Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
benign neoplasm of pancreas	MONDO_0021470	AMER1	Unknown	22158988	Open Targets	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane +8 more
		APC	Unknown	22158988	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		ASPM	Unknown	22158988	Open Targets	—
		ATRX	Unknown	22158988	Open Targets	Cell cycle
		CBL	Unknown	22158988	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +22 more
		CTNNA2	Unknown	22158988	Open Targets	Hippo signaling pathway Adherens junction Leukocyte transendothelial migration +6 more
		CTNND2	Unknown	22158988	Open Targets	Wnt signaling pathway
		DDX10	Unknown	22158988	Open Targets	—
		EML4	Unknown	22158988	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer +1 more
		ERC1	Unknown	22158988	Open Targets	NF-kappa B signaling pathway
		FAM135B	Unknown	22158988	Open Targets	—
		FAM47C	Unknown	22158988	Open Targets	—
		FGFR2	Unknown	22158988	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +26 more
		GNAS	Unknown	31576098 22158988	Open Targets	Endocrine resistance Rap1 signaling pathway Calcium signaling pathway +58 more
		IRS4	Unknown	22158988	Open Targets	cGMP-PKG signaling pathway FoxO signaling pathway Hormone signaling +11 more
		KLF4	Unknown	22158988	Open Targets	Signaling pathways regulating pluripotency of stem cells Chemical carcinogenesis - receptor activation Synthesis, secretion, and deacylation of Ghrelin +1 more
		KMT2A	Unknown	22158988	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	1845953 8121190 10982594 12021900 18343945 19412570 7820300 9047255 27705932 10206488 10522720 22723370 15456175 23565280 10923915 9351717 8968863 22158988 17097223 20495538 21876563 31576098 9041151 15069678 12749268 1955373 10189896 32704002	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		KTN1	Unknown	22158988	Open Targets	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation
		LZTR1	Unknown	22158988	Open Targets	—
		MYCN	Unknown	22158988	Open Targets	Transcriptional misregulation in cancer
		NCOR2	Unknown	22158988	Open Targets	Notch signaling pathway Epstein-Barr virus infection PPARA activates gene expression +11 more
		NOTCH2	Unknown	22158988	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		POLE	Unknown	22158988	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		PTPRT	Unknown	22158988	Open Targets	—
		RNF43	Unknown	22158988	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation
		SIRPA	Unknown	22158988	Open Targets	Efferocytosis Osteoclast differentiation Cell surface interactions at the vascular wall +2 more
		SMO	Unknown	22158988	Open Targets	Hedgehog signaling pathway Axon guidance Pathways in cancer +6 more
		STRN	Unknown	22158988	Open Targets	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling +2 more
		TP53	Unknown	12370756 31576098	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TRRAP	Unknown	22158988	Open Targets	ATP-dependent chromatin remodeling Human T-cell leukemia virus 1 infection Formation of the beta-catenin:TCF transactivating complex +1 more
		UBR5	Unknown	22158988	Open Targets	Ubiquitin mediated proteolysis
		VHL	Unknown	11141506 32792597 22158988 9327728 35350224 26253016 28481359	Open Targets	HIF-1 signaling pathway Ubiquitin mediated proteolysis Pathways in cancer +5 more

Benign neoplasm of pancreas

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