Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
colon adenoma	MONDO_0000527	AFF3	Unknown	23204322	Open Targets	—
		AMER1	Unknown	23204322 28551381	Open Targets	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane +8 more
		APC	Unknown	31269945 9566701 23204322 19026650 16258065 14502807 9731892 19684041 22287596 28548127 7515658 29368261 24005794 20544848 27816598 15376262 25604157 28551381	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		ARID1A	Unknown	23204322	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID1B	Unknown	23204322	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ASPM	Unknown	23204322	Open Targets	—
		BRAF	Unknown	23204322 22233696 23376323 14688025 20305537 16404419 20444249 27239120 22684223	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		CDKN2A	Unknown	23204322	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CHST11	Unknown	23204322	Open Targets	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Chondroitin sulfate biosynthesis
		CNBD1	Unknown	23204322	Open Targets	—
		CNTNAP2	Unknown	23204322	Open Targets	Cell adhesion molecules
		CSMD3	Unknown	23204322	Open Targets	—
		CTNNB1	Unknown	23204322 28548127 24212608 20544848 10197610 12838317	Open Targets	Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway +51 more
		DCC	Unknown	23204322	Open Targets	Axon guidance Pathways in cancer Colorectal cancer +3 more
		DDX5	Unknown	23204322	Open Targets	Spliceosome Transcriptional misregulation in cancer Proteoglycans in cancer +3 more
		ERBB2	Unknown	23204322	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +48 more
		FAT1	Unknown	23204322	Open Targets	—
		FAT3	Unknown	23204322	Open Targets	—
		FAT4	Unknown	23204322 28551381	Open Targets	Hippo signaling pathway - multiple species
		FBXW7	Unknown	19420964	Open Targets	Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling +3 more
		GAS7	Unknown	23204322	Open Targets	—
		GNAS	Unknown	23204322	Open Targets	Endocrine resistance Rap1 signaling pathway Calcium signaling pathway +58 more
		GRM3	Unknown	23204322	Open Targets	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +3 more
		HOXC13	Unknown	23204322	Open Targets	—
		KRAS	Unknown	14502807 22178590 10220498 8187064 1566048 22233696 21369707 8621253 12012008 7578594 23204322 3587348 19637313 7731696 7797596 24005794 28551381 21536390 22394035 18980800 8283788 9097977 19026650 11215737 28548127 18398843	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LRIG3	Unknown	23204322	Open Targets	—
		MN1	Unknown	23204322	Open Targets	—
		PIK3CA	Unknown	28551381	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3R3	Unknown	23204322	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +116 more
		PLAG1	Unknown	23204322	Open Targets	—
		RNF43	Unknown	28548127	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation
		ROBO2	Unknown	23204322	Open Targets	Axon guidance Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO
		RUNX1T1	Unknown	23204322	Open Targets	Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia
		SEPTIN9	Unknown	23204322	Open Targets	Bacterial invasion of epithelial cells Shigellosis
		SMAD4	Unknown	11196171	Open Targets	FoxO signaling pathway Hormone signaling Cell cycle +30 more
		SYK	Unknown	23204322	Open Targets	NF-kappa B signaling pathway Phospholipase D signaling pathway PI3K-Akt signaling pathway +30 more
		TGFBR2	Unknown	9566701 8978340	Open Targets	MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway +28 more
		TNC	Unknown	23204322	Open Targets	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +6 more
		TP53	Unknown	23204322 14688025 12010886	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TPR	Unknown	23204322	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Pathways in cancer +27 more

Colon adenoma

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