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Gene Gene information from NCBI Gene database.
Entrez ID 5534
Gene name Protein phosphatase 3 regulatory subunit B, alpha
Gene symbol PPP3R1
Synonyms (NCBI Gene)
CALNB1CNBCNB1
Chromosome 2
Chromosome location 2p14
miRNA miRNA information provided by mirtarbase database.
763 Show/Hide all (763)
miRTarBase ID miRNA Experiments Reference
MIRT005180 hsa-miR-30a-5p pSILAC 18668040
MIRT025005 hsa-miR-183-5p Sequencing 20371350
MIRT025426 hsa-miR-34a-5p Sequencing 20371350
MIRT005180 hsa-miR-30a-5p Proteomics;Other 18668040
MIRT029303 hsa-miR-26b-5p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
49 Show/Hide all (49)
GO ID Ontology Definition Evidence Reference
GO:0001569 Process Branching involved in blood vessel morphogenesis IEA
GO:0001837 Process Epithelial to mesenchymal transition IEA
GO:0004721 Function Phosphoprotein phosphatase activity IEA
GO:0004723 Function Calcium-dependent protein serine/threonine phosphatase activity NAS 2558868
GO:0005509 Function Calcium ion binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601302 9317 ENSG00000221823
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P63098
Protein name Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1)
Protein function Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
PDB 1AUI , 1M63 , 1MF8 , 2P6B , 3LL8 , 4F0Z , 4OR9 , 4ORA , 4ORC , 5SVE , 6NUC , 6NUF , 6NUU , 7U0T , 9B9G , 9CHU , 9CHV , 9CHX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00036 EF-hand_1 132 → 160 EF hand Domain
PF13499 EF-hand_7 89 → 158 EF-hand domain pair Domain
PF13499 EF-hand_7 20 → 80 EF-hand domain pair Domain
Sequence
Sequence length 170
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
MAPK signaling pathway Activation of BAD and translocation to mitochondria
Calcium signaling pathway Calcineurin activates NFAT
cGMP-PKG signaling pathway FCERI mediated Ca+2 mobilization
Oocyte meiosis Ca2+ pathway
Cellular senescence CLEC7A (Dectin-1) induces NFAT activation
Wnt signaling pathway  
Axon guidance  
VEGF signaling pathway  
Osteoclast differentiation  
C-type lectin receptor signaling pathway  
Natural killer cell mediated cytotoxicity  
Th1 and Th2 cell differentiation  
Th17 cell differentiation  
T cell receptor signaling pathway  
B cell receptor signaling pathway  
Long-term potentiation  
Glutamatergic synapse  
Oxytocin signaling pathway  
Glucagon signaling pathway  
Renin secretion  
Alzheimer disease  
Amyotrophic lateral sclerosis  
Prion disease  
Pathways of neurodegeneration - multiple diseases  
Amphetamine addiction  
Tuberculosis  
Human cytomegalovirus infection  
Human T-cell leukemia virus 1 infection  
Kaposi sarcoma-associated herpesvirus infection  
Human immunodeficiency virus 1 infection  
PD-L1 expression and PD-1 checkpoint pathway in cancer  
Lipid and atherosclerosis  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
8
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (8)
Phenotype Name Clinical Significance Source Reference Evidence Score
ALZHEIMERS DISEASE — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARDIOMYOPATHY, DILATED — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPERTROPHY, LEFT VENTRICULAR — CTD 18344631
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LEFT VENTRICULAR HYPERTROPHY — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MYOCARDIAL ISCHEMIA — CTD, Disgenet
CTD, Disgenet
16214533
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (36)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 23727081, 31745181, 36569892 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Amyloidosis Amyloidosis BEFREE 23785163
★★★★★
★☆☆☆☆
Found in Text Mining only
Atrial Fibrillation Atrial fibrillation Pubtator 34198460 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Atypical Ductal Breast Hyperplasia Breast Hyperplasia BEFREE 31013355
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 29972239
★★★★★
★☆☆☆☆
Found in Text Mining only
Cardiomyopathy Dilated Dilated cardiomyopathy Pubtator 15012912 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Cardiomyopathy Hypertrophic Familial Cardiomyopathy Pubtator 31754133 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Cervical lymphadenopathy Cervical lymphadenopathy BEFREE 29188372
★★★★★
★☆☆☆☆
Found in Text Mining only
Colitis Colitis BEFREE 29549257
★★★★★
★☆☆☆☆
Found in Text Mining only
Cornea plana Cornea Plana BEFREE 7601455, 8723718, 8825624, 8929947
★★★★★
★☆☆☆☆
Found in Text Mining only