PPP1R16B (protein phosphatase 1 regulatory subunit 16B)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 26051 |
| Gene name | Protein phosphatase 1 regulatory subunit 16B |
| Gene symbol | PPP1R16B |
| Synonyms (NCBI Gene) |
ANKRD4TIMAP
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| Chromosome | 20 |
| Chromosome location | 20q11.23 |
| Summary | The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q96T49 | |||||||||||||||
| Protein name | Protein phosphatase 1 regulatory inhibitor subunit 16B (Ankyrin repeat domain-containing protein 4) (CAAX box protein TIMAP) (TGF-beta-inhibited membrane-associated protein) (hTIMAP) | |||||||||||||||
| Protein function | Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function (PubMed:18586956). Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell pro | |||||||||||||||
| Family and domains |
Pfam
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| Sequence |
MASHVDLLTELQLLEKVPTLERLRAAQKRRAQQLKKWAQYEQDLQHRKRKHERKRSTGGR |
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| Sequence length | 567 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with PPP1R16B across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to PPP1R16B (see Related Genes above), that are NOT already directly curated for PPP1R16B itself -- a lead worth checking, not a confirmed association.
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