DALRD3 (DALR anticodon binding domain containing 3)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55152
• Gene name: DALR anticodon binding domain containing 3
• Gene symbol: DALRD3
• Synonyms (NCBI Gene): DEE86, EIEE86
• Chromosome: 3
• Chromosome location: 3p21.31
• Summary: The exact function of this gene is not known. It encodes a protein with a DALR anticodon binding domain similar to that of class Ia aminoacyl tRNA synthetases. This gene is located in a cluster of genes (with a complex sense-anti-sense genome architecture

miRNA Show/Hide all (128)

miRTarBase ID	miRNA	Experiments	Reference
MIRT040896	hsa-miR-18a-3p	CLASH	23622248
MIRT1973452	hsa-miR-129-5p	CLIP-seq
MIRT1973453	hsa-miR-3140-3p	CLIP-seq
MIRT1973454	hsa-miR-629	CLIP-seq
MIRT2447995	hsa-miR-101	CLIP-seq
MIRT1973452	hsa-miR-129-5p	CLIP-seq
MIRT2447996	hsa-miR-145	CLIP-seq
MIRT2447997	hsa-miR-1587	CLIP-seq
MIRT2447998	hsa-miR-1915	CLIP-seq
MIRT2447999	hsa-miR-194	CLIP-seq
MIRT2448000	hsa-miR-3120-5p	CLIP-seq
MIRT1973453	hsa-miR-3140-3p	CLIP-seq
MIRT2448001	hsa-miR-3180-5p	CLIP-seq
MIRT2448002	hsa-miR-3184	CLIP-seq
MIRT2448003	hsa-miR-3611	CLIP-seq
MIRT2448004	hsa-miR-3689d	CLIP-seq
MIRT2448005	hsa-miR-423-5p	CLIP-seq
MIRT2448006	hsa-miR-4310	CLIP-seq
MIRT2448007	hsa-miR-4312	CLIP-seq
MIRT2448008	hsa-miR-4492	CLIP-seq
MIRT2448009	hsa-miR-4498	CLIP-seq
MIRT2448010	hsa-miR-4641	CLIP-seq
MIRT2448011	hsa-miR-4656	CLIP-seq
MIRT2448012	hsa-miR-4675	CLIP-seq
MIRT2448013	hsa-miR-4678	CLIP-seq
MIRT2448014	hsa-miR-4726-3p	CLIP-seq
MIRT2448015	hsa-miR-4741	CLIP-seq
MIRT2448016	hsa-miR-495	CLIP-seq
MIRT2448017	hsa-miR-532-5p	CLIP-seq
MIRT2448018	hsa-miR-543	CLIP-seq
MIRT2448019	hsa-miR-626	CLIP-seq
MIRT1973454	hsa-miR-629	CLIP-seq
MIRT2448020	hsa-miR-758	CLIP-seq
MIRT2448021	hsa-miR-762	CLIP-seq
MIRT2448022	hsa-miR-765	CLIP-seq
MIRT2447995	hsa-miR-101	CLIP-seq
MIRT1973452	hsa-miR-129-5p	CLIP-seq
MIRT2447996	hsa-miR-145	CLIP-seq
MIRT2447997	hsa-miR-1587	CLIP-seq
MIRT2447998	hsa-miR-1915	CLIP-seq
MIRT2447999	hsa-miR-194	CLIP-seq
MIRT2448000	hsa-miR-3120-5p	CLIP-seq
MIRT1973453	hsa-miR-3140-3p	CLIP-seq
MIRT2448001	hsa-miR-3180-5p	CLIP-seq
MIRT2448002	hsa-miR-3184	CLIP-seq
MIRT2448003	hsa-miR-3611	CLIP-seq
MIRT2448004	hsa-miR-3689d	CLIP-seq
MIRT2448005	hsa-miR-423-5p	CLIP-seq
MIRT2448006	hsa-miR-4310	CLIP-seq
MIRT2448007	hsa-miR-4312	CLIP-seq
MIRT2448008	hsa-miR-4492	CLIP-seq
MIRT2448009	hsa-miR-4498	CLIP-seq
MIRT2448010	hsa-miR-4641	CLIP-seq
MIRT2448011	hsa-miR-4656	CLIP-seq
MIRT2448012	hsa-miR-4675	CLIP-seq
MIRT2448013	hsa-miR-4678	CLIP-seq
MIRT2448014	hsa-miR-4726-3p	CLIP-seq
MIRT2448015	hsa-miR-4741	CLIP-seq
MIRT2448016	hsa-miR-495	CLIP-seq
MIRT2448017	hsa-miR-532-5p	CLIP-seq
MIRT2448018	hsa-miR-543	CLIP-seq
MIRT2448019	hsa-miR-626	CLIP-seq
MIRT1973454	hsa-miR-629	CLIP-seq
MIRT2448020	hsa-miR-758	CLIP-seq
MIRT2448021	hsa-miR-762	CLIP-seq
MIRT2448022	hsa-miR-765	CLIP-seq
MIRT2447995	hsa-miR-101	CLIP-seq
MIRT1973452	hsa-miR-129-5p	CLIP-seq
MIRT2447996	hsa-miR-145	CLIP-seq
MIRT2447997	hsa-miR-1587	CLIP-seq
MIRT2447998	hsa-miR-1915	CLIP-seq
MIRT2447999	hsa-miR-194	CLIP-seq
MIRT2448000	hsa-miR-3120-5p	CLIP-seq
MIRT1973453	hsa-miR-3140-3p	CLIP-seq
MIRT2448001	hsa-miR-3180-5p	CLIP-seq
MIRT2448002	hsa-miR-3184	CLIP-seq
MIRT2448003	hsa-miR-3611	CLIP-seq
MIRT2448004	hsa-miR-3689d	CLIP-seq
MIRT2448005	hsa-miR-423-5p	CLIP-seq
MIRT2448006	hsa-miR-4310	CLIP-seq
MIRT2448007	hsa-miR-4312	CLIP-seq
MIRT2448008	hsa-miR-4492	CLIP-seq
MIRT2448009	hsa-miR-4498	CLIP-seq
MIRT2448010	hsa-miR-4641	CLIP-seq
MIRT2448011	hsa-miR-4656	CLIP-seq
MIRT2448012	hsa-miR-4675	CLIP-seq
MIRT2448013	hsa-miR-4678	CLIP-seq
MIRT2448014	hsa-miR-4726-3p	CLIP-seq
MIRT2448015	hsa-miR-4741	CLIP-seq
MIRT2448016	hsa-miR-495	CLIP-seq
MIRT2448017	hsa-miR-532-5p	CLIP-seq
MIRT2448018	hsa-miR-543	CLIP-seq
MIRT2448019	hsa-miR-626	CLIP-seq
MIRT1973454	hsa-miR-629	CLIP-seq
MIRT2448020	hsa-miR-758	CLIP-seq
MIRT2448021	hsa-miR-762	CLIP-seq
MIRT2448022	hsa-miR-765	CLIP-seq
MIRT2447995	hsa-miR-101	CLIP-seq
MIRT1973452	hsa-miR-129-5p	CLIP-seq
MIRT2447996	hsa-miR-145	CLIP-seq
MIRT2447997	hsa-miR-1587	CLIP-seq
MIRT2447998	hsa-miR-1915	CLIP-seq
MIRT2447999	hsa-miR-194	CLIP-seq
MIRT2448000	hsa-miR-3120-5p	CLIP-seq
MIRT1973453	hsa-miR-3140-3p	CLIP-seq
MIRT2448001	hsa-miR-3180-5p	CLIP-seq
MIRT2448002	hsa-miR-3184	CLIP-seq
MIRT2448003	hsa-miR-3611	CLIP-seq
MIRT2448004	hsa-miR-3689d	CLIP-seq
MIRT2448005	hsa-miR-423-5p	CLIP-seq
MIRT2448006	hsa-miR-4310	CLIP-seq
MIRT2448007	hsa-miR-4312	CLIP-seq
MIRT2448008	hsa-miR-4492	CLIP-seq
MIRT2448009	hsa-miR-4498	CLIP-seq
MIRT2448010	hsa-miR-4641	CLIP-seq
MIRT2448011	hsa-miR-4656	CLIP-seq
MIRT2448012	hsa-miR-4675	CLIP-seq
MIRT2448013	hsa-miR-4678	CLIP-seq
MIRT2448014	hsa-miR-4726-3p	CLIP-seq
MIRT2448015	hsa-miR-4741	CLIP-seq
MIRT2448016	hsa-miR-495	CLIP-seq
MIRT2448017	hsa-miR-532-5p	CLIP-seq
MIRT2448018	hsa-miR-543	CLIP-seq
MIRT2448019	hsa-miR-626	CLIP-seq
MIRT1973454	hsa-miR-629	CLIP-seq
MIRT2448020	hsa-miR-758	CLIP-seq
MIRT2448021	hsa-miR-762	CLIP-seq
MIRT2448022	hsa-miR-765	CLIP-seq

Gene ontology (GO) Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000049	Function	TRNA binding	IBA
GO:0000049	Function	TRNA binding	IDA	32427860
GO:0000049	Function	TRNA binding	IMP	39482881
GO:0000166	Function	Nucleotide binding	IEA
GO:0004812	Function	Aminoacyl-tRNA ligase activity	IEA
GO:0004814	Function	Arginine-tRNA ligase activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 32427860, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0006399	Process	TRNA metabolic process	IEA
GO:0006418	Process	TRNA aminoacylation for protein translation	IEA
GO:0006420	Process	Arginyl-tRNA aminoacylation	IEA
GO:0010467	Process	Gene expression	IEA
GO:0106217	Process	TRNA C3-cytosine methylation	IBA
GO:0106217	Process	TRNA C3-cytosine methylation	IMP	32427860, 39482881

Other IDs

• MIM: 618904
• HGNC: 25536
• e!Ensembl: ENSG00000178149

Protein

• UniProt ID: Q5D0E6
• Protein name: DALR anticodon-binding domain-containing protein 3
• Protein function: Involved in tRNA methylation. Facilitates the recognition and targeting of tRNA(Arg)(CCU) and tRNA(Arg)(UCU) substrates for N(3)-methylcytidine modification by METTL2A and METTL2B.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05746	DALR_1	403 → 543	DALR anticodon binding domain	Domain

• Sequence:

  MATRRLGVGETLGALNAALGPGGPVWIKETRTRHLRSRDFLAPHRALQARFDDGQVPEHL
  LHALACLQGPGVAPVLRCAPTPAGLSLQLQRSAVFERVLSAVAAYATPASPASLGQRVLL
  HCPALRSSPCALRLSQLRTVLVADHLARALRAHGVCVRLVPAVRDPHMLTFLQQLRVDWP
  AASERASSHTLRSHALEELTSANDGRTLSPGILGRLCLKELVEEQGRTAGYDPNLDNCLV
  TEDLLSVLAELQEALWHWPEDSHPGLAGASDTGTGGCLVVHVVSCEEEFQQQKLDLLWQK
  LVDKAPLRQKHLICGPVKVAGAPGTLMTAPEYYEFRHTQVCKASALKHGGDLAQDPAWTE
  IFGVLSVATIKFEMLSTAPQSQLFLALADSSISTKGTKSGTFVMYNCARLATLFESYKCS
  MEQGLYPTFPPVSSLDFSLLHDEGEWLLLFNSILPFPDLLSRTAVLDCTAPGLHIAVRTE
  MICKFLVQLSMDFSSYYNRVHILGEPRPHLFGQMFVRLQLLRAVREVLHTGLAMLGLPPL
  SHI

• Sequence length: 543

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (6)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
DALRD3-related disorder	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 86	—	Disgenet, HPO Disgenet, HPO	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Developmental and epileptic encephalopathy, 86	Uncertain significance; Conflicting classifications of pathogenicity	ClinVar ClinVar, GWAS catalog	32427860	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
MYOCARDIAL INFARCTION	—	GWAS catalog	38072966	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SPECIFIC EARLY-ONSET EPILEPTIC ENCEPHALOPATHY	—	Disgenet, Orphanet Disgenet, Orphanet	32427860	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UNDETERMINED EARLY-ONSET EPILEPTIC ENCEPHALOPATHY	—	GWAS catalog	32427860	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Brain Diseases	Brain disease	Pubtator	32427860	Associate	★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	32427860	Associate	★☆☆☆☆ Found in Text Mining only
MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 18	Mitochondrial Complex Deficiency	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Non-specific early-onset epileptic encephalopathy	Non-Specifi Epileptic Encephalopathy	Orphanet			★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

Sort by: Blended Diseases Pathways Evidence source

FBXO28 1 shared diseaseDevelopmental and epileptic encephalopathy 5 shared evidence sourcesOrphanet (Developmental and epileptic encephalopathy), Disgenet (Developmental and epileptic encephalopathy), HPO (Developmental and epileptic encephalopathy), ClinVar (Developmental and epileptic encephalopathy), GWAS catalog (Developmental and epileptic encephalopathy) Related via 1 shared disease including Developmental and epileptic encephalopathy — evidence mostly Orphanet. CDK19 1 shared diseaseDevelopmental and epileptic encephalopathy 5 shared evidence sourcesOrphanet (Developmental and epileptic encephalopathy), Disgenet (Developmental and epileptic encephalopathy), HPO (Developmental and epileptic encephalopathy), ClinVar (Developmental and epileptic encephalopathy), GWAS catalog (Developmental and epileptic encephalopathy) Related via 1 shared disease including Developmental and epileptic encephalopathy — evidence mostly Orphanet. YWHAG 1 shared diseaseDevelopmental and epileptic encephalopathy 5 shared evidence sourcesOrphanet (Developmental and epileptic encephalopathy), Disgenet (Developmental and epileptic encephalopathy), HPO (Developmental and epileptic encephalopathy), ClinVar (Developmental and epileptic encephalopathy), GWAS catalog (Developmental and epileptic encephalopathy) Related via 1 shared disease including Developmental and epileptic encephalopathy — evidence mostly Orphanet. HID1 1 shared diseaseDevelopmental and epileptic encephalopathy 4 shared evidence sourcesDisgenet (Developmental and epileptic encephalopathy), HPO (Developmental and epileptic encephalopathy), ClinVar (Developmental and epileptic encephalopathy), GWAS catalog (Developmental and epileptic encephalopathy) Related via 1 shared disease including Developmental and epileptic encephalopathy — evidence mostly Disgenet. PACS2 1 shared diseaseDevelopmental and epileptic encephalopathy 5 shared evidence sourcesOrphanet (Developmental and epileptic encephalopathy), Disgenet (Developmental and epileptic encephalopathy), HPO (Developmental and epileptic encephalopathy), ClinVar (Developmental and epileptic encephalopathy), GWAS catalog (Developmental and epileptic encephalopathy) Related via 1 shared disease including Developmental and epileptic encephalopathy — evidence mostly Orphanet.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
FBXO28	1	["Developmental and epileptic encephalopathy"]	0	[]	5	["Orphanet (Developmental and epileptic encephalopathy)","Disgenet (Developmental and epileptic encephalopathy)","HPO (Developmental and epileptic encephalopathy)","ClinVar (Developmental and epileptic encephalopathy)","GWAS catalog (Developmental and epileptic encephalopathy)"]
CDK19	1	["Developmental and epileptic encephalopathy"]	0	[]	5	["Orphanet (Developmental and epileptic encephalopathy)","Disgenet (Developmental and epileptic encephalopathy)","HPO (Developmental and epileptic encephalopathy)","ClinVar (Developmental and epileptic encephalopathy)","GWAS catalog (Developmental and epileptic encephalopathy)"]
YWHAG	1	["Developmental and epileptic encephalopathy"]	0	[]	5	["Orphanet (Developmental and epileptic encephalopathy)","Disgenet (Developmental and epileptic encephalopathy)","HPO (Developmental and epileptic encephalopathy)","ClinVar (Developmental and epileptic encephalopathy)","GWAS catalog (Developmental and epileptic encephalopathy)"]
HID1	1	["Developmental and epileptic encephalopathy"]	0	[]	4	["Disgenet (Developmental and epileptic encephalopathy)","HPO (Developmental and epileptic encephalopathy)","ClinVar (Developmental and epileptic encephalopathy)","GWAS catalog (Developmental and epileptic encephalopathy)"]
PACS2	1	["Developmental and epileptic encephalopathy"]	0	[]	5	["Orphanet (Developmental and epileptic encephalopathy)","Disgenet (Developmental and epileptic encephalopathy)","HPO (Developmental and epileptic encephalopathy)","ClinVar (Developmental and epileptic encephalopathy)","GWAS catalog (Developmental and epileptic encephalopathy)"]

Diseases Linked via Similar Genes

Major depressive disorder Linked via 2 of 5 related genesFBXO28, CDK19 Schizophrenia Linked via 2 of 5 related genesFBXO28, YWHAG Intellectual developmental disorder Linked via 2 of 5 related genesYWHAG, PACS2 Bipolar disorder Linked via 1 of 5 related genesFBXO28 Color vision deficiency Linked via 1 of 5 related genesFBXO28

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Major depressive disorder	2	["FBXO28","CDK19"]
Schizophrenia	2	["FBXO28","YWHAG"]
Intellectual developmental disorder	2	["YWHAG","PACS2"]
Bipolar disorder	1	["FBXO28"]
Color vision deficiency	1	["FBXO28"]