Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 252

7 diseases · 9 shared-gene connections
7 Diseases
1,744 Unique genes
0.088 Avg. similarity score
Eczema Most-connected disease (4 links)
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Disease Searched: neurodevelopmental disorder with spasticity, seizures, and brain abnormalities Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Eczema 4 4 365
Asthma 3 3 1,068
Obstructive pulmonary disease 3 3 559
Respiratory system disease 3 3 241
Inflammatory skin disease 2 2 76
Intellectual developmental disorder neuropsychiatric 2 2 1
neurodevelopmental disorder with spasticity, seizures, and brain abnormalities 1 1 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
EMSY 5 / 7 Asthma, Eczema, Inflammatory skin disease, Obstructive pulmonary disease and 1 more
ADAM19 4 / 7 Asthma, Eczema, Inflammatory skin disease, Obstructive pulmonary disease
BACH2 4 / 7 Asthma, Eczema, Obstructive pulmonary disease, Respiratory system disease
CSMD1 4 / 7 Asthma, Eczema, Inflammatory skin disease, Obstructive pulmonary disease
D2HGDH 4 / 7 Asthma, Eczema, Obstructive pulmonary disease, Respiratory system disease
FADS1 4 / 7 Asthma, Eczema, Obstructive pulmonary disease, Respiratory system disease
FADS2 4 / 7 Asthma, Eczema, Obstructive pulmonary disease, Respiratory system disease
GLB1 4 / 7 Asthma, Eczema, Obstructive pulmonary disease, Respiratory system disease
HLA-DQA1 4 / 7 Asthma, Eczema, Obstructive pulmonary disease, Respiratory system disease
IL18R1 4 / 7 Asthma, Eczema, Obstructive pulmonary disease, Respiratory system disease
IL1RL1 4 / 7 Asthma, Eczema, Obstructive pulmonary disease, Respiratory system disease
IL2RA 4 / 7 Asthma, Eczema, Obstructive pulmonary disease, Respiratory system disease
ITGB8 4 / 7 Asthma, Eczema, Obstructive pulmonary disease, Respiratory system disease
OTULINL 4 / 7 Asthma, Eczema, Obstructive pulmonary disease, Respiratory system disease
PLXNC1 4 / 7 Asthma, Eczema, Obstructive pulmonary disease, Respiratory system disease
PRR5L 4 / 7 Asthma, Eczema, Inflammatory skin disease, Respiratory system disease
RERE 4 / 7 Asthma, Eczema, Obstructive pulmonary disease, Respiratory system disease
RPS26 4 / 7 Asthma, Eczema, Inflammatory skin disease, Obstructive pulmonary disease
RUNX3 4 / 7 Asthma, Eczema, Obstructive pulmonary disease, Respiratory system disease
SMAD3 4 / 7 Asthma, Eczema, Obstructive pulmonary disease, Respiratory system disease
SOCS3 4 / 7 Asthma, Eczema, Inflammatory skin disease, Respiratory system disease
TNFAIP3 4 / 7 Asthma, Eczema, Inflammatory skin disease, Respiratory system disease
TSLP 4 / 7 Asthma, Eczema, Obstructive pulmonary disease, Respiratory system disease
UBAC2 4 / 7 Asthma, Eczema, Obstructive pulmonary disease, Respiratory system disease
ZBTB38 4 / 7 Asthma, Eczema, Obstructive pulmonary disease, Respiratory system disease
ACO1 3 / 7 Asthma, Eczema, Inflammatory skin disease
ADAMTSL3 3 / 7 Asthma, Obstructive pulmonary disease, Respiratory system disease
AHI1 3 / 7 Asthma, Eczema, Respiratory system disease
AP5B1 3 / 7 Asthma, Eczema, Respiratory system disease
BLTP1 3 / 7 Asthma, Eczema, Inflammatory skin disease
CAPSL 3 / 7 Asthma, Eczema, Respiratory system disease
CARD11 3 / 7 Asthma, Eczema, Respiratory system disease
CCR7 3 / 7 Asthma, Eczema, Respiratory system disease
CD247 3 / 7 Asthma, Eczema, Respiratory system disease
CEBPA 3 / 7 Asthma, Eczema, Respiratory system disease
CLEC16A 3 / 7 Asthma, Eczema, Respiratory system disease
CRCT1 3 / 7 Asthma, Eczema, Inflammatory skin disease
CXCR5 3 / 7 Asthma, Eczema, Respiratory system disease
EEFSEC 3 / 7 Asthma, Obstructive pulmonary disease, Respiratory system disease
ERBB3 3 / 7 Asthma, Eczema, Obstructive pulmonary disease
ETS1 3 / 7 Asthma, Eczema, Respiratory system disease
FLG 3 / 7 Asthma, Eczema, Respiratory system disease
GATA3 3 / 7 Asthma, Eczema, Respiratory system disease
GRM4 3 / 7 Asthma, Eczema, Inflammatory skin disease
GSDMB 3 / 7 Asthma, Obstructive pulmonary disease, Respiratory system disease
HDAC7 3 / 7 Asthma, Obstructive pulmonary disease, Respiratory system disease
HLA-B 3 / 7 Asthma, Eczema, Obstructive pulmonary disease
HLA-DQB1 3 / 7 Asthma, Eczema, Obstructive pulmonary disease
HLA-DRB1 3 / 7 Asthma, Eczema, Respiratory system disease
HLA-DRB5 3 / 7 Asthma, Eczema, Obstructive pulmonary disease
HTR4 3 / 7 Asthma, Obstructive pulmonary disease, Respiratory system disease
IKZF1 3 / 7 Asthma, Eczema, Respiratory system disease
IL2 3 / 7 Asthma, Eczema, Respiratory system disease
IL33 3 / 7 Asthma, Obstructive pulmonary disease, Respiratory system disease
IL4R 3 / 7 Asthma, Eczema, Respiratory system disease
IL6R 3 / 7 Asthma, Eczema, Respiratory system disease
IL7R 3 / 7 Asthma, Eczema, Respiratory system disease
INPP5D 3 / 7 Asthma, Eczema, Respiratory system disease
IRF1 3 / 7 Asthma, Obstructive pulmonary disease, Respiratory system disease
ITK 3 / 7 Asthma, Eczema, Respiratory system disease
ITPKA 3 / 7 Asthma, Eczema, Respiratory system disease
KPNA3 3 / 7 Eczema, Inflammatory skin disease, Obstructive pulmonary disease
LCE3E 3 / 7 Asthma, Eczema, Inflammatory skin disease
LCE5A 3 / 7 Asthma, Eczema, Inflammatory skin disease
LMAN2 3 / 7 Asthma, Eczema, Respiratory system disease
LRRC43 3 / 7 Asthma, Eczema, Inflammatory skin disease
MAP2K4 3 / 7 Asthma, Obstructive pulmonary disease, Respiratory system disease
MYRF 3 / 7 Asthma, Eczema, Respiratory system disease
NCF4 3 / 7 Asthma, Eczema, Respiratory system disease
NDFIP1 3 / 7 Asthma, Eczema, Respiratory system disease
NFKBIA 3 / 7 Asthma, Obstructive pulmonary disease, Respiratory system disease
NOS2 3 / 7 Asthma, Eczema, Inflammatory skin disease
NPNT 3 / 7 Asthma, Obstructive pulmonary disease, Respiratory system disease
OVOL1 3 / 7 Asthma, Eczema, Respiratory system disease
POLI 3 / 7 Asthma, Eczema, Inflammatory skin disease
PSMA6 3 / 7 Asthma, Eczema, Inflammatory skin disease
RAD50 3 / 7 Asthma, Eczema, Inflammatory skin disease
RAD51B 3 / 7 Asthma, Obstructive pulmonary disease, Respiratory system disease
RAF1 3 / 7 Asthma, Obstructive pulmonary disease, Respiratory system disease
RAP1GAP2 3 / 7 Asthma, Eczema, Inflammatory skin disease
RIN3 3 / 7 Asthma, Obstructive pulmonary disease, Respiratory system disease
RORA 3 / 7 Asthma, Eczema, Respiratory system disease
RORC 3 / 7 Asthma, Eczema, Respiratory system disease
RTEL1 3 / 7 Asthma, Eczema, Respiratory system disease
RYBP 3 / 7 Asthma, Eczema, Respiratory system disease
SCAF8 3 / 7 Asthma, Eczema, Respiratory system disease
SEPTIN8 3 / 7 Asthma, Eczema, Respiratory system disease
SIK2 3 / 7 Asthma, Eczema, Respiratory system disease
SLC25A46 3 / 7 Asthma, Eczema, Respiratory system disease
SLC45A1 3 / 7 Eczema, Inflammatory skin disease, Intellectual developmental disorder neuropsychiatric
SLC7A10 3 / 7 Asthma, Eczema, Respiratory system disease
SLC9A2 3 / 7 Asthma, Eczema, Respiratory system disease
SLC9A4 3 / 7 Asthma, Eczema, Respiratory system disease
SMARCE1 3 / 7 Asthma, Eczema, Respiratory system disease
SPATA32 3 / 7 Asthma, Eczema, Respiratory system disease
SPSB1 3 / 7 Asthma, Eczema, Respiratory system disease
SRGAP2 3 / 7 Asthma, Obstructive pulmonary disease, Respiratory system disease
STAT6 3 / 7 Asthma, Eczema, Respiratory system disease
TBL1XR1 3 / 7 Asthma, Obstructive pulmonary disease, Respiratory system disease
TBX21 3 / 7 Asthma, Eczema, Respiratory system disease
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Inflammatory bowel disease
FOXP3, GATA3, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA
 KEGG 50 / 66 5.2× 5.37e-29 1.33e-25 ✓ sig.
Th17 cell differentiation
CD247, FOXP3, GATA3, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2
 KEGG 53 / 109 3.3× 2.14e-17 1.07e-14 ✓ sig.
Allograft rejection
CD28, CD40, CD80, CD86, FASLG, HLA-B, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1
 KEGG 29 / 39 5.1× 5.86e-17 2.67e-14 ✓ sig.
Type I diabetes mellitus
CD28, CD80, CD86, FASLG, HLA-B, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2
 KEGG 30 / 44 4.7× 8.35e-16 3.12e-13 ✓ sig.
Asthma
CCL11, CD40, FCER1G, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2
 KEGG 25 / 32 5.4× 1.15e-15 4.21e-13 ✓ sig.
Interleukin-4 and Interleukin-13 signaling
ALOX15, ALOX5, BATF, BCL2, CCL11, CCL2, CCL22, F13A1, FASLG, FN1, FOXO1, GATA3
 Reactome 46 / 108 2.9× 1.22e-12 2.60e-10 ✓ sig.
Graft-versus-host disease
CD28, CD80, CD86, FASLG, HLA-B, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2
 KEGG 27 / 45 4.1× 2.36e-12 4.76e-10 ✓ sig.
Intestinal immune network for IgA production
CD28, CD40, CD80, CD86, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1
 KEGG 28 / 50 3.9× 9.63e-12 1.77e-9 ✓ sig.
Cytokine-cytokine receptor interaction
CCL11, CCL2, CCL20, CCL22, CCL24, CCL26, CCL5, CCR2, CCR3, CCR5, CCR7, CD40
 KEGG 86 / 298 2.0× 8.23e-11 1.22e-8 ✓ sig.
Th1 and Th2 cell differentiation
CD247, GATA3, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA
 KEGG 39 / 93 2.9× 1.11e-10 1.62e-8 ✓ sig.
Autoimmune thyroid disease
CD28, CD40, CD80, CD86, CTLA4, FASLG, HLA-B, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1
 KEGG 28 / 54 3.6× 1.13e-10 1.64e-8 ✓ sig.
Rheumatoid arthritis
ATP6V0A1, CCL2, CCL20, CCL5, CD28, CD80, CD86, CTLA4, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1
 KEGG 39 / 95 2.8× 2.40e-10 3.22e-8 ✓ sig.
Leishmaniasis
C3, CYBA, FCGR3A, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2
 KEGG 34 / 78 3.0× 4.99e-10 6.29e-8 ✓ sig.
Human T-cell leukemia virus 1 infection
ADCY2, ADCY8, ADCY9, ANAPC1, BAX, CD40, CDK2, CREB5, EGR1, ETS1, FOSL1, HLA-B
 KEGG 66 / 224 2.0× 5.28e-9 5.25e-7 ✓ sig.
Interleukin-10 signaling
CCL2, CCL20, CCL22, CCL5, CCR2, CCR5, CD80, CD86, CSF3, ICAM1, IL10, IL12B
 Reactome 23 / 47 3.4× 2.19e-8 1.84e-6 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
immune response
AIM2, C3, CCL11, CCL2, CCL20, CCL22, CCL24, CCL26, CCL5, CCR2, CCR3, CCR5
 GO:0006955 119 / 543 2.3× 3.47e-19 4.68e-16 ✓ sig.
inflammatory response
ADORA1, ADORA2A, AGER, AIM2, ALOX15, ALOX5, AP3B1, ATRN, BDKRB2, C3, C3AR1, C5
 GO:0006954 104 / 467 2.4× 2.04e-17 2.14e-14 ✓ sig.
positive regulation of transcription by RNA polymerase II
ADRB2, AHI1, AP3B1, ARID4B, ARNT, ASXL3, BATF, BCL3, CD28, CD40, CDC5L, CDK12
 GO:0045944 191 / 1,208 1.7× 8.60e-14 4.76e-11 ✓ sig.
positive regulation of DNA-templated transcription
APOE, ARID1B, ARNT, BCL3, BLM, CAMK4, CD80, CD86, CDH1, CDK2, CDK5RAP2, CEBPA
 GO:0045893 133 / 778 1.8× 2.85e-12 1.20e-9 ✓ sig.
cytokine-mediated signaling pathway
CCL2, CCR2, CEBPA, CSF2RB, CSF3, CX3CR1, FER, FOSL1, IFNGR1, IL13RA1, IL16, IL17RD
 GO:0019221 43 / 145 3.2× 3.24e-12 1.36e-9 ✓ sig.
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3
 GO:0002504 13 / 15 9.3× 3.43e-12 1.43e-9 ✓ sig.
positive regulation of type II interferon production
BCL3, CCR2, CD14, F2RL1, HLA-DPA1, HLA-DPB1, IL12B, IL18, IL18R1, IL1B, IL1R1, IL2
 GO:0032729 29 / 77 4.0× 1.67e-11 5.91e-9 ✓ sig.
peptide antigen assembly with MHC class II protein complex
HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3
 GO:0002503 13 / 16 8.7× 1.67e-11 5.91e-9 ✓ sig.
positive regulation of inflammatory response
AIM2, CCL24, CCR2, CEBPA, ETS1, HTR2A, IL12B, IL15, IL16, IL18, IL1B, IL1RL1
 GO:0050729 37 / 122 3.2× 5.05e-11 1.58e-8 ✓ sig.
cell surface receptor signaling pathway via JAK-STAT
BRD2, CCL2, CCR2, CD40, CSF2RB, ERBB4, IFNGR1, IFNL3, IL12B, IL4, IL6, IL6R
 GO:0007259 26 / 67 4.2× 8.48e-11 2.52e-8 ✓ sig.
positive regulation of T cell activation
ADA, CARD11, CCL2, CCR2, CD28, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2
 GO:0050870 21 / 45 5.0× 8.70e-11 2.58e-8 ✓ sig.
positive regulation of immune response
FCER1G, GPR31, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA
 GO:0050778 19 / 40 5.1× 4.71e-10 1.16e-7 ✓ sig.
keratinization
HRNR, IVL, KAZN, KRT7, KRT81, KRT86, LCE1C, LCE1D, LCE3E, LCE5A, SHARPIN, SPRR2B
 GO:0031424 26 / 73 3.8× 7.73e-10 1.79e-7 ✓ sig.
positive regulation of angiogenesis
C3, C3AR1, CCL11, CCL24, CCR3, CD40, CHI3L1, CMA1, CXCR3, ETS1, GAB1, GATA4
 GO:0045766 41 / 159 2.8× 1.19e-9 2.64e-7 ✓ sig.
positive regulation of canonical NF-kappaB signal transduction
AKAP13, CARD11, CCR7, CD40, CX3CR1, CYLD, EDN1, EDNRB, F2RL1, FASLG, HLA-DRB1, HMOX1
 GO:0043123 52 / 232 2.4× 1.77e-9 3.74e-7 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Asthma Respiratory system disease 0.153 174 1.46e-149 2.64e-147 ✓ sig.
Eczema Inflammatory skin disease 0.208 76 8.22e-128 1.26e-125 ✓ sig.
Asthma Eczema 0.130 165 6.56e-95 6.53e-93 ✓ sig.
Eczema Respiratory system disease 0.137 73 4.23e-61 2.63e-59 ✓ sig.
Asthma Obstructive pulmonary disease 0.083 125 4.22e-33 1.44e-31 ✓ sig.
Obstructive pulmonary disease Respiratory system disease 0.068 51 4.47e-25 1.10e-23 ✓ sig.
Inflammatory skin disease Intellectual developmental disorder neuropsychiatric 0.013 1 4.94e-3 6.05e-3 ✓ sig.
Eczema Intellectual developmental disorder neuropsychiatric 0.003 1 2.37e-2 2.55e-2 ✓ sig.
neurodevelopmental disorder with spasticity, seizures, and brain abnormalities Obstructive pulmonary disease 0.002 1 3.63e-2 3.83e-2 ✓ sig.