IFNB1 (interferon beta 1)

Gene Gene information from NCBI Gene database.
Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID 3456
Gene name Interferon beta 1
Gene symbol IFNB1
Synonyms (NCBI Gene)
IFBIFFIFN-betaIFNB
Chromosome 9
Chromosome location 9p21.3
Summary This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are importa
miRNA miRNA information provided by mirtarbase database.
24
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all (24)
miRTarBase ID miRNA Experiments Reference
MIRT004614 hsa-let-7b-5p ELISALuciferase reporter assayqRT-PCR 20130213
MIRT004615 hsa-miR-26a-5p ELISALuciferase reporter assayqRT-PCR 20130213
MIRT004616 hsa-miR-145-5p ELISALuciferase reporter assayqRT-PCR 20130213
MIRT004617 hsa-miR-34a-5p ELISALuciferase reporter assayqRT-PCR 20130213
MIRT644955 hsa-miR-548c-3p HITS-CLIP 23824327
Transcription factors Transcription factors information provided by TRRUST V2 database.
21
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all (21)
Transcription factor Regulation Reference
ATF2 Activation 17496231
ATF2 Unknown 10848607
IRF1 Activation 8021262
IRF1 Unknown 17073600;18575764;22547704
IRF2 Activation 8021262
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
68
Gene SNPs Transcription factors Other IDs Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0002250 Process Adaptive immune response IBA
GO:0002286 Process T cell activation involved in immune response IBA
GO:0002312 Process B cell activation involved in immune response IBA
GO:0002312 Process B cell activation involved in immune response IMP 12932356
GO:0002323 Process Natural killer cell activation involved in immune response IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs Transcription factors Other IDs Associated diseases
MIM HGNC e!Ensembl
147640 5434 ENSG00000171855
Protein Protein information from UniProt database.
Gene SNPs Transcription factors Other IDs Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P01574
Protein name Interferon beta (IFN-beta) (Fibroblast interferon)
Protein function Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli (PubMed:10049744, PubMed:10556041, PubMed:6157094, PubMed:6171735, PubMed:7665574, PubMed:8027027, PubM
PDB 1AU1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00143 Interferon 27 → 185 Interferon alpha/beta domain Domain
Sequence
Sequence length 187
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
14
Gene SNPs Transcription factors Other IDs Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (14)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANUS NEOPLASMS — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BRAIN DISEASES — CTD, Disgenet
CTD, Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST NEOPLASMS — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, TRANSITIONAL CELL — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (359)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 2294436, 9922477
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute pancreatitis Pancreatitis BEFREE 31130960
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of large intestine Colorectal Cancer BEFREE 27188205
★★★★★
★☆☆☆☆
Found in Text Mining only
Adrenocortical carcinoma Adrenocortical carcinoma BEFREE 23507702
★★★★★
★☆☆☆☆
Found in Text Mining only
Adrenoleukodystrophy Adrenoleukodystrophy BEFREE 31662417
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult Acute Lymphocytic Leukemia Lymphocytic Leukemia BEFREE 9922477
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult Medulloblastoma Medulloblastoma BEFREE 24584142, 28559152
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult T-Cell Lymphoma/Leukemia T-Cell Lymphoma/Leukemia BEFREE 28768861
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult type dermatomyositis Dermatomyositis BEFREE 21177291, 21670437, 23018857, 27564228, 30101523
★★★★★
★☆☆☆☆
Found in Text Mining only
Agenesis of corpus callosum Agenesis Of Corpus Callosum BEFREE 23507702
★★★★★
★☆☆☆☆
Found in Text Mining only