Gene Gene information from NCBI Gene database.
Entrez ID 5578
Gene name Protein kinase C alpha
Gene symbol PRKCA
Synonyms (NCBI Gene)
AAG6PKC-alphaPKCAPKCI+/-PKCalphaPRKACA
Chromosome 17
Chromosome location 17q24.2
Summary Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved
SNPs SNP information provided by dbSNP.
1
SNP ID Visualize variation Clinical significance Consequence
rs16960228 G>A Drug-response Intron variant, genic downstream transcript variant
miRNA miRNA information provided by mirtarbase database.
995
miRTarBase ID miRNA Experiments Reference
MIRT006882 mmu-miR-24-2-5p Luciferase reporter assayqRT-PCRWestern blot 22911661
MIRT020045 hsa-miR-375 Microarray 20215506
MIRT050756 hsa-miR-17-3p CLASH 23622248
MIRT049636 hsa-miR-92a-3p CLASH 23622248
MIRT041382 hsa-miR-193b-3p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
RARA Activation 11525643
TFAP2A Activation 12269829
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
109
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000302 Process Response to reactive oxygen species IEA
GO:0001525 Process Angiogenesis IEA
GO:0001938 Process Positive regulation of endothelial cell proliferation IMP 11909826
GO:0002159 Process Desmosome assembly IMP 18474624
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
176960 9393 ENSG00000154229
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P17252
Protein name Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13)
Protein function Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, ca
PDB 2ELI , 3IW4 , 4DNL , 4RA4 , 8U37 , 8UAK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00130 C1_1 37 89 Phorbol esters/diacylglycerol binding domain (C1 domain) Domain
PF00130 C1_1 102 154 Phorbol esters/diacylglycerol binding domain (C1 domain) Domain
PF00168 C2 171 277 C2 domain Domain
PF00069 Pkinase 339 597 Protein kinase domain Domain
PF00433 Pkinase_C 623 658 Protein kinase C terminal domain Family
Sequence
Sequence length 672
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
27
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANDROGENETIC ALOPECIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ASTHMA, OCCUPATIONAL CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BRUGADA SYNDROME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acne Acne HPO_DG
★☆☆☆☆
Found in Text Mining only
Acquired Nephrogenic Diabetes Insipidus Diabetes Insipidus CTD_human_DG 25006961
★☆☆☆☆
Found in Text Mining only
Acth-Independent Macronodular Adrenal Hyperplasia Cushing`s Syndrome BEFREE 31276155
★☆☆☆☆
Found in Text Mining only
ACTH-Secreting Pituitary Adenoma Pituitary adenoma BEFREE 26701869
★☆☆☆☆
Found in Text Mining only
Actinic keratosis Actinic keratosis BEFREE 30944245
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 24990612
★☆☆☆☆
Found in Text Mining only
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 20200558
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of large intestine Colorectal Cancer UNIPROT_DG
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 23604119, 28751441, 31420605, 31612005
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of pancreas Pancreatic adenocarcinoma BEFREE 30904392
★☆☆☆☆
Found in Text Mining only