Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▼ Shared cluster
Cannabis abuse Substance abuse
62 genes
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8 of 62 corroborated by 2+ sources
MCCC2(1), BNC1(1), BARHL2(1), CACNA1A(1), CADM2(1), CTTNBP2(1), ERC2(1), FOXP1(1), FOXP2(1), GABRA2(2), H4C8(1), IGSF11(1) +50 more
0.109 0.534 8.53e-61 5.25e-59 ✓ sig. Cluster 2 →
Inflammatory bowel disease Multiple sclerosis
135 genes
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35 of 135 corroborated by 2+ sources
WWOX(1), GLI3(1), SH2B3(1), CEBPA(1), RBPJ(3), ABT1(1), ANKRD55(1), BTNL2(1), ELMO1(1), ETS1(1), FOXP1(1), FUT2(1) +123 more
0.119 0.234 5.64e-61 3.48e-59 ✓ sig. Cluster 28 →
Jeune thoracic dystrophy Short rib dysplasia-polydactyly syndrome
22 genes
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15 of 22 corroborated by 2+ sources
EVC2(1), IFT81(1), NEK1(3), IFT43(1), IFT80(2), CEP120(2), DYNC2H1(4), DYNC2I1(4), DYNC2I2(4), DYNC2LI1(2), DYNLT2B(2), IFT140(2) +10 more
0.611 0.917 4.57e-61 2.83e-59 ✓ sig. Cluster 22 →
Eczema Respiratory system disease
73 genes
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2 of 73 corroborated by 2+ sources
RERE(1), CEBPA(1), RTEL1(1), CARD11(1), CCR7(1), EMSY(1), ETS1(1), FADS1(1), FADS2(1), HINT1(1), HLA-DQA1(1), HLA-DRB1(1) +61 more
0.137 0.303 4.23e-61 2.63e-59 ✓ sig. Cluster 252 →
Hypothyroidism Systemic lupus erythematosus
109 genes
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21 of 109 corroborated by 2+ sources
RERE(1), SH2B3(3), TERT(3), IFIH1(3), AFF1(1), BTNL2(1), C12orf42(1), ETS1(4), FAM171A1(1), FKBPL(1), GABBR1(1), HLA-DQA1(3) +97 more
0.118 0.291 9.63e-62 6.00e-60 ✓ sig. Cluster 28 →
Asthma Crohn disease
184 genes
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58 of 184 corroborated by 2+ sources
GLI3(1), CEBPA(1), BLTP1(1), BTNL2(1), CCR7(3), CDHR3(3), CNTNAP2(1), CSMD1(1), EMSY(1), ERBB3(1), ETS1(1), FADS1(1) +172 more
0.117 0.267 9.50e-62 5.94e-60 ✓ sig. —
Hypertrophy Left ventricular disease
30 genes
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30 of 30 corroborated by 2+ sources
ACTA1(2), ACE(2), AGT(2), CKM(2), HBEGF(2), PTPRF(2), REN(2), ADRB3(2), PPP3R1(2), CTNNB1(2), GDF15(2), AHR(2) +18 more
0.349 0.612 6.46e-62 4.05e-60 ✓ sig. Cluster 4 →
Bipolar disorder Depression
123 genes
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39 of 123 corroborated by 2+ sources
COMT(2), SEC24C(1), INS(2), APP(1), GFAP(1), ACE(1), ADRA1A(1), CNTNAP2(2), CTNND2(2), DAO(1), DISC1(1), DLG2(1) +111 more
0.089 0.441 6.31e-62 3.97e-60 ✓ sig. Cluster 2 →
Major depressive disorder Obesity
359 genes
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116 of 359 corroborated by 2+ sources
SOX5(1), RERE(1), COMT(1), DMRT1(1), WWOX(1), PDE4D(2), ABT1(1), AGT(1), AKAP6(1), APOE(3), ARHGEF10L(1), AS3MT(1) +347 more
0.128 0.301 6.21e-62 3.92e-60 ✓ sig. Cluster 2 →
Developmental disability Neurodevelopmental disorder
82 genes
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47 of 82 corroborated by 2+ sources
CHD8(3), UBE3A(1), ANKRD11(2), RAI1(1), SHANK3(2), PTEN(2), ADNP(2), CTSF(1), ATRX(1), ARID1B(2), CELF4(2), DEAF1(4) +70 more
0.082 0.573 3.58e-62 2.27e-60 ✓ sig. Cluster 6 →
Insomnia Schizophrenia
395 genes
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122 of 395 corroborated by 2+ sources
SOX5(2), HMGA2(1), PAFAH1B1(2), DPYD(3), CUL9(1), WWOX(2), PRKG2(1), SPI1(1), CACNA1D(1), ALMS1(1), ADARB1(2), ADGRB3(1) +383 more
0.122 0.366 2.68e-62 1.70e-60 ✓ sig. Cluster 2 →
Cataract Congenital cataract
40 genes
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38 of 40 corroborated by 2+ sources
LSS(6), BFSP2(5), CRYBB2(6), IARS2(1), MAF(4), PITX3(5), PGRMC1(2), VIM(4), CRYAA(6), EPHA2(6), PAX6(2), CRYBA4(5) +28 more
0.180 0.667 2.38e-62 1.51e-60 ✓ sig. Cluster 43 →
Arrhythmogenic right ventricular cardiomyopathy Cardiomyopathy
40 genes
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27 of 40 corroborated by 2+ sources
ABCC9(1), ACTN2(1), CTNNA3(7), DMD(2), DSG2(6), JUP(5), PKP2(7), PRKAG2(3), RBM20(1), TRPM4(1), DSP(4), MYH6(3) +28 more
0.156 0.769 6.25e-63 3.99e-61 ✓ sig. —
Diabetes mellitus type 2 Hypertension
467 genes
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154 of 467 corroborated by 2+ sources
HMGA2(1), CYP17A1(1), BPTF(1), CYP11B2(2), CASZ1(1), RERE(1), COMT(2), INS(3), MAP3K1(1), GATA4(1), ZFPM2(1), APOA1(3) +455 more
0.124 0.406 5.12e-63 3.28e-61 ✓ sig. —
Common variable immunodeficiency Juvenile idiopathic arthritis
46 genes
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4 of 46 corroborated by 2+ sources
ADGRL2(1), ANKRD55(1), ATXN2L(1), DAG1(1), FUT2(1), IGF2(1), LRRK2(1), TENM3(1), TTC33(1), IL10(1), CRB1(1), HLA-DQB1(2) +34 more
0.155 0.613 4.84e-63 3.11e-61 ✓ sig. —
Lipidoses Lipoidosis
19 genes
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19 of 19 corroborated by 2+ sources
SCD(2), LSS(2), FADS2(2), SLC2A3(2), PPARG(2), SERPINA3(2), ASAH1(2), HPN(2), AP1S1(2), ASNS(2), FABP1(2), INHBE(2) +7 more
0.950 1.000 3.37e-63 2.17e-61 ✓ sig. —
Asthma Rheumatoid arthritis
182 genes
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82 of 182 corroborated by 2+ sources
PRDM16(1), CAT(2), RUNX1(3), BLTP1(1), AFF3(3), BTNL2(2), CEP170B(1), DDX6(3), DPP4(1), EMSY(1), EPHA4(1), ERBB3(1) +170 more
0.118 0.275 2.63e-63 1.70e-61 ✓ sig. —
Cleft lip Cleft palate
28 genes
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24 of 28 corroborated by 2+ sources
FGF8(2), FGFR3(2), KIF7(2), TP63(2), FGF10(2), IRF6(2), SPRY2(2), NOS3(2), TYMS(2), FGFR2(2), MSX1(2), PTCH1(2) +16 more
0.400 0.757 2.23e-63 1.45e-61 ✓ sig. Cluster 63 →
Coronary artery disease Metabolic syndrome
276 genes
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53 of 276 corroborated by 2+ sources
SOX5(1), DPYD(1), SKI(1), JMJD1C(1), COLEC11(1), MAP3K1(1), ZFPM2(1), APOA1(3), CELA2A(3), BMPR1B(1), SH2B3(3), DOCK6(1) +264 more
0.127 0.241 1.17e-63 7.59e-62 ✓ sig. —
Systemic lupus erythematosus Systemic sclerosis
71 genes
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24 of 71 corroborated by 2+ sources
ARHGAP31(1), AHNAK2(1), BANK1(4), CSK(3), DDX6(1), DGKQ(1), HLA-DQA1(3), HLA-DRA(1), HLA-DRB1(4), JAZF1(4), TNIP1(5), IL1B(1) +59 more
0.100 0.555 1.13e-63 7.39e-62 ✓ sig. —
Cleft palate Complete unilateral cleft lip
28 genes
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24 of 28 corroborated by 2+ sources
FGF8(2), FGFR3(2), KIF7(2), TP63(2), FGF10(2), IRF6(2), SPRY2(2), NOS3(2), TYMS(2), FGFR2(2), MSX1(2), PTCH1(2) +16 more
0.406 0.778 5.44e-64 3.56e-62 ✓ sig. Cluster 63 →
Diabetes mellitus type 2 Obesity
482 genes
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157 of 482 corroborated by 2+ sources
SOX5(1), RAI1(3), DPYD(3), RERE(1), COMT(2), INS(3), GNAT2(1), PDE4D(1), PRKAR1A(2), RBPJ(2), ABCA1(2), ADGRL2(1) +470 more
0.127 0.404 4.61e-64 3.03e-62 ✓ sig. Cluster 2 →
Autoimmune disease Juvenile idiopathic arthritis
64 genes
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11 of 64 corroborated by 2+ sources
ADGRL2(1), AFF3(1), ANKRD55(1), ATXN2L(1), DAG1(1), FUT2(1), IGF2(1), LRRK2(1), RHOH(1), TENM3(1), TTC33(1), UBE2L3(1) +52 more
0.158 0.317 2.74e-64 1.81e-62 ✓ sig. —
Insomnia Metabolic syndrome
268 genes
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2 of 268 corroborated by 2+ sources
SOX5(1), BPTF(1), DPYD(1), JMJD1C(1), RREB1(1), CACNA1D(1), ADAMTS18(1), ADARB1(1), ADGRB3(1), AFF3(1), AGAP1(1), AGBL1(1) +256 more
0.127 0.248 2.02e-64 1.33e-62 ✓ sig. Cluster 2 →
Oligoarticular juvenile idiopathic arthritis Polyarticular juvenile idiopathic arthritis
32 genes
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8 of 32 corroborated by 2+ sources
RUNX1(1), ANKRD55(2), CLIC4(1), IL6R(1), JAZF1(1), UBE2L3(1), FAS(1), IL2(1), RUNX3(1), ATXN2(1), HLA-DQB1(2), IRF1(1) +20 more
0.187 1.000 1.09e-64 7.20e-63 ✓ sig. Cluster 311 →

Showing 25 of 20813 pairs, sorted by significance (descending). Click a column header to sort.