Gene Gene information from NCBI Gene database.
Entrez ID 6776
Gene name Signal transducer and activator of transcription 5A
Gene symbol STAT5A
Synonyms (NCBI Gene)
MGFSTAT5
Chromosome 17
Chromosome location 17q21.2
Summary The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that tran
miRNA miRNA information provided by mirtarbase database.
367
miRTarBase ID miRNA Experiments Reference
MIRT000018 hsa-miR-222-3p qRT-PCRLuciferase reporter assayWestern blot 20489169
MIRT023082 hsa-miR-124-3p Microarray 18668037
MIRT438254 hsa-miR-221-3p Luciferase reporter assay 24736554
MIRT000018 hsa-miR-222-3p Luciferase reporter assay 24736554
MIRT000018 hsa-miR-222-3p Luciferase reporter assay 24736554
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
PPARA Unknown 21542777
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
115
GO ID Ontology Definition Evidence Reference
GO:0000278 Process Mitotic cell cycle IEA
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601511 11366 ENSG00000126561
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P42229
Protein name Signal transducer and activator of transcription 5A
Protein function Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated F
PDB 7TVA , 7TVB , 7UBT , 7UC6 , 7UC7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02865 STAT_int 2 124 STAT protein, protein interaction domain Domain
PF01017 STAT_alpha 141 324 STAT protein, all-alpha domain Family
PF02864 STAT_bind 336 469 STAT protein, DNA binding domain Domain
PF00017 SH2 589 670 SH2 domain Domain
Sequence
Sequence length 794
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
11
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ASTHMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, DUCTAL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Achondroplasia Achondroplasia BEFREE 19802676
★☆☆☆☆
Found in Text Mining only
Achondroplasia Achondroplasia Pubtator 19802676 Associate
★☆☆☆☆
Found in Text Mining only
Acquired Hypogammaglobulinemia Common Variable Immunodeficiency BEFREE 30064289
★☆☆☆☆
Found in Text Mining only
Acute Coronary Syndrome Coronary Syndrome BEFREE 25572535
★☆☆☆☆
Found in Text Mining only
Acute Erythroblastic Leukemia Erythroblastic Leukemia BEFREE 20667821, 8861946
★☆☆☆☆
Found in Text Mining only
Acute leukemia Leukemia BEFREE 9498707
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 18193087, 20227268, 21606506, 22685175, 30784762, 8634413
★☆☆☆☆
Found in Text Mining only
Acute monocytic leukemia Monocytic Leukemia BEFREE 28667329
★☆☆☆☆
Found in Text Mining only
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 11929748
★☆☆☆☆
Found in Text Mining only
Acute Undifferentiated Leukemia Leukemia BEFREE 19667399
★☆☆☆☆
Found in Text Mining only