Subtype of: Breast cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
breast phyllodes tumor	MONDO_0021047	HRAS	Causal	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		TP53	Causal	35365682 10547570 26832993 25593300 36271373 27255162 29066183 26437033 34091389 23895135 28481359 37706238	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		ACVR1	Unknown	26437033	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling TGF-beta signaling pathway +2 more
		AKT1	Unknown	28481359 26832993	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +131 more
		AMER1	Unknown	26832993	Open Targets	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane +8 more
		AR	Unknown	28481359	Open Targets	Oocyte meiosis Pathways in cancer Chemical carcinogenesis - receptor activation +7 more
		ARHGAP35	Unknown	26437033	Open Targets	Focal adhesion Platelet activation Leukocyte transendothelial migration +4 more
		ARID1B	Unknown	28481359	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID2	Unknown	27255162	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		ASXL1	Unknown	26437033	Open Targets	Polycomb repressive complex UCH proteinases
		ATM	Unknown	27566247 36271373	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		ATP1A1	Unknown	26437033	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway Cardiac muscle contraction +18 more
		ATR	Unknown	34091389 26832993	Open Targets	Fanconi anemia pathway Cell cycle p53 signaling pathway +13 more
		AXIN2	Unknown	36271373	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +15 more
		BAP1	Unknown	36271373	Open Targets	Polycomb repressive complex UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
		BCOR	Unknown	28481359 26437033	Open Targets	Polycomb repressive complex
		BCORL1	Unknown	27255162 37706238 26437033	Open Targets	Polycomb repressive complex
		BRAF	Unknown	27255162 37706238	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA1	Unknown	26437033	Open Targets	Platinum drug resistance Homologous recombination Fanconi anemia pathway +19 more
		BRCA2	Unknown	25593300	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		CDH1	Unknown	25593300 26832993 26437033	Open Targets	Rap1 signaling pathway Apelin signaling pathway Hippo signaling pathway +15 more
		CDKN1B	Unknown	27255162	Open Targets	Endocrine resistance ErbB signaling pathway HIF-1 signaling pathway +28 more
		CDKN2A	Unknown	27255162 27566247 18288784 28481359 24831776 37706238	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CHD4	Unknown	27255162 26437033	Open Targets	ATP-dependent chromatin remodeling Human papillomavirus infection Viral carcinogenesis +5 more
		CNOT3	Unknown	26437033	Open Targets	RNA degradation Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
		CREBBP	Unknown	28481359	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +52 more
		CTCF	Unknown	27255162 26437033	Open Targets	—
		DNMT3A	Unknown	27255162	Open Targets	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		EGFR	Unknown	28481359 27566247 26832993 26437033	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Virion - Hepatitis viruses +79 more
		ERBB2	Unknown	26832993	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +48 more
		ERBB4	Unknown	26437033	Open Targets	MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway +22 more
		ESR1	Unknown	27255162	Open Targets	Endocrine resistance Hormone signaling Estrogen signaling pathway +21 more
		FAM135B	Unknown	26437033	Open Targets	—
		FAT3	Unknown	26437033	Open Targets	—
		FBXW7	Unknown	28648934	Open Targets	Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling +3 more
		FGFR1	Unknown	27566247 27255162	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +32 more
		FGFR3	Unknown	25593300	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +27 more
		FLNA	Unknown	26437033	Open Targets	MAPK signaling pathway Focal adhesion Salmonella infection +6 more
		FLT3	Unknown	27566247	Open Targets	MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway +8 more
		GNAQ	Unknown	27255162	Open Targets	Rap1 signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +52 more
		GNAS	Unknown	34091389	Open Targets	Endocrine resistance Rap1 signaling pathway Calcium signaling pathway +58 more
		H3C2	Unknown	26832993	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +27 more
		JAK2	Unknown	26437033	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		JAK3	Unknown	26832993	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		KDM6A	Unknown	27255162	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KDR	Unknown	26832993	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +13 more
		KIAA1549	Unknown	26437033	Open Targets	Signaling by BRAF and RAF fusions
		KIT	Unknown	28648934	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KMT2D	Unknown	35365682 26832993 27255162 26437033 28481359 37706238	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		LATS1	Unknown	28481359	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo

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Breast phyllodes tumor

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