LMO7 (LIM domain 7)

Gene

• Entrez ID: 4008
• Gene name: LIM domain 7
• Gene symbol: LMO7
• Synonyms (NCBI Gene): FBX20, FBXO20, LMO7b, LOMP
• Chromosome: 13
• Chromosome location: 13q22.2
• Summary: This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain, and may be involved in protein-protein interactions. Several alternatively spliced transcript variants encoding different isoforms have been found for

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT027702	hsa-miR-98-5p	Microarray	19088304
MIRT031907	hsa-miR-16-5p	Proteomics	18668040
MIRT732828	hsa-miR-30a-3p	Immunofluorescence, Luciferase reporter assay, RNA-seq, Western blotting	33397440
MIRT732828	hsa-miR-30a-3p	Immunofluorescence, Luciferase reporter assay, RNA-seq, Western blotting	33397440
MIRT1111953	hsa-miR-1252	CLIP-seq
MIRT1111954	hsa-miR-196a	CLIP-seq
MIRT1111955	hsa-miR-196b	CLIP-seq
MIRT1111956	hsa-miR-3154	CLIP-seq
MIRT1111957	hsa-miR-3655	CLIP-seq
MIRT1111958	hsa-miR-3673	CLIP-seq
MIRT1111959	hsa-miR-3927	CLIP-seq
MIRT1111960	hsa-miR-4476	CLIP-seq
MIRT1111961	hsa-miR-4533	CLIP-seq
MIRT1111962	hsa-miR-4650-3p	CLIP-seq
MIRT1111963	hsa-miR-4797-5p	CLIP-seq
MIRT1111964	hsa-miR-511	CLIP-seq
MIRT1111965	hsa-miR-578	CLIP-seq
MIRT1111966	hsa-miR-9	CLIP-seq
MIRT1550759	hsa-miR-1226	CLIP-seq
MIRT1550760	hsa-miR-300	CLIP-seq
MIRT1550761	hsa-miR-3185	CLIP-seq
MIRT1550762	hsa-miR-325	CLIP-seq
MIRT1550763	hsa-miR-381	CLIP-seq
MIRT1550764	hsa-miR-4666-3p	CLIP-seq
MIRT1550765	hsa-miR-4733-3p	CLIP-seq
MIRT1550766	hsa-miR-4762-3p	CLIP-seq
MIRT1550767	hsa-miR-628-3p	CLIP-seq
MIRT2031251	hsa-miR-3122	CLIP-seq
MIRT2031252	hsa-miR-3133	CLIP-seq
MIRT2031253	hsa-miR-3913-5p	CLIP-seq
MIRT2031254	hsa-miR-4452	CLIP-seq
MIRT2262161	hsa-miR-105	CLIP-seq
MIRT2262162	hsa-miR-1324	CLIP-seq
MIRT2262163	hsa-miR-217	CLIP-seq
MIRT2262164	hsa-miR-3616-3p	CLIP-seq
MIRT2262165	hsa-miR-4260	CLIP-seq
MIRT2262166	hsa-miR-4446-3p	CLIP-seq
MIRT2262167	hsa-miR-4721	CLIP-seq
MIRT2262168	hsa-miR-544b	CLIP-seq
MIRT2262161	hsa-miR-105	CLIP-seq
MIRT1550759	hsa-miR-1226	CLIP-seq
MIRT2430749	hsa-miR-186	CLIP-seq
MIRT2430750	hsa-miR-200b	CLIP-seq
MIRT2430751	hsa-miR-200c	CLIP-seq
MIRT2430752	hsa-miR-205	CLIP-seq
MIRT1550760	hsa-miR-300	CLIP-seq
MIRT2430753	hsa-miR-3121-3p	CLIP-seq
MIRT2031252	hsa-miR-3133	CLIP-seq
MIRT1550761	hsa-miR-3185	CLIP-seq
MIRT2430754	hsa-miR-323-3p	CLIP-seq
MIRT1550762	hsa-miR-325	CLIP-seq
MIRT2430755	hsa-miR-338-5p	CLIP-seq
MIRT1550763	hsa-miR-381	CLIP-seq
MIRT2430756	hsa-miR-3924	CLIP-seq
MIRT2430757	hsa-miR-4284	CLIP-seq
MIRT2430758	hsa-miR-4287	CLIP-seq
MIRT2430759	hsa-miR-429	CLIP-seq
MIRT2430760	hsa-miR-4490	CLIP-seq
MIRT1550764	hsa-miR-4666-3p	CLIP-seq
MIRT2430761	hsa-miR-4685-3p	CLIP-seq
MIRT2430762	hsa-miR-4699-3p	CLIP-seq
MIRT1550765	hsa-miR-4733-3p	CLIP-seq
MIRT1550766	hsa-miR-4762-3p	CLIP-seq
MIRT2430763	hsa-miR-4766-3p	CLIP-seq
MIRT2430764	hsa-miR-4774-5p	CLIP-seq
MIRT2430765	hsa-miR-4775	CLIP-seq
MIRT2430766	hsa-miR-520d-5p	CLIP-seq
MIRT2430767	hsa-miR-524-5p	CLIP-seq
MIRT1550767	hsa-miR-628-3p	CLIP-seq
MIRT2561867	hsa-miR-1273f	CLIP-seq
MIRT2561868	hsa-miR-143	CLIP-seq
MIRT2561869	hsa-miR-4708-5p	CLIP-seq
MIRT2561870	hsa-miR-4770	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SRF	Unknown	21670154

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000151	Component	Ubiquitin ligase complex	NAS	10531035
GO:0004842	Function	Ubiquitin-protein transferase activity	NAS	10531035
GO:0005515	Function	Protein binding	IPI	15161933, 30429017, 35271311
GO:0005634	Component	Nucleus	IDA	17067998
GO:0005634	Component	Nucleus	TAS	9826547
GO:0005635	Component	Nuclear envelope	IDA	17067998
GO:0005737	Component	Cytoplasm	IDA	17067998
GO:0005737	Component	Cytoplasm	TAS	9826547
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005829	Component	Cytosol	TAS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0009986	Component	Cell surface	IDA	17067998
GO:0010604	Process	Positive regulation of macromolecule metabolic process	IEA
GO:0016324	Component	Apical plasma membrane	ISS
GO:0016567	Process	Protein ubiquitination	NAS	10531035
GO:0023051	Process	Regulation of signaling	IEA
GO:0030155	Process	Regulation of cell adhesion	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	17067998
GO:0046872	Function	Metal ion binding	IEA
GO:0080090	Process	Regulation of primary metabolic process	IEA

Other IDs

• MIM: 604362
• HGNC: 6646
• e!Ensembl: ENSG00000136153

Protein

• UniProt ID: Q8WWI1
• Protein name: LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP)
• PDB: 2EAQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00307	CH	71 → 179	Calponin homology (CH) domain	Domain
  PF15949	DUF4757	294 → 375	Domain of unknown function (DUF4757)	Family
  PF15949	DUF4757	635 → 787	Domain of unknown function (DUF4757)	Family
  PF00595	PDZ	1043 → 1119	PDZ domain	Domain
  PF00412	LIM	1614 → 1676	LIM domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Isoform 2 and isoform 4 are predominantly expressed in brain. {ECO:0000269|PubMed:11935316, ECO:0000269|PubMed:9826547}.
• Sequence:

  MKKIRICHIFTFYSWMSYDVLFQRTELGALEIWRQLICAHVCICVGWLYLRDRVCSKKDI
  ILRTEQNSGRTILIKAVTEKNFETKDFRASLENGVLLCDLINKLKPGVIKKINRLSTPIA
  GLDNINVFLKACEQIGLKEAQLFHPGDLQDLSNRVTVKQEETDRRVKNVLITLYWLGRKA
  QSNPYYNGPHLNLKAFENLLGQALTKALEDSSFLKRSGRDSGYGDIWCPERGEFLAPPRH
  HKREDSFESLDSLGSRSLTSCSSDITLRGGREGFESDTDSEFTFKMQDYNKDDMSYRRIS
  AVEPKTALPFNRFLPNKSRQPSYVPAPLRKKKPDKHEDNRRSWASPVYTEADGTFSSNQR
  RIWGTNVENWPTVQGTSKSSCYLEEEKAKTRSIPNIVKDDLYVRKLSPVMPNPGNAFDQF
  LPKCWTPEDVNWKRIKRETYKPWYKEFQGFSQFLLLQALQTYSDDILSSETHTKIDPTSG
  PRLITRRKNLSYAPGYRRDDLEMAALDPDLENDDFFVRKTGVFHANPYVLRAFEDFRKFS
  EQDDSVERDIILQCREGELVLPDLEKDDMIVRRIPAQKKEVPLSGAPDRYHPVPFPEPWT
  LPPEIQAKFLCVFERTCPSKEKSNSCRILVPSYRQKKDDMLTRKIQSWKLGTTVPPISFT
  PGPCSEADLKRWEAIREASRLRHKKRLMVERLFQKIYGENGSKSMSDVSAEDVQNLRQLR
  YEEMQKIKSQLKEQDQKWQDDLAKWKDRRKSYTSDLQKKKEEREEIEKQALEKSKRSSKT
  FKEMLQDRESQNQKSTVPSRRRMYSFDDVLEEGKRPPTMTVSEASYQSERVEEKGATYPS
  EIPKEDSTTFAKREDRVTTEIQLPSQSPVEEQSPASLSSLRSRSTQMESTRVSASLPRSY
  RKTDTVRLTSVVTPRPFGSQTRGISSLPRSYTMDDAWKYNGDVEDIKRTPNNVVSTPAPS
  PDASQLASSLSSQKEVAATEEDVTRLPSPTSPFSSLSQDQAATSKATLSSTSGLDLMSES
  GEGEISPQREVSRSQDQFSDMRISINQTPGKSLDFGFTIKWDIPGIFVASVEAGSPAEFS
  QLQVDDEIIAINNTKFSYNDSKEWEEAMAKAQETGHLVMDVRRYGKAGSPETKWIDATSG
  IYNSEKSSNLSVTTDFSESLQSSNIESKEINGIHDESNAFESKASESISLKNLKRRSQFF
  EQGSSDSVVPDLPVPTISAPSRWVWDQEEERKRQERWQKEQDRLLQEKYQREQEKLREEW
  QRAKQEAERENSKYLDEELMVLSSNSMSLTTREPSLATWEATWSEGSKSSDREGTRAGEE
  ERRQPQEEVVHEDQGKKPQDQLVIERERKWEQQLQEEQEQKRLQAEAEEQKRPAEEQKRQ
  AEIERETSVRIYQYRRPVDSYDIPKTEEASSGFLPGDRNKSRSTTELDDYSTNKNGNNKY
  LDQIGNMTSSQRRSKKEQVPSGAELERQQILQEMRKRTPLHNDNSWIRQRSASVNKEPVS
  LPGIMRRGESLDNLDSPRSNSWRQPPWLNQPTGFYASSSVQDFSRPPPQLVSTSNRAYMR
  NPSSSVPPPSAGSVKTSTTGVATTQSPTPRSHSPSASQSGSQLRNRSVSGKRICSYCNNI
  LGKGAAMIIESLGLCYHLHCFKCVACECDLGGSSSGAEVRIRNHQLYCNDCYLRFKSGRP
  TAM

• Sequence length: 1683

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ASTROCYTOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BLADDER EXSTROPHY AND EPISPADIAS COMPLEX	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bladder exstrophy-epispadias-cloacal extrophy complex	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORNEAL ASTIGMATISM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CUTANEOUS MELANOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLAUCOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEARING LOSS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEMORRHOID	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LMO7-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSESSIVE-COMPULSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 1 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Bipolar Disorder	Bipolar Disorder	GWASCAT_DG	29064472		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	21670154	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	28026121, 30429017		★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	35046938	Stimulate	★☆☆☆☆ Found in Text Mining only
Cardiomyopathy, Dilated	Cardiomyopathy	BEFREE	27988857		★☆☆☆☆ Found in Text Mining only
Cardiomyopathy, Familial Idiopathic	Cardiomyopathy	BEFREE	27988857		★☆☆☆☆ Found in Text Mining only
Ciliopathies	Ciliopathy	Pubtator	28800606	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	GWASCAT_DG	21980299		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	GWASDB_DG	21980299		★☆☆☆☆ Found in Text Mining only
Diabetic Retinopathy	Diabetic Retinopathy	GWASDB_DG	23562823		★☆☆☆☆ Found in Text Mining only
Dry Eye Syndromes	Dry eye syndrome	Pubtator	30312344	Associate	★☆☆☆☆ Found in Text Mining only
Glaucoma	Glaucoma	Pubtator	29449654	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glaucoma Open Angle	Open angle glaucoma	Pubtator	29449654	Associate	★☆☆☆☆ Found in Text Mining only
Glaucoma, Open-Angle	Glaucoma	GWASCAT_DG	29449654		★☆☆☆☆ Found in Text Mining only
LEOPARD Syndrome	Leopard syndrome	Pubtator	21179469	Associate	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	28026121	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	28026121, 30429017		★☆☆☆☆ Found in Text Mining only
Muscular Dystrophy, Emery-Dreifuss	Emery-Dreifuss Muscular Dystrophy	BEFREE	24825363, 29158164, 29912636		★☆☆☆☆ Found in Text Mining only
Myopathy	Myopathy	BEFREE	21179469		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29768105, 30429017, 31059071		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	30429017		★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	29768105		★☆☆☆☆ Found in Text Mining only
Psychotic Disorders	Psychotic disorders	Pubtator	29064472	Associate	★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	31952466	Associate	★☆☆☆☆ Found in Text Mining only
Retinal Degeneration	Retinal degeneration	Pubtator	29064472	Associate	★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	BEFREE	24825363		★☆☆☆☆ Found in Text Mining only
Schizoaffective Disorder	Schizoaffective Disorder	GWASCAT_DG	29064472		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	GWASCAT_DG	29064472		★☆☆☆☆ Found in Text Mining only
Sjogren's Syndrome	Sjogren syndrome	Pubtator	30312344	Associate	★☆☆☆☆ Found in Text Mining only
Sjogren's Syndrome	Sjogren syndrome	Pubtator	31366407	Stimulate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of vulva	Carcinoma Of Vulva	BEFREE	31059071		★☆☆☆☆ Found in Text Mining only
Vascular Diseases	Vascular Diseases	BEFREE	30586711		★☆☆☆☆ Found in Text Mining only
Wilms Tumor	Wilms tumor	Pubtator	32149111	Associate	★☆☆☆☆ Found in Text Mining only