FBXL17 (F-box and leucine rich repeat protein 17)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 64839
• Gene name: F-box and leucine rich repeat protein 17
• Gene symbol: FBXL17
• Synonyms (NCBI Gene): FBXO13, Fbl17, Fbx13
• Chromosome: 5
• Chromosome location: 5q21.3
• Summary: Members of the F-box protein family, such as FBXL17, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box pr

miRNA Show/Hide all (145)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030830	hsa-miR-21-5p	Microarray	18591254
MIRT715556	hsa-miR-330-3p	HITS-CLIP	19536157
MIRT715555	hsa-miR-548b-3p	HITS-CLIP	19536157
MIRT715554	hsa-miR-548p	HITS-CLIP	19536157
MIRT715553	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT715556	hsa-miR-330-3p	HITS-CLIP	19536157
MIRT715555	hsa-miR-548b-3p	HITS-CLIP	19536157
MIRT715554	hsa-miR-548p	HITS-CLIP	19536157
MIRT715553	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT715556	hsa-miR-330-3p	HITS-CLIP	19536157
MIRT715555	hsa-miR-548b-3p	HITS-CLIP	19536157
MIRT715554	hsa-miR-548p	HITS-CLIP	19536157
MIRT715553	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT715556	hsa-miR-330-3p	HITS-CLIP	19536157
MIRT715555	hsa-miR-548b-3p	HITS-CLIP	19536157
MIRT715554	hsa-miR-548p	HITS-CLIP	19536157
MIRT715553	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT715556	hsa-miR-330-3p	HITS-CLIP	19536157
MIRT715555	hsa-miR-548b-3p	HITS-CLIP	19536157
MIRT715554	hsa-miR-548p	HITS-CLIP	19536157
MIRT715553	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT990365	hsa-miR-1185	CLIP-seq
MIRT990366	hsa-miR-1227	CLIP-seq
MIRT990367	hsa-miR-1261	CLIP-seq
MIRT990368	hsa-miR-127-5p	CLIP-seq
MIRT990369	hsa-miR-128	CLIP-seq
MIRT990370	hsa-miR-141	CLIP-seq
MIRT990371	hsa-miR-154	CLIP-seq
MIRT990372	hsa-miR-194	CLIP-seq
MIRT990373	hsa-miR-200a	CLIP-seq
MIRT990374	hsa-miR-2682	CLIP-seq
MIRT990375	hsa-miR-28-3p	CLIP-seq
MIRT990376	hsa-miR-3064-3p	CLIP-seq
MIRT990377	hsa-miR-3128	CLIP-seq
MIRT990378	hsa-miR-3145-5p	CLIP-seq
MIRT990379	hsa-miR-320e	CLIP-seq
MIRT990380	hsa-miR-34a	CLIP-seq
MIRT990381	hsa-miR-34c-5p	CLIP-seq
MIRT990382	hsa-miR-3653	CLIP-seq
MIRT990383	hsa-miR-3677-5p	CLIP-seq
MIRT990384	hsa-miR-3679-5p	CLIP-seq
MIRT990385	hsa-miR-3681	CLIP-seq
MIRT990386	hsa-miR-3685	CLIP-seq
MIRT990387	hsa-miR-3691-3p	CLIP-seq
MIRT990388	hsa-miR-384	CLIP-seq
MIRT990389	hsa-miR-409-3p	CLIP-seq
MIRT990390	hsa-miR-4423-3p	CLIP-seq
MIRT990391	hsa-miR-4460	CLIP-seq
MIRT990392	hsa-miR-449a	CLIP-seq
MIRT990393	hsa-miR-449b	CLIP-seq
MIRT990394	hsa-miR-449c	CLIP-seq
MIRT990395	hsa-miR-450b-3p	CLIP-seq
MIRT990396	hsa-miR-4653-3p	CLIP-seq
MIRT990397	hsa-miR-4727-3p	CLIP-seq
MIRT990398	hsa-miR-489	CLIP-seq
MIRT990399	hsa-miR-494	CLIP-seq
MIRT990400	hsa-miR-500a	CLIP-seq
MIRT990401	hsa-miR-515-5p	CLIP-seq
MIRT990402	hsa-miR-548g	CLIP-seq
MIRT990403	hsa-miR-556-3p	CLIP-seq
MIRT990404	hsa-miR-602	CLIP-seq
MIRT990405	hsa-miR-769-3p	CLIP-seq
MIRT990406	hsa-miR-885-3p	CLIP-seq
MIRT990407	hsa-miR-940	CLIP-seq
MIRT1993607	hsa-miR-3121-3p	CLIP-seq
MIRT1993608	hsa-miR-3143	CLIP-seq
MIRT1993609	hsa-miR-3647-3p	CLIP-seq
MIRT1993610	hsa-miR-3941	CLIP-seq
MIRT1993611	hsa-miR-421	CLIP-seq
MIRT1993612	hsa-miR-4435	CLIP-seq
MIRT1993613	hsa-miR-466	CLIP-seq
MIRT1993614	hsa-miR-4672	CLIP-seq
MIRT1993615	hsa-miR-4718	CLIP-seq
MIRT1993616	hsa-miR-4719	CLIP-seq
MIRT1993617	hsa-miR-4731-3p	CLIP-seq
MIRT1993618	hsa-miR-4738-3p	CLIP-seq
MIRT1993619	hsa-miR-4801	CLIP-seq
MIRT1993620	hsa-miR-4803	CLIP-seq
MIRT1993621	hsa-miR-548aa	CLIP-seq
MIRT1993622	hsa-miR-590-3p	CLIP-seq
MIRT1993623	hsa-miR-600	CLIP-seq
MIRT990404	hsa-miR-602	CLIP-seq
MIRT2227357	hsa-miR-125a-3p	CLIP-seq
MIRT2227358	hsa-miR-1324	CLIP-seq
MIRT1993607	hsa-miR-3121-3p	CLIP-seq
MIRT2227359	hsa-miR-3148	CLIP-seq
MIRT2227360	hsa-miR-3194-3p	CLIP-seq
MIRT2227361	hsa-miR-4279	CLIP-seq
MIRT2227362	hsa-miR-4457	CLIP-seq
MIRT2227363	hsa-miR-4668-5p	CLIP-seq
MIRT2227364	hsa-miR-513b	CLIP-seq
MIRT2227365	hsa-miR-552	CLIP-seq
MIRT2227366	hsa-miR-607	CLIP-seq
MIRT2227367	hsa-miR-767-3p	CLIP-seq
MIRT2227368	hsa-miR-891b	CLIP-seq
MIRT2387910	hsa-miR-296-3p	CLIP-seq
MIRT2227362	hsa-miR-4457	CLIP-seq
MIRT2227364	hsa-miR-513b	CLIP-seq
MIRT2227368	hsa-miR-891b	CLIP-seq
MIRT2437224	hsa-miR-1267	CLIP-seq
MIRT2437225	hsa-miR-1270	CLIP-seq
MIRT2437226	hsa-miR-185	CLIP-seq
MIRT2437227	hsa-miR-200b	CLIP-seq
MIRT2437228	hsa-miR-200c	CLIP-seq
MIRT2437229	hsa-miR-30a	CLIP-seq
MIRT2437230	hsa-miR-30b	CLIP-seq
MIRT2437231	hsa-miR-30c	CLIP-seq
MIRT2437232	hsa-miR-30d	CLIP-seq
MIRT2437233	hsa-miR-30e	CLIP-seq
MIRT1993609	hsa-miR-3647-3p	CLIP-seq
MIRT2437234	hsa-miR-429	CLIP-seq
MIRT2437235	hsa-miR-4306	CLIP-seq
MIRT2437236	hsa-miR-452	CLIP-seq
MIRT2437237	hsa-miR-4531	CLIP-seq
MIRT2437238	hsa-miR-4644	CLIP-seq
MIRT2437239	hsa-miR-4676-3p	CLIP-seq
MIRT990398	hsa-miR-489	CLIP-seq
MIRT2437240	hsa-miR-620	CLIP-seq
MIRT2437224	hsa-miR-1267	CLIP-seq
MIRT2437225	hsa-miR-1270	CLIP-seq
MIRT2437226	hsa-miR-185	CLIP-seq
MIRT2437227	hsa-miR-200b	CLIP-seq
MIRT2437228	hsa-miR-200c	CLIP-seq
MIRT1993609	hsa-miR-3647-3p	CLIP-seq
MIRT2437234	hsa-miR-429	CLIP-seq
MIRT2437235	hsa-miR-4306	CLIP-seq
MIRT2437236	hsa-miR-452	CLIP-seq
MIRT2437237	hsa-miR-4531	CLIP-seq
MIRT2437238	hsa-miR-4644	CLIP-seq
MIRT2437239	hsa-miR-4676-3p	CLIP-seq
MIRT990398	hsa-miR-489	CLIP-seq
MIRT2437240	hsa-miR-620	CLIP-seq
MIRT990376	hsa-miR-3064-3p	CLIP-seq
MIRT990395	hsa-miR-450b-3p	CLIP-seq
MIRT990405	hsa-miR-769-3p	CLIP-seq
MIRT2531315	hsa-miR-149	CLIP-seq
MIRT2531316	hsa-miR-3064-5p	CLIP-seq
MIRT2531317	hsa-miR-3140-3p	CLIP-seq
MIRT2531318	hsa-miR-4687-3p	CLIP-seq
MIRT2531319	hsa-miR-4794	CLIP-seq
MIRT2531315	hsa-miR-149	CLIP-seq
MIRT2531316	hsa-miR-3064-5p	CLIP-seq
MIRT2531317	hsa-miR-3140-3p	CLIP-seq
MIRT2531318	hsa-miR-4687-3p	CLIP-seq
MIRT2531319	hsa-miR-4794	CLIP-seq

Gene ontology (GO) Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	IDA	27234298
GO:0005515	Function	Protein binding	IPI	24035498, 27234298, 27705803, 30190310, 33961781, 35869491
GO:0005634	Component	Nucleus	IDA	24035498, 27234298
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	24035498
GO:0005737	Component	Cytoplasm	IEA
GO:0006515	Process	Protein quality control for misfolded or incompletely synthesized proteins	IDA	30190310
GO:0007399	Process	Nervous system development	IEA
GO:0007399	Process	Nervous system development	ISS
GO:0008589	Process	Regulation of smoothened signaling pathway	IMP	27234298
GO:0014033	Process	Neural crest cell differentiation	ISS
GO:0016567	Process	Protein ubiquitination	IDA	24035498, 30190310
GO:0019005	Component	SCF ubiquitin ligase complex	IBA
GO:0019005	Component	SCF ubiquitin ligase complex	IDA	24035498
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA	24035498, 27234298
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	30190310

Other IDs

• MIM: 609083
• HGNC: 13615
• e!Ensembl: ENSG00000145743

Protein

• UniProt ID: Q9UF56
• Protein name: F-box/LRR-repeat protein 17 (F-box and leucine-rich repeat protein 17) (F-box only protein 13)
• Protein function: Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) (PubMed
• PDB: 6W66 , 6WCQ , 8UAH , 8UBT , 8UBU , 8UBV
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12937	F-box-like	321 → 368	F-box-like	Domain
  PF13516	LRR_6	615 → 639	Leucine Rich repeat	Repeat

• Sequence:

  MGHLLSKEPRNRPSQKRPRCCSWCRRRRPLLRLPRRTPAKVPPQPAAPRSRDCFFRGPCM
  LCFIVHSPGAPAPAGPEEEPPLSPPPRDGAYAAASSSQHLARRYAALAAEDCAAAARRFL
  LSSAAAAAAAAASASSPASCCKELGLAAAAAWEQQGRSLFLASLGPVRFLGPPAAVQLFR
  GPTPSPAELPTPPEMVCKRKGAGVPACTPCKQPRCGGGGCGGGGGGGGGGGPAGGGASPP
  RPPDAGCCQAPEQPPQPLCPPPSSPTSEGAPTEAGGDAVRAGGTAPLSAQQQHECGDADC
  RESPENPCDCHREPPPETPDINQLPPSILLKIFSNLSLDERCLSASLVCKYWRDLCLDFQ
  FWKQLDLSSRQQVTDELLEKIASRSQNIIEINISDCRSMSDNGVCVLAFKCPGLLRYTAY
  RCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDE
  GMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLTKLR
  NLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLV
  SCKITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVT
  VEQLVQQYPHITFSTVLQDCKRTLERAYQMGWTPNMSAASS

• Sequence length: 701

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (20)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ANOREXIA NERVOSA	—	GWAS catalog	36738649	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	34446935, 35764056, 36738649	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	35764056	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	24322204	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	35915156	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	38965376	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	30804565, 35835914	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	36738649, 37464041, 38177345	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	39349817	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	29255261, 29942085, 30595370, 32231276	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	37386247	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POST-TRAUMATIC STRESS DISORDER	—	GWAS catalog	34865855, 35181757, 38637617	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	31374203, 35396580	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	34446935	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	38162683	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	36738649, 39349817	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	20848476	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (9)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Atherosclerosis	Atherosclerosis	Pubtator	35165267	Associate	★☆☆☆☆ Found in Text Mining only
Attention Deficit Disorder with Hyperactivity	Attention deficit hyperactivity disorder	Pubtator	34573389	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	31560077		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	18820369, 24528085, 31560077	Associate	★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular disease	Pubtator	35165267	Associate	★☆☆☆☆ Found in Text Mining only
Cholangitis Sclerosing	Sclerosing cholangitis	Pubtator	38302916	Associate	★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	38302916	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	31560077		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	LHGDN	18820369		★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

TSNARE1 2 shared diseasesAnorexia nervosa, Post-traumatic stress disorder 2 shared evidence sourcesGWAS catalog (Anorexia nervosa), GWAS catalog (Post-traumatic stress disorder) Related via 2 shared diseases including Anorexia nervosa, Post-traumatic stress disorder — evidence mostly GWAS catalog. RBM6 2 shared diseasesAnorexia nervosa, Post-traumatic stress disorder 2 shared evidence sourcesGWAS catalog (Anorexia nervosa), GWAS catalog (Post-traumatic stress disorder) Related via 2 shared diseases including Anorexia nervosa, Post-traumatic stress disorder — evidence mostly GWAS catalog. FAM120A 2 shared diseasesAnorexia nervosa, Post-traumatic stress disorder 2 shared evidence sourcesGWAS catalog (Anorexia nervosa), GWAS catalog (Post-traumatic stress disorder) Related via 2 shared diseases including Anorexia nervosa, Post-traumatic stress disorder — evidence mostly GWAS catalog. IMMP2L 2 shared diseasesAnorexia nervosa, Post-traumatic stress disorder 2 shared evidence sourcesGWAS catalog (Anorexia nervosa), GWAS catalog (Post-traumatic stress disorder) Related via 2 shared diseases including Anorexia nervosa, Post-traumatic stress disorder — evidence mostly GWAS catalog. RPL10L 2 shared diseasesAnorexia nervosa, Post-traumatic stress disorder 2 shared evidence sourcesGWAS catalog (Anorexia nervosa), GWAS catalog (Post-traumatic stress disorder) Related via 2 shared diseases including Anorexia nervosa, Post-traumatic stress disorder — evidence mostly GWAS catalog.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
TSNARE1	2	["Anorexia nervosa","Post-traumatic stress disorder"]	0	[]	2	["GWAS catalog (Anorexia nervosa)","GWAS catalog (Post-traumatic stress disorder)"]
RBM6	2	["Anorexia nervosa","Post-traumatic stress disorder"]	0	[]	2	["GWAS catalog (Anorexia nervosa)","GWAS catalog (Post-traumatic stress disorder)"]
FAM120A	2	["Anorexia nervosa","Post-traumatic stress disorder"]	0	[]	2	["GWAS catalog (Anorexia nervosa)","GWAS catalog (Post-traumatic stress disorder)"]
IMMP2L	2	["Anorexia nervosa","Post-traumatic stress disorder"]	0	[]	2	["GWAS catalog (Anorexia nervosa)","GWAS catalog (Post-traumatic stress disorder)"]
RPL10L	2	["Anorexia nervosa","Post-traumatic stress disorder"]	0	[]	2	["GWAS catalog (Anorexia nervosa)","GWAS catalog (Post-traumatic stress disorder)"]

Diseases Linked via Similar Genes

Obesity Linked via 3 of 5 related genesTSNARE1, IMMP2L, RPL10L Tourette syndrome Linked via 3 of 5 related genesTSNARE1, FAM120A, IMMP2L Gastroesophageal reflux disease Linked via 2 of 5 related genesTSNARE1, RBM6 Obsessive-compulsive disorder Linked via 2 of 5 related genesTSNARE1, IMMP2L Osteoarthritis Linked via 2 of 5 related genesRBM6, IMMP2L

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Obesity	3	["TSNARE1","IMMP2L","RPL10L"]
Tourette syndrome	3	["TSNARE1","FAM120A","IMMP2L"]
Gastroesophageal reflux disease	2	["TSNARE1","RBM6"]
Obsessive-compulsive disorder	2	["TSNARE1","IMMP2L"]
Osteoarthritis	2	["RBM6","IMMP2L"]