PPP1R12B (protein phosphatase 1 regulatory subunit 12B)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 4660 |
| Gene name | Protein phosphatase 1 regulatory subunit 12B |
| Gene symbol | PPP1R12B |
| Synonyms (NCBI Gene) |
MYPT2PP1bp55
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| Chromosome | 1 |
| Chromosome location | 1q32.1 |
| Summary | Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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O60237 | |||||||||||||||||||||||||
| Protein name | Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) | |||||||||||||||||||||||||
| Protein function | Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. | |||||||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Detected in skeletal muscle, fetal and adult heart, brain, placenta, kidney, spleen, thymus, pancreas and lung. Isoform 3 and isoform 4 are heart specific. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}. | |||||||||||||||||||||||||
| Sequence |
MAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGA |
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| Sequence length | 982 | |||||||||||||||||||||||||
| Interactions | View interactions | |||||||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with PPP1R12B across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to PPP1R12B (see Related Genes above), that are NOT already directly curated for PPP1R12B itself -- a lead worth checking, not a confirmed association.
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