Log in to save this analysis

Save This Analysis

Gene Gene information from NCBI Gene database.
Entrez ID 1211
Gene name Clathrin light chain A
Gene symbol CLTA
Synonyms (NCBI Gene)
LCA
Chromosome 9
Chromosome location 9p13.3
Summary Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytos
miRNA miRNA information provided by mirtarbase database.
116 Show/Hide all (116)
miRTarBase ID miRNA Experiments Reference
MIRT020728 hsa-miR-155-5p Proteomics 18668040
MIRT022724 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT029517 hsa-miR-26b-5p Microarray 19088304
MIRT046362 hsa-miR-23b-3p CLASH 23622248
MIRT107700 hsa-miR-142-3p PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
44 Show/Hide all (44)
GO ID Ontology Definition Evidence Reference
GO:0005198 Function Structural molecule activity IEA
GO:0005515 Function Protein binding IPI 16595675, 21297582, 30021884, 32814053, 35271311
GO:0005737 Component Cytoplasm IEA
GO:0005764 Component Lysosome IDA
GO:0005768 Component Endosome IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
118960 2090 ENSG00000122705
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P09496
Protein name Clathrin light chain A (Lca)
Protein function Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-mi
PDB 6E5N
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01086 Clathrin_lg_ch 15 → 247 Clathrin light chain Family
Sequence
Sequence length 248
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Lysosome Entry of Influenza Virion into Host Cell via Endocytosis
Endocytosis Retrograde neurotrophin signalling
Synaptic vesicle cycle Gap junction degradation
Endocrine and other factor-regulated calcium reabsorption Formation of annular gap junctions
Huntington disease MHC class II antigen presentation
Bacterial invasion of epithelial cells EPH-ephrin mediated repulsion of cells
  Lysosome Vesicle Biogenesis
  Golgi Associated Vesicle Biogenesis
  Recycling pathway of L1
  WNT5A-dependent internalization of FZD4
  WNT5A-dependent internalization of FZD2, FZD5 and ROR2
  Cargo recognition for clathrin-mediated endocytosis
  Clathrin-mediated endocytosis
  VLDLR internalisation and degradation
  LDL clearance
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
ATYPICAL FEMORAL FRACTURE — GWAS catalog 31006051
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER — GWAS catalog 25781172
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER — GWAS catalog 37359372
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
FATTY LIVER DISEASE — GWAS catalog 35611668
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (50)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Amaurosis congenita of Leber, type 1 Leber congenital amaurosis BEFREE 11528500, 18055821, 18632300, 18936139, 20079931, 20104588, 22261762, 23308101, 23661368, 24066033, 27010695, 27422788, 31693188, 8750633
★★★★★
★☆☆☆☆
Found in Text Mining only
Aortic Valve Stenosis Aortic Valve Sclerosis BEFREE 29378976
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 35273614 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Attention Deficit Disorder Attention Deficit Hyperactivity Disorder BEFREE 29454227
★★★★★
★☆☆☆☆
Found in Text Mining only
Attention deficit hyperactivity disorder Attention Deficit Hyperactivity Disorder BEFREE 29454227
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 29655782
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Carcinoma Pubtator 40214395 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Cholestasis Cholestasis BEFREE 25660334
★★★★★
★☆☆☆☆
Found in Text Mining only
Chondrosarcoma Extraskeletal Myxoid Extraskeletal myxoid chondrosarcoma Pubtator 24293381 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Cone-Rod Dystrophies Cone-rod dystrophy BEFREE 28369829
★★★★★
★☆☆☆☆
Found in Text Mining only