Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs Associated diseases
Entrez ID	5527
Gene name	Protein phosphatase 2 regulatory subunit B'gamma
Gene symbol	PPP2R5C
Synonyms (NCBI Gene)	B56GB56gammaHJS4PR61G
Chromosome	14
Chromosome location	14q32.31
Summary	The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common het

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1595460164	G>A	Likely-pathogenic	Missense variant, coding sequence variant

322

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miRTarBase ID	miRNA	Experiments	Reference
MIRT001428	hsa-miR-16-5p	pSILAC	18668040
MIRT028561	hsa-miR-30a-5p	Proteomics	18668040
MIRT001428	hsa-miR-16-5p	Proteomics;Other	18668040
MIRT038933	hsa-miR-31-3p	CLASH	23622248
MIRT053099	hsa-miR-135b-5p	Luciferase reporter assayqRT-PCRWestern blot	23594704
MIRT053099	hsa-miR-135b-5p	Luciferase reporter assayqRT-PCRWestern blot	23594704
MIRT277505	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT277506	hsa-miR-107	PAR-CLIP	20371350
MIRT277507	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT277510	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT277508	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT277509	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT277504	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT001428	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT277520	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT555315	hsa-miR-548ao-3p	PAR-CLIP	20371350
MIRT277511	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT555313	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT555312	hsa-miR-646	PAR-CLIP	20371350
MIRT277516	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT277513	hsa-miR-3607-5p	PAR-CLIP	20371350
MIRT555309	hsa-miR-29c-5p	PAR-CLIP	20371350
MIRT277512	hsa-miR-3190-3p	PAR-CLIP	20371350
MIRT277515	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT277517	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT277518	hsa-miR-6505-5p	PAR-CLIP	20371350
MIRT277514	hsa-miR-3611	PAR-CLIP	20371350
MIRT277519	hsa-miR-6833-5p	PAR-CLIP	20371350
MIRT277505	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT277506	hsa-miR-107	PAR-CLIP	21572407
MIRT277507	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT277510	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT277508	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT277509	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT277504	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT001428	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT277520	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT555315	hsa-miR-548ao-3p	PAR-CLIP	21572407
MIRT277511	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT555314	hsa-miR-3664-5p	PAR-CLIP	21572407
MIRT555313	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT555312	hsa-miR-646	PAR-CLIP	21572407
MIRT277516	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT277513	hsa-miR-3607-5p	PAR-CLIP	21572407
MIRT277521	hsa-miR-7114-5p	PAR-CLIP	21572407
MIRT555311	hsa-miR-134-3p	PAR-CLIP	21572407
MIRT555310	hsa-miR-4680-5p	PAR-CLIP	21572407
MIRT555309	hsa-miR-29c-5p	PAR-CLIP	21572407
MIRT277512	hsa-miR-3190-3p	PAR-CLIP	21572407
MIRT277515	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT277517	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT277518	hsa-miR-6505-5p	PAR-CLIP	21572407
MIRT277514	hsa-miR-3611	PAR-CLIP	21572407
MIRT277519	hsa-miR-6833-5p	PAR-CLIP	21572407
MIRT726880	hsa-miR-193a-3p	HITS-CLIP	22473208
MIRT726879	hsa-miR-193b-3p	HITS-CLIP	22473208
MIRT277505	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT277506	hsa-miR-107	PAR-CLIP	20371350
MIRT277507	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT277510	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT277508	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT277509	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT277504	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT001428	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT277520	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT555315	hsa-miR-548ao-3p	PAR-CLIP	20371350
MIRT277511	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT555313	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT555312	hsa-miR-646	PAR-CLIP	20371350
MIRT277516	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT277513	hsa-miR-3607-5p	PAR-CLIP	20371350
MIRT555309	hsa-miR-29c-5p	PAR-CLIP	20371350
MIRT277512	hsa-miR-3190-3p	PAR-CLIP	20371350
MIRT277515	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT277517	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT277518	hsa-miR-6505-5p	PAR-CLIP	20371350
MIRT277514	hsa-miR-3611	PAR-CLIP	20371350
MIRT277519	hsa-miR-6833-5p	PAR-CLIP	20371350
MIRT277505	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT277506	hsa-miR-107	PAR-CLIP	21572407
MIRT277507	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT277510	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT277508	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT277509	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT277504	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT001428	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT277520	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT555315	hsa-miR-548ao-3p	PAR-CLIP	21572407
MIRT277511	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT555314	hsa-miR-3664-5p	PAR-CLIP	21572407
MIRT555313	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT555312	hsa-miR-646	PAR-CLIP	21572407
MIRT277516	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT277513	hsa-miR-3607-5p	PAR-CLIP	21572407
MIRT277521	hsa-miR-7114-5p	PAR-CLIP	21572407
MIRT555311	hsa-miR-134-3p	PAR-CLIP	21572407
MIRT555310	hsa-miR-4680-5p	PAR-CLIP	21572407
MIRT555309	hsa-miR-29c-5p	PAR-CLIP	21572407
MIRT277512	hsa-miR-3190-3p	PAR-CLIP	21572407
MIRT277515	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT277517	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT277518	hsa-miR-6505-5p	PAR-CLIP	21572407
MIRT277514	hsa-miR-3611	PAR-CLIP	21572407
MIRT277519	hsa-miR-6833-5p	PAR-CLIP	21572407
MIRT1257994	hsa-miR-1185	CLIP-seq
MIRT1257995	hsa-miR-139-5p	CLIP-seq
MIRT1257996	hsa-miR-141	CLIP-seq
MIRT1257997	hsa-miR-146a	CLIP-seq
MIRT1257998	hsa-miR-146b-5p	CLIP-seq
MIRT1257999	hsa-miR-183	CLIP-seq
MIRT1258000	hsa-miR-200a	CLIP-seq
MIRT1258001	hsa-miR-216b	CLIP-seq
MIRT1258002	hsa-miR-219-5p	CLIP-seq
MIRT1258003	hsa-miR-3074-3p	CLIP-seq
MIRT1258004	hsa-miR-3124-3p	CLIP-seq
MIRT1258005	hsa-miR-3133	CLIP-seq
MIRT1258006	hsa-miR-3148	CLIP-seq
MIRT1258007	hsa-miR-3160-5p	CLIP-seq
MIRT1258008	hsa-miR-3171	CLIP-seq
MIRT1258009	hsa-miR-337-3p	CLIP-seq
MIRT1258010	hsa-miR-345	CLIP-seq
MIRT1258011	hsa-miR-3605-5p	CLIP-seq
MIRT1258012	hsa-miR-3614-5p	CLIP-seq
MIRT1258013	hsa-miR-3673	CLIP-seq
MIRT1258014	hsa-miR-3679-5p	CLIP-seq
MIRT1258015	hsa-miR-3685	CLIP-seq
MIRT1258016	hsa-miR-384	CLIP-seq
MIRT1258017	hsa-miR-3924	CLIP-seq
MIRT1258018	hsa-miR-3942-3p	CLIP-seq
MIRT1258019	hsa-miR-3978	CLIP-seq
MIRT1258020	hsa-miR-4502	CLIP-seq
MIRT1258021	hsa-miR-4511	CLIP-seq
MIRT1258022	hsa-miR-4699-5p	CLIP-seq
MIRT1258023	hsa-miR-4712-5p	CLIP-seq
MIRT1258024	hsa-miR-4744	CLIP-seq
MIRT1258025	hsa-miR-4753-3p	CLIP-seq
MIRT1258026	hsa-miR-4762-3p	CLIP-seq
MIRT1258027	hsa-miR-4782-3p	CLIP-seq
MIRT1258028	hsa-miR-509-3p	CLIP-seq
MIRT1258029	hsa-miR-548u	CLIP-seq
MIRT1258030	hsa-miR-570	CLIP-seq
MIRT1258031	hsa-miR-579	CLIP-seq
MIRT1258032	hsa-miR-580	CLIP-seq
MIRT1258033	hsa-miR-589	CLIP-seq
MIRT1258034	hsa-miR-616	CLIP-seq
MIRT1258035	hsa-miR-758	CLIP-seq
MIRT1258036	hsa-miR-770-5p	CLIP-seq
MIRT1258037	hsa-miR-890	CLIP-seq
MIRT1258038	hsa-miR-1184	CLIP-seq
MIRT1258039	hsa-miR-1229	CLIP-seq
MIRT1258040	hsa-miR-1538	CLIP-seq
MIRT1258041	hsa-miR-200b	CLIP-seq
MIRT1258042	hsa-miR-200c	CLIP-seq
MIRT1258043	hsa-miR-346	CLIP-seq
MIRT1258044	hsa-miR-34a	CLIP-seq
MIRT1258045	hsa-miR-34c-5p	CLIP-seq
MIRT1258046	hsa-miR-3614-3p	CLIP-seq
MIRT1258047	hsa-miR-371-3p	CLIP-seq
MIRT1258048	hsa-miR-3714	CLIP-seq
MIRT1258049	hsa-miR-4261	CLIP-seq
MIRT1258050	hsa-miR-4276	CLIP-seq
MIRT1258051	hsa-miR-4288	CLIP-seq
MIRT1258052	hsa-miR-429	CLIP-seq
MIRT1258053	hsa-miR-4330	CLIP-seq
MIRT1258054	hsa-miR-4418	CLIP-seq
MIRT1258055	hsa-miR-4420	CLIP-seq
MIRT1258056	hsa-miR-4457	CLIP-seq
MIRT1258057	hsa-miR-4459	CLIP-seq
MIRT1258058	hsa-miR-4477a	CLIP-seq
MIRT1258059	hsa-miR-4493	CLIP-seq
MIRT1258060	hsa-miR-449a	CLIP-seq
MIRT1258061	hsa-miR-449b	CLIP-seq
MIRT1258062	hsa-miR-4519	CLIP-seq
MIRT1258063	hsa-miR-4705	CLIP-seq
MIRT1258064	hsa-miR-4722-5p	CLIP-seq
MIRT1258065	hsa-miR-4745-3p	CLIP-seq
MIRT1258066	hsa-miR-4773	CLIP-seq
MIRT1258067	hsa-miR-509-3-5p	CLIP-seq
MIRT1258068	hsa-miR-509-5p	CLIP-seq
MIRT1258069	hsa-miR-558	CLIP-seq
MIRT1258070	hsa-miR-632	CLIP-seq
MIRT1258071	hsa-miR-885-3p	CLIP-seq
MIRT1258072	hsa-miR-137	CLIP-seq
MIRT1258073	hsa-miR-25	CLIP-seq
MIRT1258074	hsa-miR-32	CLIP-seq
MIRT1258075	hsa-miR-363	CLIP-seq
MIRT1258076	hsa-miR-367	CLIP-seq
MIRT1258077	hsa-miR-548k	CLIP-seq
MIRT1258078	hsa-miR-548n	CLIP-seq
MIRT1258079	hsa-miR-548t	CLIP-seq
MIRT1258080	hsa-miR-561	CLIP-seq
MIRT1258081	hsa-miR-92a	CLIP-seq
MIRT1258082	hsa-miR-92b	CLIP-seq
MIRT1258041	hsa-miR-200b	CLIP-seq
MIRT1258042	hsa-miR-200c	CLIP-seq
MIRT2076023	hsa-miR-224	CLIP-seq
MIRT2076024	hsa-miR-3659	CLIP-seq
MIRT1258052	hsa-miR-429	CLIP-seq
MIRT2076025	hsa-miR-4658	CLIP-seq
MIRT2076026	hsa-miR-4742-3p	CLIP-seq
MIRT2076027	hsa-miR-4761-5p	CLIP-seq
MIRT2076028	hsa-miR-574-5p	CLIP-seq
MIRT2076029	hsa-miR-624	CLIP-seq
MIRT1258038	hsa-miR-1184	CLIP-seq
MIRT2302620	hsa-miR-1202	CLIP-seq
MIRT2302621	hsa-miR-1289	CLIP-seq
MIRT2302622	hsa-miR-140-3p	CLIP-seq
MIRT2302623	hsa-miR-1911	CLIP-seq
MIRT2302624	hsa-miR-2277-3p	CLIP-seq
MIRT2302625	hsa-miR-3131	CLIP-seq
MIRT2302626	hsa-miR-320e	CLIP-seq
MIRT1258046	hsa-miR-3614-3p	CLIP-seq
MIRT2302627	hsa-miR-3662	CLIP-seq
MIRT2302628	hsa-miR-3690	CLIP-seq
MIRT2302629	hsa-miR-3972	CLIP-seq
MIRT2302630	hsa-miR-4254	CLIP-seq
MIRT1258053	hsa-miR-4330	CLIP-seq
MIRT1258054	hsa-miR-4418	CLIP-seq
MIRT2302631	hsa-miR-4433	CLIP-seq
MIRT1258062	hsa-miR-4519	CLIP-seq
MIRT2302632	hsa-miR-4694-3p	CLIP-seq
MIRT2302633	hsa-miR-4698	CLIP-seq
MIRT1258024	hsa-miR-4744	CLIP-seq
MIRT1258066	hsa-miR-4773	CLIP-seq
MIRT2302634	hsa-miR-485-3p	CLIP-seq
MIRT2302635	hsa-miR-486-3p	CLIP-seq
MIRT2302636	hsa-miR-499a-5p	CLIP-seq
MIRT1258067	hsa-miR-509-3-5p	CLIP-seq
MIRT1258068	hsa-miR-509-5p	CLIP-seq
MIRT2302637	hsa-miR-542-3p	CLIP-seq
MIRT1258029	hsa-miR-548u	CLIP-seq
MIRT2302638	hsa-miR-611	CLIP-seq
MIRT2302621	hsa-miR-1289	CLIP-seq
MIRT1258041	hsa-miR-200b	CLIP-seq
MIRT1258042	hsa-miR-200c	CLIP-seq
MIRT2599263	hsa-miR-2276	CLIP-seq
MIRT2599264	hsa-miR-3140-3p	CLIP-seq
MIRT2599265	hsa-miR-3145-3p	CLIP-seq
MIRT2599266	hsa-miR-3145-5p	CLIP-seq
MIRT2599267	hsa-miR-3183	CLIP-seq
MIRT2599268	hsa-miR-329	CLIP-seq
MIRT2599269	hsa-miR-342-3p	CLIP-seq
MIRT2599270	hsa-miR-3616-3p	CLIP-seq
MIRT2599271	hsa-miR-362-3p	CLIP-seq
MIRT2599272	hsa-miR-3926	CLIP-seq
MIRT2599273	hsa-miR-3941	CLIP-seq
MIRT2599274	hsa-miR-4266	CLIP-seq
MIRT1258052	hsa-miR-429	CLIP-seq
MIRT2599275	hsa-miR-4311	CLIP-seq
MIRT2302631	hsa-miR-4433	CLIP-seq
MIRT2599276	hsa-miR-4446-5p	CLIP-seq
MIRT1258058	hsa-miR-4477a	CLIP-seq
MIRT2599277	hsa-miR-4637	CLIP-seq
MIRT2599278	hsa-miR-4652-3p	CLIP-seq
MIRT2599279	hsa-miR-466	CLIP-seq
MIRT2599280	hsa-miR-4672	CLIP-seq
MIRT2599281	hsa-miR-4695-5p	CLIP-seq
MIRT2599282	hsa-miR-4704-3p	CLIP-seq
MIRT2599283	hsa-miR-4719	CLIP-seq
MIRT2599284	hsa-miR-4723-3p	CLIP-seq
MIRT2599285	hsa-miR-4724-5p	CLIP-seq
MIRT2599286	hsa-miR-4740-3p	CLIP-seq
MIRT2599287	hsa-miR-4772-3p	CLIP-seq
MIRT2599288	hsa-miR-4775	CLIP-seq
MIRT2599289	hsa-miR-4779	CLIP-seq
MIRT2599290	hsa-miR-4789-3p	CLIP-seq
MIRT2599291	hsa-miR-548a-3p	CLIP-seq
MIRT2599292	hsa-miR-548c-3p	CLIP-seq
MIRT2599293	hsa-miR-548e	CLIP-seq
MIRT2599294	hsa-miR-548f	CLIP-seq
MIRT1258032	hsa-miR-580	CLIP-seq
MIRT2599295	hsa-miR-590-3p	CLIP-seq
MIRT2599296	hsa-miR-603	CLIP-seq
MIRT2599297	hsa-miR-651	CLIP-seq
MIRT2599298	hsa-miR-924	CLIP-seq
MIRT2302621	hsa-miR-1289	CLIP-seq
MIRT1258041	hsa-miR-200b	CLIP-seq
MIRT1258042	hsa-miR-200c	CLIP-seq
MIRT2599263	hsa-miR-2276	CLIP-seq
MIRT2599264	hsa-miR-3140-3p	CLIP-seq
MIRT2599265	hsa-miR-3145-3p	CLIP-seq
MIRT2599266	hsa-miR-3145-5p	CLIP-seq
MIRT2599267	hsa-miR-3183	CLIP-seq
MIRT2599268	hsa-miR-329	CLIP-seq
MIRT2599269	hsa-miR-342-3p	CLIP-seq
MIRT2599270	hsa-miR-3616-3p	CLIP-seq
MIRT2599271	hsa-miR-362-3p	CLIP-seq
MIRT2688471	hsa-miR-3647-3p	CLIP-seq
MIRT2688472	hsa-miR-3921	CLIP-seq
MIRT2599272	hsa-miR-3926	CLIP-seq
MIRT2599273	hsa-miR-3941	CLIP-seq
MIRT2599274	hsa-miR-4266	CLIP-seq
MIRT1258052	hsa-miR-429	CLIP-seq
MIRT2599275	hsa-miR-4311	CLIP-seq
MIRT2302631	hsa-miR-4433	CLIP-seq
MIRT2599276	hsa-miR-4446-5p	CLIP-seq
MIRT1258058	hsa-miR-4477a	CLIP-seq
MIRT2599277	hsa-miR-4637	CLIP-seq
MIRT2599278	hsa-miR-4652-3p	CLIP-seq
MIRT2688473	hsa-miR-4653-5p	CLIP-seq
MIRT2599279	hsa-miR-466	CLIP-seq
MIRT2599280	hsa-miR-4672	CLIP-seq
MIRT2599281	hsa-miR-4695-5p	CLIP-seq
MIRT2599282	hsa-miR-4704-3p	CLIP-seq
MIRT2599283	hsa-miR-4719	CLIP-seq
MIRT2599284	hsa-miR-4723-3p	CLIP-seq
MIRT2599286	hsa-miR-4740-3p	CLIP-seq
MIRT2688474	hsa-miR-4766-5p	CLIP-seq
MIRT2688475	hsa-miR-4768-5p	CLIP-seq
MIRT2599287	hsa-miR-4772-3p	CLIP-seq
MIRT2599288	hsa-miR-4775	CLIP-seq
MIRT2599289	hsa-miR-4779	CLIP-seq
MIRT2599290	hsa-miR-4789-3p	CLIP-seq
MIRT2599291	hsa-miR-548a-3p	CLIP-seq
MIRT2599292	hsa-miR-548c-3p	CLIP-seq
MIRT2599293	hsa-miR-548e	CLIP-seq
MIRT2599294	hsa-miR-548f	CLIP-seq
MIRT1258030	hsa-miR-570	CLIP-seq
MIRT2599295	hsa-miR-590-3p	CLIP-seq
MIRT2599296	hsa-miR-603	CLIP-seq
MIRT2599297	hsa-miR-651	CLIP-seq
MIRT2599298	hsa-miR-924	CLIP-seq

Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000159	Component	Protein phosphatase type 2A complex	IBA
GO:0000159	Component	Protein phosphatase type 2A complex	IDA	17174897, 17245430
GO:0000159	Component	Protein phosphatase type 2A complex	IEA
GO:0000159	Component	Protein phosphatase type 2A complex	NAS	8703017
GO:0000775	Component	Chromosome, centromeric region	IDA	16580887
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0005515	Function	Protein binding	IPI	1328865, 7592815, 8617797, 15380617, 16239230, 16456541, 16580887, 17245430, 17529992, 17540176, 18782753, 19156129, 19915589, 21460856, 25241761, 27173435, 27880917, 28174209, 28330616, 30595372, 33961781, 35271311
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	8703017
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	NAS	8703017
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	17245430
GO:0019888	Function	Protein phosphatase regulator activity	IDA	17245430
GO:0019888	Function	Protein phosphatase regulator activity	IEA
GO:0019888	Function	Protein phosphatase regulator activity	NAS	8703017
GO:0030330	Process	DNA damage response, signal transduction by p53 class mediator	IDA	17245430
GO:0042771	Process	Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP	17245430
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IMP	16717086
GO:0051177	Process	Meiotic sister chromatid cohesion	IBA
GO:0072542	Function	Protein phosphatase activator activity	IBA

MIM	HGNC	e!Ensembl
601645	9311	ENSG00000078304

Q13362

Protein name

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29)

Protein function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphor

PDB

2IAE , 2JAK , 2NPP , 2NYL , 2NYM , 3FGA , 5JJA , 5K6S , 5SW9 , 5SWF , 6OYL , 6TOQ , 6VOY , 6VRO , 7OUF , 7OUG , 7OUH , 7PEL , 7SOY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01603	B56	27 → 437	Protein phosphatase 2A regulatory B subunit (B56 family)	Family

Tissue specificity

TISSUE SPECIFICITY: Highest levels in heart, skeletal muscle and brain. Lower levels in pancreas, kidney, lung and placenta. Very low levels in liver.

Sequence

MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDPL
SDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDP
EEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERD
FLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLK
EEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPK
EVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLIS
DNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEK
LKMKEREEAWVKIENLAKANPQYTVYSQASTMSIPVAMETDGPLFEDVQMLRKTVKDEAH
QAQKDPKKDRPLARRKSELPQDPHTKKALEAHCRADELASQDGR

Sequence length

524

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Global developmental delay	Likely pathogenic	rs2140903557	RCV001391100	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
PPP2R5C-related neurodevelopmental disorder	Likely pathogenic	rs2140903557	RCV005867013	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (18)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHROMOSOMAL INSTABILITY	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COMPLEX NEURODEVELOPMENTAL DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Houge-Janssens syndrome 4	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL RECESSIVE 41	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Intellectual disability	Conflicting classifications of pathogenicity	ClinVar Disgenet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Macrocephaly-developmental delay syndrome	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurodevelopmental disorder	Uncertain significance	ClinVar GenCC	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SPECIFIC SYNDROMIC INTELLECTUAL DISABILITY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PPP2R5C-related disorder	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESTLESS LEGS SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
THYROID CANCER, PAPILLARY	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VITILIGO	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (28)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Angioedema	Angioedema	Pubtator	34539625	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune disease	Pubtator	34539625	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	16276521		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	26986830		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	20473327		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	CTD_human_DG	16038780		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	34680934, 37728516, 39199384, 40307680	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms Hereditary Nonpolyposis	Lynch syndrome	Pubtator	37728516	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	34006268	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	22653804, 37728516	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Familial Nonmedullary Thyroid Cancer	Thyroid cancer	CTD_human_DG	28030816		★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Diseases	Heart disease	Pubtator	30212560	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Irritable Bowel Syndrome	Irritable bowel syndrome	Pubtator	27445342	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	21548944		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	21548944, 23941244	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid	Myeloid leukemia	Pubtator	21548944	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	21548944	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	20473327		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	20473327, 21548944		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	24004697		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	17967874, 20470940, 20473327		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nonmedullary Thyroid Carcinoma	Nonmedullary thyroid carcinoma	CTD_human_DG	28030816		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	26440364		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	37272097	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	32192517	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	CTD_human_DG	28030816		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sezary Syndrome	Sezary syndrome	Pubtator	21548944	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Tetralogy of Fallot	Tetralogy of fallot	Pubtator	30212560	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

PPP2R5C (protein phosphatase 2 regulatory subunit B'gamma)