Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 46

16 diseases · 28 shared-gene connections
16 Diseases
490 Unique genes
0.080 Avg. similarity score
Allergic contact dermatitis Most-connected disease (7 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Allergic contact dermatitis 7 7 73
Hypersensitivity 7 7 70
Atopic dermatitis 6 6 66
Autoimmune hepatitis 6 6 38
Rhinitis 6 6 65
Behcet disease 4 4 105
Dermatitis 4 4 38
Glomerulonephritis 4 4 97
Contact dermatitis 3 3 75
Giant cell arteritis 2 2 18
Uveitis 2 2 33
Autoinflammation with episodic fever and immune dysregulation 1 1 1
Lewis lung carcinoma 1 1 2
Microscopic polyangiitis 1 1 1
phosphohydroxylysinuria 1 1 1
systemic lupus erythematosus 17 1 1 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
IL18 9 / 16 Allergic contact dermatitis, Atopic dermatitis, Autoimmune hepatitis, Behcet disease and 5 more
IL10 8 / 16 Allergic contact dermatitis, Atopic dermatitis, Autoimmune hepatitis, Behcet disease and 4 more
IL4 8 / 16 Allergic contact dermatitis, Atopic dermatitis, Autoimmune hepatitis, Behcet disease and 4 more
TNF 8 / 16 Allergic contact dermatitis, Atopic dermatitis, Behcet disease, Dermatitis and 4 more
IFNG 7 / 16 Allergic contact dermatitis, Atopic dermatitis, Autoimmune hepatitis, Giant cell arteritis and 3 more
HLA-DRB1 6 / 16 Autoimmune hepatitis, Behcet disease, Dermatitis, Giant cell arteritis and 2 more
IL13 6 / 16 Atopic dermatitis, Autoimmune hepatitis, Dermatitis, Hypersensitivity and 2 more
IL1B 6 / 16 Atopic dermatitis, Behcet disease, Glomerulonephritis, Hypersensitivity and 2 more
IL2 6 / 16 Allergic contact dermatitis, Atopic dermatitis, Autoimmune hepatitis, Behcet disease and 2 more
TLR4 6 / 16 Allergic contact dermatitis, Atopic dermatitis, Behcet disease, Contact dermatitis and 2 more
CCL2 5 / 16 Autoimmune hepatitis, Behcet disease, Giant cell arteritis, Glomerulonephritis and 1 more
CYP1A1 5 / 16 Allergic contact dermatitis, Atopic dermatitis, Behcet disease, Contact dermatitis and 1 more
HLA-B 5 / 16 Behcet disease, Dermatitis, Giant cell arteritis, Hypersensitivity and 1 more
HLA-DQA1 5 / 16 Autoimmune hepatitis, Dermatitis, Glomerulonephritis, Hypersensitivity and 1 more
IL6 5 / 16 Atopic dermatitis, Autoimmune hepatitis, Glomerulonephritis, Hypersensitivity and 1 more
TGFB1 5 / 16 Atopic dermatitis, Autoimmune hepatitis, Behcet disease, Hypersensitivity and 1 more
ALB 4 / 16 Glomerulonephritis, Hypersensitivity, Rhinitis, Uveitis
CCR1 4 / 16 Allergic contact dermatitis, Behcet disease, Contact dermatitis, Hypersensitivity
CCR2 4 / 16 Allergic contact dermatitis, Hypersensitivity, Rhinitis, Uveitis
CXCR3 4 / 16 Atopic dermatitis, Contact dermatitis, Glomerulonephritis, Hypersensitivity
HLA-DQB1 4 / 16 Autoimmune hepatitis, Behcet disease, Hypersensitivity, Rhinitis
MBL2 4 / 16 Atopic dermatitis, Behcet disease, Giant cell arteritis, Rhinitis
AHR 3 / 16 Atopic dermatitis, Behcet disease, Contact dermatitis
CCL24 3 / 16 Atopic dermatitis, Hypersensitivity, Rhinitis
CCL5 3 / 16 Atopic dermatitis, Autoimmune hepatitis, Glomerulonephritis
CCR3 3 / 16 Atopic dermatitis, Behcet disease, Rhinitis
CCR5 3 / 16 Atopic dermatitis, Behcet disease, Uveitis
CTLA4 3 / 16 Atopic dermatitis, Autoimmune hepatitis, Behcet disease
EMSY 3 / 16 Atopic dermatitis, Dermatitis, Rhinitis
FCGR3A 3 / 16 Behcet disease, Giant cell arteritis, Rhinitis
FLG 3 / 16 Atopic dermatitis, Contact dermatitis, Dermatitis
IL17A 3 / 16 Giant cell arteritis, Hypersensitivity, Rhinitis
IL23R 3 / 16 Behcet disease, Rhinitis, Uveitis
IL2RA 3 / 16 Allergic contact dermatitis, Dermatitis, Glomerulonephritis
IL5 3 / 16 Allergic contact dermatitis, Atopic dermatitis, Autoimmune hepatitis
ITGB2 3 / 16 Behcet disease, Dermatitis, Hypersensitivity
MS4A2 3 / 16 Atopic dermatitis, Hypersensitivity, Rhinitis
NAT2 3 / 16 Allergic contact dermatitis, Atopic dermatitis, Behcet disease
NOD2 3 / 16 Behcet disease, Dermatitis, Rhinitis
SERPINE1 3 / 16 Behcet disease, Glomerulonephritis, Rhinitis
TLR2 3 / 16 Atopic dermatitis, Behcet disease, Rhinitis
TNFRSF1A 3 / 16 Behcet disease, Hypersensitivity, Uveitis
VDR 3 / 16 Atopic dermatitis, Autoimmune hepatitis, Behcet disease
ABCB1 2 / 16 Behcet disease, Rhinitis
ALK 2 / 16 Behcet disease, Glomerulonephritis
BCL2 2 / 16 Allergic contact dermatitis, Contact dermatitis
BDNF 2 / 16 Atopic dermatitis, Rhinitis
CAPSL 2 / 16 Dermatitis, Rhinitis
CASP8 2 / 16 Allergic contact dermatitis, Contact dermatitis
CAT 2 / 16 Behcet disease, Rhinitis
CCL11 2 / 16 Atopic dermatitis, Hypersensitivity
CCL17 2 / 16 Atopic dermatitis, Hypersensitivity
CCL19 2 / 16 Allergic contact dermatitis, Hypersensitivity
CCL3 2 / 16 Glomerulonephritis, Hypersensitivity
CCL4 2 / 16 Glomerulonephritis, Hypersensitivity
CCL7 2 / 16 Glomerulonephritis, Hypersensitivity
CDH19 2 / 16 Glomerulonephritis, Microscopic polyangiitis
CLDN1 2 / 16 Atopic dermatitis, Contact dermatitis
CLEC16A 2 / 16 Dermatitis, Rhinitis
CXCL1 2 / 16 Autoimmune hepatitis, Hypersensitivity
CXCL8 2 / 16 Behcet disease, Glomerulonephritis
CYP2D6 2 / 16 Autoimmune hepatitis, Rhinitis
DSG1 2 / 16 Dermatitis, Hypersensitivity
EGFR 2 / 16 Behcet disease, Dermatitis
ERAP1 2 / 16 Behcet disease, Uveitis
F2 2 / 16 Autoimmune hepatitis, Glomerulonephritis
FAS 2 / 16 Behcet disease, Glomerulonephritis
GLB1 2 / 16 Atopic dermatitis, Contact dermatitis
GSTP1 2 / 16 Atopic dermatitis, Contact dermatitis
HLA-A 2 / 16 Dermatitis, Uveitis
HMOX1 2 / 16 Contact dermatitis, Rhinitis
HNMT 2 / 16 Atopic dermatitis, Rhinitis
IL1A 2 / 16 Allergic contact dermatitis, Behcet disease
IL1RN 2 / 16 Glomerulonephritis, Rhinitis
IL21R 2 / 16 Behcet disease, Giant cell arteritis
IL33 2 / 16 Atopic dermatitis, Hypersensitivity
IL4R 2 / 16 Atopic dermatitis, Rhinitis
LEP 2 / 16 Autoimmune hepatitis, Rhinitis
MRC1 2 / 16 Allergic contact dermatitis, Rhinitis
MTHFR 2 / 16 Glomerulonephritis, Hypersensitivity
PHYKPL 2 / 16 Glomerulonephritis, phosphohydroxylysinuria
PTPN22 2 / 16 Behcet disease, Giant cell arteritis
S100A8 2 / 16 Atopic dermatitis, Contact dermatitis
SELE 2 / 16 Allergic contact dermatitis, Atopic dermatitis
SELP 2 / 16 Atopic dermatitis, Hypersensitivity
SHARPIN 2 / 16 Autoinflammation with episodic fever and immune dysregulation, Dermatitis
SLC11A1 2 / 16 Atopic dermatitis, Behcet disease
SPP1 2 / 16 Allergic contact dermatitis, Hypersensitivity
STAT4 2 / 16 Autoimmune hepatitis, Behcet disease
TLR7 2 / 16 Allergic contact dermatitis, systemic lupus erythematosus 17
TSLP 2 / 16 Atopic dermatitis, Hypersensitivity
TXNRD1 2 / 16 Contact dermatitis, Lewis lung carcinoma
VEGFA 2 / 16 Contact dermatitis, Glomerulonephritis
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Cytokine-cytokine receptor interaction
IFNG, IL10, IL13, IL17A, IL18, IL4, CCL2, CCL5, CXCL1, IL2, IL22, IL5
 KEGG 85 / 298 7.0× 3.68e-49 4.51e-45 ✓ sig.
Viral protein interaction with cytokine and cytokine receptor
IL10, IL18, CCL2, CCL5, CXCL1, IL2, IL6, CCR1, CCR5, CXCL8, IL18R1, TNF
 KEGG 48 / 100 11.8× 2.84e-40 1.96e-36 ✓ sig.
Inflammatory bowel disease
IFNG, IL10, IL13, IL17A, IL18, IL4, TLR2, TLR4, HLA-DPB1, HLA-DQB1, HLA-DRB1, IL2
 KEGG 38 / 66 14.1× 4.65e-36 2.16e-32 ✓ sig.
Interleukin-10 signaling
IL10, IL18, PTGS2, CCL2, CCL5, CXCL1, IL6, CCR1, IL12A, CCR5, CXCL8, ICAM1
 Reactome 31 / 47 16.2× 2.76e-32 9.82e-29 ✓ sig.
Interleukin-4 and Interleukin-13 signaling
HMOX1, IL10, IL13, IL17A, IL18, IL4, PTGS2, CCL2, IL6, TGFB1, IL12A, IL23R
 Reactome 43 / 108 9.8× 6.90e-32 2.31e-28 ✓ sig.
Chemokine receptors bind chemokines
CCL2, CCL5, CXCL1, CCR1, CCR5, CXCL8, CCR3, CCL27, CXCR3, CCR7, CXCL12, CCL19
 Reactome 31 / 59 12.9× 6.44e-28 1.58e-24 ✓ sig.
Rheumatoid arthritis
IFNG, IL17A, IL18, TLR2, TLR4, CCL2, CCL5, CTLA4, CXCL1, HLA-DPB1, HLA-DQB1, HLA-DRB1
 KEGG 33 / 95 8.5× 1.79e-22 2.27e-19 ✓ sig.
Th17 cell differentiation
IFNG, IL17A, IL4, HLA-DPB1, HLA-DQB1, HLA-DRB1, IL2, IL22, IL6, TGFB1, HLA-DQA1, IFNGR1
 KEGG 34 / 109 7.6× 2.18e-21 2.19e-18 ✓ sig.
JAK-STAT signaling pathway
IFNG, IL10, IL13, IL4, HRAS, IL2, IL22, IL5, IL6, IL9, LEP, STAT4
 KEGG 41 / 168 6.0× 4.49e-21 4.31e-18 ✓ sig.
Lipid and atherosclerosis
IL18, TLR2, TLR4, CCL2, CCL5, CXCL1, HRAS, IL6, FAS, IL12A, APOA1, APOB
 KEGG 44 / 216 5.0× 3.14e-19 2.28e-16 ✓ sig.
Chemokine signaling pathway
CCL2, CCL5, CXCL1, HRAS, CCR1, CCR5, CXCL8, IKBKG, STAT3, ARRB2, CCR3, CCL27
 KEGG 41 / 193 5.2× 1.09e-18 7.32e-16 ✓ sig.
IL-17 signaling pathway
IFNG, IL13, IL17A, IL4, PTGS2, CCL2, CXCL1, IL5, IL6, CXCL8, IKBKG, TNF
 KEGG 29 / 94 7.6× 2.88e-18 1.76e-15 ✓ sig.
Tuberculosis
FCGR3A, IFNG, IL10, IL18, MRC1, TLR2, TLR4, HLA-DPB1, HLA-DQB1, HLA-DRB1, IL6, TGFB1
 KEGG 39 / 181 5.3× 4.69e-18 2.75e-15 ✓ sig.
Allograft rejection
IFNG, IL10, IL4, HLA-DPB1, HLA-DQB1, HLA-DRB1, IL2, IL5, HLA-DQA1, FAS, HLA-B, IL12A
 KEGG 19 / 39 11.9× 9.19e-17 4.16e-14 ✓ sig.
Malaria
IFNG, IL10, IL18, TLR2, TLR4, CCL2, IL6, TGFB1, IL12A, CXCL8, ICAM1, ITGAL
 KEGG 21 / 50 10.3× 9.81e-17 4.42e-14 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
immune response
FCGR3A, IFNG, IL10, IL13, IL17A, IL18, IL4, TLR2, TLR4, CCL2, CCL5, CTLA4
 GO:0006955 107 / 543 7.5× 1.62e-63 8.10e-59 ✓ sig.
inflammatory response
HRH1, IL13, IL17A, IL18, TLR2, TLR4, CCL2, CCL5, CXCL1, IL22, IL5, IL6
 GO:0006954 96 / 467 7.8× 1.62e-58 5.16e-54 ✓ sig.
chemotaxis
CCL2, CCL5, CXCL1, HRAS, CCR1, CCR5, CXCL8, CCR3, LECT2, CCL27, CXCL14, CXCR3
 GO:0006935 42 / 161 9.9× 3.75e-30 1.99e-26 ✓ sig.
antimicrobial humoral immune response mediated by antimicrobial peptide
CCL2, CCL5, CXCL1, F2, CXCL8, CCL27, CXCL14, DEFB1, CXCL12, CCL19, CXCL2, CCL11
 GO:0061844 35 / 124 10.8× 1.39e-26 5.07e-23 ✓ sig.
positive regulation of inflammatory response
IFNG, IL18, TLR2, TLR4, IL2, TGFB1, CCR1, MEFV, SERPINE1, STAT3, TNF, TNFRSF1A
 GO:0050729 33 / 122 10.3× 1.80e-24 5.30e-21 ✓ sig.
cytokine-mediated signaling pathway
IL18, CCL2, IL5, IL6, STAT4, LILRA4, CCR1, IFNGR1, IL23R, IL21R, STAT3, TNFRSF1A
 GO:0019221 35 / 145 9.2× 4.66e-24 1.33e-20 ✓ sig.
cellular response to lipopolysaccharide
ABCB1, IL10, IL18, MRC1, TLR4, CCL2, IL6, CCR5, CXCL8, IRF8, NOD2, SERPINE1
 GO:0071222 38 / 187 7.7× 3.91e-23 1.01e-19 ✓ sig.
response to lipopolysaccharide
ABCB1, IL10, IL13, TLR4, IL12A, IL23R, CYP1A1, NOS3, PTPN22, SLC11A1, TNF, IL12RB2
 GO:0032496 35 / 161 8.3× 2.00e-22 4.58e-19 ✓ sig.
chemokine-mediated signaling pathway
CCL2, CCL5, CCR1, CCR5, CCR3, CXCR3, CXCL12, CCL19, CCR2, CCL11, CCL22, CCL24
 GO:0070098 24 / 64 14.3× 6.07e-22 1.28e-18 ✓ sig.
positive regulation of type II interferon production
IL18, TLR4, HLA-DPB1, HRAS, IL2, IL12A, IL23R, IL18R1, IRF8, PTPN22, SLC11A1, TNF
 GO:0032729 23 / 77 11.4× 1.68e-18 2.18e-15 ✓ sig.
positive regulation of gene expression
CLDN3, GRIA1, IFNG, IL13, IL18, IL4, OCLN, TLR2, TLR4, CCL2, HRAS, IL6
 GO:0010628 53 / 504 4.0× 5.17e-18 6.20e-15 ✓ sig.
killing of cells of another organism
C1S, CXCL1, C4A, CXCL8, MBL2, CCL27, CXCL14, CXCL12, CCL19, CXCL2, NINJ1, CCL11
 GO:0031640 25 / 104 9.2× 1.74e-17 1.95e-14 ✓ sig.
positive regulation of canonical NF-kappaB signal transduction
HMOX1, TLR2, TLR4, HLA-DRB1, TGFB1, CARD10, SHARPIN, IKBKG, NOD2, STAT3, TNF, TNFRSF1A
 GO:0043123 35 / 232 5.8× 4.69e-17 4.82e-14 ✓ sig.
cell surface receptor signaling pathway
FCGR3A, IFNG, IL18, CCL2, F2, HRAS, LILRA4, CCR1, CCR5, TNFRSF1A, CCR3, EGFR
 GO:0007166 44 / 373 4.5× 5.73e-17 5.81e-14 ✓ sig.
positive regulation of tumor necrosis factor production
FCGR3A, IFNG, IL17A, TLR2, TLR4, IL6, LEP, TGFB1, IFNGR1, NOD2, STAT3, IL1A
 GO:0032760 25 / 113 8.4× 1.46e-16 1.34e-13 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Atopic dermatitis Rhinitis 0.158 18 8.10e-29 2.51e-27 ✓ sig.
Atopic dermatitis Hypersensitivity 0.151 18 3.72e-28 1.12e-26 ✓ sig.
Atopic dermatitis Behcet disease 0.117 18 1.16e-24 2.93e-23 ✓ sig.
Behcet disease Rhinitis 0.110 17 5.51e-23 1.26e-21 ✓ sig.
Hypersensitivity Rhinitis 0.115 14 2.06e-20 4.24e-19 ✓ sig.
Atopic dermatitis Autoimmune hepatitis 0.129 12 3.32e-20 6.76e-19 ✓ sig.
Autoimmune hepatitis Hypersensitivity 0.124 12 7.12e-20 1.43e-18 ✓ sig.
Hypersensitivity Uveitis 0.118 11 1.35e-18 2.52e-17 ✓ sig.
Behcet disease Giant cell arteritis 0.088 10 5.86e-18 1.06e-16 ✓ sig.
Glomerulonephritis Hypersensitivity 0.091 14 8.48e-18 1.52e-16 ✓ sig.
Autoimmune hepatitis Rhinitis 0.106 10 3.75e-16 6.12e-15 ✓ sig.
Allergic contact dermatitis Atopic dermatitis 0.085 11 1.08e-14 1.60e-13 ✓ sig.
Atopic dermatitis Contact dermatitis 0.076 10 6.85e-13 8.87e-12 ✓ sig.
Allergic contact dermatitis Hypersensitivity 0.075 10 9.57e-13 1.23e-11 ✓ sig.
Autoimmune hepatitis Glomerulonephritis 0.071 9 1.50e-12 1.89e-11 ✓ sig.
Dermatitis Rhinitis 0.083 8 2.86e-12 3.47e-11 ✓ sig.
Dermatitis Hypersensitivity 0.079 8 5.30e-12 6.32e-11 ✓ sig.
Allergic contact dermatitis Rhinitis 0.069 9 1.88e-11 2.13e-10 ✓ sig.
Allergic contact dermatitis Behcet disease 0.059 10 6.11e-11 6.57e-10 ✓ sig.
Autoimmune hepatitis Giant cell arteritis 0.096 5 5.83e-10 5.70e-9 ✓ sig.
Dermatitis Uveitis 0.075 5 1.57e-8 1.31e-7 ✓ sig.
Allergic contact dermatitis Autoimmune hepatitis 0.057 6 2.25e-8 1.85e-7 ✓ sig.
Allergic contact dermatitis Contact dermatitis 0.042 6 1.43e-6 8.64e-6 ✓ sig.
Autoinflammation with episodic fever and immune dysregulation Dermatitis 0.026 1 2.47e-3 3.36e-3 ✓ sig.
Allergic contact dermatitis systemic lupus erythematosus 17 0.014 1 4.74e-3 5.86e-3 ✓ sig.
Glomerulonephritis Microscopic polyangiitis 0.010 1 6.30e-3 7.57e-3 ✓ sig.
Glomerulonephritis phosphohydroxylysinuria 0.010 1 6.30e-3 7.57e-3 ✓ sig.
Contact dermatitis Lewis lung carcinoma 0.013 1 9.72e-3 1.10e-2 ✓ sig.