Congenital neurologic anomalies

Nucleocytoplasmic transport ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events +24 more

ABC transporters Peroxisome ABC transporters in lipid homeostasis Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Beta-oxidation of very long chain fatty acids Defective ABCD1 causes adrenoleukodystrophy (ALD) Class I peroxisomal membrane protein import +5 more

ATP-dependent chromatin remodeling Rap1 signaling pathway Phagosome Apoptosis Hippo signaling pathway Focal adhesion Adherens junction Tight junction Platelet activation Neutrophil extracellular trap formation Leukocyte transendothelial migration Thermogenesis Regulation of actin cytoskeleton Motor proteins Cytoskeleton in muscle cells Thyroid hormone signaling pathway Oxytocin signaling pathway Gastric acid secretion Amyotrophic lateral sclerosis Bacterial invasion of epithelial cells Vibrio cholerae infection Pathogenic Escherichia coli infection Shigellosis Salmonella infection Yersinia infection Influenza A Proteoglycans in cancer Hepatocellular carcinoma Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Viral myocarditis Fluid shear stress and atherosclerosis Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Cell-extracellular matrix interactions B-WICH complex positively regulates rRNA expression RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins MAP2K and MAPK activation UCH proteinases DNA Damage Recognition in GG-NER Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis Signaling downstream of RAS mutants FCGR3A-mediated phagocytosis +54 more

ATP-dependent chromatin remodeling Rap1 signaling pathway Phagosome Apoptosis Hippo signaling pathway Focal adhesion Adherens junction Tight junction Platelet activation Neutrophil extracellular trap formation Leukocyte transendothelial migration Thermogenesis Regulation of actin cytoskeleton Motor proteins Cytoskeleton in muscle cells Thyroid hormone signaling pathway Oxytocin signaling pathway Gastric acid secretion Amyotrophic lateral sclerosis Bacterial invasion of epithelial cells Vibrio cholerae infection Pathogenic Escherichia coli infection Shigellosis Salmonella infection Yersinia infection Influenza A Proteoglycans in cancer Hepatocellular carcinoma Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Viral myocarditis Fluid shear stress and atherosclerosis Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Cell-extracellular matrix interactions RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis Signaling downstream of RAS mutants FCGR3A-mediated phagocytosis +51 more

Arginine and proline metabolism Metabolic pathways Biosynthesis of amino acids Glutamate and glutamine metabolism +1 more

Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Fatty acid degradation Glycine, serine and threonine metabolism Valine, leucine and isoleucine degradation Lysine degradation Arginine and proline metabolism Histidine metabolism Tryptophan metabolism beta-Alanine metabolism Glycerolipid metabolism Pyruvate metabolism One carbon pool by folate Metabolic pathways Alcoholic liver disease Choline catabolism Lysine catabolism +14 more

Purine metabolism Metabolic pathways Nucleotide metabolism Cytoskeleton in muscle cells Purine salvage +2 more

Cytoskeleton in muscle cells Proteoglycans in cancer Interaction between L1 and Ankyrins COPI-mediated anterograde transport +1 more

Lysosome Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis

Lysosome Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis

Lysosome Lysosome Vesicle Biogenesis

Sphingolipid metabolism Metabolic pathways Lysosome Glycosphingolipid metabolism The activation of arylsulfatases Neutrophil degranulation +3 more

Cholesterol biosynthesis

Sphingolipid metabolism Metabolic pathways Sphingolipid signaling pathway Lysosome Glycosphingolipid metabolism Neutrophil degranulation +3 more

Cell cycle

BBSome-mediated cargo-targeting to cilium

MAPK signaling pathway Calcium signaling pathway Synaptic vesicle cycle Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Long-term depression Taste transduction Type II diabetes mellitus Spinocerebellar ataxia Morphine addiction Nicotine addiction Chemical carcinogenesis - receptor activation Presynaptic depolarization and calcium channel opening Regulation of insulin secretion +15 more

ErbB signaling pathway Calcium signaling pathway cAMP signaling pathway HIF-1 signaling pathway Oocyte meiosis Efferocytosis Necroptosis Adrenergic signaling in cardiomyocytes Wnt signaling pathway Axon guidance Circadian entrainment Long-term potentiation Neurotrophin signaling pathway Cholinergic synapse Dopaminergic synapse Olfactory transduction Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Melanogenesis Oxytocin signaling pathway Glucagon signaling pathway Aldosterone synthesis and secretion Cushing syndrome Gastric acid secretion Parkinson disease Pathways of neurodegeneration - multiple diseases Amphetamine addiction Tuberculosis Pathways in cancer Proteoglycans in cancer Glioma Diabetic cardiomyopathy Lipid and atherosclerosis HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Ion transport by P-type ATPases Signaling downstream of RAS mutants +44 more

Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins

Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Neutrophil degranulation AURKA Activation by TPX2 +5 more

Fatty acid degradation Fatty acid metabolism PPAR signaling pathway Thermogenesis Diabetic cardiomyopathy PPARA activates gene expression Carnitine metabolism +4 more

Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway HIF-1 signaling pathway FoxO signaling pathway Cell cycle Wnt signaling pathway Notch signaling pathway TGF-beta signaling pathway Adherens junction JAK-STAT signaling pathway Long-term potentiation Melanogenesis Thyroid hormone signaling pathway Glucagon signaling pathway Growth hormone synthesis, secretion and action Huntington disease Tuberculosis Hepatitis B Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Viral carcinogenesis MicroRNAs in cancer Renal cell carcinoma Prostate cancer Regulation of gene expression by Hypoxia-inducible Factor RORA activates gene expression Pre-NOTCH Transcription and Translation PPARA activates gene expression Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Attenuation phase Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock CD209 (DC-SIGN) signaling TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Activation of the TFAP2 (AP-2) family of transcription factors RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Regulation of FOXO transcriptional activity by acetylation +52 more

Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway Focal adhesion Adherens junction Signaling pathways regulating pluripotency of stem cells Leukocyte transendothelial migration Melanogenesis Thyroid hormone signaling pathway Cushing syndrome Alcoholic liver disease Alzheimer disease Pathways of neurodegeneration - multiple diseases Bacterial invasion of epithelial cells Salmonella infection Hepatitis C Human cytomegalovirus infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Proteoglycans in cancer Colorectal cancer Endometrial cancer Prostate cancer Thyroid cancer Basal cell carcinoma Breast cancer Hepatocellular carcinoma Gastric cancer Arrhythmogenic right ventricular cardiomyopathy Fluid shear stress and atherosclerosis Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Formation of the beta-catenin:TCF transactivating complex LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Apoptotic cleavage of cell adhesion proteins Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Adherens junctions interactions Binding of TCF/LEF:CTNNB1 to target gene promoters Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability Myogenesis Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated RHO GTPases activate IQGAPs Transcriptional Regulation by VENTX InlA-mediated entry of Listeria monocytogenes into host cells RUNX3 regulates WNT signaling +51 more

Fatty acid degradation Arachidonic acid metabolism Metabolic pathways Miscellaneous substrates Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) +3 more

Cysteine and methionine metabolism Metabolic pathways Efferocytosis MicroRNAs in cancer PRC2 methylates histones and DNA RMTs methylate histone arginines +3 more

Phagosome Motor proteins Vasopressin-regulated water reabsorption Salmonella infection Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy EML4 and NUDC in mitotic spindle formation +21 more

Herpes simplex virus 1 infection Recycling of eIF2:GDP

Glycogen synthesis Myoclonic epilepsy of Lafora

Nucleotide excision repair Ubiquitin mediated proteolysis Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation +4 more

ABC-family proteins mediated transport Signaling by FGFR1 in disease Defective CFTR causes cystic fibrosis Signaling by plasma membrane FGFR1 fusions +1 more

Sulfur metabolism Metabolic pathways Sulfide oxidation to sulfate

RNA degradation ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol +4 more

Regulation of actin cytoskeleton NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events +1 more

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway Endocytosis PI3K-Akt signaling pathway Signaling pathways regulating pluripotency of stem cells Regulation of actin cytoskeleton Pathways in cancer MicroRNAs in cancer Bladder cancer Central carbon metabolism in cancer PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR3 FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR3 mutant receptor activation t(4;14) translocations of FGFR3 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR3 SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 Negative regulation of FGFR3 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer +27 more

FoxO signaling pathway FOXO-mediated transcription of cell cycle genes

Other glycan degradation Lysosome Neutrophil degranulation Reactions specific to the complex N-glycan synthesis pathway +1 more

Sphingolipid metabolism Metabolic pathways Lysosome Glycosphingolipid metabolism +1 more

Glycine, serine and threonine metabolism Arginine and proline metabolism Metabolic pathways Creatine metabolism +1 more

Gap junction assembly

Rap1 signaling pathway Hormone signaling Circadian entrainment Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Long-term depression Estrogen signaling pathway Melanogenesis Oxytocin signaling pathway Relaxin signaling pathway Morphine addiction Alcoholism Chagas disease Toxoplasmosis Human cytomegalovirus infection Human immunodeficiency virus 1 infection PLC beta mediated events G-protein activation Ca2+ pathway Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding +21 more