Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
COMPLEX NEURODEVELOPMENTAL DISORDER	MONDO:0100038	ANK2	Causal	22542183 25363768 27479843 28554332 30564305 30755392 31285321 31981491	ClinGen, GWAS catalog	Cytoskeleton in muscle cells Proteoglycans in cancer Interaction between L1 and Ankyrins +1 more
		CHD2	Causal	23708187 23934111 24207121 25786798	ClinGen, GWAS catalog	—
		CUL3	Causal	15107402 22495309 22914163 24463507 25969726 26785492 27479843 27561354 27824329 28135719 28191889 28263302 30311385 30564305 31337872 31455858 31696658 31780330 31981491 32341456	ClinGen, GWAS catalog	Ubiquitin mediated proteolysis Hedgehog signaling pathway Degradation of DVL +4 more
		DYRK1A	Causal	12192061 18364031 18648535 21294719 23099646 23160955 25156961 25167861 25641759 25920557 28167836 29223763 30831192 7857639	ClinGen, Disgenet	G0 and Early G1
		EEF1A2	Causal	23033978 23647072 24309898 24697219 26682508 26740508 27441201 27626380 27652284	ClinGen, GenCC	Nucleocytoplasmic transport Legionellosis Leishmaniasis
		GRIN2B	Causal	—	ClinGen, GenCC	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +22 more
		KCNQ2	Causal	23934111 26138355 27861786 33754465	CTD, ClinGen	Cholinergic synapse Voltage gated Potassium channels
		NR4A2	Causal	20016108 30504930 31428396 31922365 32366965	ClinGen, GWAS catalog	Aldosterone synthesis and secretion Parathyroid hormone synthesis, secretion and action Nuclear Receptor transcription pathway
		SCAF4	Causal	32730804 36333968 37394306	ClinGen, Disgenet	—
		SCN2A	Causal	11166117 19783390 19786696 28379373	ClinGen, Disgenet	Taste transduction Phase 0 - rapid depolarisation
		SCN8A	Causal	22365152 23708187 24352161 24874546 25227913 25568300 26900580 9828131	ClinGen, GWAS catalog	Phase 0 - rapid depolarisation
		SYNGAP1	Causal	24945774 26989088 30541864	ClinGen, GWAS catalog	Ras signaling pathway Regulation of RAS by GAPs
		AGO1	Unknown	—	ClinGen	Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Oxidative Stress Induced Senescence +15 more
		ALDH1B1	Unknown	—	GenCC	Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Fatty acid degradation +13 more
		ARHGAP35	Unknown	—	GenCC	Focal adhesion Platelet activation Leukocyte transendothelial migration +4 more
		ATP6V0A1	Unknown	—	GenCC	Oxidative phosphorylation Metabolic pathways Lysosome +13 more
		BAZ2B	Unknown	25363768 28554332 28867142 31398340 31981491 31999386 33057194	ClinGen, GWAS catalog	ATP-dependent chromatin remodeling
		BRSK2	Unknown	15705853 22495309 25363760 28135719 30307479 30879638 31452935 31981491 33057194	CTD, ClinGen	—
		CACNA1I	Unknown	27541642 28714951 31785789 33704440 35229910	Disgenet	MAPK signaling pathway Calcium signaling pathway Circadian entrainment +4 more
		CLCN3	Unknown	34186028 8155321	GWAS catalog	Neutrophil extracellular trap formation
		EXOC2	Unknown	12575951 26582389 30510181 32639540	ClinGen, Disgenet	Ras signaling pathway Salmonella infection Insulin processing +1 more
		EXOC7	Unknown	32103185	ClinGen, Disgenet	Insulin signaling pathway Salmonella infection Insulin processing +1 more
		GABBR2	Unknown	25262651 26740508 28856709 29100083 29369404	ClinGen, GWAS catalog	cAMP signaling pathway Neuroactive ligand-receptor interaction GABAergic synapse +9 more
		GIGYF1	Unknown	—	GenCC	—
		GNAI1	Unknown	14715142 28135719 33473207	ClinGen, Disgenet	Rap1 signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +47 more
		GRIK2	Unknown	28180184 34375587	ClinGen, ClinVar	Neuroactive ligand-receptor interaction Glutamatergic synapse Activation of Na-permeable kainate receptors +1 more
		GRIN1	Unknown	21376300 27164704 28228639	ClinGen, GWAS catalog	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +20 more
		GRIN2A	Unknown	11399431 20890276 23933819 27839871 7816096	CTD, ClinGen	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +19 more
		HECW2	Unknown	12890487 27334371 27389779 29395664 29807643 32814609 33205896 34047014 34321324 35987951	ClinGen, ClinVar	Antigen processing: Ubiquitination & Proteasome degradation
		INTS11	Unknown	—	GenCC	RNA polymerase II transcribes snRNA genes
		KLHL20	Unknown	36214804	ClinGen, GWAS catalog	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		KMT2E	Unknown	31079897 33111303 35273928	ClinGen, Disgenet	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		MEF2C	Unknown	19592390 20513142 23001426 23389741 27255693 27779093 28794905 30376817 7679508	ClinGen, GWAS catalog	MAPK signaling pathway cGMP-PKG signaling pathway Apelin signaling pathway +7 more
		NBEA	Unknown	15071111 23100440 23153818 25363760 25363768 25484298 26100104 30269351 31452935	CTD, ClinGen	—
		NOVA2	Unknown	23359859 27223325 32197073 35607920	ClinGen, Disgenet	—
		OTUD7A	Unknown	31997314 33381903	ClinGen, GWAS catalog	Ovarian tumor domain proteases
		PIGA	Unknown	22305531 24259184 24259288 24357517 24706016 25326635 25473036 25885527 26545172 26923721 26993267 27126216 28133863 28441409 29414593 29502866 29656098 29974678 32452540 32694024 34875027 36324500 37961693	ClinGen, Disgenet	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Metabolic pathways Synthesis of glycosylphosphatidylinositol (GPI)
		PTRHD1	Unknown	—	GenCC	—
		RALGAPA1	Unknown	—	GenCC	Ras signaling pathway
		SATB1	Unknown	—	ClinGen, GenCC	Apoptotic cleavage of cellular proteins SUMOylation of chromatin organization proteins
		SHMT2	Unknown	—	GenCC	Glycine, serine and threonine metabolism Glyoxylate and dicarboxylate metabolism One carbon pool by folate +7 more
		SLC4A10	Unknown	18165320 37459438 38054405	ClinGen, GWAS catalog	Bicarbonate transporters
		SNF8	Unknown	—	GenCC	Endocytosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events
		SPOUT1	Unknown	—	GenCC	—
		SUPT16H	Unknown	—	GenCC	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes +2 more
		TMEM147	Unknown	—	GenCC	—
		TNRC6B	Unknown	25363768 29463886 32152250	ClinGen	Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence +12 more
		ZFHX4	Unknown	—	GenCC	—
		ZFTRAF1	Unknown	—	GenCC	—
		ZMIZ1	Unknown	30639322 31833199	ClinGen, GWAS catalog	—
NEURODEVELOPMENTAL DISORDER	MONDO:0700092	ARHGAP35	Causal	28641477 33057194	Disgenet	Focal adhesion Platelet activation Leukocyte transendothelial migration +4 more
		BAZ2B	Causal	—	GenCC	ATP-dependent chromatin remodeling
		BRSK2	Causal	30879638	Disgenet	—
		GIGYF1	Causal	33057194	GWAS catalog	—
		GRIN2A	Causal	35983985	GWAS catalog	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +19 more
		KLHL20	Causal	—	GenCC	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		NR4A2	Causal	—	GenCC	Aldosterone synthesis and secretion Parathyroid hormone synthesis, secretion and action Nuclear Receptor transcription pathway
		SATB1	Causal	33057194	Disgenet	Apoptotic cleavage of cellular proteins SUMOylation of chromatin organization proteins
		ZFHX4	Causal	11935336 33057194	GWAS catalog	—
		ANK2	Unknown	30755392 22542183 25356970 28191889	GWAS catalog	Cytoskeleton in muscle cells Proteoglycans in cancer Interaction between L1 and Ankyrins +1 more
		ZFTRAF1	Unknown	38641995	GWAS catalog	—
NEURODEVELOPMENTAL DISORDER PLUS OPTIC ATROPHY	620784 C5935605 MONDO:0968947	SNF8	Causal	38423010	ClinVar, Disgenet, GenCC, HPO	Endocytosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events
NEURODEVELOPMENTAL DISORDER WITH CARDIOMYOPATHY, SPASTICITY, AND BRAIN ABNORMALITIES	619121 C5436848 MONDO:0030866	SHMT2	Causal	33015733	ClinGen, ClinVar, Disgenet, GWAS catalog, HPO	Glycine, serine and threonine metabolism Glyoxylate and dicarboxylate metabolism One carbon pool by folate +7 more
NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND CEREBELLAR HYPOPLASIA	619306 C5543332 MONDO:0859141	EXOC2	Causal	21700618 23548203 25261932 28135719 31981491 32639540	ClinVar, Disgenet, GWAS catalog, HPO	Ras signaling pathway Salmonella infection Insulin processing +1 more
NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND DISTAL LIMB ANOMALIES	C4540327	KMT2E	Causal	—	Disgenet	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		SCAF4	Causal	—	Disgenet	—
		TNRC6B	Causal	—	Disgenet	Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence +12 more
NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND DISTAL SKELETAL ANOMALIES	618659 C5231448 MONDO:0032855	ZMIZ1	Causal	26163108 29225144 30639322 31785789 31833199 32368696 32399599 34918830 35432459 36360260	ClinVar, Disgenet, GWAS catalog, HPO	—
NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND THIN CORPUS CALLOSUM	619480 C5551361 MONDO:0859179	SUPT16H	Causal	26834018 27519580 30670789 31823155 31924697	ClinVar, Disgenet, GenCC, HPO	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes +2 more
NEURODEVELOPMENTAL DISORDER WITH EARLY-ONSET PARKINSONISM AND BEHAVIORAL ABNORMALITIES	620747 C5935590 MONDO:0958323	PTRHD1	Causal	—	ClinVar, Disgenet, HPO	—
NEURODEVELOPMENTAL DISORDER WITH EPILEPSY AND BRAIN ATROPHY	619971 C5774184 MONDO:0859265	ATP6V0A1	Causal	33833240 34909687	ClinVar, Disgenet, GWAS catalog, HPO	Oxidative phosphorylation Metabolic pathways Lysosome +13 more
NEURODEVELOPMENTAL DISORDER WITH EPILEPSY AND HEMOCHROMATOSIS	301072	PIGA	Causal	—	ClinVar, HPO	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Metabolic pathways Synthesis of glycosylphosphatidylinositol (GPI)
NEURODEVELOPMENTAL DISORDER WITH FACIAL DYSMORPHISM, ABSENT LANGUAGE, AND PSEUDO-PELGER-HUET ANOMALY	620075 C5774232 MONDO:0859298	TMEM147	Causal	28097321 28472652 36044892	CTD, ClinVar, Disgenet, HPO	—
NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA AND BRAIN ABNORMALITIES	619512 C5561977 MONDO:0859187	CLCN3	Causal	34186028 36536096	ClinVar, Disgenet, GWAS catalog, HPO	Neutrophil extracellular trap formation
NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA AND CHARACTERISTIC BRAIN ABNORMALITIES	620746 C5935589 MONDO:0958278	SLC4A10	Causal	37459438 38054405	ClinVar, Disgenet, GWAS catalog, HPO	Bicarbonate transporters
NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA AND GROSS MOTOR AND SPEECH DELAY	C5562031	ZFTRAF1	Causal	—	Disgenet	—
NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA AND SEIZURES	620790 C5935609 MONDO:0968979	OTUD7A	Causal	—	ClinVar, Disgenet, HPO	Ovarian tumor domain proteases
NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA, IMPAIRED LANGUAGE, AND DYSMORPHIC FEATURES	C5676894	KMT2E	Unknown	—	Disgenet	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA, IMPAIRED SPEECH, AND BEHAVIORAL ABNORMALITIES	619854 C5676975 MONDO:0859243	GNAI1	Causal	28135719 31164858 33473207	ClinVar, Disgenet, HPO	Rap1 signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +47 more
NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA, NEONATAL RESPIRATORY INSUFFICIENCY, AND THERMODYSREGULATION	618797 C5394091 MONDO:0032921	RALGAPA1	Causal	19733229 28940419 32004447	ClinVar, Disgenet, GWAS catalog, HPO	Ras signaling pathway
NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA, SEIZURES, AND ABSENT LANGUAGE	617268 C4310643 MONDO:0014995 OMIM:617268	HECW2	Causal	27389779 27334371 34321324 29395664 29807643 32814609 33205896 34047014 34327820 35987951 37280227	CTD, ClinVar, Disgenet, HPO	Antigen processing: Ubiquitination & Proteasome degradation
NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA, STEREOTYPIC HAND MOVEMENTS, AND IMPAIRED LANGUAGE	613443 C3150700 MONDO:0013266 OMIM:613443	MEF2C	Causal	20513142 19592390 23001426 34022131 35719119	CTD, ClinVar, Disgenet, HPO	MAPK signaling pathway cGMP-PKG signaling pathway Apelin signaling pathway +7 more
NEURODEVELOPMENTAL DISORDER WITH IMPAIRED LANGUAGE AND ATAXIA AND WITH OR WITHOUT SEIZURES	619580 C5562006 MONDO:0859201	GRIK2	Causal	34375587	ClinVar, Disgenet, HPO	Neuroactive ligand-receptor interaction Glutamatergic synapse Activation of Na-permeable kainate receptors +1 more
NEURODEVELOPMENTAL DISORDER WITH LANGUAGE DELAY AND BEHAVIORAL ABNORMALITIES, WITH OR WITHOUT SEIZURES	620292 C5830365 MONDO:0859531	AGO1	Causal	—	ClinVar, Disgenet, GenCC, HPO	Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Oxidative Stress Induced Senescence +15 more
NEURODEVELOPMENTAL DISORDER WITH MOTOR AND LANGUAGE DELAY, OCULAR DEFECTS, AND BRAIN ABNORMALITIES	620428 C5830596 MONDO:0957386	INTS11	Causal	37054711 37980560	ClinVar, Disgenet, GWAS catalog, HPO	RNA polymerase II transcribes snRNA genes
NEURODEVELOPMENTAL DISORDER WITH OR WITHOUT AUTISM OR SEIZURES	619239 C5543225 MONDO:0030994	CUL3	Causal	27824329 31696658 33097317 32341456	ClinVar, Disgenet, GWAS catalog, HPO	Ubiquitin mediated proteolysis Hedgehog signaling pathway Degradation of DVL +4 more
NEURODEVELOPMENTAL DISORDER WITH OR WITHOUT AUTISTIC FEATURES AND/OR STRUCTURAL BRAIN ABNORMALITIES	618859 C5394311 MONDO:0030024	NOVA2	Causal	31231135 32197073	ClinVar, Disgenet, HPO	—
NEURODEVELOPMENTAL DISORDER WITH OR WITHOUT EARLY-ONSET GENERALIZED EPILEPSY	619157 C5436914 MONDO:0030930	NBEA	Causal	28554332 30269351	CTD, ClinVar, Disgenet, HPO	—
NEURODEVELOPMENTAL DISORDER WITH OR WITHOUT HYPERKINETIC MOVEMENTS AND SEIZURES, AUTOSOMAL DOMINANT	614254 C3280282 MONDO:0013655 OMIM:614254	GRIN1	Causal	23934111 27164704 35393335 25864721 26933583 28228639 28389307 29194067 29365063 30355546 31176596 33062288 33403508 34227748 34413877 34884460	CTD, ClinVar, Disgenet, HPO	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +20 more
NEURODEVELOPMENTAL DISORDER WITH OR WITHOUT HYPERKINETIC MOVEMENTS AND SEIZURES, AUTOSOMAL RECESSIVE	617820 C4693325 MONDO:0060629	GRIN1	Causal	34611970 26350515 27164704 28051072	CTD, ClinVar, Disgenet, HPO	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +20 more
NEURODEVELOPMENTAL DISORDER WITH POOR GROWTH, SEIZURES, AND BRAIN ABNORMALITIES	MONDO:0976265	SPOUT1	Causal	—	ClinVar	—
NEURODEVELOPMENTAL DISORDER WITH POOR LANGUAGE AND LOSS OF HAND SKILLS	617903 C4693546 MONDO:0060659	GABBR2	Causal	25262651 26740508 27541642 28135719 28191890 28856709 28867141 29346770 30174453 31785789 31957018 34800434 35599849 35616356 35872528	ClinVar, Disgenet, GWAS catalog, HPO	cAMP signaling pathway Neuroactive ligand-receptor interaction GABAergic synapse +9 more
NEURODEVELOPMENTAL DISORDER WITH SEIZURES AND BRAIN ABNORMALITIES	619517 C5561979 MONDO:0859188	CLCN3	Causal	—	ClinVar, Disgenet, GenCC, HPO	Neutrophil extracellular trap formation
NEURODEVELOPMENTAL DISORDER WITH SEIZURES AND BRAIN ATROPHY	619072 C5436732 MONDO:0033658	EXOC7	Causal	32103185 4057982	ClinVar, Disgenet, GWAS catalog, HPO	Insulin signaling pathway Salmonella infection Insulin processing +1 more
NEURODEVELOPMENTAL DISORDER WITH SPEECH IMPAIRMENT AND WITH OR WITHOUT SEIZURES	620114 C5774252 MONDO:0859313	CACNA1I	Causal	33704440	ClinVar, Disgenet, HPO	MAPK signaling pathway Calcium signaling pathway Circadian entrainment +4 more
NEURODEVELOPMENTAL DISORDER-SLIT-LIKE LATERAL VENTRICLES-INTELLECTUAL DISABILITY SYNDROME	664430 C5925058	SLC4A10	Unknown	37459438	Disgenet, Orphanet	Bicarbonate transporters
NEURODEVELOPMENTAL DISORDERS	C1535926 MESH:D065886	AGO1	Unknown	—	Disgenet	Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Oxidative Stress Induced Senescence +15 more
		ANK2	Unknown	28191889	CTD, Disgenet	Cytoskeleton in muscle cells Proteoglycans in cancer Interaction between L1 and Ankyrins +1 more
		ARHGAP35	Unknown	—	Disgenet	Focal adhesion Platelet activation Leukocyte transendothelial migration +4 more
		BAZ2B	Unknown	31999386 37872713	Disgenet	ATP-dependent chromatin remodeling
		BRSK2	Unknown	30879638	Disgenet	—
		CHD2	Unknown	29942082	CTD, Disgenet	—
		CLCN3	Unknown	—	Disgenet	Neutrophil extracellular trap formation
		CUL3	Unknown	28191889	CTD, Disgenet	Ubiquitin mediated proteolysis Hedgehog signaling pathway Degradation of DVL +4 more
		DYRK1A	Unknown	28191889 29942082	CTD, Disgenet	G0 and Early G1
		EEF1A2	Unknown	29942082	CTD, Disgenet	Nucleocytoplasmic transport Legionellosis Leishmaniasis
		GIGYF1	Unknown	—	Disgenet	—
		GNAI1	Unknown	—	Disgenet	Rap1 signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +47 more
		GRIN1	Unknown	—	Disgenet	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +20 more
		GRIN2A	Unknown	35983985	Disgenet	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +19 more
		GRIN2B	Unknown	28191889 29942082	CTD, Disgenet	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +22 more
		KCNQ2	Unknown	29942082	CTD, Disgenet	Cholinergic synapse Voltage gated Potassium channels
		KLHL20	Unknown	—	Disgenet	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		KMT2E	Unknown	28191889	CTD, Disgenet	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		MEF2C	Unknown	29942082	CTD, Disgenet	MAPK signaling pathway cGMP-PKG signaling pathway Apelin signaling pathway +7 more
		NBEA	Unknown	—	Disgenet	—
		NR4A2	Unknown	—	Disgenet	Aldosterone synthesis and secretion Parathyroid hormone synthesis, secretion and action Nuclear Receptor transcription pathway
		OTUD7A	Unknown	—	Disgenet	Ovarian tumor domain proteases
		SATB1	Unknown	33513338	Disgenet	Apoptotic cleavage of cellular proteins SUMOylation of chromatin organization proteins
		SCAF4	Unknown	32730804 36333968	Disgenet	—
		SCN2A	Unknown	28191889 29942082	CTD, Disgenet	Taste transduction Phase 0 - rapid depolarisation
		SCN8A	Unknown	29942082	CTD, Disgenet	Phase 0 - rapid depolarisation
		SHMT2	Unknown	—	Disgenet	Glycine, serine and threonine metabolism Glyoxylate and dicarboxylate metabolism One carbon pool by folate +7 more
		SPOUT1	Unknown	—	Disgenet	—
		SUPT16H	Unknown	31924697	Disgenet	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes +2 more
		SYNGAP1	Unknown	28191889 29942082	CTD, Disgenet	Ras signaling pathway Regulation of RAS by GAPs
		TNRC6B	Unknown	28191889	CTD, Disgenet	Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence +12 more
		ZFHX4	Unknown	—	Disgenet	—
		ZFTRAF1	Unknown	38641995	Disgenet	—
		ZMIZ1	Unknown	—	Disgenet	—

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Neurodevelopmental disorder

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