Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 1
266
Diseases
2,192
Unique genes
0.173
Avg. similarity score
Nasal cavity and paranasal sinus carcinoma
Most-connected disease (33 links)
Disease
Searched: Borderline ovarian serous tumor
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Borderline ovarian serous tumor
Nasal cavity and paranasal sinus carcinoma
Thyroid gland undifferentiated (anaplastic) carcinoma
Epidermal appendage tumor
Mixed lobular and ductal breast carcinoma
Conjunctival intraepithelial neoplasm
Ovarian yolk sac tumor
Breast carcinoma by gene expression profile
Endometrium adenocarcinoma
Lobular carcinoma
Pancreatic neuroendocrine tumor
Endometrial undifferentiated carcinoma
Leiomyosarcoma
Endometrial endometrioid adenocarcinoma
Breast phyllodes tumor
Ovarian clear cell adenocarcinoma
Sebaceous gland neoplasms
Ocular sebaceous carcinoma
Ovarian carcinosarcoma
Sebaceous adenoma
Bile duct papillary neoplasm
Medullary carcinoma
Anaplastic oligodendroglioma
Wolffian duct adenocarcinoma
Appendix adenocarcinoma
Bladder cancer
Carcinosarcoma
Peripheral t-cell lymphoma, not otherwise specified
Ovarian teratoma
Uterine carcinosarcoma
Uterine corpus adenosarcoma
Adrenal cortex carcinoma
Clear cell adenocarcinoma
Malignant conjunctival melanoma
Syndromic intellectual disability
Testicular sex cord-stromal neoplasm
Appendix goblet cell carcinoid
Bladder urachal adenocarcinoma
Gallbladder papillary neoplasm
Sinonasal undifferentiated carcinoma
Wolffian adnexal tumor
Anaplastic ependymoma
Borderline ovarian mucinous tumor
Carcinoma of pharynx
Combined hepatocellular carcinoma and cholangiocarcinoma
Immunoblastic lymphadenopathy
Ovarian neoplasms
Desmoplastic/nodular medulloblastoma
Differentiated thyroid carcinoma
Endometrial clear cell adenocarcinoma
Endometrial mixed adenocarcinoma
Ganglioglioma
Hairy cell leukemia
Head and neck cancer
Ileal neuroendocrine tumor g1
Pseudomyxoma peritonei
Aggressive nk-cell leukemia
Cerebellar pilocytic astrocytoma
Choriocarcinoma of testis
Colon adenoma
Extranodal nasal nk/t cell lymphoma
Follicular variant thyroid gland papillary carcinoma
Gastric adenosquamous carcinoma
Luminal b breast carcinoma
Lung adenocarcinoma in situ
Testicular seminoma
Thymoma
Thymoma type b3
Urinary bladder neoplasms
Adrenal gland pheochromocytoma
Adrenocorticotropic hormone-producing pituitary gland adenoma
Carcinoid tumor
Carcinoma in situ
Choroid plexus papilloma
Colorectal neuroendocrine tumor g1
Fibroadenoma
Langerhans cell histiocytosis
Luminal a breast carcinoma
Lung benign neoplasm
Lung sclerosing hemangioma
Mucoepidermoid carcinoma of parotid gland
Pleomorphic xanthoastrocytoma
Pleural biphasic mesothelioma
Primary cutaneous t-cell non-hodgkin lymphoma
Pulmonary blastoma
Rectum adenoma
Seminoma
Skin appendage carcinoma
Small intestine adenocarcinoma
Solid pseudopapillary neoplasm of the pancreas
Testicular sertoli cell tumor
Urethra clear cell adenocarcinoma
Vulvar intraepithelial neoplasia
Acinic cell breast carcinoma
Anaplastic large cell lymphoma
Anaplastic oligoastrocytoma
Benign thyroid gland neoplasm
Breast adenosis
Cholangiocarcinoma
Clear cell meningioma
Giant cell tumor of bone
Granulosa cell tumor of ovary
Hepatocellular adenoma
Keratocystic odontogenic tumor
Leiomyoma
Liver neoplasms
Lung adenoma
Lung inflammatory myofibroblastic tumor
Lung neoplasms
Major salivary gland carcinoma
Malignant epithelioid mesothelioma
Malignant ovarian mixed epithelial tumor
Malignant pancreatic neoplasm
Malignant syringoma
Melanocytic neoplasm
Myxofibrosarcoma
Nasopharyngeal carcinoma
Ovarian mucinous adenocarcinoma
Pancreatic neoplasms
Parathyroid gland adenoma
Pleural epithelioid mesothelioma
Rectum malignant melanoma
Renal cell carcinoma
Sertoli-leydig cell tumor of ovary
Sezary syndrome
Spitz nevus
Testicular teratoma
Testicular yolk sac tumor
Thyroid gland oncocytic adenoma
Urethra adenocarcinoma
Uveal melanoma
Adnexal spiradenoma/cylindroma of a sweat gland
Adrenal gland neuroblastoma
Benign adrenal gland pheochromocytoma
Benign neoplasm of pancreas
Capillary hemangioma
Carcinoma of liver and intrahepatic biliary tract
Cervical adenosquamous carcinoma
Craniopharyngioma
Cystic neoplasm
Endometrioid stromal sarcoma
Giant cell glioblastoma
Gliosarcoma
Hepatoblastoma
Kidney neoplasms
Kidney oncocytoma
Lung sarcomatoid carcinoma
Malignant germ cell tumor
Mediastinal malignant germ cell tumor
Melanocytic nevus
Mesothelioma
Mucoepidermoid carcinoma
Neoplasm of mature b-cells
Neuroblastoma
Neurodevelopmental disorder with seizures, microcephaly, and brain abnormalities
Oligoastrocytoma
Ovarian endometrioid adenocarcinoma
Pancreatic insulinoma
Pancreatoblastoma
Parotid gland carcinoma ex pleomorphic adenoma
Poroma
Primary central chondrosarcoma
Prostate neuroendocrine neoplasm
Salivary duct carcinoma
Salivary gland neoplasms
Sarcoma
Skin angiosarcoma
Spinal cord astrocytoma
Spindle cell intraocular melanoma
Spindle cell melanoma
Spleen angiosarcoma
Testicular carcinoma
Testicular germ cell tumor
Thymic undifferentiated carcinoma
Thymoma type ab
Undifferentiated gallbladder carcinoma
Well-differentiated liposarcoma
Wilms tumor
Yolk sac tumor
Ameloblastoma
Benign monoclonal gammopathy
Benign spiradenoma
Blue nevus
Carcinoma of esophagus
Cervical clear cell adenocarcinoma
Chondrosarcoma
Colorectal adenoma
Colorectal neoplasms
Digestive system neoplasms
Endometrial neoplasms
Follicular dendritic cell sarcoma
Ganglioneuroblastoma
Hamartoma of lung
Hepatosplenic t-cell lymphoma
Hyperplasia
Invasive breast carcinoma
Mediastinal yolk sac tumor
Melanocytic skin neoplasm
Mesonephric adenocarcinoma
Moyamoya angiopathy
Non-functional pancreatic neuroendocrine tumor
Ovarian mixed germ cell neoplasm
Pulmonary alveolar microlithiasis
Rectal neoplasm
Schwannoma
Shukla-vernon syndrome
Small intestinal neuroendocrine tumor g1
Thrombocytopenia 6
Thyroid neoplasms
Undifferentiated pancreatic carcinoma with osteoclast-like giant cells
Uterine neoplasms
Bone osteosarcoma
Carcinogenesis
Chordoma
Cortisol-producing adrenal cortex adenoma
Extraoral halitosis due to methanethiol oxidase deficiency
Familial platelet disorder with associated myeloid malignancy
Hyperplastic polyp
Immunodeficiency 92
Intellectual developmental disorder, autosomal dominant 48
Joint contractures, osteochondromas, and b-cell lymphoma
Kinsship syndrome
Malignant adrenal gland pheochromocytoma
Mast cell leukemia
Metaplastic breast carcinoma
Mixed germ cell tumor
Nasal cavity and paranasal sinus squamous cell carcinoma
Non-functioning adrenal cortex adenoma
Normal breast-like subtype of breast carcinoma
Oculomotor-abducens synkinesis
Polydactyly-macrocephaly syndrome
Primary peritoneal carcinoma
Sifrim-hitz-weiss syndrome
Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies
Atypical teratoid rhabdoid tumor
Autoinflammatory disease, systemic, with vasculitis
Cervicitis
Cortical thymoma
Diaphragm disease
Hyperchlorhidrosis, isolated
Intellectual developmental disorder, autosomal recessive 34, with variant lissencephaly
Mountain sickness
Orbit embryonal rhabdomyosarcoma
Papillary hidradenoma
Parotid gland acinic cell carcinoma
Pituitary adenoma
Pulmonary agenesis
Abdominal obesity-metabolic syndrome 3
Autosomal recessive osteopetrosis 8
Borderline personality disorder
Colobomatous macrophthalmia microcornea syndrome
Diets-jongmans syndrome
Fibromatosis, gingival, 5
Gabriele-de vries syndrome
Immunodeficiency 109 with lymphoproliferation
Immunodeficiency 96
Intellectual developmental disorder dysmorphic ocular
Lymphangiosarcoma
Mental retardation, autosomal recessive 67
Neurodevelopmental disorder with craniofacial dysmorphism and skeletal defects
Neurodevelopmental disorder with dysmorphic facies and skeletal and brain abnormalities
Neurodevelopmental disorder with impaired intellectual development, hypotonia, and ataxia
Neurodevelopmental disorder with thin corpus callosum, hypotonia, and absent language
Neurodevelopmental, jaw, eye, and digital syndrome
Retinitis pigmentosa, hearing loss, premature aging, short stature, facial dysmorphism syndrome
Skeletal defects, genital hypoplasia, and impaired intellectual development
Member diseases (most connected first ‐ the cluster's core)
Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| TP53 | 177 / 266 | Acinic cell breast carcinoma, Adnexal spiradenoma/cylindroma of a sweat gland, Adrenal cortex carcinoma, Adrenal gland pheochromocytoma and 173 more |
| KRAS | 123 / 266 | Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Aggressive nk-cell leukemia, Ameloblastoma and 119 more |
| PIK3CA | 114 / 266 | Acinic cell breast carcinoma, Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Adrenocorticotropic hormone-producing pituitary gland adenoma and 110 more |
| BRAF | 112 / 266 | Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Aggressive nk-cell leukemia, Ameloblastoma and 108 more |
| CDKN2A | 106 / 266 | Adrenal cortex carcinoma, Adrenal gland pheochromocytoma, Anaplastic ependymoma, Anaplastic large cell lymphoma and 102 more |
| NF1 | 103 / 266 | Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Adrenocorticotropic hormone-producing pituitary gland adenoma, Aggressive nk-cell leukemia and 99 more |
| KMT2D | 102 / 266 | Acinic cell breast carcinoma, Adnexal spiradenoma/cylindroma of a sweat gland, Adrenal cortex carcinoma, Adrenal gland pheochromocytoma and 98 more |
| CTNNB1 | 101 / 266 | Acinic cell breast carcinoma, Adrenal cortex carcinoma, Aggressive nk-cell leukemia, Ameloblastoma and 97 more |
| APC | 99 / 266 | Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Ameloblastoma, Anaplastic oligodendroglioma and 95 more |
| ATM | 96 / 266 | Adrenal cortex carcinoma, Anaplastic large cell lymphoma, Anaplastic oligoastrocytoma, Anaplastic oligodendroglioma and 92 more |
| ARID1A | 95 / 266 | Acinic cell breast carcinoma, Adrenal cortex carcinoma, Anaplastic oligoastrocytoma, Anaplastic oligodendroglioma and 91 more |
| PTEN | 92 / 266 | Adrenal cortex carcinoma, Anaplastic ependymoma, Anaplastic oligoastrocytoma, Anaplastic oligodendroglioma and 88 more |
| EGFR | 91 / 266 | Adrenal cortex carcinoma, Anaplastic ependymoma, Anaplastic oligodendroglioma, Appendix adenocarcinoma and 87 more |
| KMT2C | 91 / 266 | Acinic cell breast carcinoma, Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Adrenocorticotropic hormone-producing pituitary gland adenoma and 87 more |
| CREBBP | 84 / 266 | Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Aggressive nk-cell leukemia, Anaplastic large cell lymphoma and 80 more |
| BRCA2 | 82 / 266 | Acinic cell breast carcinoma, Adrenal cortex carcinoma, Aggressive nk-cell leukemia, Anaplastic oligoastrocytoma and 78 more |
| NRAS | 82 / 266 | Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Aggressive nk-cell leukemia, Ameloblastoma and 78 more |
| ALK | 81 / 266 | Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Anaplastic ependymoma, Anaplastic large cell lymphoma and 77 more |
| FBXW7 | 77 / 266 | Adrenal cortex carcinoma, Aggressive nk-cell leukemia, Anaplastic ependymoma, Anaplastic oligodendroglioma and 73 more |
| NOTCH1 | 75 / 266 | Adnexal spiradenoma/cylindroma of a sweat gland, Adrenal cortex carcinoma, Aggressive nk-cell leukemia, Anaplastic ependymoma and 71 more |
| EP300 | 73 / 266 | Adrenal cortex carcinoma, Anaplastic large cell lymphoma, Anaplastic oligodendroglioma, Appendix goblet cell carcinoid and 69 more |
| ERBB4 | 73 / 266 | Acinic cell breast carcinoma, Adrenal cortex carcinoma, Adrenocorticotropic hormone-producing pituitary gland adenoma, Anaplastic ependymoma and 69 more |
| SMARCA4 | 73 / 266 | Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Aggressive nk-cell leukemia, Anaplastic oligoastrocytoma and 69 more |
| TSC2 | 70 / 266 | Adrenal cortex carcinoma, Adrenal gland pheochromocytoma, Anaplastic oligodendroglioma, Appendix adenocarcinoma and 66 more |
| GNAS | 69 / 266 | Adrenal cortex carcinoma, Adrenal gland pheochromocytoma, Adrenocorticotropic hormone-producing pituitary gland adenoma, Anaplastic oligodendroglioma and 65 more |
| RB1 | 69 / 266 | Adrenal cortex carcinoma, Anaplastic ependymoma, Anaplastic oligoastrocytoma, Anaplastic oligodendroglioma and 65 more |
| RET | 69 / 266 | Acinic cell breast carcinoma, Adrenal cortex carcinoma, Adrenal gland pheochromocytoma, Anaplastic ependymoma and 65 more |
| ERBB2 | 68 / 266 | Adrenal gland neuroblastoma, Anaplastic oligodendroglioma, Appendix adenocarcinoma, Appendix goblet cell carcinoid and 64 more |
| ATRX | 67 / 266 | Acinic cell breast carcinoma, Adrenal cortex carcinoma, Adrenal gland pheochromocytoma, Adrenocorticotropic hormone-producing pituitary gland adenoma and 63 more |
| SMAD4 | 67 / 266 | Adrenal cortex carcinoma, Anaplastic oligodendroglioma, Appendix adenocarcinoma, Appendix goblet cell carcinoid and 63 more |
| ARID2 | 66 / 266 | Adrenal cortex carcinoma, Aggressive nk-cell leukemia, Anaplastic oligodendroglioma, Appendix adenocarcinoma and 62 more |
| BCOR | 66 / 266 | Adnexal spiradenoma/cylindroma of a sweat gland, Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Adrenocorticotropic hormone-producing pituitary gland adenoma and 62 more |
| KIT | 66 / 266 | Adrenal cortex carcinoma, Anaplastic oligodendroglioma, Appendix goblet cell carcinoid, Breast carcinoma by gene expression profile and 62 more |
| NOTCH2 | 66 / 266 | Adnexal spiradenoma/cylindroma of a sweat gland, Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Anaplastic large cell lymphoma and 62 more |
| KMT2A | 64 / 266 | Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Anaplastic oligodendroglioma, Appendix goblet cell carcinoid and 60 more |
| FAT1 | 63 / 266 | Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Adrenocorticotropic hormone-producing pituitary gland adenoma, Aggressive nk-cell leukemia and 59 more |
| LRP1B | 63 / 266 | Adnexal spiradenoma/cylindroma of a sweat gland, Adrenal cortex carcinoma, Adrenocorticotropic hormone-producing pituitary gland adenoma, Aggressive nk-cell leukemia and 59 more |
| MTOR | 63 / 266 | Acinic cell breast carcinoma, Adrenal cortex carcinoma, Anaplastic oligodendroglioma, Appendix adenocarcinoma and 59 more |
| BRCA1 | 62 / 266 | Acinic cell breast carcinoma, Adrenal cortex carcinoma, Anaplastic ependymoma, Anaplastic oligodendroglioma and 58 more |
| KDR | 62 / 266 | Adrenal cortex carcinoma, Adrenocorticotropic hormone-producing pituitary gland adenoma, Anaplastic ependymoma, Anaplastic oligodendroglioma and 58 more |
| MET | 62 / 266 | Adnexal spiradenoma/cylindroma of a sweat gland, Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Anaplastic oligodendroglioma and 58 more |
| PTCH1 | 62 / 266 | Adnexal spiradenoma/cylindroma of a sweat gland, Adrenal cortex carcinoma, Aggressive nk-cell leukemia, Anaplastic oligodendroglioma and 58 more |
| SETD2 | 62 / 266 | Acinic cell breast carcinoma, Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Aggressive nk-cell leukemia and 58 more |
| HRAS | 60 / 266 | Adrenal gland pheochromocytoma, Adrenocorticotropic hormone-producing pituitary gland adenoma, Ameloblastoma, Benign adrenal gland pheochromocytoma and 56 more |
| MED12 | 60 / 266 | Acinic cell breast carcinoma, Adrenal cortex carcinoma, Anaplastic oligodendroglioma, Appendix goblet cell carcinoid and 56 more |
| AKT1 | 58 / 266 | Adrenal cortex carcinoma, Appendix adenocarcinoma, Benign spiradenoma, Benign thyroid gland neoplasm and 54 more |
| ARID1B | 58 / 266 | Adnexal spiradenoma/cylindroma of a sweat gland, Adrenal gland neuroblastoma, Anaplastic large cell lymphoma, Anaplastic oligodendroglioma and 54 more |
| DICER1 | 58 / 266 | Adrenocorticotropic hormone-producing pituitary gland adenoma, Anaplastic oligodendroglioma, Appendix adenocarcinoma, Appendix goblet cell carcinoid and 54 more |
| ZFHX3 | 58 / 266 | Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Aggressive nk-cell leukemia, Anaplastic oligodendroglioma and 54 more |
| FGFR2 | 57 / 266 | Acinic cell breast carcinoma, Adrenal cortex carcinoma, Ameloblastoma, Anaplastic oligodendroglioma and 53 more |
| POLE | 57 / 266 | Adrenal cortex carcinoma, Aggressive nk-cell leukemia, Anaplastic oligodendroglioma, Benign adrenal gland pheochromocytoma and 53 more |
| TET2 | 56 / 266 | Adrenal cortex carcinoma, Aggressive nk-cell leukemia, Anaplastic large cell lymphoma, Anaplastic oligodendroglioma and 52 more |
| DNMT3A | 55 / 266 | Adnexal spiradenoma/cylindroma of a sweat gland, Adrenal cortex carcinoma, Anaplastic ependymoma, Anaplastic large cell lymphoma and 51 more |
| ERBB3 | 55 / 266 | Acinic cell breast carcinoma, Adrenal cortex carcinoma, Anaplastic ependymoma, Anaplastic oligodendroglioma and 51 more |
| FGFR3 | 55 / 266 | Adrenal cortex carcinoma, Anaplastic ependymoma, Bladder cancer, Breast carcinoma by gene expression profile and 51 more |
| CDH1 | 54 / 266 | Acinic cell breast carcinoma, Adrenal cortex carcinoma, Anaplastic oligodendroglioma, Appendix adenocarcinoma and 50 more |
| KDM6A | 53 / 266 | Adrenal cortex carcinoma, Aggressive nk-cell leukemia, Appendix adenocarcinoma, Appendix goblet cell carcinoid and 49 more |
| FBXO11 | 52 / 266 | Adrenal cortex carcinoma, Aggressive nk-cell leukemia, Anaplastic oligodendroglioma, Appendix goblet cell carcinoid and 48 more |
| MUC16 | 52 / 266 | Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Aggressive nk-cell leukemia, Anaplastic oligoastrocytoma and 48 more |
| MSH6 | 51 / 266 | Adrenal cortex carcinoma, Aggressive nk-cell leukemia, Anaplastic oligodendroglioma, Appendix goblet cell carcinoid and 47 more |
| PIK3R1 | 51 / 266 | Adrenal cortex carcinoma, Adrenocorticotropic hormone-producing pituitary gland adenoma, Anaplastic large cell lymphoma, Anaplastic oligodendroglioma and 47 more |
| PTPRD | 51 / 266 | Adrenal cortex carcinoma, Adrenal gland pheochromocytoma, Anaplastic large cell lymphoma, Anaplastic oligodendroglioma and 47 more |
| BAP1 | 50 / 266 | Adrenal cortex carcinoma, Adrenocorticotropic hormone-producing pituitary gland adenoma, Appendix adenocarcinoma, Bile duct papillary neoplasm and 46 more |
| ROS1 | 50 / 266 | Adrenal cortex carcinoma, Anaplastic oligodendroglioma, Appendix adenocarcinoma, Benign thyroid gland neoplasm and 46 more |
| CARD11 | 49 / 266 | Adrenal cortex carcinoma, Anaplastic oligodendroglioma, Appendix adenocarcinoma, Appendix goblet cell carcinoid and 45 more |
| TSC1 | 49 / 266 | Acinic cell breast carcinoma, Adrenal cortex carcinoma, Anaplastic oligodendroglioma, Bladder cancer and 45 more |
| ABL1 | 48 / 266 | Adrenal cortex carcinoma, Appendix adenocarcinoma, Appendix goblet cell carcinoid, Breast carcinoma by gene expression profile and 44 more |
| FLT4 | 48 / 266 | Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Anaplastic oligodendroglioma, Appendix goblet cell carcinoid and 44 more |
| MLH1 | 48 / 266 | Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Anaplastic oligodendroglioma, Appendix adenocarcinoma and 44 more |
| SMARCB1 | 48 / 266 | Adrenal cortex carcinoma, Ameloblastoma, Anaplastic ependymoma, Anaplastic oligodendroglioma and 44 more |
| TERT | 48 / 266 | Adrenal cortex carcinoma, Aggressive nk-cell leukemia, Anaplastic oligodendroglioma, Breast carcinoma by gene expression profile and 44 more |
| AR | 47 / 266 | Adnexal spiradenoma/cylindroma of a sweat gland, Adrenal cortex carcinoma, Appendix adenocarcinoma, Appendix goblet cell carcinoid and 43 more |
| MSH2 | 47 / 266 | Adnexal spiradenoma/cylindroma of a sweat gland, Adrenal cortex carcinoma, Aggressive nk-cell leukemia, Anaplastic ependymoma and 43 more |
| PDGFRA | 47 / 266 | Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Ameloblastoma, Anaplastic oligoastrocytoma and 43 more |
| STK11 | 47 / 266 | Adrenal cortex carcinoma, Anaplastic oligodendroglioma, Appendix adenocarcinoma, Bile duct papillary neoplasm and 43 more |
| ASXL1 | 46 / 266 | Adrenal cortex carcinoma, Anaplastic large cell lymphoma, Anaplastic oligodendroglioma, Borderline ovarian mucinous tumor and 42 more |
| ATR | 46 / 266 | Adrenal cortex carcinoma, Anaplastic oligodendroglioma, Breast carcinoma by gene expression profile, Breast phyllodes tumor and 42 more |
| EPHA3 | 46 / 266 | Adrenal cortex carcinoma, Aggressive nk-cell leukemia, Anaplastic oligodendroglioma, Appendix adenocarcinoma and 42 more |
| IDH1 | 46 / 266 | Aggressive nk-cell leukemia, Anaplastic ependymoma, Anaplastic oligodendroglioma, Appendix adenocarcinoma and 42 more |
| SPEN | 46 / 266 | Acinic cell breast carcinoma, Adrenal cortex carcinoma, Aggressive nk-cell leukemia, Anaplastic large cell lymphoma and 42 more |
| CHEK2 | 45 / 266 | Adrenal cortex carcinoma, Anaplastic large cell lymphoma, Anaplastic oligodendroglioma, Appendix adenocarcinoma and 41 more |
| NSD1 | 45 / 266 | Adrenal cortex carcinoma, Anaplastic oligodendroglioma, Benign thyroid gland neoplasm, Breast carcinoma by gene expression profile and 41 more |
| CSMD3 | 44 / 266 | Anaplastic large cell lymphoma, Anaplastic oligoastrocytoma, Borderline ovarian mucinous tumor, Breast carcinoma by gene expression profile and 40 more |
| ESR1 | 44 / 266 | Acinic cell breast carcinoma, Adrenal cortex carcinoma, Anaplastic oligoastrocytoma, Appendix goblet cell carcinoid and 40 more |
| IDH2 | 44 / 266 | Adrenal cortex carcinoma, Anaplastic oligoastrocytoma, Anaplastic oligodendroglioma, Bladder cancer and 40 more |
| JAK3 | 44 / 266 | Acinic cell breast carcinoma, Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Breast carcinoma by gene expression profile and 40 more |
| SMO | 44 / 266 | Adrenal cortex carcinoma, Adrenocorticotropic hormone-producing pituitary gland adenoma, Ameloblastoma, Anaplastic oligodendroglioma and 40 more |
| GRIN2A | 43 / 266 | Acinic cell breast carcinoma, Adrenal cortex carcinoma, Anaplastic oligodendroglioma, Appendix adenocarcinoma and 39 more |
| NCOR1 | 43 / 266 | Adrenal gland neuroblastoma, Anaplastic oligodendroglioma, Appendix adenocarcinoma, Appendix goblet cell carcinoid and 39 more |
| SF3B1 | 43 / 266 | Adrenal gland neuroblastoma, Anaplastic oligoastrocytoma, Anaplastic oligodendroglioma, Blue nevus and 39 more |
| FLT3 | 42 / 266 | Adrenal cortex carcinoma, Anaplastic ependymoma, Anaplastic large cell lymphoma, Benign adrenal gland pheochromocytoma and 38 more |
| PBRM1 | 42 / 266 | Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Anaplastic ependymoma, Anaplastic large cell lymphoma and 38 more |
| PTPRT | 42 / 266 | Adrenal cortex carcinoma, Adrenal gland neuroblastoma, Aggressive nk-cell leukemia, Anaplastic oligodendroglioma and 38 more |
| STAG2 | 42 / 266 | Adrenal gland pheochromocytoma, Adrenocorticotropic hormone-producing pituitary gland adenoma, Anaplastic oligodendroglioma, Bladder cancer and 38 more |
| VHL | 42 / 266 | Adrenal cortex carcinoma, Adrenal gland pheochromocytoma, Anaplastic oligodendroglioma, Benign adrenal gland pheochromocytoma and 38 more |
| BRD4 | 41 / 266 | Anaplastic oligodendroglioma, Breast carcinoma by gene expression profile, Carcinoid tumor, Cervical adenosquamous carcinoma and 37 more |
| JAK1 | 41 / 266 | Adrenal cortex carcinoma, Anaplastic large cell lymphoma, Anaplastic oligodendroglioma, Breast carcinoma by gene expression profile and 37 more |
| NTRK3 | 41 / 266 | Adrenal cortex carcinoma, Anaplastic oligodendroglioma, Appendix adenocarcinoma, Breast carcinoma by gene expression profile and 37 more |
| FGFR1 | 40 / 266 | Adrenal gland neuroblastoma, Anaplastic oligodendroglioma, Appendix adenocarcinoma, Appendix goblet cell carcinoid and 36 more |
| KDM5C | 40 / 266 | Adrenal cortex carcinoma, Anaplastic oligodendroglioma, Appendix adenocarcinoma, Breast carcinoma by gene expression profile and 36 more |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Pathways in cancer | KEGG | 262 / 533 | 2.7× | 2.03e-62 | 6.50e-58 ✓ sig. |
| Transcriptional misregulation in cancer | KEGG | 108 / 198 | 3.0× | 6.28e-31 | 2.01e-27 ✓ sig. |
| Prostate cancer | KEGG | 70 / 98 | 3.9× | 9.18e-31 | 2.86e-27 ✓ sig. |
| Colorectal cancer | KEGG | 63 / 87 | 4.0× | 2.32e-28 | 6.17e-25 ✓ sig. |
| EGFR tyrosine kinase inhibitor resistance | KEGG | 58 / 80 | 4.0× | 2.97e-26 | 5.85e-23 ✓ sig. |
| PI3K-Akt signaling pathway | KEGG | 148 / 361 | 2.2× | 1.25e-24 | 1.93e-21 ✓ sig. |
| Proteoglycans in cancer | KEGG | 101 / 204 | 2.7× | 1.38e-24 | 2.09e-21 ✓ sig. |
| Endometrial cancer | KEGG | 47 / 59 | 4.4× | 1.40e-24 | 2.11e-21 ✓ sig. |
| Non-small cell lung cancer | KEGG | 53 / 73 | 4.0× | 3.80e-24 | 5.46e-21 ✓ sig. |
| Chronic myeloid leukemia | KEGG | 54 / 77 | 3.8× | 2.16e-23 | 2.87e-20 ✓ sig. |
| Hepatocellular carcinoma | KEGG | 88 / 170 | 2.8× | 2.72e-23 | 3.55e-20 ✓ sig. |
| Human T-cell leukemia virus 1 infection | KEGG | 104 / 224 | 2.5× | 1.65e-22 | 1.96e-19 ✓ sig. |
| Hepatitis B | KEGG | 82 / 163 | 2.8× | 9.36e-21 | 7.93e-18 ✓ sig. |
| Renal cell carcinoma | KEGG | 48 / 70 | 3.8× | 2.80e-20 | 2.16e-17 ✓ sig. |
| Melanoma | KEGG | 49 / 73 | 3.7× | 4.71e-20 | 3.50e-17 ✓ sig. |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| positive regulation of transcription by RNA polymerase II | GO:0045944 | 387 / 1,208 | 2.7× | 2.59e-85 | 2.47e-80 ✓ sig. |
| positive regulation of DNA-templated transcription | GO:0045893 | 254 / 778 | 2.8× | 1.24e-56 | 4.28e-52 ✓ sig. |
| positive regulation of gene expression | GO:0010628 | 177 / 504 | 3.0× | 3.12e-44 | 4.57e-40 ✓ sig. |
| negative regulation of transcription by RNA polymerase II | GO:0000122 | 268 / 1,002 | 2.3× | 2.63e-41 | 3.13e-37 ✓ sig. |
| positive regulation of cell population proliferation | GO:0008284 | 171 / 532 | 2.7× | 5.07e-37 | 4.95e-33 ✓ sig. |
| negative regulation of apoptotic process | GO:0043066 | 167 / 524 | 2.7× | 1.20e-35 | 9.72e-32 ✓ sig. |
| negative regulation of cell population proliferation | GO:0008285 | 145 / 444 | 2.8× | 2.54e-32 | 1.76e-28 ✓ sig. |
| apoptotic process | GO:0006915 | 194 / 747 | 2.2× | 4.75e-28 | 2.23e-24 ✓ sig. |
| regulation of cell cycle | GO:0051726 | 98 / 262 | 3.2× | 2.66e-27 | 1.11e-23 ✓ sig. |
| response to xenobiotic stimulus | GO:0009410 | 93 / 248 | 3.2× | 4.58e-26 | 1.66e-22 ✓ sig. |
| regulation of DNA-templated transcription | GO:0006355 | 305 / 1,454 | 1.8× | 4.89e-26 | 1.76e-22 ✓ sig. |
| cell population proliferation | GO:0008283 | 95 / 263 | 3.1× | 3.53e-25 | 1.13e-21 ✓ sig. |
| DNA damage response | GO:0006974 | 156 / 577 | 2.3× | 1.25e-24 | 3.70e-21 ✓ sig. |
| regulation of cell population proliferation | GO:0042127 | 80 / 201 | 3.4× | 1.45e-24 | 4.20e-21 ✓ sig. |
| cell migration | GO:0016477 | 102 / 303 | 2.9× | 3.51e-24 | 9.61e-21 ✓ sig. |