 3.21e-11 1.06e-8 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Cardiomyopathy Dilated cardiomyopathy 0.260 107 9.72e-128 1.48e-125 ✓ sig.
Cardiomyopathy Hypertrophic cardiomyopathy 0.253 101 2.63e-120 3.86e-118 ✓ sig.
Dilated cardiomyopathy Hypertrophic cardiomyopathy 0.216 94 3.68e-102 4.35e-100 ✓ sig.
Cardiomyopathy dilated cardiomyopathy 1M 0.004 1 1.58e-2 1.75e-2 ✓ sig.
dilated cardiomyopathy 1M Hypertrophic cardiomyopathy 0.004 1 1.66e-2 1.83e-2 ✓ sig.
cardiomyopathy, dilated, 2h Dilated cardiomyopathy 0.004 1 1.77e-2 1.94e-2 ✓ sig.
Dilated cardiomyopathy dilated cardiomyopathy 1M 0.004 1 1.77e-2 1.94e-2 ✓ sig.