Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 22

20 diseases · 37 shared-gene connections
20 Diseases
369 Unique genes
0.076 Avg. similarity score
Myositis Most-connected disease (9 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Myositis 9 9 61
Crest syndrome 8 8 21
Polymyositis 6 6 22
Scleroderma 6 6 28
Sjogren syndrome 6 6 71
Systemic sclerosis 6 6 128
Diffuse cutaneous systemic sclerosis 5 5 23
Dermatomyositis 4 4 31
Systemic scleroderma 4 4 15
autosomal systemic lupus erythematosus type 16 3 3 1
Autoinflammatory syndrome, familial, behcet-like 2 2 1
Dry eye syndrome 2 2 57
Irritant dermatitis 2 2 9
Kawasaki disease 2 2 64
Neuroocular syndrome 2 2 2
multiple self-healing squamous epithelioma 2 2 1
spinocerebellar ataxia, autosomal recessive 25 2 2 1
TTC8-related ciliopathy 1 1 1
developmental and epileptic encephalopathy, 41 1 1 1
immunodeficiency 25 1 1 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
STAT4 9 / 20 Crest syndrome, Dermatomyositis, Diffuse cutaneous systemic sclerosis, Myositis and 5 more
IRF5 7 / 20 Crest syndrome, Diffuse cutaneous systemic sclerosis, Myositis, Scleroderma and 3 more
HLA-DPB1 6 / 20 Dermatomyositis, Diffuse cutaneous systemic sclerosis, Irritant dermatitis, Sjogren syndrome and 2 more
HLA-DQB1 6 / 20 Kawasaki disease, Myositis, Polymyositis, Scleroderma and 2 more
TNPO3 6 / 20 Crest syndrome, Diffuse cutaneous systemic sclerosis, Myositis, Sjogren syndrome and 2 more
ATG5 5 / 20 Crest syndrome, Myositis, Sjogren syndrome, spinocerebellar ataxia, autosomal recessive 25 and 1 more
BLK 5 / 20 Kawasaki disease, Myositis, Polymyositis, Sjogren syndrome and 1 more
DGKQ 5 / 20 Crest syndrome, Myositis, Polymyositis, Sjogren syndrome and 1 more
HLA-DPA1 5 / 20 Dermatomyositis, Diffuse cutaneous systemic sclerosis, Irritant dermatitis, Systemic scleroderma and 1 more
HLA-DRB1 5 / 20 Crest syndrome, Diffuse cutaneous systemic sclerosis, Myositis, Sjogren syndrome and 1 more
TNF 5 / 20 Dermatomyositis, Kawasaki disease, Polymyositis, Scleroderma and 1 more
CAV1 4 / 20 Crest syndrome, Diffuse cutaneous systemic sclerosis, Scleroderma, Systemic sclerosis
CCN2 4 / 20 Crest syndrome, Diffuse cutaneous systemic sclerosis, Scleroderma, Systemic sclerosis
DNASE1L3 4 / 20 autosomal systemic lupus erythematosus type 16, Crest syndrome, Myositis, Systemic sclerosis
FAM167A 4 / 20 Kawasaki disease, Myositis, Polymyositis, Systemic sclerosis
HLA-DQA1 4 / 20 Diffuse cutaneous systemic sclerosis, Myositis, Sjogren syndrome, Systemic sclerosis
HLA-DRA 4 / 20 Dermatomyositis, Myositis, Sjogren syndrome, Systemic sclerosis
IL1B 4 / 20 Dermatomyositis, Dry eye syndrome, Polymyositis, Systemic sclerosis
PTPN22 4 / 20 Myositis, Polymyositis, Sjogren syndrome, Systemic sclerosis
TGFBR1 4 / 20 Dermatomyositis, Diffuse cutaneous systemic sclerosis, multiple self-healing squamous epithelioma, Scleroderma
TNFAIP3 4 / 20 Autoinflammatory syndrome, familial, behcet-like, Myositis, Sjogren syndrome, Systemic sclerosis
TNIP1 4 / 20 Myositis, Scleroderma, Sjogren syndrome, Systemic sclerosis
CCR6 3 / 20 Crest syndrome, Diffuse cutaneous systemic sclerosis, Systemic sclerosis
CD247 3 / 20 immunodeficiency 25, Scleroderma, Systemic sclerosis
FCGR2A 3 / 20 Diffuse cutaneous systemic sclerosis, Kawasaki disease, Sjogren syndrome
FCGR2B 3 / 20 Crest syndrome, Systemic scleroderma, Systemic sclerosis
FCGR3B 3 / 20 Crest syndrome, Systemic scleroderma, Systemic sclerosis
HLA-DRB5 3 / 20 Crest syndrome, Dermatomyositis, Systemic scleroderma
IL6 3 / 20 Dry eye syndrome, Polymyositis, Sjogren syndrome
LTA 3 / 20 Kawasaki disease, Sjogren syndrome, Systemic sclerosis
NAB1 3 / 20 Myositis, Polymyositis, Systemic sclerosis
PRR12 3 / 20 Myositis, Neuroocular syndrome, Systemic sclerosis
THSD7A 3 / 20 Dry eye syndrome, Polymyositis, Sjogren syndrome
ACTA2 2 / 20 Scleroderma, Systemic sclerosis
ARL14 2 / 20 Myositis, Systemic sclerosis
BANK1 2 / 20 Diffuse cutaneous systemic sclerosis, Systemic sclerosis
C1QL1 2 / 20 Dry eye syndrome, Sjogren syndrome
C2 2 / 20 Dermatomyositis, Irritant dermatitis
CCDC116 2 / 20 Myositis, Systemic sclerosis
CCN1 2 / 20 Scleroderma, Systemic sclerosis
CCNG1 2 / 20 Dry eye syndrome, Sjogren syndrome
CCR5 2 / 20 Kawasaki disease, Sjogren syndrome
CNR1 2 / 20 Scleroderma, Systemic sclerosis
CNR2 2 / 20 Scleroderma, Systemic sclerosis
COL1A2 2 / 20 Scleroderma, Systemic sclerosis
CXCR5 2 / 20 Sjogren syndrome, Systemic sclerosis
DCHS2 2 / 20 Dry eye syndrome, Sjogren syndrome
DDX6 2 / 20 Diffuse cutaneous systemic sclerosis, Systemic sclerosis
DRD4 2 / 20 Myositis, Systemic sclerosis
EIF4H 2 / 20 Myositis, Systemic sclerosis
ELN 2 / 20 Polymyositis, Systemic sclerosis
FAM241B 2 / 20 Dry eye syndrome, Sjogren syndrome
FBN1 2 / 20 Crest syndrome, Systemic sclerosis
FSTL1 2 / 20 Scleroderma, Systemic sclerosis
GLS 2 / 20 Myositis, Systemic sclerosis
GSDMA 2 / 20 Crest syndrome, Systemic sclerosis
GSDMB 2 / 20 Dermatomyositis, Systemic sclerosis
HDAC5 2 / 20 Scleroderma, Systemic sclerosis
HLA-B 2 / 20 Dermatomyositis, Sjogren syndrome
IL12RB2 2 / 20 Myositis, Systemic sclerosis
IL1A 2 / 20 Dermatomyositis, Polymyositis
IL1RN 2 / 20 Myositis, Sjogren syndrome
KCNB2 2 / 20 Dry eye syndrome, Sjogren syndrome
KCP 2 / 20 Sjogren syndrome, Systemic sclerosis
KIAA0319L 2 / 20 Crest syndrome, Systemic sclerosis
LIMK1 2 / 20 Myositis, Systemic sclerosis
MBL2 2 / 20 Dermatomyositis, Kawasaki disease
MICB 2 / 20 Kawasaki disease, Myositis
MMP9 2 / 20 Sjogren syndrome, Systemic sclerosis
NAV2 2 / 20 Dry eye syndrome, Sjogren syndrome
NCF2 2 / 20 Myositis, Systemic sclerosis
NECTIN2 2 / 20 Scleroderma, Systemic sclerosis
NMT1 2 / 20 Dry eye syndrome, Sjogren syndrome
PHTF1 2 / 20 Myositis, Systemic sclerosis
PMS1 2 / 20 Dermatomyositis, Polymyositis
PPP2R2B 2 / 20 Dry eye syndrome, Sjogren syndrome
PSORS1C1 2 / 20 Scleroderma, Systemic sclerosis
PTPN11 2 / 20 Myositis, Systemic sclerosis
RHOB 2 / 20 Scleroderma, Systemic sclerosis
RSBN1 2 / 20 Myositis, Systemic sclerosis
S1PR5 2 / 20 Scleroderma, Systemic sclerosis
SCT 2 / 20 Myositis, Systemic sclerosis
SDC2 2 / 20 Dry eye syndrome, Sjogren syndrome
SDK2 2 / 20 Myositis, Polymyositis
SIRT1 2 / 20 Scleroderma, Systemic sclerosis
SIRT7 2 / 20 Scleroderma, Systemic sclerosis
SLC1A2 2 / 20 developmental and epileptic encephalopathy, 41, Myositis
SMG7 2 / 20 Myositis, Systemic sclerosis
TAP2 2 / 20 Diffuse cutaneous systemic sclerosis, Scleroderma
TNFSF4 2 / 20 Myositis, Systemic sclerosis
TSBP1 2 / 20 Kawasaki disease, Sjogren syndrome
TTC8 2 / 20 Crest syndrome, TTC8-related ciliopathy
TWIST2 2 / 20 Dry eye syndrome, Sjogren syndrome
TYK2 2 / 20 Myositis, Systemic sclerosis
YDJC 2 / 20 Myositis, Systemic sclerosis
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Inflammatory bowel disease
HLA-DRB5, STAT4, HLA-DPA1, HLA-DPB1, HLA-DRA, IL1A, IL1B, TNF, HLA-DRB1, HLA-DQA1, IL13, TLR2
 KEGG 30 / 66 14.8× 2.64e-28 6.77e-25 ✓ sig.
Leishmaniasis
FCGR3B, HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA, IL1A, IL1B, TNF, HLA-DRB1, FCGR2A, HLA-DQA1, IRAK1
 KEGG 26 / 78 10.8× 1.60e-20 1.34e-17 ✓ sig.
Allograft rejection
HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-B, HLA-DRA, TNF, HLA-DRB1, HLA-DQA1, CD40, CD40LG, HLA-DOB, HLA-DQB1
 KEGG 19 / 39 15.9× 4.55e-19 3.22e-16 ✓ sig.
Type I diabetes mellitus
HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-B, HLA-DRA, IL1A, IL1B, TNF, HLA-DRB1, HLA-DQA1, HLA-DOB, HLA-DQB1
 KEGG 19 / 44 14.1× 8.08e-18 4.48e-15 ✓ sig.
Toxoplasmosis
HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA, TNF, HLA-DRB1, HLA-DQA1, IRAK1, TLR2, TGFB1, CASP3, CCR5
 KEGG 27 / 112 7.8× 3.37e-17 1.64e-14 ✓ sig.
Graft-versus-host disease
HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-B, HLA-DRA, IL1A, IL1B, TNF, HLA-DRB1, HLA-DQA1, IL6, HLA-DOB
 KEGG 18 / 45 13.0× 3.18e-16 1.34e-13 ✓ sig.
Th17 cell differentiation
HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA, IL1B, HLA-DRB1, HLA-DQA1, TGFBR1, IL6, TGFB1, IL17A, IL17F
 KEGG 25 / 109 7.5× 1.83e-15 6.74e-13 ✓ sig.
Phosphorylation of CD3 and TCR zeta chains
HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA, HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DQB2, PTPRC, PTPRJ, PTPN22, CD247
 Reactome 13 / 22 19.2× 6.84e-15 2.25e-12 ✓ sig.
Rheumatoid arthritis
HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA, IL1A, IL1B, TNF, HLA-DRB1, HLA-DQA1, TLR2, IL6, TGFB1
 KEGG 23 / 95 7.9× 7.14e-15 2.33e-12 ✓ sig.
Tuberculosis
FCGR2B, FCGR3B, HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA, IL1A, IL1B, TNF, HLA-DRB1, FCGR2A, HLA-DQA1
 KEGG 30 / 181 5.4× 3.07e-14 8.66e-12 ✓ sig.
Interleukin-4 and Interleukin-13 signaling
IL1A, IL1B, TNF, IL13, IL6, MUC1, TGFB1, IL17A, IL17F, IRF4, IL18, VEGFA
 Reactome 23 / 108 6.9× 1.38e-13 3.42e-11 ✓ sig.
Asthma
HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA, TNF, HLA-DRB1, HLA-DQA1, IL13, CD40, CD40LG, HLA-DOB, HLA-DQB1
 KEGG 14 / 32 14.2× 1.49e-13 3.67e-11 ✓ sig.
Autoimmune thyroid disease
HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-B, HLA-DRA, HLA-DRB1, HLA-DQA1, CD40, CD40LG, HLA-DOB, HLA-DQB1, HLA-DQB2
 KEGG 17 / 54 10.2× 2.25e-13 5.37e-11 ✓ sig.
Intestinal immune network for IgA production
HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA, HLA-DRB1, HLA-DQA1, IL6, TGFB1, CD40, CD40LG, HLA-DOB, HLA-DQB1
 KEGG 16 / 50 10.4× 8.68e-13 1.92e-10 ✓ sig.
Th1 and Th2 cell differentiation
HLA-DRB5, STAT4, HLA-DPA1, HLA-DPB1, HLA-DRA, HLA-DRB1, HLA-DQA1, IL13, MAML3, HLA-DOB, HLA-DQB1, HLA-DQB2
 KEGG 20 / 93 7.0× 4.61e-12 8.79e-10 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
immune response
FCGR3B, HLA-DRB5, STAT4, HLA-DPA1, HLA-DPB1, TLR10, C9, HLA-B, HLA-DRA, IL1A, IL1B, TNF
 GO:0006955 53 / 543 4.9× 3.54e-22 7.69e-19 ✓ sig.
positive regulation of type II interferon production
HLA-DPA1, HLA-DPB1, IL1B, TNF, CCR2, IL18, LTA, IL12RB2, PDE4D, PTPN22, TNFSF4, TYK2
 GO:0032729 20 / 77 13.2× 2.57e-17 2.78e-14 ✓ sig.
inflammatory response
FCGR2B, IRF5, TLR10, TNFAIP3, TRIM31, IL1A, IL1B, TNF, IL13, TLR2, HK1, XCL2
 GO:0006954 40 / 467 4.3× 5.64e-15 3.84e-12 ✓ sig.
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA, HLA-DRB1, HLA-DQA1, HLA-DOB, HLA-DQB1, HLA-DQB2
 GO:0002504 9 / 15 30.4× 1.87e-12 8.07e-10 ✓ sig.
peptide antigen assembly with MHC class II protein complex
HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA, HLA-DRB1, HLA-DQA1, HLA-DOB, HLA-DQB1, HLA-DQB2
 GO:0002503 9 / 16 28.5× 4.20e-12 1.67e-9 ✓ sig.
immune system process
HLA-DRB5, IRF5, HLA-DPA1, HLA-DPB1, TLR10, TNFAIP3, C2, TRIM31, C9, HLA-B, HLA-DRA, MBL2
 GO:0002376 53 / 943 2.8× 5.45e-12 2.12e-9 ✓ sig.
antigen processing and presentation of exogenous peptide antigen via MHC class II
FCGR2B, HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA, HLA-DRB1, HLA-DQA1, HLA-DOB, HLA-DQB1, HLA-DQB2, TRAF6
 GO:0019886 11 / 31 18.0× 9.12e-12 3.38e-9 ✓ sig.
cellular response to lipopolysaccharide
TNFAIP3, IL1A, IL1B, TNF, IRAK1, IL6, CCR5, CD40, IL18, NFKBIL1, TNFSF4, TNIP1
 GO:0071222 22 / 187 6.0× 2.06e-11 7.00e-9 ✓ sig.
positive regulation of T cell proliferation
HLA-DPA1, HLA-DPB1, IL1B, SELENOK, IL6, BTNL2, CD40LG, PTPRC, TNFSF4, TRAF6, TYK2, IL2
 GO:0042102 14 / 67 10.6× 4.07e-11 1.28e-8 ✓ sig.
response to lipopolysaccharide
C2, IL1B, TNF, IL13, IRAK1, DUSP10, GCH1, CYP27B1, CASP3, LTA, PELI1, IL12RB2
 GO:0032496 20 / 161 6.3× 6.33e-11 1.90e-8 ✓ sig.
cytokine-mediated signaling pathway
IRF5, STAT4, IL1A, IL1B, CAV1, IRAK1, IL6, CCR2, IL18, PTPRJ, IL12RB2, PTPN11
 GO:0019221 19 / 145 6.6× 7.51e-11 2.21e-8 ✓ sig.
positive regulation of tumor necrosis factor production
FCGR2B, IL1A, FCGR2A, TLR2, SELENOK, IL6, TGFB1, IL17A, TLR1, CCR2, PTPRC, PTPRJ
 GO:0032760 17 / 113 7.6× 8.25e-11 2.40e-8 ✓ sig.
positive regulation of immune response
HLA-DRB5, HLA-DPA1, HLA-DPB1, C9, HLA-DRA, HLA-DRB1, HLA-DQA1, HLA-DOB, HLA-DQB1, HLA-DQB2, PTPRJ
 GO:0050778 11 / 40 13.9× 2.12e-10 5.62e-8 ✓ sig.
antigen processing and presentation
HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-B, HLA-DRA, HLA-DRB1, HLA-DQA1, HLA-DOB, HLA-DQB1, HLA-DQB2, HLA-A
 GO:0019882 11 / 48 11.6× 1.80e-9 3.78e-7 ✓ sig.
positive regulation of interleukin-12 production
IRF5, TLR2, IL17A, CD40, CD40LG, TNFSF4, TRAF6, IFNG, IL23R, IRF1
 GO:0032735 10 / 43 11.8× 8.57e-9 1.49e-6 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Myositis Systemic sclerosis 0.210 33 4.07e-54 2.41e-52 ✓ sig.
Scleroderma Systemic sclerosis 0.146 20 1.55e-36 6.29e-35 ✓ sig.
Crest syndrome Systemic sclerosis 0.111 15 1.40e-27 4.10e-26 ✓ sig.
Sjogren syndrome Systemic sclerosis 0.099 18 2.24e-22 5.00e-21 ✓ sig.
Myositis Sjogren syndrome 0.118 14 9.59e-21 2.00e-19 ✓ sig.
Dry eye syndrome Sjogren syndrome 0.103 12 2.09e-17 3.69e-16 ✓ sig.
Crest syndrome Diffuse cutaneous systemic sclerosis 0.184 7 6.92e-16 1.11e-14 ✓ sig.
Myositis Polymyositis 0.105 8 1.15e-14 1.71e-13 ✓ sig.
Crest syndrome Systemic scleroderma 0.194 6 1.46e-14 2.14e-13 ✓ sig.
Polymyositis Sjogren syndrome 0.093 8 4.13e-14 5.82e-13 ✓ sig.
Crest syndrome Myositis 0.092 7 1.19e-12 1.52e-11 ✓ sig.
Diffuse cutaneous systemic sclerosis Scleroderma 0.130 6 2.01e-12 2.47e-11 ✓ sig.
Diffuse cutaneous systemic sclerosis Systemic scleroderma 0.147 5 1.39e-11 1.60e-10 ✓ sig.
Dermatomyositis Polymyositis 0.102 5 6.06e-10 5.91e-9 ✓ sig.
Kawasaki disease Sjogren syndrome 0.054 7 1.65e-8 1.37e-7 ✓ sig.
Dermatomyositis Systemic scleroderma 0.093 4 1.81e-8 1.50e-7 ✓ sig.
Crest syndrome Scleroderma 0.087 4 5.12e-8 3.96e-7 ✓ sig.
Dermatomyositis Diffuse cutaneous systemic sclerosis 0.078 4 1.16e-7 8.51e-7 ✓ sig.
Dermatomyositis Irritant dermatitis 0.079 3 6.16e-7 3.97e-6 ✓ sig.
Kawasaki disease Polymyositis 0.048 4 1.88e-6 1.11e-5 ✓ sig.
Polymyositis Scleroderma 0.063 3 8.10e-6 4.30e-5 ✓ sig.
Irritant dermatitis Systemic scleroderma 0.087 2 3.18e-5 1.55e-4 ✓ sig.
Dry eye syndrome Polymyositis 0.039 3 7.05e-5 2.53e-4 ✓ sig.
Crest syndrome spinocerebellar ataxia, autosomal recessive 25 0.045 1 1.36e-3 2.13e-3 ✓ sig.
Crest syndrome TTC8-related ciliopathy 0.045 1 1.36e-3 2.13e-3 ✓ sig.
autosomal systemic lupus erythematosus type 16 Crest syndrome 0.045 1 1.36e-3 2.13e-3 ✓ sig.
Diffuse cutaneous systemic sclerosis multiple self-healing squamous epithelioma 0.042 1 1.49e-3 2.29e-3 ✓ sig.
multiple self-healing squamous epithelioma Scleroderma 0.034 1 1.82e-3 2.66e-3 ✓ sig.
immunodeficiency 25 Scleroderma 0.034 1 1.82e-3 2.66e-3 ✓ sig.
developmental and epileptic encephalopathy, 41 Myositis 0.016 1 3.96e-3 5.01e-3 ✓ sig.
autosomal systemic lupus erythematosus type 16 Myositis 0.016 1 3.96e-3 5.01e-3 ✓ sig.
Myositis spinocerebellar ataxia, autosomal recessive 25 0.016 1 3.96e-3 5.01e-3 ✓ sig.
Autoinflammatory syndrome, familial, behcet-like Myositis 0.016 1 3.96e-3 5.01e-3 ✓ sig.
Autoinflammatory syndrome, familial, behcet-like Sjogren syndrome 0.014 1 4.61e-3 5.73e-3 ✓ sig.
Myositis Neuroocular syndrome 0.016 1 7.91e-3 9.19e-3 ✓ sig.
autosomal systemic lupus erythematosus type 16 Systemic sclerosis 0.008 1 8.31e-3 9.63e-3 ✓ sig.
Neuroocular syndrome Systemic sclerosis 0.008 1 1.66e-2 1.82e-2 ✓ sig.