Subtype of: Ovarian cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
Borderline Ovarian Mucinous Tumor	EFO_1000138	PTEN	Causal	31477716 25986173	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		ACVR2A	Unknown	26257827	Open Targets	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells +3 more
		ARID1A	Unknown	22653341 31477716	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ASXL1	Unknown	26257827	Open Targets	Polycomb repressive complex UCH proteinases
		ATM	Unknown	31477716 26257827	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		BCOR	Unknown	31477716	Open Targets	Polycomb repressive complex
		BIRC6	Unknown	26257827	Open Targets	Ubiquitin mediated proteolysis Autophagy - animal Apoptosis - multiple species
		BRAF	Unknown	22891197 31477716 26257827 19010816	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		CARD11	Unknown	31477716	Open Targets	NF-kappa B signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway +4 more
		CDH10	Unknown	26257827	Open Targets	Adherens junctions interactions
		CDK4	Unknown	31477716	Open Targets	Endocrine resistance Cell cycle p53 signaling pathway +40 more
		CDKN2A	Unknown	22891197 7478544 9133447 31477716 25986173	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CHST11	Unknown	26257827	Open Targets	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Chondroitin sulfate biosynthesis
		CSMD3	Unknown	31477716 26257827	Open Targets	—
		CTNNA1	Unknown	26257827	Open Targets	Hippo signaling pathway Adherens junction Leukocyte transendothelial migration +9 more
		CTNNB1	Unknown	31477716	Open Targets	Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway +51 more
		ELF3	Unknown	31477716 26257827	Open Targets	Pre-NOTCH Transcription and Translation
		ERBB2	Unknown	25986173	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +48 more
		ERBB3	Unknown	26257827	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +19 more
		FAT3	Unknown	26257827	Open Targets	—
		FBXW7	Unknown	31477716 26257827	Open Targets	Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling +3 more
		FGFR2	Unknown	31477716	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +26 more
		FLNA	Unknown	26257827	Open Targets	MAPK signaling pathway Focal adhesion Salmonella infection +6 more
		GNA11	Unknown	25986173	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway Hormone signaling +23 more
		GNAS	Unknown	31477716 26257827	Open Targets	Endocrine resistance Rap1 signaling pathway Calcium signaling pathway +58 more
		KMT2A	Unknown	26257827	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	31477716	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KRAS	Unknown	20955384 21926912 23000388 22891197 8261457 12694651 19010816 23174937 28498287 8384077 31477716 11727259 23096461 25986173 26257827 26870997 8319218 9166952 7852189 8651354	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LRP1B	Unknown	31477716	Open Targets	—
		MAP3K1	Unknown	31477716	Open Targets	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MAP3K13	Unknown	26257827	Open Targets	MAPK signaling pathway
		MSH2	Unknown	31477716	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +7 more
		NF1	Unknown	26257827	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NOTCH1	Unknown	31477716	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NRAS	Unknown	22891197	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		PDGFB	Unknown	26257827	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +25 more
		PIK3CA	Unknown	31477716 28498287 25986173	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3R1	Unknown	31477716	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more
		POU5F1	Unknown	26257827	Open Targets	Signaling pathways regulating pluripotency of stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation +1 more
		PTPRD	Unknown	26257827	Open Targets	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		RNF43	Unknown	26257827 31477716 23096461	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation
		SH2B3	Unknown	31477716	Open Targets	Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
		SMAD4	Unknown	31477716 10451707	Open Targets	FoxO signaling pathway Hormone signaling Cell cycle +30 more
		SPEN	Unknown	26257827	Open Targets	Notch signaling pathway
		TP53	Unknown	31477716 22891197 25986173 28498287 7852189	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TSC2	Unknown	31477716	Open Targets	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more
		U2AF1	Unknown	23280334 26257827	Open Targets	Spliceosome Shigellosis Transport of Mature mRNA derived from an Intron-Containing Transcript +3 more
		ZNF521	Unknown	26257827	Open Targets	—

Borderline ovarian mucinous tumor

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