Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
ovarian carcinosarcoma	MONDO_0003792	AKT1	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +131 more
		ARID1A	Unknown	25233892 28481359	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID1B	Unknown	25233892	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		AXIN1	Unknown	25233892 28481359	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		BCOR	Unknown	25233892	Open Targets	Polycomb repressive complex
		BRAF	Unknown	29620581	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA1	Unknown	24240112	Open Targets	Platinum drug resistance Homologous recombination Fanconi anemia pathway +19 more
		BRCA2	Unknown	27566247	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		CDK12	Unknown	28481359	Open Targets	TP53 Regulates Transcription of DNA Repair Genes
		CDKN2A	Unknown	27566247	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CTNNB1	Unknown	25233892 21168197 25962155	Open Targets	Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway +51 more
		DICER1	Unknown	22187960 26033159	Open Targets	MicroRNAs in cancer MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
		EGFR	Unknown	25233892	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Virion - Hepatitis viruses +79 more
		ERBB2	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +48 more
		FBXW7	Unknown	25233892	Open Targets	Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling +3 more
		FGFR4	Unknown	28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +20 more
		GNAS	Unknown	28481359	Open Targets	Endocrine resistance Rap1 signaling pathway Calcium signaling pathway +58 more
		JAK1	Unknown	25233892	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		KIT	Unknown	28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KMT2A	Unknown	28481359	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	25233892 28481359	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	28481359	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	28481359 25233892 20122944 25962155 31538426	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		MLH1	Unknown	8824498	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		NCOR1	Unknown	28481359	Open Targets	Endocrine resistance TGF-beta signaling pathway Thyroid hormone signaling pathway +16 more
		NFE2L2	Unknown	29620581	Open Targets	Protein processing in endoplasmic reticulum Parkinson disease Pathways in cancer +4 more
		NOTCH1	Unknown	28481359	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		PIK3CA	Unknown	20122944 27566247 25233892 28481359 25962155	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PRDM1	Unknown	28481359	Open Targets	Regulation of TP53 Expression
		PTEN	Unknown	36384753 24240112 25233892 28481359 25962155	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		RAD50	Unknown	28481359	Open Targets	Homologous recombination Non-homologous end-joining Cellular senescence +14 more
		RB1	Unknown	28481359	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		ROS1	Unknown	28481359	Open Targets	—
		TERT	Unknown	28481359	Open Targets	Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer +4 more
		TET2	Unknown	28481359	Open Targets	—
		TP53	Unknown	8272291 11244334 21168197 24240112 30913944 31217897 8481915 1333465 25962155 27566247 25233892 28481359	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TRAF7	Unknown	28481359	Open Targets	Antigen processing: Ubiquitination & Proteasome degradation

Ovarian carcinosarcoma

Bookmark This Disease