MYO18A (myosin XVIIIA)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 399687
• Gene name: Myosin XVIIIA
• Gene symbol: MYO18A
• Synonyms (NCBI Gene): MAJN, MYSPDZ, SP-R210, SPR210, TIAF1
• Chromosome: 17
• Chromosome location: 17q11.2
• Summary: The protein encoded by this gene can bind GOLPH3, linking the Golgi to the cytoskeleton and influencing Golgi membrane trafficking. The encoded protein is also part of a complex that assembles lamellar actomyosin bundles and may be required for cell migra

miRNA Show/Hide all (260)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018699	hsa-miR-335-5p	Microarray	18185580
MIRT023968	hsa-miR-1-3p	Proteomics	18668040
MIRT041599	hsa-miR-193b-3p	CLASH	23622248
MIRT667320	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT667319	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT667318	hsa-miR-378j	HITS-CLIP	23824327
MIRT667316	hsa-miR-6839-5p	HITS-CLIP	23824327
MIRT667317	hsa-miR-1299	HITS-CLIP	23824327
MIRT667315	hsa-miR-516b-5p	HITS-CLIP	23824327
MIRT667314	hsa-miR-4782-5p	HITS-CLIP	23824327
MIRT667313	hsa-miR-5706	HITS-CLIP	23824327
MIRT667312	hsa-miR-1269a	HITS-CLIP	23824327
MIRT667311	hsa-miR-1269b	HITS-CLIP	23824327
MIRT667310	hsa-miR-5009-5p	HITS-CLIP	23824327
MIRT667308	hsa-miR-8058	HITS-CLIP	23824327
MIRT667309	hsa-miR-4520-2-3p	HITS-CLIP	23824327
MIRT667307	hsa-miR-4529-3p	HITS-CLIP	23824327
MIRT667305	hsa-miR-7850-5p	HITS-CLIP	23824327
MIRT667306	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT667320	hsa-miR-204-5p	PAR-CLIP	26701625
MIRT667320	hsa-miR-204-5p	PAR-CLIP	26701625
MIRT667320	hsa-miR-204-5p	PAR-CLIP	26701625
MIRT667320	hsa-miR-204-5p	PAR-CLIP	26701625
MIRT667320	hsa-miR-204-5p	PAR-CLIP	26701625
MIRT667320	hsa-miR-204-5p	PAR-CLIP	26701625
MIRT667320	hsa-miR-204-5p	PAR-CLIP	26701625
MIRT667320	hsa-miR-204-5p	PAR-CLIP	26701625
MIRT667320	hsa-miR-204-5p	PAR-CLIP	26701625
MIRT667320	hsa-miR-204-5p	PAR-CLIP	26701625
MIRT667320	hsa-miR-204-5p	PAR-CLIP	26701625
MIRT667320	hsa-miR-204-5p	PAR-CLIP	26701625
MIRT667320	hsa-miR-204-5p	PAR-CLIP	26701625
MIRT667320	hsa-miR-204-5p	PAR-CLIP	26701625
MIRT667320	hsa-miR-204-5p	PAR-CLIP	26701625
MIRT667320	hsa-miR-204-5p	PAR-CLIP	26701625
MIRT667320	hsa-miR-204-5p	PAR-CLIP	26701625
MIRT667320	hsa-miR-204-5p	PAR-CLIP	26701625
MIRT667320	hsa-miR-204-5p	PAR-CLIP	26701625
MIRT667320	hsa-miR-204-5p	PAR-CLIP	26701625
MIRT667320	hsa-miR-204-5p	PAR-CLIP	26701625
MIRT667320	hsa-miR-204-5p	PAR-CLIP	26701625
MIRT667319	hsa-miR-211-5p	PAR-CLIP	26701625
MIRT667319	hsa-miR-211-5p	PAR-CLIP	26701625
MIRT667319	hsa-miR-211-5p	PAR-CLIP	26701625
MIRT667319	hsa-miR-211-5p	PAR-CLIP	26701625
MIRT667319	hsa-miR-211-5p	PAR-CLIP	26701625
MIRT667319	hsa-miR-211-5p	PAR-CLIP	26701625
MIRT667319	hsa-miR-211-5p	PAR-CLIP	26701625
MIRT667319	hsa-miR-211-5p	PAR-CLIP	26701625
MIRT667319	hsa-miR-211-5p	PAR-CLIP	26701625
MIRT667319	hsa-miR-211-5p	PAR-CLIP	26701625
MIRT667319	hsa-miR-211-5p	PAR-CLIP	26701625
MIRT667319	hsa-miR-211-5p	PAR-CLIP	26701625
MIRT667319	hsa-miR-211-5p	PAR-CLIP	26701625
MIRT667319	hsa-miR-211-5p	PAR-CLIP	26701625
MIRT667319	hsa-miR-211-5p	PAR-CLIP	26701625
MIRT667319	hsa-miR-211-5p	PAR-CLIP	26701625
MIRT667319	hsa-miR-211-5p	PAR-CLIP	26701625
MIRT667319	hsa-miR-211-5p	PAR-CLIP	26701625
MIRT667319	hsa-miR-211-5p	PAR-CLIP	26701625
MIRT667319	hsa-miR-211-5p	PAR-CLIP	26701625
MIRT667319	hsa-miR-211-5p	PAR-CLIP	26701625
MIRT667319	hsa-miR-211-5p	PAR-CLIP	26701625
MIRT667320	hsa-miR-204-5p	PAR-CLIP	27292025
MIRT667320	hsa-miR-204-5p	PAR-CLIP	27292025
MIRT667319	hsa-miR-211-5p	PAR-CLIP	27292025
MIRT667319	hsa-miR-211-5p	PAR-CLIP	27292025
MIRT667320	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT667319	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT667318	hsa-miR-378j	HITS-CLIP	23824327
MIRT667316	hsa-miR-6839-5p	HITS-CLIP	23824327
MIRT667317	hsa-miR-1299	HITS-CLIP	23824327
MIRT667315	hsa-miR-516b-5p	HITS-CLIP	23824327
MIRT667314	hsa-miR-4782-5p	HITS-CLIP	23824327
MIRT667313	hsa-miR-5706	HITS-CLIP	23824327
MIRT667312	hsa-miR-1269a	HITS-CLIP	23824327
MIRT667311	hsa-miR-1269b	HITS-CLIP	23824327
MIRT667310	hsa-miR-5009-5p	HITS-CLIP	23824327
MIRT667308	hsa-miR-8058	HITS-CLIP	23824327
MIRT667309	hsa-miR-4520-2-3p	HITS-CLIP	23824327
MIRT667307	hsa-miR-4529-3p	HITS-CLIP	23824327
MIRT667305	hsa-miR-7850-5p	HITS-CLIP	23824327
MIRT667306	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT1169224	hsa-miR-1225-3p	CLIP-seq
MIRT1169225	hsa-miR-1231	CLIP-seq
MIRT1169226	hsa-miR-1266	CLIP-seq
MIRT1169227	hsa-miR-147	CLIP-seq
MIRT1169228	hsa-miR-2909	CLIP-seq
MIRT1169229	hsa-miR-3151	CLIP-seq
MIRT1169230	hsa-miR-3192	CLIP-seq
MIRT1169231	hsa-miR-3664-3p	CLIP-seq
MIRT1169232	hsa-miR-3911	CLIP-seq
MIRT1169233	hsa-miR-3943	CLIP-seq
MIRT1169234	hsa-miR-4270	CLIP-seq
MIRT1169235	hsa-miR-4314	CLIP-seq
MIRT1169236	hsa-miR-4441	CLIP-seq
MIRT1169237	hsa-miR-4447	CLIP-seq
MIRT1169238	hsa-miR-4472	CLIP-seq
MIRT1169239	hsa-miR-4488	CLIP-seq
MIRT1169240	hsa-miR-4492	CLIP-seq
MIRT1169241	hsa-miR-4498	CLIP-seq
MIRT1169242	hsa-miR-4505	CLIP-seq
MIRT1169243	hsa-miR-4518	CLIP-seq
MIRT1169244	hsa-miR-4646-5p	CLIP-seq
MIRT1169245	hsa-miR-4694-5p	CLIP-seq
MIRT1169246	hsa-miR-4697-5p	CLIP-seq
MIRT1169247	hsa-miR-4711-3p	CLIP-seq
MIRT1169248	hsa-miR-4717-3p	CLIP-seq
MIRT1169249	hsa-miR-491-5p	CLIP-seq
MIRT1169250	hsa-miR-592	CLIP-seq
MIRT1169251	hsa-miR-595	CLIP-seq
MIRT1169252	hsa-miR-599	CLIP-seq
MIRT1169253	hsa-miR-644	CLIP-seq
MIRT1169254	hsa-miR-762	CLIP-seq
MIRT2048722	hsa-miR-1224-3p	CLIP-seq
MIRT2048723	hsa-miR-1343	CLIP-seq
MIRT2048724	hsa-miR-214	CLIP-seq
MIRT2048725	hsa-miR-3124-3p	CLIP-seq
MIRT2048726	hsa-miR-3189-5p	CLIP-seq
MIRT1169230	hsa-miR-3192	CLIP-seq
MIRT2048727	hsa-miR-361-3p	CLIP-seq
MIRT2048728	hsa-miR-3619-5p	CLIP-seq
MIRT2048729	hsa-miR-3679-3p	CLIP-seq
MIRT1169234	hsa-miR-4270	CLIP-seq
MIRT2048730	hsa-miR-4274	CLIP-seq
MIRT2048731	hsa-miR-4291	CLIP-seq
MIRT2048732	hsa-miR-4300	CLIP-seq
MIRT1169236	hsa-miR-4441	CLIP-seq
MIRT1169237	hsa-miR-4447	CLIP-seq
MIRT1169238	hsa-miR-4472	CLIP-seq
MIRT2048733	hsa-miR-4645-5p	CLIP-seq
MIRT2048734	hsa-miR-4673	CLIP-seq
MIRT1169248	hsa-miR-4717-3p	CLIP-seq
MIRT2048735	hsa-miR-4758-3p	CLIP-seq
MIRT2048736	hsa-miR-635	CLIP-seq
MIRT2048737	hsa-miR-761	CLIP-seq
MIRT2048738	hsa-miR-920	CLIP-seq
MIRT2048739	hsa-miR-922	CLIP-seq
MIRT1169225	hsa-miR-1231	CLIP-seq
MIRT2048723	hsa-miR-1343	CLIP-seq
MIRT1169227	hsa-miR-147	CLIP-seq
MIRT1169229	hsa-miR-3151	CLIP-seq
MIRT1169230	hsa-miR-3192	CLIP-seq
MIRT1169232	hsa-miR-3911	CLIP-seq
MIRT1169234	hsa-miR-4270	CLIP-seq
MIRT1169235	hsa-miR-4314	CLIP-seq
MIRT1169236	hsa-miR-4441	CLIP-seq
MIRT1169237	hsa-miR-4447	CLIP-seq
MIRT1169238	hsa-miR-4472	CLIP-seq
MIRT1169239	hsa-miR-4488	CLIP-seq
MIRT1169244	hsa-miR-4646-5p	CLIP-seq
MIRT1169246	hsa-miR-4697-5p	CLIP-seq
MIRT1169247	hsa-miR-4711-3p	CLIP-seq
MIRT1169249	hsa-miR-491-5p	CLIP-seq
MIRT1169250	hsa-miR-592	CLIP-seq
MIRT1169251	hsa-miR-595	CLIP-seq
MIRT1169252	hsa-miR-599	CLIP-seq
MIRT1169253	hsa-miR-644	CLIP-seq
MIRT1169226	hsa-miR-1266	CLIP-seq
MIRT1169231	hsa-miR-3664-3p	CLIP-seq
MIRT1169243	hsa-miR-4518	CLIP-seq
MIRT2048736	hsa-miR-635	CLIP-seq
MIRT2048722	hsa-miR-1224-3p	CLIP-seq
MIRT1169224	hsa-miR-1225-3p	CLIP-seq
MIRT2576351	hsa-miR-1225-5p	CLIP-seq
MIRT2576352	hsa-miR-1236	CLIP-seq
MIRT2576353	hsa-miR-1256	CLIP-seq
MIRT1169226	hsa-miR-1266	CLIP-seq
MIRT2576354	hsa-miR-1275	CLIP-seq
MIRT2576355	hsa-miR-1301	CLIP-seq
MIRT2048723	hsa-miR-1343	CLIP-seq
MIRT2576356	hsa-miR-185	CLIP-seq
MIRT2576357	hsa-miR-2117	CLIP-seq
MIRT2048724	hsa-miR-214	CLIP-seq
MIRT2576358	hsa-miR-3128	CLIP-seq
MIRT2576359	hsa-miR-3132	CLIP-seq
MIRT2576360	hsa-miR-3134	CLIP-seq
MIRT2576361	hsa-miR-3156-3p	CLIP-seq
MIRT2576362	hsa-miR-3175	CLIP-seq
MIRT2576363	hsa-miR-3185	CLIP-seq
MIRT2048726	hsa-miR-3189-5p	CLIP-seq
MIRT1169230	hsa-miR-3192	CLIP-seq
MIRT2048728	hsa-miR-3619-5p	CLIP-seq
MIRT1169231	hsa-miR-3664-3p	CLIP-seq
MIRT2576364	hsa-miR-3672	CLIP-seq
MIRT2576365	hsa-miR-3913-3p	CLIP-seq
MIRT1169233	hsa-miR-3943	CLIP-seq
MIRT2576366	hsa-miR-3974	CLIP-seq
MIRT1169234	hsa-miR-4270	CLIP-seq
MIRT2048730	hsa-miR-4274	CLIP-seq
MIRT2048731	hsa-miR-4291	CLIP-seq
MIRT2048732	hsa-miR-4300	CLIP-seq
MIRT2576367	hsa-miR-4301	CLIP-seq
MIRT2576368	hsa-miR-4306	CLIP-seq
MIRT2576369	hsa-miR-4313	CLIP-seq
MIRT2576370	hsa-miR-4323	CLIP-seq
MIRT1169236	hsa-miR-4441	CLIP-seq
MIRT1169237	hsa-miR-4447	CLIP-seq
MIRT1169238	hsa-miR-4472	CLIP-seq
MIRT1169243	hsa-miR-4518	CLIP-seq
MIRT2576371	hsa-miR-4525	CLIP-seq
MIRT2576372	hsa-miR-4534	CLIP-seq
MIRT2576373	hsa-miR-4639-3p	CLIP-seq
MIRT2576374	hsa-miR-4644	CLIP-seq
MIRT2048733	hsa-miR-4645-5p	CLIP-seq
MIRT2576375	hsa-miR-4650-3p	CLIP-seq
MIRT2576376	hsa-miR-4660	CLIP-seq
MIRT2576377	hsa-miR-4665-5p	CLIP-seq
MIRT2048734	hsa-miR-4673	CLIP-seq
MIRT2576378	hsa-miR-4679	CLIP-seq
MIRT2576379	hsa-miR-4691-3p	CLIP-seq
MIRT2576380	hsa-miR-4720-5p	CLIP-seq
MIRT2576381	hsa-miR-4723-5p	CLIP-seq
MIRT2576382	hsa-miR-4740-3p	CLIP-seq
MIRT2576383	hsa-miR-4753-3p	CLIP-seq
MIRT2048735	hsa-miR-4758-3p	CLIP-seq
MIRT2576384	hsa-miR-4786-3p	CLIP-seq
MIRT2576385	hsa-miR-4799-3p	CLIP-seq
MIRT2576386	hsa-miR-493	CLIP-seq
MIRT2576387	hsa-miR-5047	CLIP-seq
MIRT2576388	hsa-miR-532-3p	CLIP-seq
MIRT2576389	hsa-miR-548p	CLIP-seq
MIRT2576390	hsa-miR-609	CLIP-seq
MIRT2576391	hsa-miR-625	CLIP-seq
MIRT2048736	hsa-miR-635	CLIP-seq
MIRT2576392	hsa-miR-642b	CLIP-seq
MIRT2048737	hsa-miR-761	CLIP-seq
MIRT2048738	hsa-miR-920	CLIP-seq
MIRT2048739	hsa-miR-922	CLIP-seq
MIRT2576353	hsa-miR-1256	CLIP-seq
MIRT2576354	hsa-miR-1275	CLIP-seq
MIRT2048723	hsa-miR-1343	CLIP-seq
MIRT2048724	hsa-miR-214	CLIP-seq
MIRT2576358	hsa-miR-3128	CLIP-seq
MIRT2576359	hsa-miR-3132	CLIP-seq
MIRT2576362	hsa-miR-3175	CLIP-seq
MIRT2576363	hsa-miR-3185	CLIP-seq
MIRT2048726	hsa-miR-3189-5p	CLIP-seq
MIRT1169230	hsa-miR-3192	CLIP-seq
MIRT2048728	hsa-miR-3619-5p	CLIP-seq
MIRT2576364	hsa-miR-3672	CLIP-seq
MIRT2576366	hsa-miR-3974	CLIP-seq
MIRT2048730	hsa-miR-4274	CLIP-seq
MIRT2048731	hsa-miR-4291	CLIP-seq
MIRT1169237	hsa-miR-4447	CLIP-seq
MIRT1169238	hsa-miR-4472	CLIP-seq
MIRT2576371	hsa-miR-4525	CLIP-seq
MIRT2576375	hsa-miR-4650-3p	CLIP-seq
MIRT2576377	hsa-miR-4665-5p	CLIP-seq
MIRT2576380	hsa-miR-4720-5p	CLIP-seq
MIRT2576381	hsa-miR-4723-5p	CLIP-seq
MIRT2048735	hsa-miR-4758-3p	CLIP-seq
MIRT2576384	hsa-miR-4786-3p	CLIP-seq
MIRT2576385	hsa-miR-4799-3p	CLIP-seq
MIRT2576386	hsa-miR-493	CLIP-seq
MIRT2576390	hsa-miR-609	CLIP-seq
MIRT2576391	hsa-miR-625	CLIP-seq
MIRT2576392	hsa-miR-642b	CLIP-seq
MIRT2048737	hsa-miR-761	CLIP-seq
MIRT2048739	hsa-miR-922	CLIP-seq

Gene ontology (GO) Show/Hide all (46)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005515	Function	Protein binding	IPI	19837035, 21368882, 24485452, 25965346, 32296183, 32814053
GO:0005524	Function	ATP binding	IDA	23990465
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005793	Component	Endoplasmic reticulum-Golgi intermediate compartment	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005802	Component	Trans-Golgi network	IDA	19837035
GO:0005815	Component	Microtubule organizing center	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0006259	Process	DNA metabolic process	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0007030	Process	Golgi organization	IMP	19837035
GO:0007249	Process	Canonical NF-kappaB signal transduction	IDA
GO:0008094	Function	ATP-dependent activity, acting on DNA	IEA
GO:0009986	Component	Cell surface	IEA
GO:0015629	Component	Actin cytoskeleton	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016459	Component	Myosin complex	IEA
GO:0016460	Component	Myosin II complex	IBA
GO:0016477	Process	Cell migration	IMP	18854160
GO:0016887	Function	ATP hydrolysis activity	IDA	23990465
GO:0031032	Process	Actomyosin structure organization	IBA
GO:0031032	Process	Actomyosin structure organization	IMP	18854160
GO:0032982	Component	Myosin filament	IBA
GO:0042641	Component	Actomyosin	IDA	18854160
GO:0043030	Process	Regulation of macrophage activation	IEA
GO:0043030	Process	Regulation of macrophage activation	IMP	25965346
GO:0043066	Process	Negative regulation of apoptotic process	IDA
GO:0043066	Process	Negative regulation of apoptotic process	IMP	24485452
GO:0043066	Process	Negative regulation of apoptotic process	TAS
GO:0043531	Function	ADP binding	IDA	23990465
GO:0048194	Process	Golgi vesicle budding	IMP	19837035
GO:0050714	Process	Positive regulation of protein secretion	IMP	23345592
GO:0051015	Function	Actin filament binding	IBA
GO:0051015	Function	Actin filament binding	IDA	23990465
GO:0090161	Process	Golgi ribbon formation	IMP	19837035
GO:0090164	Process	Asymmetric Golgi ribbon formation	IMP	19837035
GO:1903028	Process	Positive regulation of opsonization	IEA
GO:1903028	Process	Positive regulation of opsonization	IMP	21123169

Other IDs

• MIM: 609517
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q92614
• Protein name: Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210)
• Protein function: May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi appa
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00063	Myosin_head	407 → 1062	Myosin head (motor domain)	Domain
  PF00063	Myosin_head	1081 → 1173	Myosin head (motor domain)	Domain
  PF01576	Myosin_tail_1	1204 → 1684	Myosin tail	Coiled-coil
  PF17820	PDZ_6	266 → 309	PDZ domain	Domain

• Sequence:

  MFNLMKKDKDKDGGRKEKKEKKEKKERMSAAELRSLEEMSLRRGFFNLNRSSKRESKTRL
  EISNPIPIKVASGSDLHLTDIDSDSNRGSVILDSGHLSTASSSDDLKGEEGSFRGSVLQR
  AAKFGSLAKQNSQMIVKRFSFSQRSRDESASETSTPSEHSAAPSPQVEVRTLEGQLVQHP
  GPGIPRPGHRSRAPELVTKKFPVDLRLPPVVPLPPPTLRELELQRRPTGDFGFSLRRTTM
  LDRGPEGQACRRVVHFAEPGAGTKDLALGLVPGDRLVEINGHNVESKSRDEIVEMIRQSG
  DSVRLKVQPIPELSELSRSWLRSGEGPRREPSDAKTEEQIAAEEAWNETEKVWLVHRDGF
  SLASQLKSEELNLPEGKVRVKLDHDGAILDVDEDDVEKANAPSCDRLEDLASLVYLNESS
  VLHTLRQRYGASLLHTYAGPSLLVLGPRGAPAVYSEKVMHMFKGCRREDMAPHIYAVAQT
  AYRAMLMSRQDQSIILLGSSGSGKTTSCQHLVQYLATIAGISGNKVFSVEKWQALYTLLE
  AFGNSPTIINGNATRFSQILSLDFDQAGQVASASIQTMLLEKLRVARRPASEATFNVFYY
  LLACGDGTLRTELHLNHLAENNVFGIVPLAKPEEKQKAAQQFSKLQAAMKVLGISPDEQK
  ACWFILAAIYHLGAAGATKEAAEAGRKQFARHEWAQKAAYLLGCSLEELSSAIFKHQHKG
  GTLQRSTSFRQGPEESGLGDGTGPKLSALECLEGMAAGLYSELFTLLVSLVNRALKSSQH
  SLCSMMIVDTPGFQNPEQGGSARGASFEELCHNYTQDRLQRLFHERTFVQELERYKEENI
  ELAFDDLEPPTDDSVAAVDQASHQSLVRSLARTDEARGLLWLLEEEALVPGASEDTLLER
  LFSYYGPQEGDKKGQSPLLHSSKPHHFLLGHSHGTNWVEYNVTGWLNYTKQNPATQNAPR
  LLQDSQKKIISNLFLGRAGSATVLSGSIAGLEGGSQLALRRATSMRKTFTTGMAAVKKKS
  LCIQMKLQVDALIDTIKKSKLHFVHCFLPVAEGWAGEPRSASSRRVSSSSELDLPSGDHC
  EAGLLQLDVPLLRTQLRGSRLLDAMRMYRQGYPDHMVFSEFRRRFDVLAPHLTKKHGRNY
  IVVDERRAVEELLECLDLEKSSCCMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQAACR
  GYLARQHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKD
  EEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERL
  RAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVR
  EVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQ
  DTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQ
  QLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDE
  QAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYE
  DKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAP
  SKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQRE
  KNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQAL
  QSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERD
  QRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQA
  DLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKRKNKLEGDSDVDSELEDRV
  DGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLAPDRSDDEHDPLDNTSRPRYSHSYL
  SDSDTEAKLTETNA

• Sequence length: 2054
• UniProt ID: O95411
• Protein name: Putative TGFB1-induced anti-apoptotic factor 1 (12 kDa TGF-beta-1-induced antiapoptotic factor)
• Protein function: [Isoform TIAF1]: Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation.
• Tissue specificity: TISSUE SPECIFICITY: Not detectable in normal kidney and liver. Up-regulated in chronic and acute allograft rejection: expressed in the inflammatory infiltrate and in tubular epithelial cells. {ECO:0000269|PubMed:12829915}.
• Sequence:

  MSSPSSPFREQSFLCAAGDAGEESRVQVLKNEVRRGSPVLLGWVEQAYADKCVCGPSAPP
  APTPPSLSQRVMCNDLFKVNPFQLQQFRADPSTASLLLCPGGLDHKLNLRGKAWG

• Sequence length: 115

Pathways

KEGG Pathway	Reactome Pathway
Motor proteins	Signaling by cytosolic FGFR1 fusion mutants
	Signaling by FGFR1 in disease

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (17)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Abnormal facial shape	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANOREXIA NERVOSA	—	GWAS catalog	31835028	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	31835028	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	31835028	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	31835028	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	38538606	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONTRACTURE OF MULTIPLE JOINTS	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hereditary hemochromatosis	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hydrops fetalis	Uncertain significance	ClinVar Disgenet	—	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	31835028	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Multiple joint contractures	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYO18A-related disorder	Uncertain significance; Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSESSIVE-COMPULSIVE DISORDER	—	GWAS catalog	31835028	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	31835028	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
sellar metastasis from primary bronchial carcinoid tumor	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TOURETTE SYNDROME	—	GWAS catalog	31835028	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (7)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinoma Intraductal Noninfiltrating	Intraductal noninfiltrating carcinoma	Pubtator	33237469	Associate	★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	34799729	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	22682626		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	22534828, 28213314, 31315632		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	22534828, 31315632		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	26670045	Associate	★☆☆☆☆ Found in Text Mining only
Spasms Infantile	Infantile spasms	Pubtator	29667327	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

C8orf90 3 shared diseasesAnorexia nervosa, Tourette syndrome, Obsessive-compulsive disorder 3 shared evidence sourcesGWAS catalog (Anorexia nervosa), GWAS catalog (Obsessive-compulsive disorder), GWAS catalog (Tourette syndrome) Related via 3 shared diseases including Anorexia nervosa, Tourette syndrome — evidence mostly GWAS catalog. DGKI 3 shared diseasesAnorexia nervosa, Tourette syndrome, Obsessive-compulsive disorder 3 shared evidence sourcesGWAS catalog (Anorexia nervosa), GWAS catalog (Obsessive-compulsive disorder), GWAS catalog (Tourette syndrome) Related via 3 shared diseases including Anorexia nervosa, Tourette syndrome — evidence mostly GWAS catalog. HSPE1-MOB4 3 shared diseasesAnorexia nervosa, Tourette syndrome, Obsessive-compulsive disorder 3 shared evidence sourcesGWAS catalog (Anorexia nervosa), GWAS catalog (Obsessive-compulsive disorder), GWAS catalog (Tourette syndrome) Related via 3 shared diseases including Anorexia nervosa, Tourette syndrome — evidence mostly GWAS catalog. MOB4 3 shared diseasesAnorexia nervosa, Tourette syndrome, Obsessive-compulsive disorder 3 shared evidence sourcesGWAS catalog (Anorexia nervosa), GWAS catalog (Obsessive-compulsive disorder), GWAS catalog (Tourette syndrome) Related via 3 shared diseases including Anorexia nervosa, Tourette syndrome — evidence mostly GWAS catalog. NAA40 3 shared diseasesAnorexia nervosa, Tourette syndrome, Obsessive-compulsive disorder 3 shared evidence sourcesGWAS catalog (Anorexia nervosa), GWAS catalog (Obsessive-compulsive disorder), GWAS catalog (Tourette syndrome) Related via 3 shared diseases including Anorexia nervosa, Tourette syndrome — evidence mostly GWAS catalog.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
C8orf90	3	["Anorexia nervosa","Tourette syndrome","Obsessive-compulsive disorder"]	0	[]	3	["GWAS catalog (Anorexia nervosa)","GWAS catalog (Obsessive-compulsive disorder)","GWAS catalog (Tourette syndrome)"]
DGKI	3	["Anorexia nervosa","Tourette syndrome","Obsessive-compulsive disorder"]	0	[]	3	["GWAS catalog (Anorexia nervosa)","GWAS catalog (Obsessive-compulsive disorder)","GWAS catalog (Tourette syndrome)"]
HSPE1-MOB4	3	["Anorexia nervosa","Tourette syndrome","Obsessive-compulsive disorder"]	0	[]	3	["GWAS catalog (Anorexia nervosa)","GWAS catalog (Obsessive-compulsive disorder)","GWAS catalog (Tourette syndrome)"]
MOB4	3	["Anorexia nervosa","Tourette syndrome","Obsessive-compulsive disorder"]	0	[]	3	["GWAS catalog (Anorexia nervosa)","GWAS catalog (Obsessive-compulsive disorder)","GWAS catalog (Tourette syndrome)"]
NAA40	3	["Anorexia nervosa","Tourette syndrome","Obsessive-compulsive disorder"]	0	[]	3	["GWAS catalog (Anorexia nervosa)","GWAS catalog (Obsessive-compulsive disorder)","GWAS catalog (Tourette syndrome)"]

Diseases Linked via Similar Genes

Insomnia Linked via 3 of 5 related genesDGKI, HSPE1-MOB4, MOB4 Alzheimer disease Linked via 2 of 5 related genesC8orf90, DGKI Metabolic syndrome Linked via 2 of 5 related genesC8orf90, DGKI Obesity Linked via 2 of 5 related genesC8orf90, DGKI Diabetes mellitus type 2 Linked via 2 of 5 related genesC8orf90, DGKI

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Insomnia	3	["DGKI","HSPE1-MOB4","MOB4"]
Alzheimer disease	2	["C8orf90","DGKI"]
Metabolic syndrome	2	["C8orf90","DGKI"]
Obesity	2	["C8orf90","DGKI"]
Diabetes mellitus type 2	2	["C8orf90","DGKI"]