Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 4

41 diseases · 89 shared-gene connections
41 Diseases
2,438 Unique genes
0.062 Avg. similarity score
Lung neoplasms Most-connected disease (12 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Lung neoplasms 12 12 254
Breast neoplasms 11 11 529
Urinary bladder neoplasms 11 11 142
Ovarian neoplasms 10 10 131
Stomach neoplasms 10 10 306
Colonic neoplasms 8 8 203
Non-small-cell lung carcinoma 8 8 142
Pancreatic neoplasms 8 8 117
Colorectal neoplasms 7 7 291
Liver neoplasms 7 7 152
Renal cell carcinoma 7 7 139
Carcinoma 5 5 165
Esophageal neoplasms 5 5 74
Esophageal squamous cell carcinoma 5 5 129
Hemangiosarcoma 5 5 18
Prostatic neoplasms 5 5 627
Thyroid neoplasms 5 5 46
Transitional cell carcinoma 5 5 33
Lymphatic metastasis 4 4 30
Neuroblastoma 4 4 151
extraoral halitosis due to methanethiol oxidase deficiency 4 4 1
Mesothelioma 3 3 145
Mouth neoplasms 3 3 63
Osteosarcoma 3 3 57
Uterine neoplasms 3 3 38
Anus neoplasms 2 2 1
Cholangiocarcinoma 2 2 38
Pulmonary agenesis 2 2 1
Sarcoma 2 2 33
Acantholytic blistering of oral and laryngeal mucosa 1 1 1
Cerebellar ataxia, brain abnormalities, and cardiac conduction defects 1 1 1
Colobomatous macrophthalmia microcornea syndrome 1 1 1
Diffuse lymphatic malformation 1 1 1
Hypotrichosis and recurrent skin vesicles 1 1 1
Intellectual developmental disorder seizures polymicrogyria 1 1 1
Isobutyryl-coa dehydrogenase deficiency 1 1 1
Retinitis pigmentosa, hearing loss, premature aging, short stature, facial dysmorphism syndrome 1 1 1
amyotrophic lateral sclerosis type 18 1 1 1
hereditary sclerosing poikiloderma with tendon and pulmonary involvement 1 1 1
immune dysregulation, autoimmunity, and autoinflammation 1 1 1
neurodevelopmental disorder with hypotonia, neuropathy, and deafness 1 1 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
TP53 24 / 41 Breast neoplasms, Carcinoma, Cholangiocarcinoma, Colonic neoplasms and 20 more
KRAS 18 / 41 Breast neoplasms, Carcinoma, Cholangiocarcinoma, Colonic neoplasms and 14 more
EGFR 17 / 41 Breast neoplasms, Carcinoma, Cholangiocarcinoma, Colonic neoplasms and 13 more
SOD2 16 / 41 Breast neoplasms, Carcinoma, Colonic neoplasms, Colorectal neoplasms and 12 more
CCND1 15 / 41 Breast neoplasms, Carcinoma, Colonic neoplasms, Colorectal neoplasms and 11 more
MYC 15 / 41 Carcinoma, Colonic neoplasms, Colorectal neoplasms, Hemangiosarcoma and 11 more
PTGS2 15 / 41 Breast neoplasms, Carcinoma, Cholangiocarcinoma, Colonic neoplasms and 11 more
CDKN2A 14 / 41 Breast neoplasms, Colorectal neoplasms, Esophageal neoplasms, Esophageal squamous cell carcinoma and 10 more
BAP1 13 / 41 Breast neoplasms, Cholangiocarcinoma, Colonic neoplasms, Liver neoplasms and 9 more
STAT3 13 / 41 Breast neoplasms, Carcinoma, Colonic neoplasms, Liver neoplasms and 9 more
CTNNB1 12 / 41 Breast neoplasms, Colonic neoplasms, Colorectal neoplasms, Hemangiosarcoma and 8 more
HRAS 12 / 41 Breast neoplasms, Carcinoma, Hemangiosarcoma, Liver neoplasms and 8 more
MET 12 / 41 Carcinoma, Esophageal neoplasms, Lung neoplasms, Lymphatic metastasis and 8 more
TNF 12 / 41 Breast neoplasms, Colonic neoplasms, Colorectal neoplasms, Liver neoplasms and 8 more
ERBB2 11 / 41 Breast neoplasms, Cholangiocarcinoma, Colonic neoplasms, Esophageal neoplasms and 7 more
TERT 11 / 41 Breast neoplasms, Liver neoplasms, Lung neoplasms, Neuroblastoma and 7 more
BIRC5 10 / 41 Breast neoplasms, Colonic neoplasms, Colorectal neoplasms, Lung neoplasms and 6 more
CXCL8 10 / 41 Breast neoplasms, Colorectal neoplasms, Mesothelioma, Non-small-cell lung carcinoma and 6 more
GSTP1 10 / 41 Breast neoplasms, Carcinoma, Lung neoplasms, Non-small-cell lung carcinoma and 6 more
IL6 10 / 41 Breast neoplasms, Cholangiocarcinoma, Lung neoplasms, Mesothelioma and 6 more
MTOR 10 / 41 Breast neoplasms, Colonic neoplasms, Lymphatic metastasis, Mesothelioma and 6 more
APC 9 / 41 Colonic neoplasms, Colorectal neoplasms, Liver neoplasms, Lung neoplasms and 5 more
BCL2 9 / 41 Breast neoplasms, Carcinoma, Colonic neoplasms, Colorectal neoplasms and 5 more
CCNH 9 / 41 Breast neoplasms, Carcinoma, Colonic neoplasms, Esophageal neoplasms and 5 more
CDH1 9 / 41 Breast neoplasms, Carcinoma, Colorectal neoplasms, Mesothelioma and 5 more
CDKN1A 9 / 41 Colonic neoplasms, Esophageal squamous cell carcinoma, Liver neoplasms, Lung neoplasms and 5 more
CSF3 9 / 41 Breast neoplasms, Carcinoma, Esophageal neoplasms, Hemangiosarcoma and 5 more
HNF1B 9 / 41 Cholangiocarcinoma, Colonic neoplasms, Lung neoplasms, Pancreatic neoplasms and 5 more
PIK3CA 9 / 41 Breast neoplasms, Colorectal neoplasms, Lung neoplasms, Mouth neoplasms and 5 more
TNFSF10 9 / 41 Breast neoplasms, Colonic neoplasms, Colorectal neoplasms, Liver neoplasms and 5 more
ARID1A 8 / 41 Breast neoplasms, Cholangiocarcinoma, Colorectal neoplasms, Neuroblastoma and 4 more
CASP8 8 / 41 Breast neoplasms, Colorectal neoplasms, Esophageal neoplasms, Esophageal squamous cell carcinoma and 4 more
CDKN1B 8 / 41 Breast neoplasms, Liver neoplasms, Lung neoplasms, Mesothelioma and 4 more
CHEK2 8 / 41 Breast neoplasms, Colorectal neoplasms, Esophageal squamous cell carcinoma, Lung neoplasms and 4 more
ESR1 8 / 41 Breast neoplasms, Carcinoma, Liver neoplasms, Lung neoplasms and 4 more
FHIT 8 / 41 Carcinoma, Liver neoplasms, Lung neoplasms, Mesothelioma and 4 more
HIF1A 8 / 41 Breast neoplasms, Carcinoma, Esophageal squamous cell carcinoma, Non-small-cell lung carcinoma and 4 more
MACIR 8 / 41 Breast neoplasms, Colonic neoplasms, Esophageal neoplasms, Liver neoplasms and 4 more
MTHFR 8 / 41 Breast neoplasms, Colonic neoplasms, Colorectal neoplasms, Lung neoplasms and 4 more
PTEN 8 / 41 Breast neoplasms, Carcinoma, Cholangiocarcinoma, Lung neoplasms and 4 more
RB1 8 / 41 Breast neoplasms, Carcinoma, Esophageal squamous cell carcinoma, Non-small-cell lung carcinoma and 4 more
TYMS 8 / 41 Breast neoplasms, Colonic neoplasms, Colorectal neoplasms, Lung neoplasms and 4 more
ATP7B 7 / 41 Breast neoplasms, Carcinoma, Colorectal neoplasms, Liver neoplasms and 3 more
BRCA2 7 / 41 Breast neoplasms, Cholangiocarcinoma, Lung neoplasms, Ovarian neoplasms and 3 more
GRIK2 7 / 41 Breast neoplasms, Colonic neoplasms, Esophageal neoplasms, Liver neoplasms and 3 more
GSTM1 7 / 41 Colorectal neoplasms, Liver neoplasms, Lung neoplasms, Mesothelioma and 3 more
JUN 7 / 41 Breast neoplasms, Colonic neoplasms, Hemangiosarcoma, Liver neoplasms and 3 more
KDR 7 / 41 Breast neoplasms, Colorectal neoplasms, Esophageal neoplasms, Hemangiosarcoma and 3 more
MMP9 7 / 41 Breast neoplasms, Colonic neoplasms, Neuroblastoma, Non-small-cell lung carcinoma and 3 more
TRMT11 7 / 41 Breast neoplasms, Colonic neoplasms, Esophageal neoplasms, Liver neoplasms and 3 more
TYMP 7 / 41 Carcinoma, Colonic neoplasms, Colorectal neoplasms, Esophageal squamous cell carcinoma and 3 more
VEGFA 7 / 41 Colonic neoplasms, Hemangiosarcoma, Non-small-cell lung carcinoma, Osteosarcoma and 3 more
ABCB1 6 / 41 Breast neoplasms, Carcinoma, Colorectal neoplasms, Esophageal neoplasms and 2 more
AKT1 6 / 41 Breast neoplasms, Colorectal neoplasms, Lung neoplasms, Ovarian neoplasms and 2 more
ALOX5 6 / 41 Colonic neoplasms, Ovarian neoplasms, Pancreatic neoplasms, Prostatic neoplasms and 2 more
ATM 6 / 41 Breast neoplasms, Pancreatic neoplasms, Prostatic neoplasms, Sarcoma and 2 more
BRAF 6 / 41 Colorectal neoplasms, Liver neoplasms, Lung neoplasms, Lymphatic metastasis and 2 more
BRCA1 6 / 41 Breast neoplasms, Carcinoma, Cholangiocarcinoma, Ovarian neoplasms and 2 more
CLPTM1L 6 / 41 Lung neoplasms, Mouth neoplasms, Non-small-cell lung carcinoma, Prostatic neoplasms and 2 more
CSF2 6 / 41 Breast neoplasms, Carcinoma, Colorectal neoplasms, Liver neoplasms and 2 more
CYP1B1 6 / 41 Breast neoplasms, Colorectal neoplasms, Lung neoplasms, Mouth neoplasms and 2 more
DNMT1 6 / 41 Breast neoplasms, Carcinoma, Colonic neoplasms, Prostatic neoplasms and 2 more
DPYD 6 / 41 Breast neoplasms, Colonic neoplasms, Colorectal neoplasms, Lung neoplasms and 2 more
EFEMP1 6 / 41 Breast neoplasms, Carcinoma, Colorectal neoplasms, Lung neoplasms and 2 more
ENO1 6 / 41 Breast neoplasms, Carcinoma, Esophageal neoplasms, Mouth neoplasms and 2 more
ESR2 6 / 41 Breast neoplasms, Carcinoma, Colorectal neoplasms, Prostatic neoplasms and 2 more
IFNA2 6 / 41 Colorectal neoplasms, Pancreatic neoplasms, Renal cell carcinoma, Thyroid neoplasms and 2 more
IL1B 6 / 41 Breast neoplasms, Colonic neoplasms, Lung neoplasms, Neuroblastoma and 2 more
KMT2C 6 / 41 Cholangiocarcinoma, Esophageal squamous cell carcinoma, Prostatic neoplasms, Stomach neoplasms and 2 more
MSLN 6 / 41 Cholangiocarcinoma, Lymphatic metastasis, Mesothelioma, Ovarian neoplasms and 2 more
NDRG1 6 / 41 Breast neoplasms, Liver neoplasms, Mouth neoplasms, Non-small-cell lung carcinoma and 2 more
NFE2L2 6 / 41 Breast neoplasms, Esophageal squamous cell carcinoma, Liver neoplasms, Lung neoplasms and 2 more
PPARG 6 / 41 Colonic neoplasms, Colorectal neoplasms, Liver neoplasms, Pancreatic neoplasms and 2 more
RAF1 6 / 41 Breast neoplasms, Liver neoplasms, Lung neoplasms, Mesothelioma and 2 more
SLC2A1 6 / 41 Breast neoplasms, Colonic neoplasms, Liver neoplasms, Mesothelioma and 2 more
SOX2 6 / 41 Esophageal squamous cell carcinoma, Lung neoplasms, Osteosarcoma, Prostatic neoplasms and 2 more
TGFBR2 6 / 41 Carcinoma, Colonic neoplasms, Colorectal neoplasms, Esophageal neoplasms and 2 more
UMPS 6 / 41 Breast neoplasms, Colonic neoplasms, Colorectal neoplasms, Mouth neoplasms and 2 more
WT1 6 / 41 Breast neoplasms, Colonic neoplasms, Lung neoplasms, Mesothelioma and 2 more
ACHE 5 / 41 Breast neoplasms, Colorectal neoplasms, Prostatic neoplasms, Renal cell carcinoma and 1 more
AHR 5 / 41 Breast neoplasms, Liver neoplasms, Pancreatic neoplasms, Prostatic neoplasms and 1 more
ALOX12B 5 / 41 Colonic neoplasms, Ovarian neoplasms, Pancreatic neoplasms, Prostatic neoplasms and 1 more
ANXA1 5 / 41 Carcinoma, Esophageal squamous cell carcinoma, Lymphatic metastasis, Mouth neoplasms and 1 more
AQP3 5 / 41 Esophageal neoplasms, Lymphatic metastasis, Neuroblastoma, Ovarian neoplasms and 1 more
BAX 5 / 41 Breast neoplasms, Colonic neoplasms, Colorectal neoplasms, Esophageal neoplasms and 1 more
CAT 5 / 41 Breast neoplasms, Mesothelioma, Non-small-cell lung carcinoma, Renal cell carcinoma and 1 more
CAV1 5 / 41 Breast neoplasms, Lung neoplasms, Ovarian neoplasms, Prostatic neoplasms and 1 more
CRYAB 5 / 41 Colonic neoplasms, Esophageal neoplasms, Mouth neoplasms, Prostatic neoplasms and 1 more
CYP2A6 5 / 41 Colorectal neoplasms, Esophageal squamous cell carcinoma, Lung neoplasms, Prostatic neoplasms and 1 more
EP300 5 / 41 Breast neoplasms, Colorectal neoplasms, Esophageal squamous cell carcinoma, Transitional cell carcinoma and 1 more
EPCAM 5 / 41 Carcinoma, Colorectal neoplasms, Ovarian neoplasms, Pancreatic neoplasms and 1 more
ERCC2 5 / 41 Colorectal neoplasms, Prostatic neoplasms, Sarcoma, Stomach neoplasms and 1 more
FGFR2 5 / 41 Breast neoplasms, Cholangiocarcinoma, Esophageal neoplasms, Lung neoplasms and 1 more
GPX1 5 / 41 Breast neoplasms, Lung neoplasms, Renal cell carcinoma, Transitional cell carcinoma and 1 more
GSTT1 5 / 41 Carcinoma, Esophageal squamous cell carcinoma, Lung neoplasms, Prostatic neoplasms and 1 more
HES1 5 / 41 Breast neoplasms, Colonic neoplasms, Lung neoplasms, Non-small-cell lung carcinoma and 1 more
HMOX1 5 / 41 Breast neoplasms, Liver neoplasms, Lung neoplasms, Prostatic neoplasms and 1 more
IFNB1 5 / 41 Anus neoplasms, Breast neoplasms, Neuroblastoma, Transitional cell carcinoma and 1 more
IFNG 5 / 41 Breast neoplasms, Colonic neoplasms, Lung neoplasms, Mesothelioma and 1 more
IGFBP3 5 / 41 Colorectal neoplasms, Prostatic neoplasms, Stomach neoplasms, Transitional cell carcinoma and 1 more
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Pathways in cancer
ESR1, FGFR2, ABL1, AKT1, AKT2, ALK, APC2, AR, ARAF, BAX, BCL2, BIRC2
 KEGG 269 / 533 2.5× 2.65e-57 5.85e-53 ✓ sig.
Prostate cancer
FGFR2, AKT1, AKT2, AR, ARAF, BCL2, CCND1, CCNE1, CDKN1B, CTNNB1, E2F1, EGF
 KEGG 74 / 98 3.7× 4.59e-32 1.59e-28 ✓ sig.
PI3K-Akt signaling pathway
IFNB1, FGFR2, AKT1, AKT2, AREG, ARTN, BCL2, BRCA1, CCND1, CCNE1, CDKN1B, CSF1
 KEGG 160 / 361 2.2× 6.41e-26 1.31e-22 ✓ sig.
Breast cancer
ESR1, AKT1, AKT2, APC2, ARAF, BAX, BRCA1, BRCA2, CCND1, CTNNB1, DLL1, DLL4
 KEGG 87 / 148 2.9× 5.41e-25 9.79e-22 ✓ sig.
Endocrine resistance
ESR1, AKT1, AKT2, ARAF, BAX, BCL2, CCND1, CDKN1B, CDKN2A, CYP2D6, DLL1, DLL4
 KEGG 67 / 99 3.3× 1.45e-24 2.54e-21 ✓ sig.
Non-small cell lung cancer
AKT1, AKT2, ALK, ARAF, BAX, CCND1, CDKN2A, E2F1, EGF, EGFR, ERBB2, HRAS
 KEGG 55 / 73 3.7× 4.61e-24 7.71e-21 ✓ sig.
Colorectal cancer
AKT1, AKT2, APC2, ARAF, AREG, BAX, BCL2, BIRC5, CCND1, CTNNB1, EGF, EGFR
 KEGG 61 / 87 3.5× 9.30e-24 1.36e-20 ✓ sig.
Proteoglycans in cancer
ESR1, AKT1, AKT2, ARAF, CAV1, CCND1, CTNNB1, EGFR, ERBB2, ERBB3, FGFR1, FLNA
 KEGG 105 / 204 2.5× 1.55e-23 2.22e-20 ✓ sig.
Lipid and atherosclerosis
IFNB1, AKT1, AKT2, BAX, BCL2, CASP7, CASP8, CD40, CXCL2, CXCL3, CXCL8, CYP1A1
 KEGG 109 / 216 2.5× 1.76e-23 2.49e-20 ✓ sig.
Hepatocellular carcinoma
AKT1, AKT2, APC2, ARAF, ARID1A, BAX, CCND1, CDKN2A, CTNNB1, E2F1, EGFR, GSK3B
 KEGG 92 / 170 2.7× 8.70e-23 1.16e-19 ✓ sig.
Pancreatic cancer
AKT1, AKT2, ARAF, BAX, BRCA2, CCND1, CDKN2A, E2F1, EGF, EGFR, ERBB2, KRAS
 KEGG 55 / 77 3.5× 3.58e-22 4.25e-19 ✓ sig.
Bladder cancer
ARAF, CCND1, CDH1, CDKN2A, CXCL8, E2F1, EGF, EGFR, ERBB2, HRAS, KRAS, MDM2
 KEGG 37 / 41 4.5× 7.22e-22 7.97e-19 ✓ sig.
Platinum drug resistance
AKT1, AKT2, ATM, ATP7B, BAX, BCL2, BIRC2, BIRC5, BRCA1, CASP8, CDKN2A, ERBB2
 KEGG 53 / 75 3.5× 4.60e-21 4.35e-18 ✓ sig.
Melanoma
AKT1, AKT2, ARAF, BAX, CCND1, CDH1, CDKN2A, E2F1, EGF, EGFR, FGF10, FGF3
 KEGG 52 / 73 3.5× 6.03e-21 5.51e-18 ✓ sig.
Gastric cancer
FGFR2, ABCB1, AKT1, AKT2, APC2, ARAF, BAX, BCL2, CCND1, CCNE1, CDH1, CDKN1B
 KEGG 82 / 150 2.7× 8.05e-21 7.23e-18 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
positive regulation of transcription by RNA polymerase II
IFNB1, MRTFB, ESR1, FGFR2, ABL1, ACVR1, AHR, AKT1, AR, ATM, BMP2, BMP4
 GO:0045944 357 / 1,208 2.3× 6.26e-56 1.69e-51 ✓ sig.
negative regulation of apoptotic process
AKT1, AKT2, ANGPTL4, ARAF, ARHGDIA, AURKA, BAG1, BARD1, BCL2, BCL2A1, BIRC2, BIRC5
 GO:0043066 199 / 524 2.9× 9.49e-49 1.75e-44 ✓ sig.
positive regulation of gene expression
ACTA2, AGR2, AKT1, AR, ATM, BMP2, BMP4, BMPR2, BRCA1, CAV1, CD74, CDH5
 GO:0010628 185 / 504 2.8× 7.33e-43 9.86e-39 ✓ sig.
positive regulation of cell population proliferation
FGFR2, ADAM10, AR, AREG, BCAR3, BCL2, BIRC5, BMP2, BMP4, CCND1, CDKN1B, CSF1
 GO:0008284 188 / 532 2.7× 7.72e-41 8.72e-37 ✓ sig.
apoptotic process
CHEK2, FGFR2, ABL1, ADAR, AFP, AHR, AKT1, AKT2, AURKA, BAG1, BAX, BCL2
 GO:0006915 229 / 747 2.4× 3.32e-38 3.13e-34 ✓ sig.
positive regulation of DNA-templated transcription
CHEK2, ESR1, ACVR1, AHR, AR, ARID1A, BIRC2, BMP2, BMP4, BRCA1, BRCA2, CD74
 GO:0045893 234 / 778 2.3× 1.45e-37 1.30e-33 ✓ sig.
negative regulation of transcription by RNA polymerase II
ESR1, FGFR2, AR, BMP2, BMP4, C1QBP, CASP7, CAV1, CCND1, CCNE1, CDKN2A, CTNNB1
 GO:0000122 271 / 1,002 2.1× 1.55e-34 1.13e-30 ✓ sig.
negative regulation of cell population proliferation
ADAMTS1, AR, BAP1, BAX, BCHE, BCL2, BMP2, BMP4, BMPR2, CAV1, CDH5, CDKN1B
 GO:0008285 155 / 444 2.7× 4.68e-33 3.15e-29 ✓ sig.
response to xenobiotic stimulus
ABCB1, ABCC1, ABL1, ACACB, AHR, BCAR3, BCHE, BCL2, CAT, CCND1, CDH1, CENPF
 GO:0009410 108 / 248 3.3× 6.43e-33 4.24e-29 ✓ sig.
positive regulation of apoptotic process
ABL1, ATM, BARD1, BAX, BCL2, BCL2A1, BMP2, BMP4, C1QBP, CASP8, CDKN2A, CTNNB1
 GO:0043065 126 / 326 3.0× 5.87e-32 3.60e-28 ✓ sig.
response to hypoxia
ABCB1, ANGPTL4, BIRC2, BMP2, CAT, CAV1, COMT, CPT1A, CXCL12, CXCR4, CYP1A1, DIO3
 GO:0001666 86 / 176 3.8× 5.84e-31 3.29e-27 ✓ sig.
positive regulation of cell migration
ACVR1, ADAM10, AKT1, AKT2, ATM, BMP2, BMP4, CASP8, CAV1, CDH5, CLDN1, CLDN4
 GO:0030335 116 / 292 3.1× 8.71e-31 4.84e-27 ✓ sig.
positive regulation of MAPK cascade
FGFR2, AR, BCAR3, BMP2, CD40, CD74, CDH2, CTNNB1, EFNA1, EGF, EGFR, ERBB2
 GO:0043410 95 / 224 3.3× 5.20e-28 2.39e-24 ✓ sig.
angiogenesis
FGFR2, ANGPTL4, BMP4, CASP8, CAV1, CXCL8, CYP1B1, DLL4, EFNA1, EGF, ELK3, EPHB4
 GO:0001525 108 / 284 2.9× 7.48e-27 2.87e-23 ✓ sig.
regulation of cell population proliferation
ABL1, ALK, BIRC2, BMPR2, CHEK1, CSF2, CTNNB1, CXCL9, DNMT1, EGFR, ERBB2, ERBB3
 GO:0042127 83 / 201 3.2× 1.07e-23 2.97e-20 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Breast neoplasms Prostatic neoplasms 0.110 113 8.25e-52 4.71e-50 ✓ sig.
Transitional cell carcinoma Urinary bladder neoplasms 0.173 26 4.40e-48 2.31e-46 ✓ sig.
Breast neoplasms Colorectal neoplasms 0.099 73 2.04e-43 9.73e-42 ✓ sig.
Breast neoplasms Lung neoplasms 0.097 68 1.96e-42 9.13e-41 ✓ sig.
Lung neoplasms Prostatic neoplasms 0.088 71 5.91e-40 2.62e-38 ✓ sig.
Breast neoplasms Ovarian neoplasms 0.083 50 7.70e-40 3.39e-38 ✓ sig.
Prostatic neoplasms Urinary bladder neoplasms 0.077 55 1.29e-39 5.67e-38 ✓ sig.
Breast neoplasms Non-small-cell lung carcinoma 0.082 50 8.17e-38 3.40e-36 ✓ sig.
Breast neoplasms Urinary bladder neoplasms 0.080 49 1.39e-36 5.67e-35 ✓ sig.
Breast neoplasms Stomach neoplasms 0.089 67 7.65e-36 3.02e-34 ✓ sig.
Lung neoplasms Stomach neoplasms 0.098 50 1.41e-35 5.47e-34 ✓ sig.
Prostatic neoplasms Stomach neoplasms 0.081 70 2.83e-33 1.02e-31 ✓ sig.
Lung neoplasms Non-small-cell lung carcinoma 0.094 34 3.82e-30 1.24e-28 ✓ sig.
Ovarian neoplasms Pancreatic neoplasms 0.117 26 4.26e-30 1.38e-28 ✓ sig.
Colonic neoplasms Colorectal neoplasms 0.088 40 2.07e-29 6.49e-28 ✓ sig.
Colorectal neoplasms Pancreatic neoplasms 0.085 32 1.62e-28 4.96e-27 ✓ sig.
Colonic neoplasms Stomach neoplasms 0.083 39 2.08e-27 6.07e-26 ✓ sig.
Colonic neoplasms Ovarian neoplasms 0.091 28 2.99e-26 8.20e-25 ✓ sig.
Lung neoplasms Ovarian neoplasms 0.084 30 4.62e-26 1.25e-24 ✓ sig.
Colorectal neoplasms Urinary bladder neoplasms 0.080 32 1.29e-25 3.45e-24 ✓ sig.
Colorectal neoplasms Ovarian neoplasms 0.079 31 1.54e-25 4.07e-24 ✓ sig.
Liver neoplasms Lung neoplasms 0.082 31 2.96e-25 7.75e-24 ✓ sig.
Lymphatic metastasis Ovarian neoplasms 0.102 15 5.41e-24 1.32e-22 ✓ sig.
Breast neoplasms Liver neoplasms 0.062 39 6.94e-24 1.68e-22 ✓ sig.
Breast neoplasms Mesothelioma 0.061 38 1.16e-23 2.78e-22 ✓ sig.
Pancreatic neoplasms Urinary bladder neoplasms 0.092 22 5.15e-23 1.19e-21 ✓ sig.
Colonic neoplasms Lung neoplasms 0.075 32 2.14e-22 4.79e-21 ✓ sig.
Colorectal neoplasms Stomach neoplasms 0.072 40 2.23e-22 4.97e-21 ✓ sig.
Colonic neoplasms Pancreatic neoplasms 0.081 24 3.65e-22 8.08e-21 ✓ sig.
Lung neoplasms Mesothelioma 0.070 26 7.83e-20 1.57e-18 ✓ sig.
Non-small-cell lung carcinoma Urinary bladder neoplasms 0.080 21 1.02e-19 2.03e-18 ✓ sig.
Non-small-cell lung carcinoma Uterine neoplasms 0.084 14 1.34e-19 2.64e-18 ✓ sig.
Urinary bladder neoplasms Uterine neoplasms 0.084 14 1.34e-19 2.64e-18 ✓ sig.
Carcinoma Stomach neoplasms 0.065 29 1.78e-19 3.46e-18 ✓ sig.
Carcinoma Lung neoplasms 0.069 27 1.79e-19 3.48e-18 ✓ sig.
Pancreatic neoplasms Thyroid neoplasms 0.093 14 1.88e-19 3.65e-18 ✓ sig.
Esophageal neoplasms Non-small-cell lung carcinoma 0.080 16 4.92e-18 8.96e-17 ✓ sig.
Liver neoplasms Non-small-cell lung carcinoma 0.073 20 8.69e-18 1.56e-16 ✓ sig.
Lymphatic metastasis Non-small-cell lung carcinoma 0.075 12 1.77e-17 3.14e-16 ✓ sig.
Carcinoma Pancreatic neoplasms 0.072 19 1.82e-17 3.23e-16 ✓ sig.
Carcinoma Esophageal neoplasms 0.071 16 5.68e-17 9.77e-16 ✓ sig.
Esophageal neoplasms Lymphatic metastasis 0.105 10 9.72e-17 1.66e-15 ✓ sig.
Carcinoma Urinary bladder neoplasms 0.066 19 7.64e-16 1.22e-14 ✓ sig.
Colonic neoplasms Liver neoplasms 0.063 21 7.85e-16 1.25e-14 ✓ sig.
Esophageal neoplasms Esophageal squamous cell carcinoma 0.074 14 1.22e-15 1.91e-14 ✓ sig.
Esophageal squamous cell carcinoma Urinary bladder neoplasms 0.067 17 2.80e-15 4.29e-14 ✓ sig.
Cholangiocarcinoma Pancreatic neoplasms 0.076 11 3.06e-15 4.67e-14 ✓ sig.
Esophageal neoplasms Mouth neoplasms 0.087 11 7.35e-15 1.10e-13 ✓ sig.
Mesothelioma Ovarian neoplasms 0.061 16 9.07e-14 1.24e-12 ✓ sig.
Lung neoplasms Renal cell carcinoma 0.053 20 1.30e-13 1.77e-12 ✓ sig.
Colonic neoplasms Renal cell carcinoma 0.055 18 3.11e-13 4.16e-12 ✓ sig.
Hemangiosarcoma Uterine neoplasms 0.118 6 2.71e-12 3.30e-11 ✓ sig.
Esophageal squamous cell carcinoma Mouth neoplasms 0.060 11 3.94e-12 4.73e-11 ✓ sig.
Neuroblastoma Urinary bladder neoplasms 0.054 15 8.69e-12 1.01e-10 ✓ sig.
Ovarian neoplasms Renal cell carcinoma 0.054 14 1.22e-11 1.41e-10 ✓ sig.
Non-small-cell lung carcinoma Renal cell carcinoma 0.052 14 3.69e-11 4.04e-10 ✓ sig.
Pancreatic neoplasms Renal cell carcinoma 0.053 13 4.16e-11 4.54e-10 ✓ sig.
Esophageal squamous cell carcinoma Transitional cell carcinoma 0.052 8 2.27e-10 2.32e-9 ✓ sig.
Liver neoplasms Neuroblastoma 0.048 14 2.82e-10 2.84e-9 ✓ sig.
Thyroid neoplasms Transitional cell carcinoma 0.081 6 5.28e-10 5.20e-9 ✓ sig.
Neuroblastoma Stomach neoplasms 0.041 18 1.19e-9 1.13e-8 ✓ sig.
Cholangiocarcinoma Thyroid neoplasms 0.076 6 1.30e-9 1.24e-8 ✓ sig.
Hemangiosarcoma Thyroid neoplasms 0.083 5 1.58e-9 1.49e-8 ✓ sig.
Lymphatic metastasis Mouth neoplasms 0.068 6 2.02e-9 1.87e-8 ✓ sig.
Osteosarcoma Ovarian neoplasms 0.044 8 2.58e-8 2.07e-7 ✓ sig.
Sarcoma Thyroid neoplasms 0.067 5 4.24e-8 3.35e-7 ✓ sig.
Hemangiosarcoma Transitional cell carcinoma 0.083 4 5.24e-8 4.04e-7 ✓ sig.
Hemangiosarcoma Osteosarcoma 0.056 4 4.97e-7 3.26e-6 ✓ sig.
Osteosarcoma Sarcoma 0.046 4 6.37e-6 3.43e-5 ✓ sig.
Hemangiosarcoma immune dysregulation, autoimmunity, and autoinflammation 0.053 1 1.17e-3 1.88e-3 ✓ sig.
Anus neoplasms Transitional cell carcinoma 0.029 1 2.14e-3 3.03e-3 ✓ sig.
amyotrophic lateral sclerosis type 18 Esophageal squamous cell carcinoma 0.008 1 8.38e-3 9.70e-3 ✓ sig.
extraoral halitosis due to methanethiol oxidase deficiency Ovarian neoplasms 0.008 1 8.51e-3 9.85e-3 ✓ sig.
hereditary sclerosing poikiloderma with tendon and pulmonary involvement Renal cell carcinoma 0.007 1 9.03e-3 1.03e-2 ✓ sig.
neurodevelopmental disorder with hypotonia, neuropathy, and deafness Renal cell carcinoma 0.007 1 9.03e-3 1.03e-2 ✓ sig.
Anus neoplasms Urinary bladder neoplasms 0.007 1 9.22e-3 1.05e-2 ✓ sig.
Colobomatous macrophthalmia microcornea syndrome Neuroblastoma 0.007 1 9.81e-3 1.11e-2 ✓ sig.
Liver neoplasms Retinitis pigmentosa, hearing loss, premature aging, short stature, facial dysmorphism syndrome 0.007 1 9.87e-3 1.12e-2 ✓ sig.
Liver neoplasms Pulmonary agenesis 0.007 1 9.87e-3 1.12e-2 ✓ sig.
Acantholytic blistering of oral and laryngeal mucosa Colonic neoplasms 0.005 1 1.32e-2 1.47e-2 ✓ sig.
extraoral halitosis due to methanethiol oxidase deficiency Lung neoplasms 0.004 1 1.65e-2 1.81e-2 ✓ sig.
Lung neoplasms Pulmonary agenesis 0.004 1 1.65e-2 1.81e-2 ✓ sig.
Colorectal neoplasms extraoral halitosis due to methanethiol oxidase deficiency 0.003 1 1.89e-2 2.06e-2 ✓ sig.
Cerebellar ataxia, brain abnormalities, and cardiac conduction defects Stomach neoplasms 0.003 1 1.99e-2 2.16e-2 ✓ sig.
extraoral halitosis due to methanethiol oxidase deficiency Stomach neoplasms 0.003 1 1.99e-2 2.16e-2 ✓ sig.
Isobutyryl-coa dehydrogenase deficiency Stomach neoplasms 0.003 1 1.99e-2 2.16e-2 ✓ sig.
Breast neoplasms Diffuse lymphatic malformation 0.002 1 3.36e-2 3.56e-2 ✓ sig.
Breast neoplasms Hypotrichosis and recurrent skin vesicles 0.002 1 3.36e-2 3.56e-2 ✓ sig.
Intellectual developmental disorder seizures polymicrogyria Prostatic neoplasms 0.002 1 4.07e-2 4.26e-2 ✓ sig.