Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
ACTH-producing pituitary gland adenoma	MONDO_0006068	AFDN	Unknown	25485838 33221858	Open Targets	Ras signaling pathway Rap1 signaling pathway cAMP signaling pathway +4 more
		ATRX	Unknown	33221858	Open Targets	Cell cycle
		BAP1	Unknown	33221858	Open Targets	Polycomb repressive complex UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
		BCOR	Unknown	25675982	Open Targets	Polycomb repressive complex
		CHD2	Unknown	25485838	Open Targets	—
		CNTNAP2	Unknown	25485838	Open Targets	Cell adhesion molecules
		COL3A1	Unknown	33221858	Open Targets	Platelet activation Cytoskeleton in muscle cells Relaxin signaling pathway +16 more
		CRNKL1	Unknown	33221858	Open Targets	Spliceosome mRNA Splicing - Major Pathway
		CTNND1	Unknown	33221858	Open Targets	Rap1 signaling pathway Adherens junction Leukocyte transendothelial migration +3 more
		DICER1	Unknown	33221858	Open Targets	MicroRNAs in cancer MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
		ERBB4	Unknown	33221858	Open Targets	MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway +22 more
		FAT1	Unknown	25485838	Open Targets	—
		GATA3	Unknown	33221858	Open Targets	Th1 and Th2 cell differentiation Th17 cell differentiation Parathyroid hormone synthesis, secretion and action +6 more
		GNAS	Unknown	7737262 7745022	Open Targets	Endocrine resistance Rap1 signaling pathway Calcium signaling pathway +58 more
		HRAS	Unknown	18852163	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		HSP90AB1	Unknown	33221858	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +26 more
		IL6ST	Unknown	33221858	Open Targets	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Signaling pathways regulating pluripotency of stem cells +12 more
		KAT6A	Unknown	25485838	Open Targets	Signaling pathways regulating pluripotency of stem cells HATs acetylate histones Regulation of TP53 Activity through Acetylation
		KDR	Unknown	33221858	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +13 more
		KMT2C	Unknown	33221858	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		LRP1B	Unknown	33221858	Open Targets	—
		MAP2K1	Unknown	25485838	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +99 more
		MEN1	Unknown	9407947 25485838	Open Targets	Cushing syndrome Transcriptional misregulation in cancer Formation of the beta-catenin:TCF transactivating complex +5 more
		MSN	Unknown	33221858	Open Targets	Tight junction Leukocyte transendothelial migration Regulation of actin cytoskeleton +4 more
		NF1	Unknown	33221858	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		PIK3CA	Unknown	18852163 22782554	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3CB	Unknown	33221858	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +126 more
		PIK3R1	Unknown	33221858	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more
		PPP6C	Unknown	28487882	Open Targets	COPII-mediated vesicle transport
		PREX2	Unknown	28487882	Open Targets	Regulation of PTEN stability and activity
		PRKAR1A	Unknown	33221858	Open Targets	Insulin signaling pathway PKA activation PKA activation in glucagon signalling +7 more
		RASA1	Unknown	33221858	Open Targets	MAPK signaling pathway Ras signaling pathway Axon guidance +5 more
		RBM15	Unknown	33221858	Open Targets	—
		SHTN1	Unknown	25485838	Open Targets	—
		SMAD2	Unknown	33221858	Open Targets	Cell cycle Endocytosis Cellular senescence +30 more
		SMO	Unknown	33221858	Open Targets	Hedgehog signaling pathway Axon guidance Pathways in cancer +6 more
		STAG2	Unknown	25485838 25675982	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		STAT6	Unknown	28487882	Open Targets	Necroptosis JAK-STAT signaling pathway Th1 and Th2 cell differentiation +7 more
		TMSB4X	Unknown	33221858	Open Targets	Regulation of actin cytoskeleton Platelet degranulation
		TP53	Unknown	25485838 33221858	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		USP8	Unknown	25485838 33221858 26578638 29600293 28982703 25675982 28505279 28487882 25942478	Open Targets	Mitophagy - animal Endocytosis Cushing syndrome +4 more
		WRN	Unknown	33221858	Open Targets	Processive synthesis on the C-strand of the telomere Removal of the Flap Intermediate from the C-strand SUMOylation of DNA damage response and repair proteins +9 more

Adrenocorticotropic hormone-producing pituitary gland adenoma

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