Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	22854
Gene name	Netrin G1
Gene symbol	NTNG1
Synonyms (NCBI Gene)	Lmnt1NetG1NetrinG1
Chromosome	1
Chromosome location	1p13.3
Summary	This gene encodes a preproprotein that is processed into a secreted protein containing eukaroytic growth factor (EGF)-like domains. This protein acts to guide axon growth during neuronal development. Polymorphisms in this gene may be associated with schiz

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miRTarBase ID	miRNA	Experiments	Reference
MIRT029912	hsa-miR-26b-5p	Microarray	19088304
MIRT1196182	hsa-miR-583	CLIP-seq
MIRT1196183	hsa-miR-22	CLIP-seq
MIRT1196184	hsa-miR-3135b	CLIP-seq
MIRT1196185	hsa-miR-338-5p	CLIP-seq
MIRT1196186	hsa-miR-3652	CLIP-seq
MIRT1196187	hsa-miR-3689d	CLIP-seq
MIRT1196188	hsa-miR-421	CLIP-seq
MIRT1196189	hsa-miR-4430	CLIP-seq
MIRT1196190	hsa-miR-4474-3p	CLIP-seq
MIRT1196191	hsa-miR-4505	CLIP-seq
MIRT1196192	hsa-miR-4709-5p	CLIP-seq
MIRT1196193	hsa-miR-511	CLIP-seq
MIRT1196194	hsa-miR-644	CLIP-seq
MIRT1196195	hsa-miR-889	CLIP-seq
MIRT2056947	hsa-miR-3127-5p	CLIP-seq
MIRT2056948	hsa-miR-3202	CLIP-seq
MIRT2056949	hsa-miR-4533	CLIP-seq
MIRT2686662	hsa-miR-133a	CLIP-seq
MIRT2686663	hsa-miR-133b	CLIP-seq
MIRT2686664	hsa-miR-3163	CLIP-seq
MIRT2686665	hsa-miR-3662	CLIP-seq
MIRT2686666	hsa-miR-4486	CLIP-seq
MIRT1196182	hsa-miR-583	CLIP-seq
MIRT2686667	hsa-miR-603	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	14595443, 21946559, 33961781
GO:0005576	Component	Extracellular region	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0007399	Process	Nervous system development	IEA
GO:0007409	Process	Axonogenesis	IEA
GO:0007409	Process	Axonogenesis	ISS
GO:0010975	Process	Regulation of neuron projection development	IEA
GO:0010975	Process	Regulation of neuron projection development	ISS
GO:0016020	Component	Membrane	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0048787	Component	Presynaptic active zone membrane	IEA
GO:0050804	Process	Modulation of chemical synaptic transmission	IEA
GO:0050839	Function	Cell adhesion molecule binding	IPI	23986473
GO:0098552	Component	Side of membrane	IEA
GO:0098632	Function	Cell-cell adhesion mediator activity	IGI	23986473
GO:0098685	Component	Schaffer collateral - CA1 synapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099560	Process	Synaptic membrane adhesion	IEA
GO:0099560	Process	Synaptic membrane adhesion	IGI	23986473
GO:0150011	Process	Regulation of neuron projection arborization	IEA
GO:0150011	Process	Regulation of neuron projection arborization	ISS
GO:2001222	Process	Regulation of neuron migration	IEA
GO:2001222	Process	Regulation of neuron migration	ISS

MIM	HGNC	e!Ensembl
608818	23319	ENSG00000162631

Q9Y2I2

Protein name

Netrin-G1 (Laminet-1)

Protein function

Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.

PDB

3ZYJ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00053	Laminin_EGF	297 → 343	Laminin EGF domain	Domain
PF00053	Laminin_EGF	420 → 467	Laminin EGF domain	Domain
PF00053	Laminin_EGF	364 → 417	Laminin EGF domain	Domain
PF00055	Laminin_N	50 → 295	Laminin N-terminal (Domain VI)	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in the thalamus, with very low expression, if any, in other tissues. {ECO:0000269|PubMed:14595443, ECO:0000269|PubMed:15901489}.

Sequence

MYLSRFLSIHALWVTVSSVMQPYPLVWGHYDLCKTQIYTEEGKVWDYMACQPESTDMTKY
LKVKLDPPDITCGDPPETFCAMGNPYMCNNECDASTPELAHPPELMFDFEGRHPSTFWQS
ATWKEYPKPLQVNITLSWSKTIELTDNIVITFESGRPDQMILEKSLDYGRTWQPYQYYAT
DCLDAFHMDPKSVKDLSQHTVLEIICTEEYSTGYTTNSKIIHFEIKDRFAFFAGPRLRNM
ASLYGQLDTTKKLRDFFTVTDLRIRLLRPAVGEIFVDELHLARYFYAISDIKVRGRCKCN
LHATVCVYDNSKLTCECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANTCIPSISS
IGNCECFGHSNRCSYIDLLNTVICVSCKHNTRGQHCELCRLGYFRNASAQLDDENVCIEC
YCNPLGSIHDRCNGSGFCECKTGTTGPKCDECLPGNSWHYGCQPNVCDNELLHCQNGGTC
HNNVRCLCPAAYTGILCEKLRCEEAGSCGSDSGQGAPPHGSPALLLLTTLLGTASPLVF

Sequence length

539

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Axon guidance	Post-translational modification: synthesis of GPI-anchored proteins
Cell adhesion molecules

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal. Show/Hide Unknown Diseases (18)
ANOREXIA NERVOSA	—	GWAS catalog	21079607	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATYPICAL RETT SYNDROME	—	GWAS catalog, Orphanet GWAS catalog, Orphanet	17903671, 17903671	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	CTD, Disgenet CTD, Disgenet	17507910	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR I DISORDER, MOST RECENT EPISODE MANIC	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL NEOPLASMS	—	CTD	21278247	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
complex neurodevelopmental disorder	—	ClinGen	22495309, 25411505, 27345935, 28191889, 31692205, 32348754, 33057194, ClinGen report	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEPRESSION, BIPOLAR	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EATING DISORDER	—	GWAS catalog	21079607	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	39349817	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIXED BIPOLAR I DISORDER	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MUCOCUTANEOUS LYMPH NODE SYNDROME	—	GWAS catalog	33772158	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SPECIFIC SYNDROMIC INTELLECTUAL DISABILITY	—	Disgenet, Orphanet Disgenet, Orphanet	31668703	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NTNG1-related disorder	Likely benign; Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	39024449	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEONECROSIS	—	GWAS catalog	34390503	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RETT SYNDROME, ATYPICAL	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	CTD, Disgenet CTD, Disgenet	17507910	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	38374256, 39349817	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

NTNG1 (netrin G1)

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