Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 75

13 diseases · 21 shared-gene connections
13 Diseases
816 Unique genes
0.076 Avg. similarity score
Anorexia nervosa Most-connected disease (7 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Anorexia nervosa 7 7 251
Tourette syndrome 6 6 258
Obsessive-compulsive disorder 5 5 234
Eating disorder 4 4 72
Generalized anxiety disorder 4 4 40
Psychiatric disorders 4 4 219
cardiomyopathy, dilated, 2f 4 4 1
neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities 3 3 1
Charcot-Marie-Tooth disease, axonal, type 2FF 1 1 1
Congenital thrombotic disease 1 1 1
Early-onset distal myopathy 1 1 1
Tolchin-le caignec syndrome 1 1 1
Vascular dementia 1 1 128

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
TMEM106B 6 / 13 Anorexia nervosa, Eating disorder, Generalized anxiety disorder, Psychiatric disorders and 2 more
ANKS1B 5 / 13 Anorexia nervosa, Generalized anxiety disorder, Obsessive-compulsive disorder, Psychiatric disorders and 1 more
BAG5 5 / 13 Anorexia nervosa, cardiomyopathy, dilated, 2f, Obsessive-compulsive disorder, Psychiatric disorders and 1 more
LRFN5 5 / 13 Anorexia nervosa, Generalized anxiety disorder, Obsessive-compulsive disorder, Psychiatric disorders and 1 more
AKAP6 4 / 13 Anorexia nervosa, Eating disorder, Obsessive-compulsive disorder, Tourette syndrome
CACNA1C 4 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Psychiatric disorders, Tourette syndrome
CCDC68 4 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Psychiatric disorders, Tourette syndrome
CSMD1 4 / 13 Anorexia nervosa, Eating disorder, Obsessive-compulsive disorder, Tourette syndrome
DCC 4 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Psychiatric disorders, Tourette syndrome
DRD2 4 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Psychiatric disorders, Tourette syndrome
ERCC4 4 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Psychiatric disorders, Tourette syndrome
FURIN 4 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Psychiatric disorders, Tourette syndrome
GRIN2A 4 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome, Vascular dementia
IGSF9B 4 / 13 Anorexia nervosa, Generalized anxiety disorder, Obsessive-compulsive disorder, Tourette syndrome
ITIH3 4 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Psychiatric disorders, Tourette syndrome
KIZ 4 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Psychiatric disorders, Tourette syndrome
MAD1L1 4 / 13 Anorexia nervosa, Generalized anxiety disorder, Obsessive-compulsive disorder, Tourette syndrome
MGMT 4 / 13 Anorexia nervosa, Eating disorder, Generalized anxiety disorder, Vascular dementia
NALF1 4 / 13 Anorexia nervosa, Eating disorder, Psychiatric disorders, Vascular dementia
PCLO 4 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Psychiatric disorders, Tourette syndrome
PLCL1 4 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome, Vascular dementia
PTPRF 4 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Psychiatric disorders, Tourette syndrome
RGS6 4 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Psychiatric disorders, Tourette syndrome
RIMS1 4 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Psychiatric disorders, Tourette syndrome
SHMT2 4 / 13 Anorexia nervosa, neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities, Obsessive-compulsive disorder, Tourette syndrome
SORCS3 4 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Psychiatric disorders, Tourette syndrome
SPAG16 4 / 13 Anorexia nervosa, Generalized anxiety disorder, Obsessive-compulsive disorder, Tourette syndrome
TCF4 4 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Psychiatric disorders, Tourette syndrome
TFAP2B 4 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Psychiatric disorders, Tourette syndrome
THSD7A 4 / 13 Anorexia nervosa, Eating disorder, Psychiatric disorders, Tourette syndrome
TMPRSS5 4 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Psychiatric disorders, Tourette syndrome
VRK2 4 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Psychiatric disorders, Tourette syndrome
ACADS 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
ACTR5 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
ADGRL4 3 / 13 Anorexia nervosa, Eating disorder, Generalized anxiety disorder
AMBRA1 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
ARL3 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
ASB3 3 / 13 Anorexia nervosa, Eating disorder, Generalized anxiety disorder
ATP2A2 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
BANK1 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
BCL11B 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
BRAF 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
C6ORF118 3 / 13 Obsessive-compulsive disorder, Psychiatric disorders, Vascular dementia
C8ORF90 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
CACNA1I 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
CACNB2 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
CAMTA1 3 / 13 Obsessive-compulsive disorder, Psychiatric disorders, Tourette syndrome
CHRNA3 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
CNNM4 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
CNTN4 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
CTNND1 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
DGKI 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
ENOX1 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
EPHX2 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
ESR2 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
FADS2 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
FAM120A 3 / 13 Anorexia nervosa, Generalized anxiety disorder, Tourette syndrome
FGFR1 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
FOXP1 3 / 13 Anorexia nervosa, Eating disorder, Tourette syndrome
FTCDNL1 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
GID4 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
GMIP 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
GRIK3 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
GRM3 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
GSDME 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
HCN1 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
HSPE1-MOB4 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
IFI44 3 / 13 Anorexia nervosa, Eating disorder, Generalized anxiety disorder
IMMP2L 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
KCNB1 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
KDM3B 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
L3MBTL2 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
LMAN2L 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
LSAMP 3 / 13 Obsessive-compulsive disorder, Psychiatric disorders, Tourette syndrome
MOB4 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
MPHOSPH9 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
MRPL33 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
MYO18A 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
NAA11 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
NAA40 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
NCKIPSD 3 / 13 Anorexia nervosa, Eating disorder, Obsessive-compulsive disorder
NGEF 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
NPAS3 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
NRGN 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
NT5C2 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
OLFM4 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
OSBPL3 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
PDE4B 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
PMFBP1 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
PPP1R13B 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
PPP1R16B 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
PPP2R2B 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
PPP3CA 3 / 13 Anorexia nervosa, Eating disorder, Psychiatric disorders
PXDNL 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
RBFOX1 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
RBKS 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
RCOR2 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
RERE 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
RORA 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
RPS19BP1 3 / 13 Anorexia nervosa, Obsessive-compulsive disorder, Tourette syndrome
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
cAMP signaling pathway
AKT3, ATP2A2, BRAF, CACNA1C, CREB5, DRD2, GRIN2A, PDE4B, NPPA, NPY, RYR2, HTR1B
 KEGG 29 / 226 1.9× 6.88e-4 1.02e-2 ✓ sig.
ERBB2 Regulates Cell Motility
ERBB3, ERBB4, DIAPH1, NRG3, BTC
 Reactome 5 / 15 4.9× 2.42e-3 2.62e-2 ✓ sig.
Dopamine receptors
DRD2, DRD3, DRD4
 Reactome 3 / 5 8.8× 2.82e-3 2.94e-2 ✓ sig.
SHC1 events in ERBB2 signaling
ERBB3, ERBB4, NRG3, BTC, PRKCE
 Reactome 5 / 17 4.3× 4.45e-3 4.06e-2 ✓ sig.
Signaling by ERBB4
ERBB3, ERBB4, NRG3, BTC
 Reactome 4 / 11 5.4× 4.75e-3 4.23e-2 ✓ sig.
Pre-NOTCH Processing in Golgi
FURIN, NOTCH3, NOTCH1
 Reactome 3 / 6 7.4× 5.35e-3 4.57e-2 ✓ sig.
Serotonin receptors
HTR1B, HTR1D, HTR2A, HTR1A
 Reactome 4 / 12 4.9× 6.74e-3 5.32e-2
Nectin/Necl trans heterodimerization
CADM1, CADM3, NECTIN1
 Reactome 3 / 7 6.3× 8.89e-3 6.39e-2
ERBB2 Activates PTK6 Signaling
ERBB3, ERBB4, NRG3, BTC
 Reactome 4 / 13 4.5× 9.22e-3 6.53e-2
Effects of PIP2 hydrolysis
DGKI, DGKZ, PRKCE, ITPR1, PRKCH
 Reactome 5 / 20 3.7× 9.41e-3 6.62e-2
Adherens junction
CTNND1, FGFR1, PTPRF, CCM2, IGF1R, KRIT1, SMAD4, CTNNA1, BAIAP2, LMO7, NECTIN1, CTNNA3
 KEGG 13 / 93 2.1× 9.90e-3 6.82e-2
GnRH secretion
AKT3, CACNA1C, CACNA1I, ESR2, HCN1, HRAS, PRKCB, TRPC4, GABBR1, ITPR1
 KEGG 10 / 65 2.3× 1.18e-2 7.57e-2
Regulation of TP53 Activity through Association with Co-factors
AKT3, PPP1R13B, TP53BP2, ZNF385A
 Reactome 4 / 14 4.2× 1.22e-2 7.73e-2
SHC1 events in ERBB4 signaling
ERBB4, NRG3, HRAS, BTC
 Reactome 4 / 14 4.2× 1.22e-2 7.73e-2
GRB2 events in ERBB2 signaling
ERBB4, NRG3, HRAS, BTC
 Reactome 4 / 14 4.2× 1.22e-2 7.73e-2

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
chemical synaptic transmission
BSN, CACNB2, DLG2, EXOC4, GRIN2A, GRM3, SYN2, APP, CACNA1A, SNCA, NPY, UTS2
 GO:0007268 31 / 236 3.0× 4.46e-8 6.15e-6 ✓ sig.
modulation of chemical synaptic transmission
BSN, DRD2, GRID1, GRIK3, GRIN2A, GRM3, NTNG1, PPP3CA, CACNA1A, CHMP2B, TNF, NRG3
 GO:0050804 21 / 121 4.0× 5.85e-8 7.73e-6 ✓ sig.
axonogenesis
BCL11B, CELSR3, CNTN4, DCC, DRD2, NTNG1, APP, ATP8A2, ANK3, BAIAP2, LLGL1, SLITRK1
 GO:0007409 21 / 125 3.8× 1.05e-7 1.25e-5 ✓ sig.
postsynaptic modulation of chemical synaptic transmission
BRAF, DCC, DRD2, GRM3, INA, NRGN, PPP3CA, SORCS3, RASGRF2
 GO:0099170 9 / 25 8.2× 6.00e-7 5.46e-5 ✓ sig.
negative regulation of synaptic transmission, glutamatergic
DRD2, GRIK3, HCN1, DRD3, GRIK2, HTR2A
 GO:0051967 6 / 10 13.7× 1.23e-6 9.78e-5 ✓ sig.
response to xenobiotic stimulus
ACSL1, CHUK, DRD2, GRIN2A, RPTOR, TFAP2B, GCLM, MTHFR, SNCA, TNF, SLC6A4, DRD3
 GO:0009410 27 / 248 2.5× 1.23e-5 6.14e-4 ✓ sig.
endocytosis
LRP2, MYO19, MYO1D, MYO1E, NCKIPSD, RAB5B, SGIP1, APP, TSC2, RUFY1, CLTA, CSNK1G3
 GO:0006897 25 / 223 2.6× 1.55e-5 7.40e-4 ✓ sig.
synaptic membrane adhesion
LRFN5, NTNG1, PCDH17, PTPRF, SLITRK1, SLITRK5, TENM4, CDH6
 GO:0099560 8 / 29 6.3× 2.42e-5 1.04e-3 ✓ sig.
cardiac muscle hypertrophy in response to stress
ATP2A2, PPP3CA, NPPA, SMAD4, HDAC4, KDM4A
 GO:0014898 6 / 15 9.2× 2.43e-5 1.04e-3 ✓ sig.
synaptic transmission, dopaminergic
DRD2, SNCA, DRD3, DRD4, COMT, CRH
 GO:0001963 6 / 15 9.2× 2.43e-5 1.04e-3 ✓ sig.
neuron projection development
CNTN4, FGFR1, GDNF, NEGR1, PTPRG, APP, LAMB1, NPY, MAPT, WNT7B, CNTNAP2, EDN2
 GO:0031175 20 / 161 2.8× 2.48e-5 1.06e-3 ✓ sig.
calcium-mediated signaling
CAMKK2, GRIK3, GRIN2A, MCTP1, PPP3CA, APP, TNF, CCL20, RYR2, GRIK2, P2RX7, PPP1R9A
 GO:0019722 16 / 114 3.2× 3.55e-5 1.39e-3 ✓ sig.
nervous system development
AMBRA1, BRINP1, CAMK1D, CHRNA3, CNTN4, DLG2, ERBB4, FBXL17, GDNF, IGSF9B, INA, LRP2
 GO:0007399 50 / 631 1.8× 3.61e-5 1.41e-3 ✓ sig.
regulation of synaptic plasticity
CNTN4, GRID1, GRIN2A, SORCS3, VPS13A, MAPT, BAIAP2, CPEB3, LYPD6, GRID2, IGSF11, MECP2
 GO:0048167 12 / 69 4.0× 3.94e-5 1.50e-3 ✓ sig.
positive regulation of MAPK cascade
BANK1, ERBB3, ERBB4, FGFR1, GSDME, KIT, VEGFA, APP, IGF1R, TNF, DRD4, ADRB1
 GO:0043410 24 / 224 2.5× 4.79e-5 1.74e-3 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Anorexia nervosa Obsessive-compulsive disorder 0.361 129 1.68e-180 4.63e-178 ✓ sig.
Obsessive-compulsive disorder Tourette syndrome 0.351 128 3.14e-176 8.24e-174 ✓ sig.
Anorexia nervosa Tourette syndrome 0.321 124 1.56e-162 3.59e-160 ✓ sig.
Anorexia nervosa Eating disorder 0.153 43 2.41e-59 1.54e-57 ✓ sig.
Psychiatric disorders Tourette syndrome 0.065 29 4.82e-18 8.79e-17 ✓ sig.
Anorexia nervosa Psychiatric disorders 0.063 28 2.31e-17 4.05e-16 ✓ sig.
Obsessive-compulsive disorder Psychiatric disorders 0.063 27 3.75e-17 6.52e-16 ✓ sig.
Anorexia nervosa Generalized anxiety disorder 0.039 11 2.64e-11 2.95e-10 ✓ sig.
Eating disorder Generalized anxiety disorder 0.046 5 1.12e-6 6.94e-6 ✓ sig.
Eating disorder Vascular dementia 0.036 7 2.19e-6 1.28e-5 ✓ sig.
Congenital thrombotic disease Generalized anxiety disorder 0.024 1 2.60e-3 3.50e-3 ✓ sig.
Generalized anxiety disorder Tolchin-le caignec syndrome 0.024 1 2.60e-3 3.50e-3 ✓ sig.
Charcot-Marie-Tooth disease, axonal, type 2FF Eating disorder 0.014 1 4.68e-3 5.78e-3 ✓ sig.
cardiomyopathy, dilated, 2f Psychiatric disorders 0.005 1 1.42e-2 1.58e-2 ✓ sig.
neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities Obsessive-compulsive disorder 0.004 1 1.52e-2 1.68e-2 ✓ sig.
cardiomyopathy, dilated, 2f Obsessive-compulsive disorder 0.004 1 1.52e-2 1.68e-2 ✓ sig.
Anorexia nervosa neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities 0.004 1 1.63e-2 1.79e-2 ✓ sig.
Anorexia nervosa cardiomyopathy, dilated, 2f 0.004 1 1.63e-2 1.79e-2 ✓ sig.
Early-onset distal myopathy Tourette syndrome 0.004 1 1.68e-2 1.84e-2 ✓ sig.
neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities Tourette syndrome 0.004 1 1.68e-2 1.84e-2 ✓ sig.
cardiomyopathy, dilated, 2f Tourette syndrome 0.004 1 1.68e-2 1.84e-2 ✓ sig.