Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 6
36
Diseases
1,741
Unique genes
0.040
Avg. similarity score
Neurodevelopmental disorder
Most-connected disease (18 links)
Disease
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Neurodevelopmental disorder
Intellectual developmental disorder
Non-specific syndromic intellectual disability
Global developmental delay
complex neurodevelopmental disorder
Developmental disability
Developmental and epileptic encephalopathy
Intellectual disability
Congenital neurologic anomalies
Nonsyndromic intellectual disability
Intellectual developmental disorder dysmorphic
neurodevelopmental disorder with or without variable brain abnormalities; NEDBA
Clark-baraitser syndrome
1q44 microdeletion syndrome
Usmani-riazuddin syndrome
basilicata-akhtar syndrome
glutamate pyruvate transaminase 2 deficiency
neurodevelopmental disorder with spasticity, cataracts, and cerebellar hypoplasia
Buratti-harel syndrome
Brainstem dysplasia
Dworschak-punetha neurodevelopmental syndrome
Intellectual developmental disorder dysmorphic ocular
Intellectual developmental disorder peripheral neuropathy
hypotonia, infantile, with psychomotor retardation and characteristic facies 2
neurodevelopmental disorder with epilepsy, spasticity, and brain atrophy
aspartylglucosaminuria
Al kaissi syndrome
Al-raqad syndrome
Growth retardation, impaired intellectual development, hypotonia, and hepatopathy
Intellectual developmental disorder behavioral short stature
Otofacial neurodevelopmental syndrome
developmental and epileptic encephalopathy, 55
fucosidosis
NACC1-related neurodevelopmental disorder with epilepsy, cataracts and episodic irritability
kaya-barakat-masson syndrome
neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy
Member diseases (most connected first ‐ the cluster's core)
Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| GRIN2B | 9 / 36 | complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Developmental disability, Global developmental delay and 5 more |
| SCN8A | 9 / 36 | complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Developmental disability, Global developmental delay and 5 more |
| EEF1A2 | 8 / 36 | complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Developmental disability, Global developmental delay and 4 more |
| KCNQ2 | 8 / 36 | complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Developmental disability, Global developmental delay and 4 more |
| SYNGAP1 | 8 / 36 | complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Developmental disability, Global developmental delay and 4 more |
| MBD5 | 7 / 36 | complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder and 3 more |
| PURA | 7 / 36 | complex neurodevelopmental disorder, Congenital neurologic anomalies, Developmental and epileptic encephalopathy, Global developmental delay and 3 more |
| SCN2A | 7 / 36 | complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Developmental disability, Global developmental delay and 3 more |
| ST3GAL3 | 7 / 36 | complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Intellectual developmental disorder, Intellectual disability and 3 more |
| STXBP1 | 7 / 36 | Developmental and epileptic encephalopathy, Developmental disability, Global developmental delay, Intellectual developmental disorder and 3 more |
| CAMK2B | 6 / 36 | Congenital neurologic anomalies, Developmental disability, Global developmental delay, Intellectual developmental disorder and 2 more |
| CASK | 6 / 36 | Congenital neurologic anomalies, Developmental and epileptic encephalopathy, Developmental disability, Global developmental delay and 2 more |
| CTNNB1 | 6 / 36 | Congenital neurologic anomalies, Developmental disability, Global developmental delay, Intellectual developmental disorder and 2 more |
| CYFIP2 | 6 / 36 | complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder and 2 more |
| DYRK1A | 6 / 36 | complex neurodevelopmental disorder, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 2 more |
| FOXG1 | 6 / 36 | Congenital neurologic anomalies, Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder and 2 more |
| GRIN1 | 6 / 36 | complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Intellectual developmental disorder, Neurodevelopmental disorder and 2 more |
| GRIN2A | 6 / 36 | complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder and 2 more |
| HNRNPU | 6 / 36 | 1q44 microdeletion syndrome, complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Intellectual developmental disorder and 2 more |
| KCNQ3 | 6 / 36 | complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Intellectual developmental disorder, Intellectual disability and 2 more |
| MECP2 | 6 / 36 | Congenital neurologic anomalies, Developmental and epileptic encephalopathy, Developmental disability, Global developmental delay and 2 more |
| NALCN | 6 / 36 | Congenital neurologic anomalies, Developmental disability, Global developmental delay, Intellectual developmental disorder and 2 more |
| NBEA | 6 / 36 | complex neurodevelopmental disorder, Developmental disability, Intellectual developmental disorder, Neurodevelopmental disorder and 2 more |
| NRXN1 | 6 / 36 | complex neurodevelopmental disorder, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 2 more |
| POU3F3 | 6 / 36 | complex neurodevelopmental disorder, Developmental disability, Intellectual developmental disorder, Intellectual developmental disorder dysmorphic and 2 more |
| PTEN | 6 / 36 | Congenital neurologic anomalies, Developmental and epileptic encephalopathy, Developmental disability, Global developmental delay and 2 more |
| SETBP1 | 6 / 36 | complex neurodevelopmental disorder, Congenital neurologic anomalies, Developmental disability, Intellectual developmental disorder and 2 more |
| TCF4 | 6 / 36 | Developmental disability, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 2 more |
| ZNF292 | 6 / 36 | complex neurodevelopmental disorder, Intellectual developmental disorder, Intellectual disability, Neurodevelopmental disorder and 2 more |
| ADGRL1 | 5 / 36 | complex neurodevelopmental disorder, Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| AGO1 | 5 / 36 | complex neurodevelopmental disorder, Intellectual developmental disorder, Intellectual disability, Neurodevelopmental disorder and 1 more |
| ANKRD11 | 5 / 36 | Congenital neurologic anomalies, Developmental disability, Global developmental delay, Intellectual developmental disorder and 1 more |
| ARF3 | 5 / 36 | Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder, Non-specific syndromic intellectual disability and 1 more |
| ATP6V0A1 | 5 / 36 | Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| ATRX | 5 / 36 | Congenital neurologic anomalies, Developmental disability, Global developmental delay, Intellectual developmental disorder and 1 more |
| BRSK2 | 5 / 36 | complex neurodevelopmental disorder, Intellectual developmental disorder, Neurodevelopmental disorder, Non-specific syndromic intellectual disability and 1 more |
| CACNA1A | 5 / 36 | Congenital neurologic anomalies, Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder and 1 more |
| CACNG2 | 5 / 36 | complex neurodevelopmental disorder, Intellectual developmental disorder, Neurodevelopmental disorder, Non-specific syndromic intellectual disability and 1 more |
| CAMK2A | 5 / 36 | complex neurodevelopmental disorder, Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| CAMK2G | 5 / 36 | Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 1 more |
| CC2D1A | 5 / 36 | complex neurodevelopmental disorder, Intellectual developmental disorder, Neurodevelopmental disorder, Non-specific syndromic intellectual disability and 1 more |
| CDKL5 | 5 / 36 | Congenital neurologic anomalies, Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder and 1 more |
| CHAMP1 | 5 / 36 | complex neurodevelopmental disorder, Intellectual developmental disorder, Neurodevelopmental disorder, Non-specific syndromic intellectual disability and 1 more |
| CHD2 | 5 / 36 | complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| CHD8 | 5 / 36 | complex neurodevelopmental disorder, Developmental disability, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| CIC | 5 / 36 | complex neurodevelopmental disorder, Intellectual developmental disorder, Neurodevelopmental disorder, Non-specific syndromic intellectual disability and 1 more |
| CLTC | 5 / 36 | Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| CNTNAP2 | 5 / 36 | complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| DEAF1 | 5 / 36 | Developmental disability, Intellectual developmental disorder, Neurodevelopmental disorder, Non-specific syndromic intellectual disability and 1 more |
| DOCK8 | 5 / 36 | Developmental disability, Intellectual developmental disorder, Neurodevelopmental disorder, Non-specific syndromic intellectual disability and 1 more |
| DYNC1H1 | 5 / 36 | Congenital neurologic anomalies, Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| EPB41L1 | 5 / 36 | complex neurodevelopmental disorder, Intellectual developmental disorder, Neurodevelopmental disorder, Non-specific syndromic intellectual disability and 1 more |
| FLNA | 5 / 36 | Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 1 more |
| GABBR2 | 5 / 36 | complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| GABRB2 | 5 / 36 | complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| GRIA1 | 5 / 36 | complex neurodevelopmental disorder, Intellectual developmental disorder, Neurodevelopmental disorder, Non-specific syndromic intellectual disability and 1 more |
| GRIA3 | 5 / 36 | Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 1 more |
| GRIK2 | 5 / 36 | complex neurodevelopmental disorder, Intellectual developmental disorder, Neurodevelopmental disorder, Non-specific syndromic intellectual disability and 1 more |
| GRM7 | 5 / 36 | Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| HECW2 | 5 / 36 | complex neurodevelopmental disorder, Congenital neurologic anomalies, Developmental disability, Neurodevelopmental disorder and 1 more |
| IQSEC2 | 5 / 36 | Developmental and epileptic encephalopathy, Intellectual developmental disorder, Intellectual disability, Neurodevelopmental disorder and 1 more |
| JARID2 | 5 / 36 | Intellectual developmental disorder, Intellectual disability, Neurodevelopmental disorder, Non-specific syndromic intellectual disability and 1 more |
| KCNA2 | 5 / 36 | Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| KCNB1 | 5 / 36 | complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| KDM5B | 5 / 36 | Developmental disability, Intellectual developmental disorder, intellectual disability, Neurodevelopmental disorder and 1 more |
| KIRREL3 | 5 / 36 | Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder, Non-specific syndromic intellectual disability and 1 more |
| KMT2E | 5 / 36 | complex neurodevelopmental disorder, Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| KMT5B | 5 / 36 | complex neurodevelopmental disorder, Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| LINS1 | 5 / 36 | complex neurodevelopmental disorder, Intellectual developmental disorder, Neurodevelopmental disorder, Non-specific syndromic intellectual disability and 1 more |
| MAPK8IP3 | 5 / 36 | Developmental disability, Global developmental delay, Neurodevelopmental disorder, neurodevelopmental disorder with or without variable brain abnormalities; NEDBA and 1 more |
| MBOAT7 | 5 / 36 | complex neurodevelopmental disorder, Intellectual developmental disorder, Neurodevelopmental disorder, Non-specific syndromic intellectual disability and 1 more |
| MED12L | 5 / 36 | Developmental disability, Intellectual developmental disorder, Neurodevelopmental disorder, Non-specific syndromic intellectual disability and 1 more |
| MEF2C | 5 / 36 | complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| NAA15 | 5 / 36 | Developmental disability, Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| NCKAP1 | 5 / 36 | complex neurodevelopmental disorder, Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| NOVA2 | 5 / 36 | complex neurodevelopmental disorder, Intellectual developmental disorder, Intellectual disability, Neurodevelopmental disorder and 1 more |
| PIGA | 5 / 36 | complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| PNKP | 5 / 36 | Congenital neurologic anomalies, Developmental and epileptic encephalopathy, Developmental disability, Global developmental delay and 1 more |
| PPP2R5C | 5 / 36 | complex neurodevelopmental disorder, Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| PPP2R5D | 5 / 36 | complex neurodevelopmental disorder, Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| SCN1A | 5 / 36 | Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 1 more |
| SETD5 | 5 / 36 | Developmental disability, Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| SHANK2 | 5 / 36 | complex neurodevelopmental disorder, Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| SLC6A1 | 5 / 36 | Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| SMARCA5 | 5 / 36 | complex neurodevelopmental disorder, Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| SMC1A | 5 / 36 | Congenital neurologic anomalies, Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder and 1 more |
| SNAP25 | 5 / 36 | Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 1 more |
| STAG1 | 5 / 36 | complex neurodevelopmental disorder, Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| TAOK1 | 5 / 36 | Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder, Non-specific syndromic intellectual disability and 1 more |
| TBC1D24 | 5 / 36 | Congenital neurologic anomalies, Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder and 1 more |
| TNRC6B | 5 / 36 | complex neurodevelopmental disorder, Developmental disability, Global developmental delay, Neurodevelopmental disorder and 1 more |
| TRIP12 | 5 / 36 | Clark-baraitser syndrome, complex neurodevelopmental disorder, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| TRPM3 | 5 / 36 | Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| TUSC3 | 5 / 36 | Congenital neurologic anomalies, Intellectual developmental disorder, intellectual disability, Neurodevelopmental disorder and 1 more |
| UBE3A | 5 / 36 | Developmental and epileptic encephalopathy, Developmental disability, Global developmental delay, Intellectual developmental disorder and 1 more |
| ACTL6B | 4 / 36 | Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder, Non-specific syndromic intellectual disability |
| ADNP | 4 / 36 | Developmental disability, Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder |
| ANK2 | 4 / 36 | complex neurodevelopmental disorder, Intellectual developmental disorder, Neurodevelopmental disorder, Non-specific syndromic intellectual disability |
| ANK3 | 4 / 36 | Congenital neurologic anomalies, Intellectual developmental disorder, intellectual disability, Non-specific syndromic intellectual disability |
| AP1G1 | 4 / 36 | complex neurodevelopmental disorder, Neurodevelopmental disorder, Non-specific syndromic intellectual disability, Usmani-riazuddin syndrome |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Nicotine addiction | KEGG | 24 / 41 | 4.0× | 7.96e-11 | 1.18e-8 ✓ sig. |
| Unblocking of NMDA receptors, glutamate binding and activation | Reactome | 16 / 22 | 5.0× | 1.12e-9 | 1.24e-7 ✓ sig. |
| Glutamatergic synapse | KEGG | 43 / 116 | 2.6× | 1.29e-9 | 1.39e-7 ✓ sig. |
| GABAergic synapse | KEGG | 35 / 89 | 2.7× | 7.35e-9 | 6.70e-7 ✓ sig. |
| Dopaminergic synapse | KEGG | 44 / 132 | 2.3× | 3.53e-8 | 2.63e-6 ✓ sig. |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | Reactome | 20 / 38 | 3.6× | 3.67e-8 | 2.72e-6 ✓ sig. |
| Long-term potentiation | KEGG | 27 / 67 | 2.8× | 2.10e-7 | 1.25e-5 ✓ sig. |
| Thyroid hormone signaling pathway | KEGG | 40 / 122 | 2.3× | 2.41e-7 | 1.41e-5 ✓ sig. |
| Serotonin Neurotransmitter Release Cycle | Reactome | 12 / 18 | 4.6× | 6.58e-7 | 3.39e-5 ✓ sig. |
| Interaction between L1 and Ankyrins | Reactome | 10 / 13 | 5.3× | 7.52e-7 | 3.81e-5 ✓ sig. |
| Long-term depression | KEGG | 24 / 60 | 2.8× | 1.16e-6 | 5.55e-5 ✓ sig. |
| Amphetamine addiction | KEGG | 26 / 69 | 2.6× | 1.63e-6 | 7.40e-5 ✓ sig. |
| Circadian entrainment | KEGG | 32 / 97 | 2.3× | 3.25e-6 | 1.33e-4 ✓ sig. |
| Dopamine Neurotransmitter Release Cycle | Reactome | 13 / 23 | 3.9× | 3.29e-6 | 1.34e-4 ✓ sig. |
| Phase 0 - rapid depolarisation | Reactome | 19 / 44 | 3.0× | 3.90e-6 | 1.55e-4 ✓ sig. |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| nervous system development | GO:0007399 | 177 / 631 | 3.0× | 3.61e-43 | 5.05e-39 ✓ sig. |
| chromatin organization | GO:0006325 | 124 / 449 | 3.0× | 1.25e-29 | 6.33e-26 ✓ sig. |
| chromatin remodeling | GO:0006338 | 96 / 320 | 3.2× | 4.16e-26 | 1.47e-22 ✓ sig. |
| brain development | GO:0007420 | 73 / 244 | 3.2× | 4.61e-20 | 7.63e-17 ✓ sig. |
| positive regulation of DNA-templated transcription | GO:0045893 | 147 / 778 | 2.0× | 2.84e-17 | 3.04e-14 ✓ sig. |
| monoatomic ion transmembrane transport | GO:0034220 | 94 / 404 | 2.5× | 3.35e-17 | 3.54e-14 ✓ sig. |
| synapse organization | GO:0050808 | 33 / 72 | 4.9× | 6.74e-16 | 5.46e-13 ✓ sig. |
| chemical synaptic transmission | GO:0007268 | 64 / 236 | 2.9× | 1.93e-15 | 1.44e-12 ✓ sig. |
| monoatomic ion transport | GO:0006811 | 126 / 667 | 2.0× | 6.19e-15 | 4.15e-12 ✓ sig. |
| axon guidance | GO:0007411 | 55 / 192 | 3.1× | 1.49e-14 | 9.36e-12 ✓ sig. |
| cerebral cortex development | GO:0021987 | 34 / 88 | 4.1× | 1.20e-13 | 6.53e-11 ✓ sig. |
| neuron migration | GO:0001764 | 42 / 132 | 3.4× | 3.97e-13 | 1.96e-10 ✓ sig. |
| cognition | GO:0050890 | 27 / 64 | 4.5× | 3.39e-12 | 1.38e-9 ✓ sig. |
| tRNA aminoacylation for protein translation | GO:0006418 | 20 / 36 | 6.0× | 3.70e-12 | 1.49e-9 ✓ sig. |
| positive regulation of transcription by RNA polymerase II | GO:0045944 | 182 / 1,208 | 1.6× | 2.22e-11 | 7.47e-9 ✓ sig. |