Subtype of: Adrenal gland neoplasms

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
adrenal cortex carcinoma	MONDO_0006639	ATRX	Causal	30113656 25743702 25078331 33148256 24747642 28481359	Open Targets	Cell cycle
		CTNNB1	Causal	22526905 30113656 26317117 25743702 25078331 16140927 18647815 21733995 27589897 33148256 36604647 19863445 20959480 24747642 24747643 27296931 27468715 17854394 19498322 28481359 18544621	Open Targets	Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway +51 more
		KMT2A	Causal	24747642 33148256 28481359	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		MLH1	Causal	30113656	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		TP53	Causal	22526905 30113656 25743702 25078331 23585556 36604647 27589897 15922892 28973495 33148256 24747642 17289876 22539591 8509216 26317117 28481359 23139256	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		ABL1	Unknown	30113656 33148256	Open Targets	ErbB signaling pathway Ras signaling pathway Cell cycle +17 more
		ACVR1B	Unknown	33148256	Open Targets	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells +1 more
		AFF1	Unknown	24747642	Open Targets	Transcriptional misregulation in cancer
		AFF4	Unknown	25743702	Open Targets	Viral life cycle - HIV-1 Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events +1 more
		AKT1	Unknown	33148256	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +131 more
		AKT3	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +119 more
		ALK	Unknown	24747642 33148256 28481359	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		AMER1	Unknown	24747642	Open Targets	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane +8 more
		APC	Unknown	30113656 25078331 36604647 33148256 24747642 20978149 26317117 21088256	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		AR	Unknown	24747642 30113656	Open Targets	Oocyte meiosis Pathways in cancer Chemical carcinogenesis - receptor activation +7 more
		ARHGAP35	Unknown	24747642	Open Targets	Focal adhesion Platelet activation Leukocyte transendothelial migration +4 more
		ARHGAP5	Unknown	24747642	Open Targets	Focal adhesion Leukocyte transendothelial migration Rho GTPase cycle
		ARID1A	Unknown	30113656 33148256 25743702	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID2	Unknown	24747642 28481359	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		ASXL1	Unknown	33148256	Open Targets	Polycomb repressive complex UCH proteinases
		ATM	Unknown	30113656 33148256 28481359 25078331	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		ATP2B3	Unknown	24747642	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +9 more
		ATR	Unknown	33148256	Open Targets	Fanconi anemia pathway Cell cycle p53 signaling pathway +13 more
		AXIN1	Unknown	24747642 28481359 25743702	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		AXIN2	Unknown	33148256	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +15 more
		BAP1	Unknown	33148256 28481359 25078331	Open Targets	Polycomb repressive complex UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
		BCL11B	Unknown	25743702	Open Targets	Transcriptional misregulation in cancer
		BCL6	Unknown	30113656	Open Targets	FoxO signaling pathway Transcriptional misregulation in cancer Chemical carcinogenesis - receptor activation +3 more
		BCL7A	Unknown	24747642	Open Targets	ATP-dependent chromatin remodeling
		BCL9L	Unknown	24747642	Open Targets	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
		BCLAF1	Unknown	33148256	Open Targets	—
		BCOR	Unknown	24747642 30113656 33148256 28481359	Open Targets	Polycomb repressive complex
		BIRC6	Unknown	24747642	Open Targets	Ubiquitin mediated proteolysis Autophagy - animal Apoptosis - multiple species
		BLM	Unknown	33148256	Open Targets	Homologous recombination Fanconi anemia pathway Processive synthesis on the C-strand of the telomere +10 more
		BRAF	Unknown	23585556 30113656 19190079	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA1	Unknown	30113656 33148256	Open Targets	Platinum drug resistance Homologous recombination Fanconi anemia pathway +19 more
		BRCA2	Unknown	30113656	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		BTK	Unknown	24747642	Open Targets	NF-kappa B signaling pathway Osteoclast differentiation Platelet activation +17 more
		BUB1B	Unknown	24747642 30113656	Open Targets	Cell cycle Human T-cell leukemia virus 1 infection Inactivation of APC/C via direct inhibition of the APC/C complex +9 more
		CARD11	Unknown	24747642 33148256	Open Targets	NF-kappa B signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway +4 more
		CASP8	Unknown	28481359	Open Targets	Platinum drug resistance p53 signaling pathway Apoptosis +53 more
		CBFA2T3	Unknown	24747642	Open Targets	—
		CCDC6	Unknown	25743702	Open Targets	Pathways in cancer Thyroid cancer
		CCNB1IP1	Unknown	24747642	Open Targets	—
		CD209	Unknown	25743702	Open Targets	Virion - Human immunodeficiency virus Virion - Flavivirus and Alphavirus Virion - Ebolavirus, Lyssavirus and Morbillivirus +7 more
		CDC73	Unknown	24747642	Open Targets	Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state +3 more
		CDH1	Unknown	30113656 25743702	Open Targets	Rap1 signaling pathway Apelin signaling pathway Hippo signaling pathway +15 more
		CDK12	Unknown	24747642 30113656	Open Targets	TP53 Regulates Transcription of DNA Repair Genes
		CDK4	Unknown	30113656 28481359	Open Targets	Endocrine resistance Cell cycle p53 signaling pathway +40 more
		CDKN2A	Unknown	24747642 28481359 25078331	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more

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Adrenal cortex carcinoma

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